Article
Infectious Diseases
Ayan Ali Ragueh, Mohamed Houmed Aboubaker, Sitani Idriss Mohamed, Jean-Marc Rolain, Seydina M. Diene
Summary: This study investigated the resistance rate to carbapenems among multidrug-resistant Gram-negative bacteria (MDR-GNB) in Djibouti and characterized their resistance mechanisms. The results showed that out of 256 isolates, 20 were resistant to carbapenems. Carbapenemase genes such as bla(OXA-48) and bla(NDM-5) were identified in the isolates.
Article
Infectious Diseases
Mariam Rima, Saoussen Oueslati, Laura Dabos, Dina Daaboul, Hassan Mallat, Elie Bou Raad, Marcel Achkar, Osman Mawlawi, Sandrine Bernabeu, Remy A. Bonnin, Delphine Girlich, Marwan Osman, Monzer Hamze, Thierry Naas
Summary: This study investigated the prevalence of carbapenem-resistant Gram-negative bacilli (CR-GNB) in three hospitals in northern Lebanon between 2015 and 2019. The findings highlighted a concerning situation of carbapenem resistance and emphasized the need for effective registration systems in healthcare centers to limit resistance spread.
Article
Infectious Diseases
M. Cristina Vazquez Guillamet, Christopher Damulira, Andrew Atkinson, Victoria J. Fraser, Scott Micek, Marin H. Kollef
Summary: The combination of aminoglycosides and β-lactams is more effective in reducing the incidence of infections caused by multidrug-resistant Gram-negative bacilli compared to β-lactams alone. This retrospective cohort study analyzed septic patients treated between 2010 and 2017, and found that the addition of aminoglycosides to β-lactams significantly decreased the risk of subsequent infections.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Medicine, Research & Experimental
Xiaojuan Zhang, Shaoyan Qi, Xiaoguang Duan, Bing Han, Shuguang Zhang, Shaohua Liu, Haixu Wang, Haibo Zhang, Tongwen Sun
Summary: This study evaluated the effectiveness and safety of polymyxin B in the treatment of carbapenem-resistant Gram-negative bacilli infections. The results showed positive clinical outcomes, with a relatively high bacteria eradication rate but also significant mortality at 28 days. Adverse reactions, including nephrotoxicity, were observed in a portion of patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
Flora Cruz-Lopez, Adrian Martinez-Melendez, Rayo Morfin-Otero, Eduardo Rodriguez-Noriega, Hector J. Maldonado-Garza, Elvira Garza-Gonzalez
Summary: Infections caused by Gram-negative multi-drug resistant (MDR) bacterial species are difficult to treat due to widespread antibiotic resistance. New antibiotics and combinations with existing drugs have shown potential in treating these infections, but there are reports of resistance to these treatments.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Tsegaye Alemayehu, Solomon Asnake, Bereket Tadesse, Elshaday Azerefegn, Enkosilassie Mitiku, Asnakech Agegnehu, Netsanet Nigussie, Techilo HMariam, Moges Desta
Summary: This study identified carbapenem-resistant gram-negative bacteria in 9% of clinical specimens collected from 103 patients. The majority of bacteria showed high resistance rates to antibiotics such as ampicillin, cefuroxime, and cefotaxime, while lower resistance rates were observed for piperacillin-tazobactam, chloramphenicol, meropenem, and amikacin. Measures should be taken to contain the spread of carbapenem-resistant gram-negative bacteria, and further studies with more robust methods are needed to fully understand the situation of carbapenem resistance.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Microbiology
Shuang Xiao, Qianwen Fu, Youhan Miao, Manna Zhao, Shengwei Lu, Jie Xu, Weifeng Zhao
Summary: This study retrospectively analyzed the data of 139 patients treated with Ceftazidime-Avibactam (CAZ-AVI) for Carbapenem-resistant Gram-negative bacilli (CR-GNB) infections. The results showed that CAZ-AVI had high clinical efficacy and bacterial clearance. Compared to Polymyxin B, CAZ-AVI had better outcomes and lower adverse events. However, there was a 14.6% resistance rate to CAZ-AVI, with Carbapenem-resistant Klebsiella pneumoniae (CRKP) and Carbapenem-resistant Pseudomonas aeruginosa (CRPA) showing resistance rates of 13.5% and 15.4%, respectively.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Min Hao, Yang Yang, Yan Guo, Shi Wu, Fupin Hu, Xiaohua Qin
Summary: Combination therapies with colistin sulfate are recommended for the treatment of carbapenem-resistant Gram-negative bacilli (CR-GNB) infections, as they have better clinical efficacy compared to colistin sulfate monotherapy.
Article
Pharmacology & Pharmacy
Xuedong Jia, Zhao Yin, Wan Zhang, Conghui Guo, Shuzhang Du, Xiaojian Zhang
Summary: This study retrospectively analyzed the use of polymyxin B in Chinese children and found that it can be an effective treatment for CR-GNB infection. However, monitoring of kidney function should be strengthened during treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Orthopedics
Vikas M. Agashe, Rajeev Soman, Camilla Rodrigues, Anjali Shetty, Ayesha Sunavala, Sagar Raghuvanshi, Aditya Menon
Summary: In this retrospective study, the treatment outcomes of 26 patients with carbapenem-resistant Gram-negative infections were analyzed. A multi-disciplinary team approach was utilized, focusing on source control and preventing recurrence. The study found that by modifying treatment goals to salvage lives and achieve infection remission, the majority of patients' lives could be saved.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Microbiology
Alicia Macias-Valcayo, John-Jairo Aguilera-Correa, Antonio Broncano, Raul Parron, Alvaro Aunon, Joaquin Garcia-Canete, Antonio Blanco, Jaime Esteban
Summary: This study analyzed a large number of isolates of Gram-negative bacilli that cause prosthetic joint infection. The study includes biofilm development and antimicrobial susceptibility testing of both planktonic and sessile bacteria. The results obtained support the clinical knowledge about the treatment of these bacteria when biofilms are involved.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
James A. Karlowsky, Sibylle H. Lob, Tsz K. Khan, Wei -Ting Chen, Patrick C. Y. Woo, Wing Hong Seto, Margaret Ip, Stanley W. M. Leung, Queenie W. -L. Wongc, Rene W. Y. Chau, C. Andrew DeRyke, Katherine Young, Mary R. Motyl, Daniel F. Sahm
Summary: This study aimed to estimate carbapenem resistance in Pseudomonas aeruginosa and Enterobacterales isolated from infected patients in intensive care unit (ICU) and non-ICU hospital wards in Hong Kong. The results showed that ceftolozane/tazobactam demonstrated potent in vitro activity against both P. aeruginosa and Enterobacterales, while meropenem and imipenem had lower susceptibility rates. Carbapenemases were rare in both P. aeruginosa and Enterobacterales isolates, and most Enterobacterales had high susceptibility to meropenem and ertapenem.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)
Article
Microbiology
Carmen Antonia Sanches Ito, Larissa Bail, Lavinia Nery Villa Stangler Arend, Kleber Oliveira Silva, Simone Sebold Michelotto, Keite da Silva Nogueira, Felipe Francisco Tuon
Summary: The study evaluated the performance of a new MicroScan Neg multidrug-resistant MIC 1 (NMR1) panel for clinical carbapenem-nonsusceptible Gram-negative bacilli isolates, demonstrating high reliability in detecting ceftazidime-avibactam and ceftolozane-tazobactam. The panel is a viable option for clinical applications, especially for KPC-producing Enterobacterales and carbapenem-nonsusceptible P. aeruginosa.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Review
Immunology
Arsheena Yassin, Mariya Huralska, Jason M. Pogue, Deepali Dixit, Robert G. Sawyer, Keith S. Kaye
Summary: The prevalence of multidrug-resistant gram-negative bacterial infections has significantly increased in the past decade, leading to higher rates of morbidity and mortality. Treating these infections presents challenges, particularly for critically ill patients with limited margin for error. The availability of new therapies has improved treatment options, but optimal clinical and therapeutic approaches for managing these infections still need to be established.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Gunasekaran Rameshkumar, Ranjithkumar Dhandapani, Prajna Lalitha, Siva Ganesa Karthikeyan Rajapandian, Velmurugan Palanivel, Sathiamoorthi Thangavelu, Abdullah A. Alyousef, Thamer Albalawi, Pravej Alam, Mohammad Zubair, Fayez M. Saleh, Fuad Abdullah Alatawi, Fohad M. Husain
Summary: In this study, the prevalence, antibacterial sensitivity patterns, and molecular characterization of MβL associated resistant genes in gram-negative bacteria isolated from ocular infections were investigated. The study found a high prevalence of MβL production in Pseudomonas aeruginosa, leading to high resistance to certain antibiotics. The bla(VIM) gene was also detected at a high rate in eye infections.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Johanna M. Vanegas, Lorena Salazar-Ospina, Gustavo E. Roncancio, J. Natalia Jimenez
Summary: This study found an association between Staphylococcus aureus colonization and bacteremia in hemodialysis patients, as well as a relationship between colonization and infection recurrence. Prompt identification of colonized patients and evaluation of decolonization protocols are essential for managing infections in this population.
AMERICAN JOURNAL OF INFECTION CONTROL
(2021)
Article
Microbiology
Johanna M. Vanegas, Lorena Salazar-Ospina, Marlon A. Gallego, J. Natalia Jimenez
Summary: Colonization by Staphylococcus aureus in hemodialysis patients is dynamic, with a high genetic diversity and frequent acquisition of new clones over time. Factors such as current smoking, Charlson index, and previous S. aureus infection are associated with colonization, which increases the risk of bacteremia.
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
L. Salazar-Ospina, J. M. Vanegas, J. N. Jimenez
Summary: The study found high intermittent colonization of beta-lactam-resistant Gram-negative bacilli in haemodialysis patients, with diverse clones identified. Fluoroquinolone use and chronic obstructive lung disease were associated with colonization by ESBL-producing Gram-negative bacilli.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Immunology
Erika A. Rodriguez, Nancy J. Pino, J. Natalia Jimenez
Summary: In this study conducted in a wastewater treatment plant in Colombia, the abundance of antibiotic resistance genes (ARGs) and their related factors were investigated. The absolute abundance of ARGs was found to be significantly correlated with factors such as temperature, pH, oxygen, and precipitation. Interestingly, a higher absolute abundance of ARGs was observed in the WWTP effluent during the rainy season.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Environmental Sciences
Martha I. Verbel-Olarte, Efraim A. Serna-Galvis, Lorena Salazar-Ospina, J. Natalia Jimenez, Jazmin Porras, Cesar Pulgarin, Ricardo A. Torres-Palma
Summary: Carbapenem-resistant Klebsiella pneumoniae is classified as a critical priority pathogen by the World Health Organization. Effluents from municipal wastewater treatment plants may contribute to the dissemination of K. pneumoniae. In this study, photo-electro-oxidation (PEO) and photo-electro-Fenton (PEF) processes were found to be effective in inactivating K. pneumoniae in simulated EWWTP, with PEO achieving faster inactivation and PEF showing stronger degrading action on the resistance gene.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Urology & Nephrology
Johanna M. Vanegas, Lorena Salazar-Ospina, Gustavo A. Roncancio, Julian Builes, Judy Natalia Jimenez
Summary: The emergence of resistance mechanisms limits treatment options and increases the risk of infections in patients. Two hemodialysis patients were simultaneously colonized and developed bacteremia by multidrug-resistant bacteria.
JORNAL BRASILEIRO DE NEFROLOGIA
(2021)
Article
Multidisciplinary Sciences
Daniela Montoya Urrego, Johanna M. Vanegas, J. Natalia Jimenez
Summary: This study reveals a high prevalence of S. aureus colonization in both hemodialysis patients and their household contacts, and a significant genetic relationship between their isolates. This highlights the importance of implementing prevention strategies outside the hospital to avoid future infections.
Article
Public, Environmental & Occupational Health
Daniela Montoya-Urrego, Sara Tellez-Carrasquilla, Johanna M. Vanegas, Judy Natalia Jimenez Quiceno
Summary: There is a high rate of colonization of BR-GNB in hemodialysis patients and their household contacts, with genetic relationships found between isolates. Potentially pathogenic BR-GBN are present in both hospitals and the community.
EPIDEMIOLOGY AND HEALTH
(2022)
Article
Immunology
G. Torres, K. Vargas, J. Reyes-Velez, N. Jimenez, A. Blanchard, M. Olivera-Angel
Summary: This study aimed to describe the frequency of genotypes of Staphylococcus aureus strains isolated from intramammary infections, as well as to evaluate their ability to form biofilm under in vitro conditions. The results showed the presence of 19 different spa types, with t521, t267, and t605 being the most common. Strains from the t605 spa type exhibited the highest biofilm production. The high frequency of spa types with zoonotic potential suggests that cattle serve as an important reservoir for these clones, posing a risk to individuals in close proximity.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
A. M. Aristizabal-Hoyos, Erika A. Rodriguez, Ricardo A. Torres-Palma, J. Natalia Jimenez
Summary: Hospital wastewater is a major source of antibiotic-resistant bacteria. This study detected a high frequency of beta-lactamase-producing Gram-negative Bacilli in hospital wastewater from different regions of Colombia, even in the presence of wastewater treatment plants, highlighting the importance of regulating these environments in developing countries.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2023)
Article
Infectious Diseases
Daniela Montoya-Urrego, Juan Jose Velasco-Castano, Juan C. Quintero Velez, Natalia Jimenez Quiceno
Summary: This study investigated the knowledge, attitudes, and practices regarding antibiotic use and bacterial resistance among hemodialysis patients and their household contacts in Medellin-Colombia. The findings revealed limited understanding of when antibiotics should be used and gaps in knowledge about antibacterial resistance. Additionally, some participants discontinued antibiotic treatment when they felt better and agreed to keep antibiotics in their homes. It was also common for pharmacists and family members to recommend or sell antibiotics without prescription. The study highlights the importance of increasing awareness about the correct use of antibiotics and the consequences of bacterial resistance among this vulnerable population.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Medicine, General & Internal
Yesid Leandro Torres-Cuadros, Juan Guillermo Velez-Montoya, Johanna Marcela Vanegas-Munera, Gustavo Eduardo Roncancio-Villamil, Judy Natalia Jimenez-Quiceno
Summary: This study found a high susceptibility of Staphylococcus aureus isolates in hemodialysis patients to mupirocin, suggesting its use as prophylactic therapy for high-risk infection patients. The colonization rate of methicillin-resistant isolates was relatively low, but efforts are needed to strengthen the rational use of antibiotics to prevent the spread of resistance mechanisms.