Article
Microbiology
Yiwei Zhu, Jie Chen, Han Shen, Zhongju Chen, Qi-Wen Yang, Jin Zhu, Xi Li, Qing Yang, Feng Zhao, Jingshu Ji, Heng Cai, Yue Li, Linghong Zhang, Sebastian Leptihn, Xiaoting Hua, Yunsong Yu
Summary: Klebsiella pneumoniae carbapenemase (KPC)-producing Pseudomonas aeruginosa (KPC-PA) strains were found in 40.4% of carbapenem-resistant P. aeruginosa (CRPA) isolates, with half of them resistant to ceftazidime-avibactam (CAZ-AVI). Eight plasmid types and two mobile genetic elements mediating bla(KPC-2) transmission were identified through sequencing. Curing bla(KPC-2) plasmids in 28 strains restored CAZ-AVI susceptibility, indicating its role in resistance.
Article
Infectious Diseases
Benjamin Davido, Anne-Claude Cremieux, Isabelle Vaugier, Laure Gatin, Latifa Noussair, Laurent Massias, Frederic Laurent, Azzam Saleh-Mghir
Summary: This study evaluated the efficacy of ceftazidime-avibactam (CAZ-AVI), a novel beta-lactam-beta-lactamase inhibitor, in combination with different antibiotics for the treatment of carbapenemase-producing Enterobacterales (CPE) bone infections. The results demonstrated that the combination of CAZ-AVI with colistin or gentamicin significantly reduced bacterial counts in the bone, achieving a bactericidal effect. CAZ-AVI plus gentamicin was found to be the most effective combination therapy.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Infectious Diseases
Jose Joao Sumbana, Antonella Santona, Nader Abdelmalek, Maura Fiamma, Massimo Deligios, Alice Manjate, Jahit Sacarlal, Salvatore Rubino, Bianca Paglietti
Summary: Globally, antibiotic-resistant Klebsiella spp. cause healthcare-associated infections with high mortality rates. The study investigated the phenotypic and genetic features of Klebsiella isolates from invasive infections in Mozambique. The majority of isolates displayed multidrug resistance, with ESBL-producing strains carrying various beta-lactamase genes. The study also identified susceptible hypervirulent Klebsiella pneumoniae isolates associated with severe infections. The findings highlight the importance of surveillance strategies to prevent the emergence of multidrug-resistant hypervirulent Klebsiella pneumoniae.
Article
Immunology
F. Morales-Leon, A. Opazo-Capurro, C. Caro, N. Lincopan, A. Cardenas-Arias, F. Esposito, V. Illesca, M. L. Rioseco, M. Dominguez-Yevenes, C. A. Lima, H. Bello-Toledo, Gerardo Gonzalez-Rocha
Summary: The convergence of virulence and multidrug-resistant phenotype is reported for the first time in Chile in Klebsiella pneumoniae complex isolates, indicating a clinical problem that requires special attention and continuous surveillance in South America. The detected hypervirulent isolates displayed resistance to broad-spectrum cephalosporins and carried multiple antibiotic-resistance genes, leading to a multidrug-resistant phenotype. In vivo virulence testing confirmed higher virulence of the isolates compared to the control strain.
Article
Infectious Diseases
Esther Wohlfarth, Michael Kresken, Fabian Deuchert, Soeren G. Gatermann, Yvonne Pfeifer, Niels Pfennigwerth, Harald G. Seifert, Paul Higgins, Guido Werner
Summary: Antimicrobial resistance is a global threat to public health. The novel siderophore cephaloporin cefiderocol has shown good in vitro activity against carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacterales. The study identified eight CID-resistant isolates with acquired β-lactamase genes (bla(NDM-1), (bla)(SHV-12)) and naturally occurring bla(OXA-396), (bla)ACT-type, and bla(CMH-3) in A. baumannii, E. cloacae complex, and P. aeruginosa.
Article
Microbiology
Wendy Kloezen, Ria J. Melchers, Panagiota-Christina Georgiou, Johan W. Mouton, Joseph Meletiadis
Summary: The combination of taniborbactam and cefepime showed potent activity against ESBL-producing strains, restoring susceptibility in all Enterobacterales and two-thirds of P. aeruginosa isolates.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Carolina Sabenca, Eliana Costa, Sara Sousa, Lillian Barros, Ana Oliveira, Sonia Ramos, Gilberto Igrejas, Carmen Torres, Patricia Poeta
Summary: The emergence of Klebsiella pneumoniae strains producing ESBL and KPC has become a major public health concern. The ability of these strains to form biofilms is worrisome as it can facilitate the spread of antibiotic resistance and prolong infections in healthcare facilities.
Article
Immunology
Pranita D. Tamma, Samuel L. Aitken, Robert A. Bonomo, Amy J. Mathers, David van Duin, Cornelius J. Clancy
Summary: This guidance document provides recommendations for the treatment of antimicrobial-resistant infections caused by ESBL-E, CRE, and DTR-P. aeruginosa, with a focus on the United States. It discusses empiric treatment selection, duration of therapy, and other management considerations for both adults and children. The current version of the guidance is valid as of September 17, 2020, and will be updated periodically.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Samanta Freire, Teresa Grilo, Bruna Rodrigues, Rui Oliveira, Carla Esteves, Antonio Marques, Laurent Poirel, Marta Aires-de-Sousa
Summary: This study aimed to analyze the occurrence and characteristics of ESBL- and carbapenemase-producing E. coli among bivalves. Out of 522 collected bivalve samples, E. coli growth was observed in 39% of the samples. Nine samples (4.4%) were contaminated with ESBL producers and one sample (0.5%) was contaminated with a carbapenemase-producing K. pneumoniae. The presence of ESBL- and carbapenemase-producing Enterobacteriaceae in bivalves indicates that the marine environment could be a reservoir of critical bacterial pathogens, posing a potential risk to human health.
Article
Infectious Diseases
Peng Lan, Ye Lu, Yan Jiang, Xueqing Wu, Yunsong Yu, Jiancang Zhou
Summary: Cefiderocol, a cephalosporin antibiotic, exhibits expanded antimicrobial activity. CirA1 has higher iron-transporting ability than CirA198, leading to increased susceptibility to Cefiderocol.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Infectious Diseases
Miki Takemura, Mark G. Wise, Meredith A. Hackel, Daniel F. Sahm, Yoshinori Yamano
Summary: This study evaluated the in vitro antibacterial activity of siderophore cephalosporin cefiderocol against MBL-producing clinical isolates. The results showed that cefiderocol exhibited potent in vitro activity against MBL-producing strains of different bacterial species.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Engineering, Multidisciplinary
Cemile Bagkur, Emrah Guler, Bilgen Kaymakamzade, Evren Hincal, Kaya Suer
Summary: While antibiotic resistance is a growing concern, this study focuses on the future clinical situation of ESBL-producing K. pneumoniae. By using mathematical modeling, the study evaluates the severity of the issue and identifies critical points to prevent the spread of the ESBL-producing strain. The results show that the use of antibiotics and hospital admissions play a major role in the spread of ESBL-producing K. pneumoniae, and recovery from infections is the most effective way to limit its spread.
CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES
(2022)
Article
Infectious Diseases
Katie A. Parsels, Keri A. Mastro, Jeffrey M. Steele, Stephen J. Thomas, Wesley D. Kufel
Summary: Cefiderocol is a novel siderophore cephalosporin that has shown activity against clinically relevant MDR Gram-negative bacteria. FDA-approved indications include complicated urinary tract infections and hospital-acquired bacterial pneumonia. Clinical trials have demonstrated non-inferiority to standard treatments, but higher all-cause mortality was observed in certain cases.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Immunology
Lisandra Aguilar-Bultet, Claudia Bagutti, Adrian Egli, Monica Alt, Laura Maurer Pekerman, Ruth Schindler, Reto Furger, Lucas Eichenberger, Tim Roloff, Ingrid Steffen, Philipp Huebner, Tanja Stadler, Sarah Tschudin-Sutter
Summary: This report describes a cluster of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae sequence type 101, derived from 1 poultry and 2 clinical samples collected within the setting of a prospective study designed to determine the diversity and migration of ESBL-producing Enterobacterales between humans, foodstuffs, and wastewater.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
F. Gravey, S. Wilson, A. Denisenko, C. Lehoussel, Marguerite Fines-Guyon, S. Le Hello, C. Jeanne-Leroyer
Summary: Whole genome sequencing is now the standard method used for microbiological investigations, enabling the detection of undisclosed outbreaks. By utilizing this approach, we were able to investigate and ultimately halt an uncommon epidemic caused by the extended-spectrum beta-lactamase-producing Klebsiella pneumoniae ST584 strain that spanned over four months in two intensive care units.
Article
Critical Care Medicine
K. Chandra Vemulapalli, Guillermo R. Pechero, Stephen J. Warner, Timothy S. Achor, Joshua L. Gary, John W. Munz, Andrew M. Choo, Mark L. Prasarn, Milton L. Chip Routt
Summary: This study compared the outcomes of complete articular distal femur fractures treated with lateral locked plating (LLP) versus retrograde intramedullary nailing (rIMN). The results showed a higher nonunion rate and coronal plane malalignment with LLP compared to rIMN.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Critical Care Medicine
Jacob A. Heiner, Katherine A. Banner, Victor J. Wu, Timothy S. Achor, Joshua L. Gary, John W. Munz, Andrew M. Choo, James F. Kellam, Stephen J. Warner
Summary: This retrospective case series analyzed 61 cases of open pilon fractures in 60 patients, finding that factors such as bone loss grade, fall height, articular surface condition, and segmental fibula fracture were associated with early amputations and major wound complications.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Orthopedics
Joseph F. Levy, Lisa Reider, Daniel O. Scharfstein, Andrew N. Pollak, Saam Morshed, Reza Firoozabadi, Kristin R. Archer, Joshua L. Gary, Robert O'Toole, Renan C. Castillo, Stephen M. Quinnan, Laurence B. Kempton, Clifford B. Jones, Michael J. Bosse, Ellen J. MacKenzie
Summary: This study examined the work and productivity loss associated with lower extremity trauma and calculated the economic losses. The results showed that patients with severe lower extremity trauma carried a significant economic burden, with a total economic loss of $64,427 per patient in one year. The majority of lost work hours were due to unemployment, followed by absenteeism and decreased productivity while working. Older adults, men, those with physically demanding jobs, and those with more severe injuries experienced higher productivity loss.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Orthopedics
Todd O. McKinley, Greg E. Gaski, Timothy R. Billiar, Yoram Vodovotz, Krista M. Brown, Eric A. Elster, Greg M. Constantine, Seth A. Schobel, Henry T. Robertson, Ashley D. Meagher, Reza Firoozabadi, Joshua L. Gary, Robert O'Toole, Arun Aneja, Karen M. Trochez, Laurence B. Kempton, Scott D. Steenburg, Susan C. Collins, Katherine P. Frey, Renan C. Castillo
Summary: This study aims to develop precision medicine approach in managing multiply injured patients by quantifying patient-specific indices and predicting outcomes and guiding intervention decisions.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2022)
Article
Orthopedics
Kristin R. Archer, Claudia A. Davidson, Dana Alkhoury, Susan W. Vanston, Tanisha L. Moore, Andrea Deluca, Joshua F. Betz, Richard E. Thompson, William T. Obremskey, Gerard P. Slobogean, Danielle H. Melton, Jason M. Wilken, Madhav A. Karunakar, Jessica C. Rivera, Hassan R. Mir, Todd O. McKinley, Katherine P. Frey, Renan C. Castillo, Stephen T. Wegener
Summary: Physical and psychological impairment resulting from traumatic injuries affects employment and functional independence. Extremity trauma negatively affects long-term physical function, work ability, recreational activities, and mental health. Pain levels and psychosocial factors play a crucial role in recovery.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2022)
Article
Orthopedics
Daniel J. Stinner, Jessica C. Rivera, Christopher S. Smith, David B. Weiss, Robert A. Hymes, Paul E. Matuszewski, Joshua L. Gary, Saam Morshed, Andrew H. Schmidt, Jason M. Wilken, Kristin R. Archer, Lane Bailey, Jacquelyn Kleihege, Kevin H. McLaughlin, Richard E. Thompson, Suna Chung, Craig Remenapp, Ellen J. MacKenzie, Lisa Reider
Summary: In current clinical practice, restricting weight-bearing after lower extremity periarticular fractures has negative effects on bone healing and limb function. Antigravity treadmill therapy allows patients to safely load the limb during therapy, reducing the negative consequences of non-weight-bearing. A randomized controlled trial aims to compare outcomes between patients receiving antigravity treadmill therapy and standard care for periarticular fractures, hypothesizing that the former group will report better function after 6 months.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2022)
Article
Orthopedics
Anthony R. Carlini, Susan C. Collins, Elena D. Staguhn, Katherine P. Frey, Robert O'Toole, Kristin R. Archer, William T. Obremskey, Julie Agel, Conor P. Kleweno, Saam Morshed, Michael J. Weaver, Thomas F. Higgins, Michael J. Bosse, Joseph F. Levy, Albert W. Wu, Renan C. Castillo
Summary: The feasibility of using PROMIS tools in a large multicenter trauma orthopaedics research setting was examined. Efficient assessment of various domains is critically important for the successful completion of future large-scale trials.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2022)
Article
Emergency Medicine
Abdulai Bangura, Cynthia E. Burke, Blessing Enobun, Nathan N. O'Hara, Joshua L. Gary, Doug Floccare, Timothy Chizmar, Andrew N. Pollak, Gerard P. Slobogean
Summary: The adoption of prehospital pelvic circumferential compression devices (PCCDs) by emergency medical services (EMS) systems in the United States is slow and variable. This study found wide practice variation in the use of prehospital PCCDs, and no clinical benefits were identified in terms of early hemorrhagic shock outcomes.
PREHOSPITAL EMERGENCY CARE
(2023)
Article
Orthopedics
Javad Parvizi
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Orthopedics
Krishna Chandra Vemulapalli, David A. Zuelzer, Heba A. Ahmad, Stephen J. Warner, Milton L. Chip Routt, Joshua L. Gary
Summary: This study compared the posterior acetabular exposure achieved with the Kocher-Langenbeck (K-L) and Gibson approaches. Results showed that the exposure with the K-L approach was higher than the Gibson approach before gluteus minimus debridement. However, after debridement, the K-L approach provided significantly increased exposure, similar to the Gibson approach.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2022)
Article
Orthopedics
Patrick J. Kellam, Dillon C. O'Neill, Joshua R. Daryoush, Graham J. Dekeyser, Lillia N. Steffenson, Joshua L. Gary, Thomas F. Higgins, James F. Kellam, David L. Rothberg, Marcus Sciadini, Stephen Warner, Zachary Working, Lucas S. Marchand, Justin M. Haller
Summary: Reformatted CT scans can increase surgeons' confidence in placing a trans sacral screw, especially in patients with evidence of sacral dysplasia.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2022)
Article
Orthopedics
Brennan Roper, Heba Ahmad, Joshua L. L. Gary
Summary: Ankle fractures are a common occurrence and often require surgical treatment. The limited soft tissue surrounding the ankle bones can benefit from delaying definitive fixation to minimize complications. Temporary fixation using external fixation techniques can be used to maintain alignment before definitive fixation. However, these techniques may not directly restore fibular length and rotation, requiring additional internal fixation.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2023)
Article
Orthopedics
Nathan N. O'Hara, Renan C. Castillo, Anthony R. Carlini, Manjari Joshi, Clinton K. Murray, Lauren E. Allen, Yanjie Huang, Joshua L. Gary, Michael J. Bosse, William T. Obremskey, Todd O. McKinley, Andrew H. Schmidt, Robert O'Toole
Summary: A secondary analysis using Bayesian methods in a randomized clinical trial conducted in 36 US trauma centers found that intrawound vancomycin powder can significantly reduce the risk of deep surgical site infections in patients with tibial plateau or pilon fractures who are at high risk of infection, especially in reducing infections caused by gram-positive pathogens.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2023)
Article
Orthopedics
Joseph T. Patterson, Nathan N. O'Hara, Daniel O. Scharfstein, Renan C. Castillo, Robert O'Toole, Reza Firoozabadi
Summary: Superficial infection after open reduction and internal fixation of tibial plateau and pilon fractures does not commonly lead to deep infection requiring surgical debridement. The association between superficial infection and subsequent deep infection remains inconclusive in this study.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)
Article
Infectious Diseases
Truc T. Tran, Nicolo L. Cabrera, Anne J. Gonzales-Luna, Travis J. Carlson, Faris Alnezary, William R. Miller, Aki Sakurai, An Q. Dinh, Kirsten Rydell, Rafael Rios, Lorena Diaz, Blake M. Hanson, Jose M. Munita, Claudia Pedroza, Samuel A. Shelburne, Samuel L. Aitken, Kevin W. Garey, Ryan Dillon, Laura Puzniak, Cesar A. Arias
Summary: A multicentre retrospective study was conducted in Houston, Texas, USA to evaluate the utilization of ceftolozane/tazobactam in treating bacterial infections. Out of 263 patients enrolled, 70.3% achieved composite clinical success, with severity of illness being the most consistent predictor. Combination therapy with ceftolozane/tazobactam and another Gram-negative-active agent was associated with reduced odds of clinical success.
JAC-ANTIMICROBIAL RESISTANCE
(2022)
