期刊
ANTICANCER RESEARCH
卷 40, 期 1, 页码 9-26出版社
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.13922
关键词
Apoptosis; epithelial-to-mesenchymal transition; breast cancer; cancer epigenetics; DNMT inhibitors; HDAC inhibitors; phytochemicals
类别
资金
- National Cancer Institute [R01 CA178441, R01 CA204346]
- Susan G. Komen Graduate Training in Disparities Research National Award [GTDR15329376]
Background/Aim: Inhibition of apoptosis is one of the hallmarks of cancer, and anti-apoptotic genes are often targets of genetic and epigenetic alterations. Cellular inhibitor of apoptosis 2 (cIAP2) has a role in degrading caspases by linking them to ubiquitin molecules, and is upregulated in triple-negative breast cancer (TNBC). Previous studies have demonstrated that cIAP2 may play a role in the epithelial-to-mesenchymal transition (EMT). Materials and Methods: Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase (HDAC) inhibitor, was administered to triple-negative breast cancer ( TNBC) cells alone or in combination with epigallocatechin-3-gallate (EGCG), a DNA methyltransferase (DNMT) inhibitor isolated from green tea. Results: The compounds were able to decrease the expression of cIAP2 while increasing the expression of pro-apoptotic caspase 7. There were also changes in histone modifications, suggesting a role of epigenetic mechanisms in these changes in expression of cIAP2. These changes resulted in an increase in apoptosis. SAHA and EGCG were also capable of limiting TNBC cell migration across a fibronectin (FN) matrix. Conclusion: SAHA and EGCG reduce the metastatic potential of TNBC by inducing the apoptotic pathway.
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