期刊
ANNUAL REVIEW OF BIOPHYSICS, VOL 49, 2020
卷 49, 期 -, 页码 181-197出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biophys-070317-032939
关键词
epistasis; regulation networks; evolutionary constraint; gene regulation; pleiotropy; prediction
资金
- Netherlands Organization for Scientific Research (NWO)
- European Research Council (ERC) under the European Union [758132]
- European Research Council (ERC) [758132] Funding Source: European Research Council (ERC)
The limits of evolution have long fascinated biologists. However, the causes of evolutionary constraint have remained elusive due to a poor mechanistic understanding of studied phenotypes. Recently, a range of innovative approaches have leveraged mechanistic information on regulatory networks and cellular biology. These methods combine systems biology models with population and single-cell quantification and with new genetic tools, and they have been applied to a range of complex cellular functions and engineered networks. In this article, we review these developments, which are revealing the mechanistic causes of epistasis at different levels of biological organization-in molecular recognition, within a single regulatory network, and between different networks-providing first indications of predictable features of evolutionary constraint.
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