Article
Surgery
Ryan Petrucci, Michael Papanikolas, Andrew Gilmore
Summary: This study reports the short-term results of side-to-side isoperistaltic stricturoplasty (SSIS) for long segment stricturing Crohn's disease in Australia. The SSIS technique is safe and effective, with few surgical complications. Surgeons in Australia should consider using Michelassi stricturoplasty and its variants for the management of long Crohn's strictures.
ANZ JOURNAL OF SURGERY
(2023)
Article
Surgery
Imerio Angriman, Silvia Degasperi, Claudia Mescoli, Carmelo Lacognata, Claudia Armellin, Antonino Caruso, Federico Scognamiglio, Matteo Fassan, Renata D'Inca, Edoardo Savarino, Fabiana Zingone, Gaya Spolverato, Salvatore Pucciarelli, Romeo Bardini, Cesare Ruffolo, Marco Scarpa
Summary: This retrospective study analyzed the intestinal and systemic inflammation after surgery in Crohn's disease patients with strictures where the diseased bowel was left behind. The results showed that the intestinal inflammatory activity decreased even with the preservation of the diseased bowel, but the presence of the diseased bowel increased the risk of reoperation.
Review
Gastroenterology & Hepatology
Bo Shen
Summary: Endoscopic therapy has become the main treatment for inflammatory bowel diseases and associated complications, such as strictures, fistulas, abscesses, bleeding lesions, and polyps. The development of interventional IBD is supported by a better understanding of the disease process, advancements in endoscopic technology, and the training of next-generation specialists.
GASTROENTEROLOGY REPORT
(2022)
Article
Gastroenterology & Hepatology
Gianluca M. Sampietro, Francesco Colombo, Alice Frontali, Caterina Baldi, Lorenzo Conti, Dario Dilillo, Francesca Penagini, Manuela Nebuloni, Francesca D'Addio, Paolo Fiorina, Giovanni Maconi, Fabio Corsi, Gianvincenzo Zuccotti, Sandro Ardizzone, Diego Foschi
Summary: This study aimed to investigate the feasibility and safety of conventional and non-conventional strictureplasties for complicated Crohn's Disease using laparoscopy. The results showed that both SP and NCSP can be performed laparoscopically with low morbidity rates.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
Gabriele Bislenghi, Steffen Fieuws, Albert Wolthuis, Dirk Vanbeckevoort, Marc Ferrante, Joao Sabino, Severine Vermeire, Andre D'Hoore
Summary: This study compared modified side-to-side isoperistaltic strictureplasty (mSSIS) with traditional ileocecal resection for extensive Crohn's disease terminal ileitis. The results showed that mSSIS seems to be non-inferior in terms of safety, recurrence, and durability to traditional resections, with the added advantage of reducing the risk of short bowel syndrome. Larger prospective studies are needed to confirm these findings.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
Yipeng Zhu, Wenwei Qian, Liangyu Huang, Yihan Xu, Zhen Guo, Lei Cao, Jianfeng Gong, J. Calvin Coffey, Bo Shen, Yi Li, Weiming Zhu
Summary: This study found that including the mesentery in colorectal surgery for patients with Crohn's colitis (CC) was associated with similar short-term outcomes and improved long-term outcomes compared to retaining the mesentery.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
G. Bislenghi, F. Sucameli, S. Fieuws, M. Ferrante, J. Sabino, A. Wolthuis, S. Vermeire, A. D'Hoore
Summary: Non-conventional SXP did not differ from conventional SXP in terms of safety and long-term recurrence when treating Crohn's disease.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Thomas Chateau, Ferdinando Damico, Camille Zallot, Nicolas Mathieu, Laurent Peyrin-Biroulet
Summary: This study investigated the characteristics of patients with Crohn's disease only visible on small bowel capsule endoscopy (SBCE), finding it to be a rare condition with a more favorable disease course and treatment outcomes compared to general Crohn's disease.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Ayseguel Aksan, Karima Farrag, Irina Blumenstein, Oliver Schroeder, Axel U. Dignass, Juergen Stein
Summary: Chronic intestinal failure, a rare complication of Crohn's disease, can greatly impact quality of life and treatment options include home-based parenteral nutrition and intravenous infusion. However, 60% of patients may need lifelong reliance on parenteral nutrition, and promising new drugs have brought new dimensions to therapy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Aito Ueno, Humberto B. Jijon, Richard Peng, Steven Sparksman, Barbara Mainoli, Alexis Filyk, Yan Li, Stephanie Wilson, Kerri Novak, Remo Panaccione, Simon Hirota, Antoine Dufour, Cathy Lu, Paul L. Beck
Summary: This study provides evidence supporting a potential role of fibrocytes in collagen deposition in Crohn's disease strictures and suggests that fibrocyte numbers may predict the need for therapy escalation.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Robert H. Hollis, Nicholas Smith, Ipek Sapci, Benjamin Click, Miguel Regueiro, Tracy L. Hull, Amy L. Lightner
Summary: This retrospective cohort study found that over one third of patients who underwent total proctocolectomy for Crohn's disease were estimated to have small bowel Crohn's recurrence at 5 years after surgery. Patients with a history of small bowel surgery for Crohn's and diagnosis at any early age may have a higher risk of recurrence.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Surgery
Sandra L. Kavalukas, Katharina M. Scheurlen, Susan Galandiuk
Summary: The management of Crohn's disease has significantly changed over the past 20 years, with the introduction of biologic therapies and new surgical techniques leading to improved outcomes and reduced rates of surgery for refractory disease. This article provides an overview of these advancements, with a focus on terminal ileal and ileocolic disease in the first part of a three-part series.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Review
Gastroenterology & Hepatology
Joseph Sleiman, Sara El Ouali, Taha Qazi, Benjamin Cohen, Scott R. Steele, Mark E. Baker, Florian Rieder
Summary: Fibrostenosis is a major feature of Crohn's disease (CD) and poses a challenge in the clinical management of inflammatory bowel disease patients. While there are no specific therapies to prevent or treat fibrosis in CD currently, efforts are being made to standardize definitions and propose endpoints for better management, along with research to develop future anti-fibrotic therapies.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Engineering, Biomedical
Jingbo Zhao, Donghua Liao, Rune Wilkens, Klaus Krogh, Henning Glerup, Hans Gregersen
Summary: This study aimed to quantify the mechanical properties of intestinal stenosis in CD patients and found that the changes in mechanical properties were mainly associated with chronic inflammation, fibrosis, and collagen fraction.
ACTA BIOMATERIALIA
(2021)
Article
Surgery
Wenhao Chen, Junjie Zhou, Min Chen, Congqing Jiang, Qun Qian, Zhao Ding
Summary: This study suggests that isoperistaltic side-to-side anastomosis (ISSA) may be more effective in reducing postoperative recurrence in Crohn's disease patients compared to antiperistaltic side-to-side anastomosis (ASSA). While no significant differences were observed in safety issues between the two groups, the ISSA group showed a lower rate of endoscopic recurrence within 24 months postoperatively.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2022)