Review
Biochemistry & Molecular Biology
Matej Vicen, Ivone Cristina Igreja Sa, Katarina Tripska, Barbora Vitverova, Iveta Najmanova, Samira Eissazadeh, Stanislav Micuda, Petr Nachtigal
Summary: Membrane endoglin (Eng) and soluble endoglin (sEng) play important roles in metabolic syndrome-related disorders, including endothelial dysfunction, arterial hypertension, hyperglycemia, and diabetes. Reduced Eng expression is a hallmark of chronic pathologies related to metabolic syndrome, while sEng is considered a biomarker of preeclampsia.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Medicine, General & Internal
Veronika Tomaskova, Alexandra Mytnikova, Marcela Hortova Kohoutkova, Ondrej Mrkva, Monika Skotakova, Michal Sitina, Katerina Helanova, Jan Fric, Jiri Parenica, Vladimir Sramek, Martin Helan
Summary: This study examined the ability of sEng to predict mortality and its correlation with other clinical characteristics in septic shock patients and severe COVID-19 patients. The results showed that sEng was not predictive of mortality or correlated with organ dysfunction markers in COVID-19 patients. However, in septic shock patients, sEng levels were significantly higher in patients with early mortality and correlated with signs of circulatory failure.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Aleksandra Klisic, Dimitrios Patoulias
Summary: Discovered twenty years ago, endocan is still an intriguing biomarker associated with inflammation. It is a soluble dermatan sulphate proteoglycan secreted by endothelial cells and expressed in tissues related to enhanced proliferation. Endocan has been extensively studied in various cardiometabolic disorders, such as type 2 diabetes, hypertension, atherosclerosis, kidney disease, obesity, polycystic ovary syndrome, metabolic syndrome, and fatty liver disease. Understanding the role of endocan in these disorders is important for developing potential therapeutic strategies to delay or prevent related complications.
Review
Cardiac & Cardiovascular Systems
Jinzhi Chen, Liping Jiang, Xiao-Hua Yu, Mi Hu, Yang-Kai Zhang, Xin Liu, Pingping He, Xinping Ouyang
Summary: Endocan, also known as endothelial cell specific molecule-1, is a soluble proteoglycan mainly secreted by endothelial cells. Increased plasma levels of endocan may reflect endothelial activation and dysfunction, and are considered a potential immuno-inflammatory marker related to cardiovascular disease. Endocan shows promise as a prognostic biomarker for cardiovascular disease, but further research into its mechanisms of action is needed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Serap Ozer Yaman, Fulya Balaban Yucesan, Cihan Orem, Birgul Vanizor Kural, Asim Orem
Summary: This study aimed to investigate the circulating levels of endocan in PPL subjects and determine its association with endothelial and inflammatory factors. The results showed that the levels of endocan were significantly higher in PPL subjects and positively correlated with other endothelial and inflammation factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jakub Kornacki, Pawel Gutaj, Anastasia Kalantarova, Rafal Sibiak, Maurycy Jankowski, Ewa Wender-Ozegowska
Summary: The endothelium, crucial in various physiological functions, undergoes changes during pregnancy that are associated with gestational complications. Research is needed to elucidate mechanisms, find specific clinical markers, and incorporate them into predictive models for improved prognostic value. Further studies are required to fine-tune clinical markers and explore therapeutic techniques for preventing or reversing endothelial damage.
Review
Cell Biology
Shuo Feng, Jia Wei Chen, Xin Yi Shu, Muladili Aihemaiti, Jin Wei Quan, Lin Lu, Rui Yan Zhang, Chen Die Yang, Xiao Qun Wang
Summary: Hemodynamic shear stress (SS) regulates vascular homeostasis and injury through the release of endothelial microparticles (EMP), affecting physiological function of endothelial cells, inflammatory response, vascular permeability, and the coagulation system.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Microbiology
Carlos Alonso Dominguez-Aleman, Luis Alberto Sanchez-Vargas, Karina Guadalupe Hernandez-Flores, Andrea Isabel Torres-Zugaide, Arturo Reyes-Sandoval, Leticia Cedillo-Barron, Ricardo Remes-Ruiz, Hector Vivanco-Cid
Summary: The study found that recombinant NS1 proteins can promote the expression and release of the endothelial cell activation marker endocan, and increase its levels within cells. These findings help us to further understand the dysfunction of vascular endothelial cells in dengue virus infections.
Article
Medicine, General & Internal
Katarina Tripska, Ivone Cristina Igreja Sa, Martina Vasinova, Matej Vicen, Radim Havelek, Samira Eissazadeh, Zuzana Svobodova, Barbora Vitverova, Charles Theuer, Carmelo Bernabeu, Petr Nachtigal
Summary: This study found that blocking the endoglin receptor using TRC105 can counteract endothelial dysfunction induced by high cholesterol and high glucose, suggesting that endoglin may be a potential therapeutic target for disorders associated with elevated cholesterol and glucose levels.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chrysi Keskinidou, Alice G. Vassiliou, Edison Jahaj, Zafeiria Mastora, Nikolaos Athanasiou, Anastasia Roumpaki, Stamatios Tsipilis, Ioanna Dimopoulou, Stylianos E. Orfanos, Anastasia Kotanidou
Summary: Aging negatively affects the endothelium. Endocan (ESM-1), an endothelium-derived soluble proteoglycan, plays a role in endothelial dysfunction and age-related outcomes in critical illness. ESM-1 levels were measured in different groups of critically ill patients, and it was found that COVID-19 patients had higher ESM-1 levels compared to septic and non-septic patients. The prognostic ability of ESM-1 was influenced by age and the extent of endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Axel Haarmann, Christoph Vollmuth, Alexander M. M. Kollikowski, Peter U. U. Heuschmann, Mirko Pham, Guido Stoll, Hermann Neugebauer, Michael K. K. Schuhmann
Summary: Now that mechanical thrombectomy has improved outcomes after large-vessel occlusion stroke, the focus is on futile reperfusion. Unfortunately, blood-based biomarkers that identify compromised yet reperfused tissue are lacking. In this study, soluble endoglin was identified as a potential biomarker for severe ischemia with recanalization/reperfusion, as its concentrations were significantly higher in patients with successful recanalization and indicated larger infarct volumes at admission.
Article
Peripheral Vascular Disease
Filiz Mercantepe, Serap Baydur Sahin, Medine Cumhur Cure, Zakir Karadag
Summary: The study aimed to investigate the correlation between serum Endocan levels and the presence and severity of endothelial dysfunction, as well as its relationships with other markers. The results showed no correlation between serum Endocan values and endothelial dysfunction markers in obese women.
Article
Cardiac & Cardiovascular Systems
Takahiko Kiyooka, Vahagn Ohanyan, Liya Yin, Yuh Fen Pung, Yeong-Renn Chen, Chwen-Lih Chen, Patrick T. Kang, James P. Hardwick, June Yun, Danielle Janota, Joanna Peng, Christopher Kolz, Giacinta Guarini, Glenn Wilson, Inna Shokolenko, Donte A. Stevens, William M. Chilian
Summary: Endothelial dysfunction in diabetes is mainly attributed to impaired mitochondrial function, not just the result of oxidative stress. Restoring mitochondrial function can reverse endothelial dysfunction, indicating the critical role of mitochondrial function in endothelium-dependent vasodilation.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Daniele Santi, Giorgia Spaggiari, Carla Greco, Clara Lazzaretti, Elia Paradiso, Livio Casarini, Francesco Poti, Giulia Brigante, Manuela Simoni
Summary: Endothelial dysfunction is an early indicator of atherosclerosis and cardiovascular diseases, while also playing a crucial role in human fertility and reproduction. Evaluating markers of endothelial health is essential for clinical practice and research, shedding light on the connection between endothelial and reproductive health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ronodeep Mitra, Alina Nersesyan, Kaleigh Pentland, M. Mark Melin, Robert M. Levy, Eno E. Ebong
Summary: The endothelial glycocalyx (GCX), a protective covering for endothelial cells, plays an important role in maintaining endothelial function. This study investigated the effect of diosmin on GCX integrity and endothelial function in a mouse model. The results showed that diosmin treatment improved GCX coverage, reduced inflammation, and restored vascular tone. These findings suggest that diosmin may be a potential therapy for endothelial dysfunction.
Review
Cardiac & Cardiovascular Systems
Pedro Vaz-Salvador, Rui Adao, Ines Vasconcelos, Adelino F. Leite-Moreira, Carmen Bras-Silva
Summary: While guidelines for heart failure with reduced ejection fraction (HFrEF) have led to improved survival, treatment options for heart failure with preserved ejection fraction (HFpEF) remain limited. This review summarizes recent clinical trial results for HFpEF and discusses the challenges in developing new pharmacotherapeutic options.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Nursing
Fernando Mendonca, Joao Sergio Neves, Maria Manuel Silva, Daniela Salazar, Maria Joao Ferreira, Vanessa Guerreiro, Jorge Pedro, Ana Varela, Selma Souto, Eva Lau, John Preto, Paula Freitas, Davide Carvalho
Summary: Type 2 diabetes status is associated with a significant increase in PTH levels during the first 36 months after bariatric surgery, but there are no significant variations in Ca and VitD levels.
BARIATRIC SURGICAL PRACTICE AND PATIENT CARE
(2022)
Article
Endocrinology & Metabolism
Joao Pedro Ferreira, Francisco Vasques-Novoa, Diana Ferrao, Francisca Saraiva, Ines Falcao-Pires, Joao Sergio Neves, Abhinav Sharma, Patrick Rossignol, Faiez Zannad, Adelino Leite-Moreira
Summary: In patients with type 2 diabetes treated with simvastatin, fenofibrate can reduce the composite outcome of heart failure hospitalizations or cardiovascular mortality, with a more significant effect observed in patients receiving standard background glucose-lowering therapy.
Article
Endocrinology & Metabolism
Joao Sergio Neves, Francisco Vasques-Novoa, Marta Borges-Canha, Ana Rita Leite, Abhinav Sharma, Davide Carvalho, Milton Packer, Faiez Zannad, Adelino Leite-Moreira, Joao Pedro Ferreira
Summary: In patients with HFrEF, the use of liraglutide may increase the risk of cardiovascular adverse effects, possibly driven by an increased risk of arrhythmias and worsening heart failure events. These results should be interpreted as exploratory and hypothesis-generating, and further randomized controlled trials are needed before drawing definitive conclusions.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Joao Pedro Ferreira, Francisca Saraiva, Abhinav Sharma, Francisco Vasques-Novoa, Antonio Angelico-Goncalves, Ana Rita Leite, Marta Borges-Canha, Davide Carvalho, Milton Packer, Faiez Zannad, Adelino Leite-Moreira, Joao Sergio Neves
Summary: This meta-analysis aims to assess the effect of GLP1-RA on heart failure in patients with and without a history of HF. The results showed that GLP1-RA can reduce the risk of HF and mortality in T2D patients without a history of HF. However, the effect of GLP1-RA on HF in patients with a history of HF was not significant.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Joaeo Sergio Neves, Milton Packer, Joaeo Pedro Ferreira
JOURNAL OF CARDIAC FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Andreas S. Papazoglou, Ana Rita Leite
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Marta Nascimento Soares, Marta Borges-Canha, Celestino Neves, Joao Sergio Neves, Davide Carvalho
Summary: The prevalence of thyroid nodules and cancer in patients with Graves' disease was evaluated in a retrospective observational study. It was found that patients with multiple and larger nodules had a greater risk of thyroid cancer diagnosis, with most cases being low-grade papillary thyroid cancer. Further studies are needed to clarify the clinical relevance of these findings.
EUROPEAN THYROID JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Ana Filipa Ferreira, Maria Joao Azevedo, Juliana Morais, Fabio Trindade, Francisca Saraiva, Silvia Oliveira Diaz, Ines Nuno Alves, Mariana Fragao-Marques, Carla Sousa, Ana Paula Machado, Adelino Leite-Moreira, Benedita Sampaio-Maia, Carla Ramalho, Antonio Sousa Barros, Ines Falcao-Marques
Summary: Pregnant women with cardiovascular risk factors are at high risk of developing cardiovascular disease later in life. Our study found that pregnant women undergo cardiovascular remodeling during pregnancy, which reverses after delivery. Arterial hypertension, smoking, and obesity are independent predictors of increased left ventricular mass. Additionally, circulating biomarkers such as C-reactive protein and ST2/IL33 receptors may be associated with worse cardiac remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Mariana Ornelas, Marta Borges-Canha, Pedro Gouveia, Margarida Ferreira, Eduarda Resende, Maritza Sa, Silvestre Abreu
Summary: This retrospective observational study found an association between the development of endocrine-related adverse effects (ERAE) and mortality in patients undergoing immunotherapy. The study showed a significant negative association between ERAE development and death. However, no associations were found between ERAE and characteristics such as age, sex, diabetes, medical history, immunotherapy duration, and immune checkpoint inhibitor type.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Ana Rita Leite, Joao Sergio Neves, Antonio Angelico-Goncalves, Francisco Vasques-Novoa, Francisca A. Saraiva, Ines Beatriz Pinho, Ana Cristina Oliveira, Marta Borges-Canha, Madalena von Hafe, Catarina Vale, Andre P. Lourenco, Filipe Macedo, Jose Paulo Araujo, Pedro von Hafe, Jorge Almeida, Joao Pedro Ferreira, Adelino Leite-Moreira
Summary: Decreased FT4 to FT3 conversion is associated with clinical features such as increased body fat, elevated pulmonary arterial systolic pressure, and reduced left ventricular ejection fraction in patients with HFpEF. Lower FT3/FT4 ratio predicts a higher risk of diuretic intensification, urgent HF visits, HF hospitalization, or cardiovascular death.
Article
Endocrinology & Metabolism
Carolina Sousa, Joao Sergio Neves, Claudia Camila Dias, Rute Sampaio
Summary: This study aims to predict the adherence behavior of patients with Type 1 Diabetes to intermittently scanned continuous glucose monitoring (isCGM). The findings suggest that age, time in target, isCGM necessity, body mass index, and sex are predictors of adherence. Therefore, personalized strategies should be implemented to promote treatment adherence in patients with these characteristics.
Article
Urology & Nephrology
Luis Mendonca, Miguel Bigotte Vieira, Joao Sergio Neves
Summary: The combined effects of FePi and serum FGF23 contribute to heart failure and cardiovascular death in patients with moderate to advanced CKD.
JOURNAL OF NEPHROLOGY
(2023)
