Article
Chemistry, Analytical
Ming-Hao Hu
Summary: The study designed two pyrazine-based G4 fluorescent probes based on the AIE or DIE principles and investigated the fluorescence-triggering mechanisms upon binding to G4s; one probe was selected for further studies, demonstrating its ability to selectively sense various G4s; By exploring the binding modes, it was revealed that G4s could dissociate the probe aggregate and trigger its fluorescence through a specific end-stacking mode.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Analytical
Zheng Wang, Ji Ma, Changlin Li, Haichang Zhang
Summary: Fluorescent conjugated materials commonly exhibit weak or quenching luminescent phenomena in the solid or aggregate state, limiting their applications in medicine and biology. However, aggregation-induced emission (AIE) fluorescent materials have shown strong luminescent properties in the aggregate state, overcoming the ACQ phenomenon. These AIE materials have been successfully used in biolabeling to detect ions and monitor physiological activity, making them popular biofluorescent probe materials.
Article
Chemistry, Multidisciplinary
Manish Kumar Dixit, Chinthakuntla Mahendar, Mrigendra Dubey
Summary: This study synthesized a fluorescent metallogel and investigated its gelation mechanism in detail. The results showed that the metallogel exhibited reversible stimuli-responsive behavior towards heating and mechanical shaking, while being resistant to ultrasound. Fluorescence experiments confirmed the involvement of chelation-enhanced fluorescence, aggregation-induced emission, and aggregation-caused quenching in the gelation process.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Lu Zhang, Jiang-Lin Wang, Xiao-Xu Ba, Si-Yu Hua, Peng Jiang, Feng-Lei Jiang, Yi Liu
Summary: HJS and DHJS are newly designed therapy probes that can rapidly enter cancer cells and selectively target mitochondria, exhibiting photothermal and photodynamic cytotoxicity while possessing dual-channel fluorescence imaging capability.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Inorganic & Nuclear
Juan Ouyang, Lihe Sun, Fang Zeng, Shuizhu Wu
Summary: Fluorophores with aggregation-induced emission (AIE) have many advantageous features for biomedical applications, especially for early diagnosis of diseases. Probes play a crucial role in fluorescent and optoacoustic imaging, and biomarker-activatable probes based on smart AIEgens have been widely researched and applied in this field.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Wang Wan, Lianggang Zeng, Wenhan Jin, Xinxin Chen, Di Shen, Yanan Huang, Mengdie Wang, Yulong Bai, Haochen Lyu, Xuepeng Dong, Zhenming Gao, Lei Wang, Xiaojing Liu, Yu Liu
Summary: A new crystallization-induced emission fluorophore was developed to quantitatively investigate the polarity of aggregated proteins, providing insights into protein status based on changes in solvent polarity; The probe can be used for live cell quantification of aggregated protein polarity, revealing heterogeneity within cellular aggregates and potentially correlating to their biochemical properties and pathogenicity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Spectroscopy
Xinyue Kou, Li Li, Qian Mei, Wen-Fei Dong, Yucai Wang
Summary: Aggregation-induced emission luminogens (AIEgens) have attracted significant attention due to their excellent photophysical characteristics. However, their synthesis is complex and requires expensive raw materials, limiting their applications. In this study, we developed a new type of carbon dots (O-CDs) using a simple solvothermal method, which show potential as a new AIEgen. O-CDs exhibit different fluorescence colors in different solvents and show an AIE effect when water is added. We used the AIE properties of O-CDs to create an anti-counterfeiting luminous ink for encryption in a reversible double switch mode.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Chemistry, Inorganic & Nuclear
Wei Quan, Wenhui Song, Qian Zhang, Huawei Huang, Weiying Lin
Summary: The liver, as the metabolic and detoxification center, plays a vital role in various physiological processes. Normal liver function is crucial for maintaining overall health, while abnormal liver function can lead to liver diseases. Early diagnosis of liver diseases is essential for timely treatment. The use of fluorescent probes for detecting biomarkers of liver diseases has provided valuable insights for pathological studies, drug development, and disease diagnosis and treatment in recent years. This review summarizes the progress of fluorescence probes in detecting hepatopathy-related biomarkers and discusses the current challenges and future directions. The development of long wavelength probes, multi-detection probes, quantitative analysis probes, and multi-modal probes is expected to be a popular trend. This review aims to facilitate the development of novel fluorescent probes for disease detection and provide guidance for diagnosis and treatment.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Analytical
Guannan Liu, Guishan Peng, Jianan Dai, Ri Zhou, Chenguang Wang, Xu Yan, Xiaoteng Jia, Xiaomin Liu, Yuan Gao, Lijun Wang, Geyu Lu
Summary: The newly developed Lipi-BDTO molecule fluorescent probe achieves a high resolution of 65 nm in STED imaging with high photostability. This probe not only allows monitoring of LDs dynamics but also visualizes the 3D spatial distribution of LDs through 3D STED imaging.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Yong Cheng, Alex E. Clark, Wonjun Yim, Raina M. Borum, Yu-Ci Chang, Zhicheng Jin, Tengyu He, Aaron F. Carlin, Jesse V. Jokerst
Summary: TMPRSS2 is a protease that activates coronaviruses and promotes tumor progression. Inhibiting TMPRSS2 can reduce cancer invasion and prevent SARS-CoV-2 infection. Researchers have developed a responsive peptide-conjugated probe that can selectively image and screen TMPRSS2 inhibitors, which may have value in cancer detection, SARS-CoV-2 targeting, and protease inhibitor screening.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
He Tian, Adam C. Sedgwick, Hai-Hao Han, Sajal Sen, Guo-Rong Chen, Yi Zang, Jonathan L. Sessler, Tony D. James, Jia Li, Xiao-Peng He
Summary: Lipid droplets (LDs) are essential organelles for lipid and energy homeostasis. Despite progress in understanding LDs, there are still many fundamental questions unanswered. Effective imaging agents can help bridge the knowledge gap and facilitate the development of new therapeutics.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Zhirong Zhu, Qi Wang, Xiaoyan Chen, Quan Wang, Chengxu Yan, Xiaolei Zhao, Weijun Zhao, Wei-Hong Zhu
Summary: In this study, an enzyme-activated aggregation-induced-emission (AIE) probe for high-contrast fluorescence diagnosis of pancreatic cancer (PC) was developed by monitoring the specific overexpressed enzyme Cathepsin E (CTSE). The probe successfully achieved intraoperative diagnosis and tracking of PC in living animal models, addressing accuracy and penetration issues simultaneously. This strategy can expand the database of biocompatible AIE-active probes, especially for establishing intraoperative pathological fluorescent diagnosis.
ADVANCED MATERIALS
(2022)
Review
Polymer Science
Ting Han, Lijie Liu, Dong Wang, Jinglei Yang, Ben Zhong Tang
Summary: MFP systems use sensitive fluorescent motifs to detect polymer chain events under mechanical stimuli, utilizing the aggregation-induced emission (AIE) effect to self-report their mechanical states and changes. Design principles include physically doping AIE luminogens into polymer matrix, chemically linking AIEgens in polymer backbones, and utilizing clusterization-triggered emission in polymers with nonconventional luminogens. The article discusses recent progress enabled by AIE process and addresses existing challenges in the field for future development.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Spectroscopy
Ying Zhang, Weihua Zhuang, Jingruo Chen, Chengming Li, Shufen Li, Mao Chen
Summary: This study developed two probes with aggregation-induced emission properties for efficient imaging of lipid droplets in atherosclerotic heart diseases. The probes showed low emissions in water but significantly increased emissions in oil. They exhibited great biocompatibility and resistance to photobleaching, and successfully illuminated intracellular lipid droplets in mice. This research provides a simple tool for studying atherosclerosis and contributes to the development of fluorescent probes for specific imaging applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Spectroscopy
Zhiping Song, Zhongpu Fang, Jingru Chen, Yongfan Zhang, Liangqia Guo, Fengfu Fu
Summary: Highly fluorescent carbon nitride oligomer (CNO) with aggregation-induced emission (AIE) characteristic was successfully synthesized via solid-phase condensation, providing a solid-state strategy for synthesizing fluorescent materials and extending the application of polymeric carbon nitride.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Lifang Guo, Minggang Tian, Zhiyun Zhang, Qing Lu, Zhiqiang Liu, Guangle Niu, Xiaoqiang Yu
Summary: The study introduces two novel SF-probes based on ESIPT, enabling simultaneous two-color imaging of lipid droplets and endoplasmic reticulum, providing a powerful tool for unraveling the biological processes related to LD-ER interactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Fangfang Meng, Jie Niu, Huamiao Zhang, Rui Yang, Qing Lu, Yi Yu, Zhiqiang Liu, Guangle Niu, Xiaoqiang Yu
Summary: The study developed a polarity-sensitive naphthalimide derivative fluorescent probe LD-Lys with high photostability and low cytotoxicity, which can simultaneously image LDs and lysosomes by showing strong and weak fluorescence, respectively. The dual-color imaging of LDs with bright yellow emission and lysosomes with weak red emission was achieved using a confocal laser scanning microscope. By monitoring the location changes, real-time tracking of LDs and lysosomes in cells and visualizing the size, morphology, and distribution of LDs and lysosomes in different tissues were feasible with LD-Lys, making it a promising fluorescent agent for studying the LD-lysosome interplay and metabolism diseases.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Spectroscopy
Rui Yang, Qiuhua Hao, Qing Lu, Fangfang Meng, Jie Niu, Zhiqiang Liu, Guangle Niu, Xiaoqiang Yu
Summary: This study successfully visualized the plasma membrane in living cells and tissues using two small-molecule plasma membrane fluorescent probes, providing new tools and methods for cancer diagnosis and histopathology research.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Multidisciplinary
Rui Yang, Xiuquan He, Guangle Niu, Fangfang Meng, Qing Lu, Zhiqiang Liu, Xiaoqiang Yu
Summary: The study introduces a pH-sensitive single fluorescent probe named HMBI, which allows simultaneous two-color visualization of nuclei and mitochondria, and monitoring of cell apoptosis. HMBI exhibits different emission spectra in different subcellular organelles, making it a valuable tool for studying dynamic changes in nuclei and mitochondria during physiological processes.
Article
Chemistry, Analytical
Xuechen Li, Guangle Niu, Minggang Tian, Qing Lu, Yuezhi Cui, Xiaoqiang Yu
Summary: A new imaging strategy was proposed to visualize cholesterol fluctuation in plasma membranes by controlling the spatial distribution of single fluorescent probes based on permeability changes triggered by different CL contents. The SF-probes developed in this study target plasma membranes and mitochondria, with distinct emission colors, allowing for clear visualization of CL fluctuation.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Fangfang Meng, Jie Niu, Huamiao Zhang, Rui Yang, Qing Lu, Guangle Niu, Zhiqiang Liu, Xiaoqiang Yu
Summary: In this study, a reliable strategy based on pH-sensitive intramolecular spirocyclization was developed to design and synthesize a single fluorescent probe (SFP) CMHCH for targeting lipid droplets and lysosomes simultaneously and selectively, enabling real-time monitoring of lipophagy.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Cheng-Juan Wu, Xin-Yu Li, Ting Zhu, Mengying Zhao, Zhuoyue Song, Shijie Li, Guo-Gang Shan, Guangle Niu
Summary: In this study, we developed a novel fluorescent probe ANI for wash-free visualization of lipid droplets and fatty liver disease characteristics. ANI showed enhanced fluorescence in low-polar environments, allowing for selective lighting up of lipid droplets with high contrast. The probe successfully demonstrated the excessive accumulation of lipid droplets in a fatty liver disease model mouse.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Environmental
Li Huang, Deyan Qing, Shaojing Zhao, Xiaoli Wu, Ke Yang, Xiaojie Ren, Xiuli Zheng, Minhuan Lan, Jun Ye, Lintao Zeng, Guangle Niu
Summary: BTZPP NPs exhibit a deep-red emission peaked at 635 nm, a large Stokes shift of 195 nm, and a high O-1(2) generation quantum yield of 72.3%. These NPs can selectively target lysosomes in live cells, and image mouse tumors with a high contrast and long-term tracking capability (up to 14 days). High-efficiency imaging-guided PDT against cancer cells and tumors has been successfully demonstrated in vitro and in vivo.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Applied
Xichao Hu, Lirong Jiang, Huan Ye, Beitong Zhu, Guangle Niu
Summary: The designed amphiphilic fluorescent probe CS-PyB showed high selectivity and low detection limit for LPS, allowing successful discrimination between Gram-negative bacteria and Gram-positive bacteria.
Article
Chemistry, Multidisciplinary
Hojeong Park, Guangle Niu, Chao Wu, Chungwon Park, Haixiang Liu, Hyokeun Park, Ryan T. K. Kwok, Jing Zhang, Benzhao He, Ben Zhong Tang
Summary: This study developed a novel fluorescent dye that can accurately and long-term track the movement of mitochondria in neurons.
Article
Chemistry, Analytical
Mingyue Cao, Ting Zhu, Mengying Zhao, Fanda Meng, Zhiqiang Liu, Jianguo Wang, Guangle Niu, Xiaoqiang Yu
Summary: This study synthesized a series of ultrabright fluorescent probes for visualization of cytosolic and nuclear lipid droplets (LDs) and achieved high-resolution imaging using structured illumination microscopy (SIM). These probes exhibited high fluorescence quantum yields and fluorescence enhancement in lipid environments, enabling specific illumination of subcellular LDs at ultralow concentrations.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
E. Pang, Shaojing Zhao, Benhua Wang, Guangle Niu, Xiangzhi Song, Minhuan Lan
Summary: This article systematically summarizes various strategies to improve the generation efficiency of singlet oxygen (O-1(2)) in photosensitizers (PS) and discusses their advantages, disadvantages, and challenges.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Organic
Xiaoming Zhu, Lu Feng, Shixian Cao, Jianguo Wang, Guangle Niu
Summary: The effect of acceptor unit order on the photophysical properties of two distinct donor-acceptor-acceptor conjugated fluorescent acrylonitriles was systematically investigated. The study found that TPA-BT-ANPh showed stronger fluorescence and two-photon absorption compared to TPA-AN-PhBT, demonstrating enhanced luminescent performance in the solid state. Additionally, these dyes served as excellent fluorescent markers for specific lipid droplet imaging.
Article
Chemistry, Physical
Shixian Cao, Xiaoyuan Tian, Mingyue Cao, Jianguo Wang, Guangle Niu, Ben Zhong Tang
Summary: A series of donor-acceptor-acceptor structured fluorescent acrylonitriles featuring aggregation-induced emission (AIE) were developed for low depletion power STED super-resolution imaging. These materials exhibited tunable near-infrared emissions, high fluorescence quantum yields, significant Stokes shifts, and large two-photon absorption cross-sections. They also showed solvatochromic effect and ultrahigh fluorescence quantum yields in low-polarity solvents.
CHEMISTRY OF MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Xiaoyuan Tian, Hui Wang, Shixian Cao, Yunting Liu, Fanda Meng, Xiaoyan Zheng, Guangle Niu
Summary: We synthesized cationic regioisomeric acrylonitriles with aggregation-induced emission (AIE) properties by conjugating tetraphenylethylene at different ortho/meta/para positions. The regioisomerism significantly influenced their photophysical characteristics and solid-state intermolecular interactions. These AIE luminogens showed enhanced fluorescence behavior in the solid state compared to solution, with o-TPE-ANPy(+) and m-TPE-ANPy(+) emitting yellow light and p-TPE-ANPy(+) emitting red-shifted light. Additionally, m-TPE-ANPy(+) and p-TPE-ANPy(+) displayed higher fluorescence enhancements with increasing viscosity than o-TPE-ANPy(+). Lastly, o-TPE-ANPy(+) was successfully applied for reversible mechanochromic performance and wash-free imaging of mitochondria. These findings contribute to a better understanding of the structure-property relationships in fluorescent regioisomers.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
