Article
Engineering, Biomedical
Jigai li, Xianfa Du, Xin Zhou, Juyoung Yoon
Summary: A simple and effective approach is developed to create heavy-atom-free photosensitizers (PSs) for photodynamic therapy (PDT) by self-assembling long-tailed boron dipyrromethene dyes (BODIPYs). The resulting PSs can efficiently convert their excited energy to the triplet state, producing reactive oxygen species that are essential for PDT. The aggregation and PDT performance of the PSs can be regulated by adjusting the length of the tailed alkyl chains. Efficacy of these heavy-atom-free PSs is demonstrated in vitro and in vivo under both normoxic and hypoxic conditions.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Environmental
Qiang Yue, Xuewen He, Neng Yan, Sidan Tian, Chenchen Liu, Wen-Xiong Wang, Liang Luo, Ben Zhong Tang
Summary: TVP-A is an effective, non-toxic, and environmentally friendly candidate for the management of harmful algal blooms.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Kristy W. K. Lam, Joe H. C. Chau, Eric Y. Yu, Feiyi Sun, Jacky W. Y. Lam, Dan Ding, Ryan T. K. Kwok, Jianwei Sun, Xuewen He, Ben Zhong Tang
Summary: In this study, a phosphate group was introduced as a cancer-specific biomarker of alkaline phosphatase (ALP) on a photosensitizer (PS) with aggregation-induced emission (AIE) for cancer cell imaging and therapy. The phosphate group on the PS is selectively hydrolyzed by ALP in high ALP expressing cancer cells, leading to aggregation and fluorescent response. Furthermore, fluorescence-guided photodynamic therapy (PDT) was achieved by using the aggregates of PS with strong reactive oxygen species (ROS) generation efficiency under white light irradiation.
Article
Chemistry, Multidisciplinary
Yujie Bai, Eric Y. Y. Yu, Yongsai Liu, Hongli Jin, Xingqi Liu, Xiaoyu Wu, Mengyao Zhang, Na Feng, Pei Huang, Haili Zhang, Ryan. T. K. Kwok, Xianzhu Xia, Yuanyuan Li, Ben Zhong Tang, Hualei Wang
Summary: Rabies is a fatal disease caused by the rabies virus, and more efficient antiviral methods are needed. Photodynamic therapy and immunotherapy using a photosensitizer with high reactive oxygen species generation ability can inactivate the virus and activate the immune response. This study demonstrates the potential of combining these two approaches for future antiviral research.
Article
Chemistry, Applied
Xiangmin Wang, Xiaofan Fu, Weibin Bu, Changjian Yu, Erhong Hao, Lijuan Jiao, Qinghua Wu, Rentian Wang, Jinjun Wang, Jiazhu Li
Summary: Fusion of thiophene to BODIPY allows for the development of novel symmetric bisbenzothieno[b]-fused BODIPYs (BTBs) with absorption maxima in the range of 643-665 nm, large molar extinction coefficients, and high singlet oxygen generation. Theoretical calculations show that the smaller singlet-triplet energy gap and larger spin-orbit coupling contribute to efficient intersystem crossing and increased singlet oxygen generation yield. Interestingly, a methyl diphenyl substituted BTB exhibits good reactive oxygen species generation efficiency (0.41) and remarkable photo-cytotoxicity (IC50 = 83.5 nM) in HeLa cells, demonstrating its potential in low-dose photodynamic therapy.
Article
Chemistry, Multidisciplinary
Peihong Xiao, Zipeng Shen, Deliang Wang, Yinzhen Pan, Ying Li, Junyi Gong, Lei Wang, Dong Wang, Ben Zhong Tang
Summary: A series of near-infrared anion-pi(+) photosensitizers with aggregation-induced emission were designed and developed for broad-spectrum MDR bacteria eradication, achieving up to 99% photodynamic killing efficacy against MRSA and MDR E. coli. Due to enhanced ROS generation capability, these AIE-PSs exhibited excellent therapeutic performance under white light irradiation.
Article
Biochemistry & Molecular Biology
Wojciech Krzemien, Monika Rohlickova, Miloslav Machacek, Veronika Novakova, Jaroslaw Piskorz, Petr Zimcik
Summary: Halogenation in the 2,6 position of BODIPY dyes significantly increases the singlet oxygen production, enhancing the photodynamic properties and anti-cancer activity against skin melanoma cancer cells. These compounds primarily induce apoptosis in cancer cells while maintaining limited dark toxicity.
Article
Chemistry, Multidisciplinary
Shi Ruijie, Sui Guomin, Lin Yanxin, Wang Ning, Fan Chencheng, Jiang Xu, Liu Yanhui, Gu Chengzhi, Feng Yaqing, Meng Shuxian
Summary: The novel intermolecular system D-pi-pi'-A showed synergistic effects on PDT and PTT, with potential for effective therapeutic applications.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Applied
Peng Zhao, Zhen Wang, Yanan Wang, Zibo Wu, Yurong Guo, Chao Wang, Xiaoxue Fang, Zongjin Qu, Haiyuan Wang, Guangjiu Zhao
Summary: This study reports a novel lysosome-targeted boron dipyrromethene (BODIPY) photosensitizer, Lyso-BDP, which has lower side effects and higher phototoxicity for 4T1 cells in photodynamic therapy (PDT). Lyso-BDP achieves lysosomal targeting treatment through the production of singlet oxygen under light excitation at 600 nm. The high singlet oxygen quantum yield and low IC50 value of Lyso-BDP make it a promising strategy to address the shortcomings of classical photosensitizers.
Article
Chemistry, Medicinal
Elif Yildiz Gul, Elanur Aydin Karatas, Hatice Aydin Dogan, Omer Faruk Karatas, Buenyemin Cosut, Esra Tanriverdi Ecik
Summary: In this study, smart photosensitizers containing BODIPY, erlotinib, and hydrophilic units were prepared and their physicochemical properties and PDT effects were investigated. The halogenated derivatives showed lower fluorescence and good ROS generation ability under red light. In vitro experiments demonstrated the potent activity of the halogenated conjugates on cancer cell viability and their low dark toxicity.
Article
Chemistry, Multidisciplinary
Keita Hoshi, Masami Itaya, Koki Tahara, Airi Matsumoto, Atsuhi Tabata, Hideaki Nagamune, Yasushi Yoshida, Eiji Hase, Takeo Minamikawa, Takeshi Yasui, Tetsuro Katayama, Akihiro Furube, Keiji Minagawa, Yasushi Imada, Fumitoshi Yagishita
Summary: The synthesized cyan fluorescent boron complex shows potential applications as a chiroptical material and a heavy-atom-free mitochondria-targeted photosensitizer for cancer treatment.
Article
Chemistry, Applied
Jianwen Tian, Muzhou Teng, Mu Song, Zhijia Li, Xiaoyong Zhang, Youqin Xu
Summary: Researchers have developed a feasible molecular engineering approach to design aggregation-induced emission (AIE)-active photosensitizers with unique free radical reactive oxygen species by exploring the molecular structure-property relationship. These new AIE-active photogenerators show bright fluorescence at aggregation and low O2-dependence during the generation of free radical ROS, making them promising candidates for fluorescence imaging-guided PDT.
Article
Engineering, Environmental
Muzhou Teng, Jialin Tong, Yili Xie, Yumin Li, Zhijia Li, Guogang Shan, Yin Li, Qing Wan, Zhiming Wang, Tao Liu
Summary: The fluorescence quenching phenomenon caused by heavy atom effect and intramolecular charge transfer is not universal in some aggregation-induced emission luminogens (AIEgens). By studying the structure-properties relationship, it was found that the introduction of bromine and nitro groups in cyanostyrene-based AIEgens induced abnormal fluorescence enhancement and boosted reactive oxygen species generation. This research has important implications for the design of novel functional materials in various applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Thanh Chung Pham, Moonyeon Cho, Van-Nghia Nguyen, Thuy Kieu Van Nguyen, Gyoungmi Kim, Suhong Min, Mi-Ra Kim, Juyoung Yoon, Songyi Lee
Summary: In this study, heavy-atom-free photosensitizer molecules were designed and the correlation between ISC rate and 1O2 generation was investigated. Among the designed structures, Cbz-SB showed the best performance in terms of fluorescence emission and 1O2 generation, demonstrating its potential applicability in mitochondria-targeted fluorescence bioimaging and PDT of HeLa cells.
Article
Engineering, Environmental
Tianwei Li, Zhe Xu, Hong Chen, Shijie Zhen, Hua Gu, Zujin Zhao, Ben Zhong Tang
Summary: Photodynamic therapy (PDT) has many advantages including precise control, noninvasiveness, high efficiency, and spatiotemporal selectivity. However, most currently used photosensitizers have drawbacks of weak light absorption and low reactive oxygen species generation ability. By introducing highly electronegative nitrogen atom, two photostable photosensitizers are designed to have high absorption coefficient and efficient ROS generation ability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Rui Wang, Kyu-Hwan Kim, Jiyoon Yoo, Xingshu Li, Nahyun Kwon, Yun-Hui Jeon, Suk-kyung Shin, Seung Seok Han, Dong-Sup Lee, Juyoung Yoon
Summary: The study successfully developed smart phototheranostic nanomaterials NanoPcM for low-background and tumor-targeted fluorescence imaging, as well as superior immunogenic photodynamic therapy against solid tumors. The combination of NanoPcM-based PDT and alpha PD-I-based immunotherapy efficiently inhibited tumor growth and triggered abscopal effects. This approach shows promise for the future design of nanomaterials in cancer imaging and therapy.
Review
Chemistry, Multidisciplinary
Xiaofeng Wu, Rui Wang, Nahyun Kwon, Huimin Ma, Juyoung Yoon
Summary: This article summarizes the methods for in situ imaging of enzymes using activatable fluorescent probes, and proposes that fluorescent probes with both activatable and in situ properties will facilitate high-resolution studies of enzymes in living systems.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Chemistry, Inorganic & Nuclear
Ji-Ting Hou, Nahyun Kwon, Shan Wang, Bingya Wang, Xiaojun He, Juyoung Yoon, Jianliang Shen
Summary: Hypochlorous acid is an endogenously produced reactive oxygen species that plays a crucial role in various diseases. Sulfur-based fluorescent probes for HOCl have shown excellent performance in terms of rapid reaction rate, high selectivity, and sensitivity, which are essential for better understanding the role of HOCl in chemical biology.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Wen-Qi Meng, Adam C. Sedgwick, Nahyun Kwon, Mingxue Sun, Kai Xiao, Xiao-Peng He, Eric Anslyn, Tony D. James, Juyoung Yoon
Summary: Chemical warfare agents (CWAs) are targeted toxic chemicals that pose serious threats to public health and global peace. Accurate detection methods for CWAs are essential for security measures. Small molecule fluorescent probes have emerged as attractive tools for CWA detection due to their simplicity, selectivity, and sensitivity, and their ability to be translated into handheld devices.
CHEMICAL SOCIETY REVIEWS
(2023)
Editorial Material
Chemistry, Multidisciplinary
Heejeong Kim, Mengyao Yang, Nahyun Kwon, Moonyeon Cho, Jingjing Han, Rui Wang, Sujie Qi, Haidong Li, Van-Nghia Nguyen, Xingshu Li, Hong-Bo Cheng, Juyoung Yoon
Summary: Noninvasive treatments for terminal cancer patients, such as photodynamic therapy (PDT) and photothermal therapy (PTT), have gained significant interest. These treatments utilize light and photosensitizers (PS) to generate reactive oxygen species (ROS) or heat. Designing new PSs, specifically activatable and heavy-atom-free PSs, is an active area of research in this field. This article discusses recent contributions to PDT and PTT.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2023)
Article
Nanoscience & Nanotechnology
Na Yeon Kwon, Su Hong Park, Chang Woo Koh, Jin Young Park, Min Ji Kang, Heume Il Baek, Junho Youn, Sungnam Park, Chang Wook Han, Min Ju Cho, Dong Hoon Choi
Summary: A novel core molecule for V-shaped host molecules, with two carbazoles directly linked to cyclohexane, was synthesized. Cy-mCP and Cy-mCBP hosts were prepared for solution-processable TADF-OLEDs, demonstrating improved thermal stability and film-forming ability compared to lower molecular weight hosts.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Nahyun Kwon, Gabriel O. Jasinevicius, Giulia Kassab, Lili Ding, Jiachuan Bu, Leticia P. Martinelli, Vinicius G. Ferreira, Alexander Dhaliwal, Harley H. L. Chan, Yulin Mo, Vanderlei S. Bagnato, Cristina Kurachi, Juan Chen, Gang Zheng, Hilde H. Buzza
Summary: By stabilizing nanoemulsions with ICG, we discovered a nanostructure of dimeric ICG (Nano-dICG) that showed improved photothermal conversion, reduced photodegradation, and undiminished photothermal effect compared to ICG. Nano-dICG also demonstrated excellent colloidal and structural stabilities, allowing real-time tracking of its delivery to mouse tumors for effective photothermal therapy. This finding provides an unprecedented ultra-stable phototheranostic platform.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Inorganic & Nuclear
Van-Nghia Nguyen, Thuy Nguyen Thi Dao, Moonyeon Cho, Hyunsun Jeong, Minh-Tri Nguyen-Le, Yong Shin, Juyoung Yoon
Summary: Due to the limitations of conventional antitumor agents, efforts are being made to develop advanced drug delivery systems using extracellular vesicles, particularly exosomes. These membrane-bound vesicles, secreted by various human cells, have unique features that make them promising nanocarriers for cancer therapy. This review provides knowledge on extracellular vesicles and highlights exosomes as potential nanocarriers for drug delivery. It also discusses recent developments of exosome-based nanotherapeutic agents for cancer treatment and presents challenges and prospects for the future development of exosomal drug delivery systems.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Multidisciplinary Sciences
Jinwoo Shin, Dong Won Kang, Jong Hyeon Lim, Jong Min An, Youngseo Kim, Ji Hyeon Kim, Myung Sun Ji, Sungnam Park, Dokyoung Kim, Jin Yong Lee, Jong Seung Kim, Chang Seop Hong
Summary: A wavelength-engineerable organic photocatalytic system for generating reactive oxygen species (ROS) has been developed, allowing for efficient and tunable production of ROS without the need for metal ions or heavy atoms. The system demonstrates superior tumor eradication and biocompatibility in biological assays, and provides a potential basis for designing nanoscale photosensitizers in various ROS-utilizing applications.
NATURE COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Dinh Khoi Dang, Van-Nghia Nguyen, Zeeshan Tahir, Hyunsun Jeong, Sungdo Kim, Hong Nhan Tran, Shinuk Cho, Yun Chang Park, Jong-Seong Bae, Chinh Tam Le, Juyoung Yoon, Yong Soo Kim
Summary: A cost-effective and environmentally friendly approach is proposed for producing N- and S-codoped multicolor-emission carbon dots at a mild reaction temperature and relatively short time. The obtained N- and S-codoped MCDs exhibit considerable fluorescence intensities, and their emission color can be adjusted from blue to yellow. Due to their favorable optical properties, good water solubility and biocompatibility, and low cytotoxicity, these N- and S-codoped MCDs are successfully applied as fluorescent probes for bioimaging.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Applied
Thanh Chung Pham, Moonyeon Cho, Van-Nghia Nguyen, Thuy Kieu Van Nguyen, Gyoungmi Kim, Suhong Min, Mi-Ra Kim, Juyoung Yoon, Songyi Lee
Summary: In this study, heavy-atom-free photosensitizer molecules were designed and the correlation between ISC rate and 1O2 generation was investigated. Among the designed structures, Cbz-SB showed the best performance in terms of fluorescence emission and 1O2 generation, demonstrating its potential applicability in mitochondria-targeted fluorescence bioimaging and PDT of HeLa cells.
Review
Biochemistry & Molecular Biology
Van-Nghia Nguyen, Haidong Li
Summary: This review discusses the technology and methods of using fluorescent ROS probes to monitor ROS in lysosomes, and examines the latest advancements and future directions of organic small-molecule fluorescent probes in this field.
Article
Materials Science, Multidisciplinary
Jaewan Ko, Hyeondoo Je, Kitae Kim, Taejun Eom, Joonyoung F. Joung, Sungnam Park, Joona Bang, Dong Hoon Choi
Summary: Proper management of surface defects in perovskite nanocrystals and surface tailoring with organic pseudohalide ligands can significantly improve optical properties and colloidal stability, providing a promising platform for green and blue PeNC-based LEDs.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Chemistry, Physical
Joonyoung F. Joung, Minseok Jeong, Sungnam Park
Summary: This paper evaluates the reliability of experimentally determined photoacidity values using a theoretical method. Density functional theory (DFT) and time-dependent DFT calculations are employed to calculate the changes in Gibbs free energy for acid dissociation reactions, which are directly related to photoacidity values. The results show that using the optical bandgap as the transition energy in the Forster cycle yields the most consistent pK(a)* values compared to quantum chemical calculations.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
