期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 22, 页码 8456-8459出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202000937
关键词
boron; cross-coupling; enantioselectivity; palladium; silicon
资金
- US National Institutes of Health [NIGMS GM-R35-127140]
Chiral 1,2-bimetallic reagents are useful motifs in synthetic chemistry. Although syn-1,2-bimetallic compounds can be prepared by alkene dimetallation, anti-1,2-bimetallics are still rare. The stereospecific 1,2-metallate shift that occurs during conjunctive cross-coupling is shown to enable a practical and modular approach to the catalytic synthesis of enantioenriched anti-1,2-borosilanes. In addition to reaction development, the synthetic utility of anti-1,2-borosilanes was investigated, including applications to the synthesis of anti-1,2-diols and anti-1,2-amino alcohols
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