期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 19, 页码 7439-7443出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202001142
关键词
aluminum; cyclization; nickel; reaction mechanisms; synthetic methods
资金
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China [21871145, 91856104, 21672107] Funding Source: Medline
- the National Natural Science Foundation of China [21890722 and 21702109, 21871145, 91856104, 21672107,21890722,21702109] Funding Source: Medline
- Tianjin Research Innovation Project for Postgraduate Stdents [2019YJSB081] Funding Source: Medline
- the Natural Science Foundation of Tianjin Municipality [19JCZDJC37900,18JCYBJC21400, 19JCJQJC62300, 19JCZDJC37900, 18JCYBJC21400, 19JCJQJC62300] Funding Source: Medline
- Fundamental Research Funds for Central Universities of the Central South University [63191601, 63191515, 63196021] Funding Source: Medline
A chiral aluminum complex controlled, enantioselective nickel-catalyzed domino reaction of aryl nitriles and alkynes proceeding by C-CN bond activation was developed. The reaction provides various indenes, bearing chiral all-carbon quaternary centers, under mild reaction conditions in yields of 32 to 91 % and ee values within the 73-98 % range. The reaction mechanism and aspects of stereocontrol were investigated by DFT calculations.
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