期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 20, 页码 7669-7677出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201915521
关键词
bioorthogonal labeling; biosensors; drug delivery; fluorescent probes; genetically encoded tags
资金
- ETH Zurich [ETH-02 16-1]
- EPF Lausanne
- Swiss National Science Foundation [200021 165551]
- European Research Council [801572]
- European Research Council (ERC) [801572] Funding Source: European Research Council (ERC)
Chemical biologists have developed many tools based on genetically encoded macromolecules and small, synthetic compounds. The two different approaches are extremely useful, but they have inherent limitations. In this Minireview, we highlight examples of strategies that combine both concepts to tackle challenging problems in chemical biology. We discuss applications in imaging, with a focus on super-resolved techniques, and in probe and drug delivery. We propose future directions in this field, hoping to inspire chemical biologists to develop new combinations of synthetic and genetically encoded probes.
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