Homogeneous, Low-volume, Efficient, and Sensitive Quantitation of Circulating Exosomal PD-L1 for Cancer Diagnosis and Immunotherapy Response Prediction

Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers

(2019) Chao Liu et al.   Nature Biomedical Engineering

λ-DNA- and Aptamer-Mediated Sorting and Analysis of Extracellular Vesicles

(2019) Chao Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Avoiding Pre-Isolation Step in Exosome Analysis: Direct Isolation and Sensitive Detection of Exosomes Using Gold-Loaded Nanoporous Ferric Oxide Nanozymes

(2019) Kseniia Boriachek et al.   ANALYTICAL CHEMISTRY

Label-free detection of exosomes using a surface plasmon resonance biosensor

(2019) Abu Ali Ibn Sina et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip

(2019) Peng Zhang et al.   Nature Biomedical Engineering

Rapid Detection of Exosomal MicroRNAs Using Virus-Mimicking Fusogenic Vesicles

(2019) Xihui Gao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Engineering-Based Aptamer-Drug Conjugates with Accurate Tunability of Drug Ratios for Drug Combination Cancer Targeted Therapy

(2019) Fang Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy

(2019) Heng-Huan Lee et al.   CANCER CELL

Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1

(2018) Chia-Wei Li et al.   CANCER CELL

High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

(2018) Carsten Krieg et al.   NATURE MEDICINE

Adjuvant Pembrolizumab versus Placebo in Resected Stage III Melanoma

(2018) Alexander M.M. Eggermont et al.   NEW ENGLAND JOURNAL OF MEDICINE

Temperature-Responsive Magnetic Nanoparticles for Enabling Affinity Separation of Extracellular Vesicles

(2018) Ramon Jauregui et al.   ACS Applied Materials & Interfaces

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

(2018) Peng Jiang et al.   NATURE MEDICINE

Molecular Recognition-Based DNA Nanoassemblies on the Surfaces of Nanosized Exosomes

(2017) Shuo Wan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An aptamer for recognizing the transmembrane protein PDL-1 (programmed death-ligand 1), and its application to fluorometric single cell detection of human ovarian carcinoma cells

(2017) Rezvan Yazdian-Robati et al.   MICROCHIMICA ACTA

Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers

(2017) Aaron M. Goodman et al.   MOLECULAR CANCER THERAPEUTICS

Intercellular Connections Related to Cell-Cell Crosstalk Specifically Recognized by an Aptamer

(2016) Nan Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial

(2016) Louis Fehrenbacher et al.   LANCET

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

(2016) Chia-Wei Li et al.   Nature Communications

A Novel PD-L1-targeting Antagonistic DNA Aptamer With Antitumor Effects

(2016) Wei-Yun Lai et al.   Molecular Therapy-Nucleic Acids

Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future

(2015) Lieping Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Detecting Exosomes Specifically: A Multiplexed Device Based on Alternating Current Electrohydrodynamic Induced Nanoshearing

(2014) Ramanathan Vaidyanathan et al.   ANALYTICAL CHEMISTRY

Thermophoresis in Nanoliter Droplets to Quantify Aptamer Binding

(2014) Susanne A. I. Seidel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Label-Free Microscale Thermophoresis Discriminates Sites and Affinity of Protein-Ligand Binding

(2012) Susanne A. I. Seidel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Optical Thermophoresis for Quantifying the Buffer Dependence of Aptamer Binding

(2010) Philipp Baaske et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thermophoresis of single stranded DNA

(2010) Philipp Reineck et al.   ELECTROPHORESIS

Protein-binding assays in biological liquids using microscale thermophoresis

(2010) Christoph J. Wienken et al.   Nature Communications

Aptamers Generated from Cell-SELEX for Molecular Medicine: A Chemical Biology Approach

(2009) Xiaohong Fang et al.   ACCOUNTS OF CHEMICAL RESEARCH