Article
Chemistry, Analytical
Yiwei Han, Jianyang Lu, Minghui Wang, Chunxiao Sun, Jie Yang, Genxi Li
Summary: In this study, a COF-based nanoconjugate was designed and fabricated for the construction of an electrochemical biosensor for exosome detection. The nanoconjugate exhibited good recognition ability and catalytic ability, resulting in a simple and sensitive detection of exosomes.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Minghui Wang, Yuxin Lin, Shuai Wu, Ying Deng, Yuanyuan Zhang, Jie Yang, Genxi Li
Summary: This study presents an electrochemical biosensor based on 2D COF NSs and CRISPR Cas 12a for the detection of PD-L1(+) exosomes. The sensor shows high sensitivity and a wide linear range, and can be used for clinical diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Yuxin Lin, Beibei Nie, Xinyu Qu, Minghui Wang, Jie Yang, Genxi Li
Summary: Covalent organic frameworks (COFs) have attracted much attention for their unique physical-chemical characteristics and potential applications in biosensing. In this study, spherical COFs with regular shape and good dispersion were synthesized, and a novel nanoprobe was developed by modifying Histostar on the COFs surface. The nanoprobe was then applied to fabricate an electrochemical biosensor for exosomes detection, achieving a low detection limit and wide linear detection range. This work offers a promising platform for ultrasensitive detection of exosomes.
Article
Chemistry, Analytical
Yi Feng, Yuting Zhao, Jun Ge
Summary: Metal-organic frameworks (MOFs) are promising carriers for enzymes and other biomolecules due to their stability, selectivity, and controllability. However, enzyme-MOF complexes often result in decreased enzyme activity and substrate affinity. In this study, enzyme-MOF composites were synthesized using ZIF-8, with adjusted sizes leading to enhanced substrate affinity and enzyme activity, showing potential for efficient biosensors in biomedicine.
ANALYTICA CHIMICA ACTA
(2021)
Article
Spectroscopy
Xiaoting Zhang, Ying Li, Lei Zhang
Summary: This study successfully constructed a Eu3+ functionalized Zr-metal-organic framework as a fluorescent probe for rapid monitoring of four commonly used dyes, showing excellent sensing performances and promising applications in water quality monitoring. The probe demonstrated high sensitivity in screening dyes in real samples and developed a portable test reagent bottle for on-site screening with naked eyes under UV light.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biophysics
Rui Pei, Li Ye, Chuanyong Jing
Summary: In this study, the researchers modulated the spatial conformation of arsenite oxidase AioAB by using the metal-organic framework ZIF-8, which enhanced its specificity towards antimonite. The developed electrochemical biosensor, AioAB@ZIF-8, showed a substrate specificity towards antimonite that was one order of magnitude higher than that of arsenite. Raman spectroscopy confirmed the structural changes of AioAB in ZIF-8, indicating the breakage of S-S bond and conversion of α-helix to random coil. This study provides new insights into tuning enzyme specificity and offers a new approach for biosensing metal(loid)s without specific proteins.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Huacong Chu, Xin Sun, Xiaoqian Zha, Shifa Ullah Khan, Yang Wang
Summary: In this study, three novel two-dimensional metalloporphyrin COFs were fabricated by changing the metal atoms in the porphyrin framework. The FePor-COF-366/GCE sensor showed excellent electrocatalytic performance in the detection of butylated hydroxy anisole (BHA), compared to MnPor-COF-366/GCE and CuPor-COF-366/GCE sensors. The designed sensor was successfully employed for the detection of BHA in practical samples.
Article
Chemistry, Multidisciplinary
Baohong Sun, Fan Wu, Xinye Wang, Qiuxian Song, Ziqiu Ye, Mohsen Mohammadniaei, Ming Zhang, Xiaohong Chu, Sheng Xi, Ninglin Zhou, Wentao Wang, Cheng Yao, Jian Shen
Summary: This study reports a versatile integrated nanoagent for comprehensive treatment of diabetic wounds. The nanoagent effectively scavenges reactive oxygen species, induces anti-inflammatory response, and exhibits bactericidal capabilities. In vivo experiments demonstrate that the nanoagent can accelerate the healing of infected diabetic wounds with better therapeutic benefits than monotherapy or individual antibiotics.
Article
Biotechnology & Applied Microbiology
Fanyu Meng, Wenjun Yu, Minjia Niu, Xiaoting Tian, Yayou Miao, Xvelian Li, Yan Zhou, Lifang Ma, Xiao Zhang, Kun Qian, Yongchun Yu, Jiayi Wang, Lin Huang
Summary: Non-small cell lung cancer(NSCLC) is the most common type of lung cancer and the main cause of cancer death, while circulating exosomes have been identified as a valuable biomarker for NSCLC diagnosis. In this study, a ratiometric biosensor integrated with an OR logic gate was developed for surface protein profiling of NSCLC-derived exosomes in clinical serum samples. The assay showed ultrasensitive detection of trace levels of NSCLC-derived exosomes in complex serum samples, outperforming the analysis of six serum biomarkers for accurate NSCLC diagnosis, staging, and prognosis, even at an early stage with a diagnostic sensitivity of 93.3%. This assay provides an advanced tool for exosome quantification and facilitates exosome-based liquid biopsies for cancer management in clinics.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Yuxin Shi, Binbin Zhu, Xiaotian Guo, Wenting Li, Wenzhuo Ma, Xinyue Wu, Huan Pang
Summary: This review summarizes the recent progress in the synthesis, composition, structure, and reaction mechanisms of MOF-derived metal sulfides for batteries, supercapacitors, and electrocatalysis, highlighting their potential in improving catalytic activity and energy storage. The challenges and opportunities for future development in this field are also discussed, aiming to inspire the synthesis of more efficient and durable electrochemical energy storage and conversion systems.
ENERGY STORAGE MATERIALS
(2022)
Article
Chemistry, Analytical
Chenxi Zhou, Kang Cui, Yue Liu, Shiji Hao, Lina Zhang, Shenguang Ge, Jinghua Yu
Summary: This study utilized Pd@hollow Zn/Co core-shell ZIF67/ZIF8 nanoparticles with superior electrocatalytic performance to detect prostate-specific antigen (PSA), demonstrating the potential of introducing noble metal element Pd into MOF hollow structures to improve electrocatalytic efficiency. The high-performance microfluidic paper-based analytical device (μPAD) constructed in this work allowed for dual-mode ultrasensitive detection of biomarkers such as PSA.
ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Soheila Sanati, Reza Abazari, Josep Albero, Ali Morsali, Hermenegildo Garcia, Zibin Liang, Ruqiang Zou
Summary: This review focuses on the use of MOF-derived bimetallic materials in supercapacitors, highlighting their advantages including tunable electrochemical activity, high charge capacity, and improved electrical conductivity. The challenges and perspectives in this research area are also discussed.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Lianli Zou, Yong-Sheng Wei, Chun-Chao Hou, Caixia Li, Qiang Xu
Summary: This review summarizes the progress in the synthesis of MOF-derived SACs and their electrochemical applications. The synthetic approaches based on MOFs, characterization techniques for SACs, and their electrochemical applications including ORR, OER, HER, CO2RR, NRR, and other energy-related reactions are discussed. Insights into the current challenges and future prospects of this field are also briefly presented.
Article
Chemistry, Multidisciplinary
Samar S. Sandhu, Yugender Goud Kotagiri, P. U. Ashvin Iresh I. Fernando, Mark Kalaj, Nicholas Tostado, Hazhir Teymourian, Erik M. Alberts, Travis L. Thornell, Glen R. Jenness, Steven P. Harvey, Seth M. Cohen, Lee C. Moores, Joseph Wang
Summary: This study introduces a new, green, thermally stable, and biocompatible zirconium metal-organic framework (Zr-MOF) catalyst for rapid and efficient detection of nerve agent threats. The catalytic degradation of diisopropylfluorophosphate (DFP) by the MIP-202(Zr) catalyst showed exceptional performance at near-neutral pH, as validated by various analytical techniques. The MIP-202(Zr)/F-ISE sensor demonstrated high thermal and storage stability, paving the way for remote or wearable field detection of G-type nerve agents in real-world environments.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biophysics
Deng Pan, Yan Lin, Xiao Liu, Yanming Xin, Qingwu Tian, Jiayou Zhang
Summary: A novel electrochemical sensing platform was successfully designed in this study for high sensitivity detection of tumor-derived exosomes without the need for preprocessing steps, which has the potential to improve the accuracy of early cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2022)