Review
Medicine, Research & Experimental
Kelsey P. Kubelick, Mohammad Mehrmohammadi
Summary: Superparamagnetic nanoparticles have become an important tool in biomedicine due to their controllable small size, biocompatibility, and magnetic properties. The magnetically-induced motion of these nanoparticles has been investigated as a new source of imaging contrast. Multiple imaging modalities can utilize magneto-motive contrast to monitor smaller scale biological events with enhanced contrast and sensitivity.
Article
Engineering, Biomedical
Isabel Gessner, Jin-Ho Park, Hsing-Ying Lin, Hakho Lee, Ralph Weissleder
Summary: A novel synthesis method for magneto-plasmonic nanoparticles has been developed to minimize nonspecific protein adsorption, enhancing protein detection capabilities. The newly developed nanomaterial MAGIC exhibits low protein adsorption and can detect specific biomarkers in the presence of other proteins.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Analytical
Tianfeng Wan, Wenqing Li, Zilin Chen
Summary: A novel magnetic solid-phase extraction method based on MOF-801 modified magnetic nanoparticles was developed for the extraction of preterm labor treatment drugs from human plasma, showing high extraction efficiency and low detection limits.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Food Science & Technology
Xiaobo Hu, Junpeng Zhao, Xinrui Cheng, Xufeng Wang, Xiya Zhang, Yiping Chen
Summary: This study developed a quantity-based magnetic relaxation switching (sMRS) sensor using polydopamine (PDA) for signal amplification, which enables rapid and sensitive detection of chloramphenicol in fish samples.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Materials Science, Multidisciplinary
N. Novosel, N. Kalcec, I. Delac Marion, I. Srut Rakic, D. Drobac, Z. Marohnic, M. Prester
Summary: The magnetic dynamics of iron oxyhydroxide akaganeite nanoparticles, which are functional building blocks of the iron deficiency drug Ferinject, have been studied. The low temperature magnetic dynamics of Ferinject differs significantly from other iron-oxides-based intravenous drugs, with a clear separation of high-temperature and low-temperature regimes. The complex magnetic dynamics are interpreted to rely on the presence of two assemblies of nanoparticles with significantly different average sizes.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2022)
Article
Environmental Sciences
Shujuan Xu, Biao Ma, Jiali Li, Wei Su, Tianran Xu, Mingzhou Zhang
Summary: Drug abuse is a growing concern due to its increasing danger. Morphine, methamphetamine, and ketamine are the commonly abused drugs. Unsupervised abuse of these drugs can cause serious harm to the human body and pose a threat to public safety. Developing a rapid and accurate method for screening drug suspects and controlling these drugs is crucial for public safety.
Article
Green & Sustainable Science & Technology
Jingge Chen, Quanliang Cao, Xiaotao Han
Summary: The article introduces a smart water-based ferrofluid that can easily separate magnetic nanoparticles from the solution after adsorbing dyes, showing great potential in wastewater treatment. The ferrofluid exhibits superparamagnetism, high saturation magnetization, and strong colloidal stability, making it efficient in adsorbing dyes in a short time. The experimental data suggest that the ferrofluid follows pseudo-second-order kinetics and the Langmuir isotherm model for adsorption processes.
JOURNAL OF CLEANER PRODUCTION
(2021)
Review
Biotechnology & Applied Microbiology
Yuyun Yang, Yuejun Liu, Laiming Song, Xiufang Cui, Juncen Zhou, Guo Jin, Aldo R. Boccaccini, Sannakaisa Virtanen
Summary: Iron-oxide-based biomagnetic nanocomposites have significant potential for biomedical applications such as MRI and cancer treatment. By modifying their properties and structure, their performance can be optimized. However, rigorous evaluation of their biosafety is needed before clinical translation.
TRENDS IN BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Natalie J. Nicolas, Meredith A. Duffy, Anne Hansen, Joanna Aizenberg
Summary: A non-invasive, at-home test for neonatal jaundice can improve diagnostic accuracy, enhance treatment outcomes, and prevent complications. Using a photonic sensor to measure changes in urinary surface tension provides valuable information for jaundice diagnosis, reducing unnecessary interventions for healthy infants.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Medical Laboratory Technology
Sanam Dolati, Jafar Soleymani, Seyed Kazem Shakouri, Ahmad Mobed
Summary: Acute ischemic stroke is the second leading cause of death globally, with challenging diagnosis and a lack of rapid diagnostic tests. Biomarker-based diagnostic approaches have shown significant value in stroke management. The review focuses on summarizing optical and electrochemical biosensors for detecting critical biomarkers in stroke.
CLINICA CHIMICA ACTA
(2021)
Review
Chemistry, Multidisciplinary
Teresa Lage, Raquel O. Rodrigues, Susana Catarino, Juan Gallo, Manuel Banobre-Lopez, Graca Minas
Summary: Graphene-based Magnetic Nanoparticles (GbMNPs) have been identified as promising theranostic platforms combining the unique properties of graphene-based materials with the excellent magnetic performance of magnetic nanoparticles. Research focuses on the synergistic theranostic effects of these hybrid nanosystems and explores potential clinical applications in the future.
Review
Biotechnology & Applied Microbiology
Smriti Sharma, Vinayak Bhatia
Summary: This review highlights the potential of magnetic nanoparticles in microfluidics and discusses the challenges and future directions in this emerging field. The use of MNPs in microfluidic devices can contribute to the development of decentralized healthcare testing globally, particularly benefiting middle- and low-income developing countries.
Article
Chemistry, Analytical
Leticia M. Alencar, Ana W. B. N. A. Silva, Magno A. G. Trindade, Rodrigo Salvatierra, Caue Martins, Victor H. R. Souza
Summary: In this study, 3D graphene-based composites in dry state form were synthesized in one single step, with carbon nanostructure controlling the nucleation and growth of copper-based nanoparticles. The composites showed excellent performance as an electrochemical sensor for hydrogen peroxide, highlighting the synergism between crumpled graphene and copper-based nanoparticles.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Nanoscience & Nanotechnology
Akhil K. Ramesh, Yi-Ting Chou, Mu-Ting Lu, Pushparaj Singh, Yuan-Chieh Tseng
Summary: This paper presents an approach to biological sensing using spintronic devices to detect magnetic particles attached to biological carriers. The proposed sensor offers real-time measurement results and is compatible with semiconductor fabrication technology, allowing for integration with semiconductor chips and reducing manufacturing cost and power consumption.
Article
Chemistry, Analytical
Yaqi Song, Min Chen, Zhongyu Yan, Lu Han, Leiqing Pan, Kang Tu
Summary: A novel nanoplatform based on biofunctionalized magnetic nanoparticles (MNPs) modified upconversion nanoparticles (UCNPs) was reported for rapid and specific determination of Shigella. The MNPs@UCNPs fluorescence biosensor achieved the detection of Shigella in 1 h, with a limit of detection of 32 CFU/mL.
Article
Engineering, Electrical & Electronic
Faezeh Ghorbanizamani, Hichem Moulahoum, Suna Timur
Summary: Drug abuse is a concerning issue, and current monitoring methods lack standardization, invasiveness, and efficiency. This study proposes a colorimetric lateral flow immunoassay (LFIA) method for detecting cocaine and methamphetamine in saliva samples. The LFIA method shows high sensitivity, specificity, and accuracy, and maintains stability under different salivary conditions.
IEEE SENSORS JOURNAL
(2022)
Review
Chemistry, Analytical
Hichem Moulahoum, Faezeh Ghorbanizamani, Emine Guler Celik, Suna Timur
Summary: The evolution of biosensors and diagnostic devices has facilitated the development of sensing materials, strategies, and device structures. Polymeric composite materials, with their biocompatibility, flexibility, and low cost, show great promise in future lab-on-chip devices. They can also enhance the sensing capabilities of traditional 2D biosensors.
Article
Biochemical Research Methods
Hichem Moulahoum, Faezeh Ghorbanizamani, Zineb Khiari, Mohamed Toumi, Yasmina Benazzoug, Suna Timur, Figen Zihnioglu
Summary: This study explores the effects of two Artemisia plant extracts on mitigating AGEs and their induced cell redox dysregulation in the liver. The results demonstrate that Artemisia absinthium phytoniosomes have a significant anti-AGE effect and can restore cell dysfunction and protect against apoptosis. Network pharmacology and bioinformatics analyses provide insights into the underlying mechanisms.
PHYTOCHEMICAL ANALYSIS
(2022)
Article
Food Science & Technology
Zinar Pinar Gumus, Hichem Moulahoum, Kerem Tok, Ebru Kocadag Kocazorbaz, Figen Zihnioglu
Summary: This study aimed to purify and identify potential endogenous peptides of barley sprouts for potential type 2 diabetes (T2D) treatment. The findings showed that peptide fractions with molecular weights lower than 3 kDa were the only ones with antiglycation activities. Among them, F11 demonstrated the highest potential as a T2D treatment.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Inorganic & Nuclear
Simge Balaban Hanoglu, Duygu Harmanci, Nursima Ucar, Serap Evran, Suna Timur
Summary: In recent years, magnetic nanoparticles (MNPs) have been widely used in various fields, including cancer detection, due to their beneficial properties. Detecting microRNAs (miRNAs) in biological samples is challenging, but MNPs provide an effective solution with their large surface areas and magnetic moments. This article discusses the synthesis and characterization methods of MNPs and their application in miRNA detection using biosensing systems, considering the challenges and prospects in terms of development stages, sensitivity, and selectivity.
Article
Chemistry, Analytical
Huseyin Furkan Kiyikci, Okan Avci, Yudum Tepeli Buyuksunetci, Suna Timur, Ulku Anik
Summary: A facile amperometric biosensor was developed using a Co/2Fe metal-organic framework (MOF) with oxidase mimicking properties for the detection of sialic acid (SA). The biosensor was constructed by immobilizing Co/2Fe MOF and N-acetylneuraminic Acid Aldolase (NANA-Aldolase) enzyme on a gold screen-printed electrode. The sensor showed a linear range of 0.02 mM-1.00 mM for SA concentration and a limit of detection of 0.026 mM. The developed biosensor was successfully applied for the detection of SA in GD3 ganglioside and HeLa cancer cell lines, providing a more practical and accurate system.
Review
Chemistry, Multidisciplinary
Faezeh Ghorbanizamani, Hichem Moulahoum, Emine Guler Celik, Suna Timur
Summary: The growing demand for personalized treatments and constant vital signs observation has led to the development of implantable biosensors that can temporarily or permanently be introduced into the human body. However, ensuring reliable functionality in the complex environment of the human body remains a critical challenge.
APPLIED SCIENCES-BASEL
(2023)
Review
Chemistry, Analytical
Bilge Asci Erkocyigit, Ozge Ozufuklar, Aysenur Yardim, Emine Guler Celik, Suna Timur
Summary: Microfluidics plays a crucial role in lab-on-a-chip systems, allowing for manipulation of fluid behavior and control on a small platform. Paper-based microfluidic analytical devices (muPADs) have numerous advantages, especially in cancer biomarker detection, and have the potential to improve diagnosis and treatment outcomes.
Review
Chemistry, Analytical
Nur Melis Kilic, Sima Singh, Gulsu Keles, Stefano Cinti, Sevinc Kurbanoglu, Dilek Odaci
Summary: Electrochemistry is an interdisciplinary science that has applications in various domains. The use of biosensors to measure biological or biochemical processes is critical in medical and biotechnological fields. There are electrochemical biosensors available for healthcare applications such as glucose, lactate, and nucleic acid detection. Enzyme-based biosensors using carbon-based nanomaterials are highly sensitive and selective, with fast reaction times. However, they can be influenced by environmental factors and the cost of enzymes and their immobilization can hinder their widespread use. This review discusses the design and applications of enzyme-based electrochemical nanobiosensors.
Review
Chemistry, Analytical
Faezeh Ghorbanizamani, Hichem Moulahoum, Emine Guler Celik, Figen Zihnioglu, Tutku Beduk, Tuncay Goksel, Kutsal Turhan, Suna Timur
Summary: Minimally invasive approaches in cancer diagnosis, such as liquid biopsies using blood samples, provide valuable information about the tumor and its state. However, isolating and detecting markers in complex matrices is challenging. Advances in polymer synthesis have led to enhanced platforms for liquid biopsies analysis, improving biosensor performance through increased sensitivity, improved binding, and avoidance of non-specific interactions. Additionally, polymer-based materials aid in signal amplification for low-concentration targets. This technology plays an essential role in oncology and clinical biomedicine, as shown by its critical application in liquid biopsies diagnosis.
Review
Nanoscience & Nanotechnology
Mohd. Rahil Hasan, Pradakshina Sharma, Shariq Suleman, Shouvik Mukherjee, Emine Guler Celik, Suna Timur, Roberto Pilloton, Jagriti Narang
Summary: Integrating electronic applications with paper can expand the uses of paper substrates, but putting electronics on paper is not easy. However, methods like building electronic devices on a rough, absorbent surface of the paper have made significant progress in paper electronics.
ACS APPLIED BIO MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Hichem Moulahoum, Faezeh Ghorbanizamani, Kerem Tok, Figen Zihnioglu
Summary: Peptides are important biomolecules with various applications. However, they have limitations such as flexible conformations and susceptibility to degradation. The discovery of cyclic peptides in plants has provided new insights for overcoming these issues.
Review
Nanoscience & Nanotechnology
Mohd Rahil Hasan, Pradakshina Sharma, Shariq Suleman, Shouvik Mukherjee, Emine Guler Celik, Suna Timur, Roberto Pilloton, Jagriti Narang
Summary: Integrating electronic applications with paper substrates can expand the potential uses of paper. While paper has advantages such as being disposable, inexpensive, and environmentally friendly, its rough and porous surface poses a challenge for putting electronics on paper. However, there are methods to make electronic devices compatible with the absorbent surface of paper.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Applied
Serdar Sanli
Summary: In this study, a portable electrochemical immunosensor based on 3D-printed technology was developed for rapid detection of amoxicillin in milk samples. The sensor showed a linear response in the range of 0.5-100 μM with a low detection limit.
Article
Chemistry, Physical
Faezeh Ghorbanizamani, Hichem Moulahoum, Emine Guler Celik, Suna Timur
Summary: The pursuit of novel materials and enhanced analytical efficiency in biomaterial engineering has led to a strong interest in hydrogels and ion gels for biosensing applications. This review provides an overview of these two materials and highlights recent impactful research in the field.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
