Article
Cell Biology
Sheng Xia, Heather L. Menden, Sherry M. Mabry, Venkatesh Sampath
Summary: HDAC6 regulates VEGF-induced angiogenesis through acetylation and repression of NICD and SNW1 transcriptional regulators.
Article
Gastroenterology & Hepatology
Juan-Li Duan, Zi-Yi Zhou, Bai Ruan, Zhi-Qiang Fang, Jian Ding, Jing-Jing Liu, Ping Song, Hao Xu, Chen Xu, Zhen-Sheng Yue, Hua Han, Guo-Rui Dou, Lin Wang
Summary: c-Kit-positive liver sinusoidal endothelial cells play a role in promoting hepatocyte proliferation and reducing liver injuries. Mutation in the Notch pathway affects the distribution of these cells and liver zonation. Activation of Notch signaling impedes liver regeneration and weakens the positive regulatory effects of c-Kit-positive liver sinusoidal endothelial cells on hepatocytes.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dongqing Mo, Chenglin Liu, Yao Chen, Xinkai Cheng, Jie Shen, Long Zhao, Junzheng Zhang
Summary: A study has found that mRpL4, a mitochondrial ribosomal protein, plays a crucial role in the Notch signaling pathway. It is involved in gene transcription during wing development in frogs and has a similar function to human mRpL4. This research reveals a previously unknown function of mRpL4 in animal development.
Article
Multidisciplinary Sciences
Shota Shimizu, Kazuaki Yoshioka, Sho Aki, Yoh Takuwa
Summary: PI3K-C2 alpha is essential for clathrin-mediated endocytosis of the gamma-secretase complex, facilitating the cleavage of endocytosed Notch1 by the gamma-secretase complex to generate NICD1 in ECs.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Jian-Hong Fang, Jie-Ying Chen, Jia-Lin Zheng, Hui-Xian Zeng, Jun-Guang Chen, Chen-Hui Wu, Jia-Li Cai, Zhi-Yong Wang, Shi-Mei Zhuang
Summary: Angiogenesis plays a crucial role in tumor growth and metastasis, and emerging evidence suggests that metabolic reprogramming in endothelial cells can impact angiogenesis. This study identified multiple regulators in the fructose metabolism pathway that were upregulated in tumor endothelial cells from hepatocellular carcinoma (HCC). It was found that dietary fructose enhanced tumor angiogenesis, growth, and metastasis, which could be attenuated by an inhibitor of fructose transporter SLC2A5. Fructose treatment also promoted endothelial cell proliferation, migration, tube formation, and mitochondrial respiration, while inhibiting fructose metabolism significantly abolished fructose-induced tumor angiogenesis.
Article
Biochemistry & Molecular Biology
Chenge Zhang, Yinhua Jin, Marco Marchetti, Mitchell R. Lewis, Omar T. Hammouda, Bruce A. Edgar
Summary: This study reveals that the transcriptional repressor Cic and its targets, pnt and Ets21C, are downstream effectors of mitogenic EGFR signaling in Drosophila intestinal stem cells. These factors promote metabolic changes that increase ISC mass, mitochondrial growth, and activity. The study also shows that Pnt and Ets21C directly upregulate genes involved in DNA replication, cell cycle, oxidative phosphorylation, TCA cycle, and fatty acid beta-oxidation. The work highlights the role of EGFR signaling in coordinating cell growth and division through alterations in metabolism.
Article
Developmental Biology
Nathalia Azevedo Portilho, Rebecca Scarfo, Elisa Bertesago, Ismail Ismailoglu, Michael Kyba, Michihiro Kobayashi, Andrea Ditadi, Momoko Yoshimoto
Summary: Research has shown that Notch signaling is not essential for the formation of B1 cells, while it has a promoting effect on the formation of B2 lymphoid cells. These findings are crucial for understanding the differentiation of B-cell lineages and for their in vitro generation for therapeutic applications.
Article
Multidisciplinary Sciences
Arlet Hernandez, Manoj Sonavane, Kelly R. Smith, Jensyn Seiger, Marie E. Migaud, Natalie R. Gassman
Summary: Dihydroxyacetone (DHA), the active ingredient in sunless tanning products and a byproduct of e-cigarette combustion, has various effects on cells including cell cycle arrest, reactive oxygen species generation, and mitochondrial dysfunction. In this study, the toxic effects of millimolar doses of DHA on HepG3 cells were investigated, revealing suppression of glycolysis and oxidative phosphorylation pathways and altered mTOR signaling. Increased mitochondrial reactive oxygen species and mitochondrial-specific injury led to cell cycle arrest and cell death through a non-classical apoptotic mechanism.
Article
Food Science & Technology
Qing Li, Qiaoling Yuan, Tianjie Wang, Yang Zhan, Lingchen Yang, Ying Fan, Hongyu Lei, Jianming Su
Summary: The research suggests that FB1 inhibits cell proliferation and disrupts the barrier function of SUVECs by regulating cell cycle-related genes, leading to increased blood vessel permeability.
Article
Engineering, Biomedical
Muhammad Rizwan, Christopher Ling, Chengyu Guo, Tracy Liu, Jia-Xin Jiang, Christine E. Bear, Shinichiro Ogawa, Molly S. Shoichet
Summary: A defined viscoelastic hyaluronan hydrogel is designed to mimic the stress relaxation rate of liver tissue, promoting cholangiocyte organoid growth. Hydrogel viscoelasticity, YAP signaling, and Notch activation play critical roles in cholangiocyte organogenesis.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Oncology
Manish Kumar, Subhransu S. S. Sahoo, M. Fairuz B. Jamaluddin, Pradeep S. S. Tanwar
Summary: Testicular cancer, originating from defective germ cells, is a common malignancy in young males. Our study suggests that LKB1 plays a role in the pathogenesis of testicular germ cell cancer. We detected reduced expression of LKB1 in seminoma samples and developed a 3D culture model using TCam-2 cells to demonstrate the efficacy of mTOR inhibitors against this cancer. In conclusion, downregulation or loss of LKB1 marks the early stages of seminoma, and targeting the downstream signaling of LKB1 may be an effective therapeutic strategy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Wenyan Chen, Yining Liu, Jing Chen, Yemei Ma, Yawen Song, Yanli Cen, Mingdan You, Guanghong Yang
Summary: The liver plays a crucial role in metabolism and immune response in the human body. Macrophages are essential for defending against foreign pathogens and can polarize into different states to respond to various invaders. The Notch signaling pathway is believed to regulate the polarization of macrophages in liver diseases, impacting inflammation and tumor growth.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Cell Biology
Can Huang, Dawei Yang, George W. Ye, Charles A. Powell, Peipei Guo
Summary: Canonical Notch signaling is crucial for cell proliferation, differentiation, and fate maintenance in development and cancer, with distinctive roles in hematopoietic stem cell emergence during embryonic development and lineage choices in adult hematopoiesis. Studies continue to debate the necessity of Notch signaling for adult HSC maintenance, urging for more detailed investigations into specific biological contexts to better understand the therapeutic implications of Notch-related pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yali Niu, Yixuan Xi, Yutong Jing, Ziyi Zhou, Xiaojia Sun, Guoheng Zhang, Tianhao Yuan, Tianfang Chang, Guorui Dou
Summary: This study discovered that choroid endothelial cells play an essential role in the formation and function of the RPE barrier. The modulation of endothelial Notch signaling regulates the expression of HBEGF and MMP-9 in RPE cells, affecting the RPE barrier function. This finding suggests a novel therapeutic strategy for retinal degenerative diseases.
Article
Biotechnology & Applied Microbiology
Jian Yang, Yong Hu, Lu Wang, Xiangran Sun, Ling Yu, Weichun Guo
Summary: This study demonstrated that HUVECs-exosomes promoted cell stemness in osteosarcoma by activating the Notch signaling pathway, providing a theoretical basis for osteosarcoma treatment using exosomes.
Article
Peripheral Vascular Disease
Adam Schultz, Olubunmi A. Olorundami, Ru-Jeng Teng, Jason Jarzembowski, Zheng-Zheng Shi, Suresh N. Kumar, Kirkwood Pritchard, Girija G. Konduri, Adeleye J. Afolayan
Article
Medicine, General & Internal
Shao-Hua Bi, Liang-Liang Jiang, Li-Ying Dai, Hong Zheng, Jian Zhang, Li-Li Wang, Chao Wang, Qiao Jiang, Yu Liu, Yong-Li Zhang, Juan Wang, Chao Zhu, Guang-Hui Liu, Ru-Jeng Teng
WORLD JOURNAL OF CLINICAL CASES
(2019)
Article
Biochemistry & Molecular Biology
Ru-Jeng Teng, Xigang Jing, Dustin P. Martin, Neil Hogg, Aaron Haefke, Girija G. Konduri, Billy W. Day, Stephen Naylor, Kirkwood A. Pritchard Jr
Summary: The study demonstrates that KYC can improve lung structure and reduce the occurrence of BPD mainly by inhibiting oxidative stress and inflammation, reducing toxic oxidant production, activating Nrf2, and increasing antioxidant enzyme expression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Megha Sharma, Ujala Rana, Chintamani Joshi, Teresa Michalkiewicz, Adeleye Afolayan, Abdul Parchur, Amit Joshi, Ru-Jeng Teng, Girija G. Konduri
Summary: Impaired angiogenesis function in pulmonary artery endothelial cells (PAEC) contributes to persistent pulmonary hypertension of the newborn (PPHN) due to decreased nitric oxide (NO) levels leading to impaired mitochondrial biogenesis and angiogenesis in the lung. The decreased cGMP-PKG signaling pathway in NO downstream appears to be a potential therapeutic target to restore the impaired mitochondrial biogenesis and angiogenesis in PPHN. This study provides insights into the mechanisms underlying the development of PPHN and suggests potential new treatment strategies targeting the cGMP-PKG pathway.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Review
Medicine, General & Internal
Shao-Hua Bi, Liang-Liang Jiang, Li-Ying Dai, Li-Li Wang, Guang-Hui Liu, Ru-Jeng Teng
Summary: Familial hemophagocytic lymphohistiocytosis type 2 (FHL2) is a rare genetic disorder that usually presents after 1 year old, but our case describes a newborn with symptoms before 1 month old. A literature review of Chinese FHL2 patients found that only 5 out of 75 presented in the first year of life.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Obstetrics & Gynecology
Megha Sharma, Emily Callan, G. Ganesh Konduri
Summary: Inhaled nitric oxide therapy has significantly impacted the management of persistent pulmonary hypertension of the newborn. However, a considerable proportion of patients do not respond adequately to this treatment. Optimizing the response to inhaled nitric oxide can be achieved by combining other lung recruitment strategies and alternate pulmonary vasodilators.
CLINICS IN PERINATOLOGY
(2022)
Article
Multidisciplinary Sciences
Kirkwood A. Pritchard, Xigang Jing, Michelle Teng, Clive Wells, Shuang Jia, Adeleye J. Afolayan, Jason Jarzembowski, Billy W. Day, Stephen Naylor, Martin J. Hessner, G. Ganesh Konduri, Ru-Jeng Teng
Summary: This study found that oxidative stress, myeloperoxidase, and endoplasmic reticulum stress are increased in a rat model of bronchopulmonary dysplasia (BPD). Treatment with tunicamycin or hyperoxia further increased endoplasmic reticulum stress and decreased lung complexity, resembling the BPD phenotype. Inhibition of endoplasmic reticulum stress with tauroursodeoxycholic acid improved lung complexity and decreased myeloid cells and myeloperoxidase levels. These findings suggest a causal role of endoplasmic reticulum stress in BPD and highlight the potential of tauroursodeoxycholic acid as a treatment.
Article
Gastroenterology & Hepatology
Pinar Sargin, Mark F. Roethle, Shuang Jia, Tarun Pant, Ashley E. Ciecko, Samantha N. Atkinson, Nita H. Salzman, Ru-Jeng Teng, Yi-Guang Chen, Susanne M. Cabrera, Martin J. Hessner
Summary: The increasing incidence of Type 1 diabetes may be related to the low-fiber, high-gluten Western diet and other environmental factors. Supplementation with Lactiplantibacillus plantarum 299 v (Lp299v) can improve gut barrier function and reduce systemic inflammation, thereby delaying the onset of diabetes. Lp299v supplementation modulates antioxidative defense and ER stress responses in beta-cells, offering a potential new therapeutic direction for diabetes treatment and insulin secretion preservation.
Article
Biochemistry & Molecular Biology
Paul Sidlowski, Amanda Czerwinski, Yong Liu, Pengyuan Liu, Ru-Jeng Teng, Suresh Kumar, Clive Wells, Kirkwood Pritchard, Girija G. Konduri, Adeleye J. Afolayan
Summary: Human OLA1 protein couples redox signals to metabolic response pathway by activating metabolic gene transcription in the nucleus, which is regulated by ERK1/2 and PP1A. Nuclear translocation of OLA1 and mitochondrial metabolic dysfunction result in abnormal behaviors of pulmonary vascular cells and significant vascular remodeling.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Review
Genetics & Heredity
Shaohua Bi, Liying Dai, Liangliang Jiang, Lili Wang, Mia Teng, Guanghui Liu, Ru-Jeng Teng
Summary: This article reports a rare case of Xp21.1 contiguous gene deletion syndrome, in which a male neonate presented with sepsis at 19 days of age. CNV-seq revealed an extensive 7.5 Mb deletion of Xp21.2-Xp11.4, leading to the diagnosis of both CGD and DMD. This case represents the most extensive deletion of genes in this region ever reported.
FRONTIERS IN GENETICS
(2023)
Article
Physiology
Abha Yadav, Ujala Rana, Teresa Michalkiewicz, Ru-Jeng Teng, Girija G. Konduri
PHYSIOLOGICAL REPORTS
(2020)
Article
Physiology
Kartikeya Makker, Adeleye J. Afolayan, Ru-Jeng Teng, Girija G. Konduri
PHYSIOLOGICAL REPORTS
(2019)