期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 318, 期 4, 页码 G717-G724出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00304.2019
关键词
adipose tissue; metabolism; metabolites; microbiome
资金
- National Institutes of Health Director's New Innovator Award [DP2 AG-067492]
- Edward Mallinckrodt, Jr. Foundation
- Global Probiotics Council
- Mouse Microbiome Metabolic Research Program of the National Mouse Metabolic Phenotyping Centers
- PennCHOP Microbiome Program
- Penn Institute for Immunology
- Penn Center for Molecular Studies in Digestive and Liver Diseases [P30-DK-050306]
- Penn Skin Biology and Diseases Resource-based Center [P30 AR-069589]
- Penn Diabetes Research Center [P30 DK-019525]
- Penn Institute on Aging
The intestinal commensal microbiome is an important component of host health, in part by contributing an abundance of metabolites that gain access to the systemic circulation. The microbiome thereby influences the physiology of numerous organ systems outside the gastrointestinal tract. The consequences of this signaling axis between the intestinal microbiome and host are profound, in particular for the modulation of organismal metabolism. Here, we review recent examples whereby the intestinal microbiome influences host metabolism by influencing the biology of adipose tissue. We place a special emphasis on metabolite-driven pathways by which adipose tissue responds to alterations in intestinal microbial colonization. Given its accessibility for therapeutic interventions, the gut microbiome is an attractive relay module for the remote control of systemic metabolism.
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