Article
Pediatrics
Jose A. Castro-Rodriguez, Fiorella Biancardi, Oslando Padilla, Andrea A. Beckhaus, Ignacio E. Tapia
Summary: This study analyzed the effects of adenotonsillectomy (AT) on asthma/wheezing and found that AT decreased the risk of wheezing.
PEDIATRIC PULMONOLOGY
(2023)
Article
Allergy
Kathleen Lee-Sarwar, Sandra Dedrick, Babak Momeni, Rachel S. Kelly, Robert S. Zeiger, George T. O'Connor, Megan T. Sandel, Leonard B. Bacharier, Avraham Beigelman, Nancy Laranjo, Diane R. Gold, Jessica Lasky-Su, Augusto A. Litonjua, Yang-Yu Liu, Scott T. Weiss
Summary: This study analyzed the relationship between gut microbiome and metabolome and wheeze frequency in children with asthma. The results showed that specific microbial taxa and metabolites were associated with high wheeze proportion in children. This finding suggests the impact of the gut microbiome on asthma morbidity in children.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mei Xue, Qiong Wang, Bo Pang, Xiaoqian Zhang, Yicheng Zhang, Xiangling Deng, Zhixin Zhang, Wenquan Niu
Summary: This meta-analysis found a significant association between circulating zinc and the risk of childhood asthma and wheezing. Subgroup analysis showed that children with asthma or wheezing in the Middle Eastern countries had significantly lower circulating zinc levels than controls. The results suggest an important relationship between circulating zinc and childhood asthma and its related symptom wheezing.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Microbiology
Rozlyn C. T. Boutin, Hind Sbihi, Ryan J. McLaughlin, Aria S. Hahn, Kishori M. Konwar, Rachelle S. Loo, Darlene Dai, Charisse Petersen, Fiona S. L. Brinkman, Geoffrey L. Winsor, Malcolm R. Sears, Theo J. Moraes, Allan B. Becker, Meghan B. Azad, Piush J. Mandhane, Padmaja Subbarao, Stuart E. Turvey, B. Brett Finlay
Summary: This study found that the composition of gut mycobiota in Canadian infants changes significantly within the first year of life, with early-life environmental factors influencing the composition and development of inhalant allergic sensitization by age 5 years. The study developed a predictive model using a combination of early-life environmental factors and fungal community composition at 1 year old, achieving 81% accuracy in predicting inhalant atopy status at age 5 years.
Article
Microbiology
Yinthe Dockx, Martin Taeubel, Janneke Hogervorst, Leen Luyten, Martien Peusens, Leen Rasking, Hanne Sleurs, Katrien Witters, Michelle Plusquin, Maria Valkonen, Tim S. Nawrot, Lidia Casas
Summary: This study investigates the association between residential indoor microbiota and cognition and behavior among preschoolers. The results show that early-life exposure to diverse indoor fungal communities is associated with better behavioral and cognitive outcomes, whereas higher indoor microbial load is associated with worse outcomes.
Article
Pediatrics
Peter Csonka, Terhi Tapiainen, Mika J. Makela, Lauri Lehtimaki
Summary: Guidelines for treating preschool children with wheezing in emergency rooms are not well supported, highlighting the need for research to identify specific approaches for guideline implementation in primary care. Clinical research needs to focus on strengthening recommendations that are currently not embraced.
Article
Clinical Neurology
Yanan Wang, Marcel van de Wouw, Lauren Drogos, Elnaz Vaghef-Mehrabani, Raylene A. Reimer, Lianne Tomfohr-Madsen, Gerald F. Giesbrecht
Summary: The study reveals a novel association between sleep and gut microbiota in preschool-aged children. Longer night-time sleep and greater sleep efficiency were associated with specific commensal bacteria that may regulate sleep through modulating neurotransmitter metabolism and the immune system. Additionally, fecal metabolites like tryptophan and propionate show associations with sleep parameters.
Article
Pediatrics
Ramin Beheshti, E. Scott Halstead, Daniel McKeone, Steven D. Hicks
Summary: This study suggests that host-microbiome interactions in saliva may provide pathophysiological clues about the origins of wheezing and aid in identifying infants at risk for wheezing. The findings highlight the importance of understanding the relative contributions of infant traits, environment, and underlying biology in wheezing.
PEDIATRIC RESEARCH
(2023)
Review
Infectious Diseases
Cristina Garcia-Maurino Alcazar, Veena Mazarello Paes, Yan Shao, Clarissa Oesser, Ada Miltz, Trevor D. Lawley, Peter Brocklehurst, Alison Rodger, Nigel Field
Summary: Data from animal models suggest that early-life gut microbiota plays a role in lung immune development and susceptibility to respiratory diseases in humans. This systematic review summarises the association between infant gut microbiota composition and childhood respiratory diseases. The results show that low diversity and abundance of specific gut commensal bacteria genera are associated with childhood respiratory diseases, although the results are inconsistent and have limitations.
Article
Allergy
Abby D. Mutic, David T. Mauger, Jocelyn R. Grunwell, Cydney Opolka, Anne M. Fitzpatrick
Summary: The study shows that social vulnerability may lead to more severe symptoms and exacerbations in preschool children with recurrent wheezing, despite receiving standardized and supervised care. These children experience more severe symptoms during upper respiratory infections and respiratory flare days, and their exacerbations result in significantly poorer caregiver quality of life. Social vulnerability is also associated with poorer housing conditions and other environmental factors.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Immunology
Ville Forsstroem, Laura Toivonen, Kiara Homil, Matti Waris, Casper-Emil T. Pedersen, Klaus Bonnelykke, Tuomas Jartti, Ville Peltola
Summary: This study found that genetic predisposition to childhood asthma is associated with early respiratory tract infections, particularly in the 17q21 and CDHR3 genes. Multiple asthma risk alleles are also associated with viral respiratory infections and asthma. Therefore, non-wheezing and wheezing respiratory infections and asthma may share common genetic risk factors.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Pediatrics
Alex Gileles-Hillel, Sharon Guttman, Oded Breuer, Joel Reiter, Regina Leshem, David Shoseyov, Eitan Kerem, Malena Cohen-Cymberknoh
Summary: The study compared the efficacy of betamethasone and dexamethasone in treating preschool children hospitalized for acute wheezing, finding that both achieved similar clinical responses but dexamethasone was used in higher cumulative doses. Further research is needed to explore additional benefits of betamethasone over other steroids or placebo.
PEDIATRIC PULMONOLOGY
(2021)
Article
Medicine, General & Internal
Xiangling Deng, Min Yang, Shunan Wang, Qiong Wang, Bo Pang, Kundi Wang, Zhixin Zhang, Wenquan Niu
Summary: The study identified factors associated with childhood asthma and wheeze in Chinese preschool-aged children, highlighting the contribution of inherited, nutritional, unhealthy lifestyles, and a history of allergic disease. Modeling significant factors in nomograms showed decent prediction accuracies for asthma and wheeze, indicating the complex interplay of multiple factors in the development of these conditions. Internal validation also supported the findings, showing good consistency in the results.
FRONTIERS IN MEDICINE
(2021)
Review
Nutrition & Dietetics
Alexandru Cosmin Pantazi, Cristina Maria Mihai, Adriana Luminita Balasa, Tatiana Chisnoiu, Ancuta Lupu, Corina Elena Frecus, Larisia Mihai, Adina Ungureanu, Mustafa Ali Kassim Kassim, Antonio Andrusca, Maria Nicolae, Viviana Cuzic, Vasile Valeriu Lupu, Simona Claudia Cambrea
Summary: The intestinal microbiota is a diverse and complex microecosystem that stabilizes by the age of three and plays a crucial role in human health, particularly in early childhood. Dysbiosis has been linked to the development of allergic diseases, such as atopic dermatitis, asthma, and food allergies. Next-generation sequencing methods have improved our understanding of the relationship between dysbiosis and allergic diseases. This review paper aims to synthesize the current knowledge on the development of the intestinal microbiota, its long-term impact on health, and the connection between dysbiosis and allergic diseases, as well as interventions for prevention and treatment.
Article
Pediatrics
Jingjing Xiong, Hongwei Hu, Chuanzhi Xu, Jianwen Yin, Mei Liu, Lizhi Zhang, Yong Duan, Yongkun Huang
Summary: The age of 6 months may be a critical period for the development of intestinal microflora in children. The composition and function of intestinal microflora are unstable in the neonatal period but significantly improve at 6 months after birth, gradually stabilizing after 2-3 years old.
Editorial Material
Gastroenterology & Hepatology
Heike E. F. Becker, John Penders, Daisy M. A. E. Jonkers
Article
Biochemistry & Molecular Biology
Armand M. A. Linkens, Niels van Best, Petra M. Niessen, Nicole E. G. Wijckmans, Erica E. C. de Goei, Jean L. J. M. Scheijen, Martien C. J. M. van Dongen, Christel C. J. A. W. van Gool, Willem M. de Vos, Alfons J. H. M. Houben, Coen D. A. Stehouwer, Simone J. M. P. Eussen, John Penders, Casper G. Schalkwijk
Summary: The study found that a 4-week diet low or high in AGEs has limited impact on the gut microbial composition of abdominally obese humans, with only Anaerostipes spp. showing a relative abundance difference. The habitual intake of dicarbonyls was not associated with microbial richness or general community structure, but the intake of 3-deoxyglucosone was linked to several genera abundances. Further investigation into the effects of dietary dicarbonyls on gut microbiota composition is warranted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Casper M. Kersten, Sergei M. Hermelijn, Dhanya Mullassery, Nagarajan Muthialu, Nazan Cobanoglu, Silvia Gartner, Pietro Bagolan, Carmen Mesas Burgos, Alberto Sgro, Stijn Heyman, Holger Till, Janne Suominen, Maarten Schurink, Liesbeth Desender, Paul Losty, Henri Steyaert, Suzanne Terheggen-Lagro, Martin Metzelder, Arnaud Bonnard, Rony Sfeir, Michael Singh, Iain Yardley, Noor R. V. M. Rikkers-Mutsaerts, Cornelis K. van der Ent, Niels Qvist, Des W. Cox, Robert Peters, Michiel A. G. E. Bannier, Lucas Wessel, Marijke Proesmans, Michael Stanton, Edward Hannon, Marco Zampoli, Francesco Morini, Harm A. W. M. Tiddens, Rene M. H. Wijnen, Johannes M. Schnater
Summary: This study aimed to define a core outcome set for pediatric patients with an asymptomatic CPAM. Through a Delphi survey, the final core outcome set includes seven outcome parameters, including respiratory insufficiency, surgical complications, mass effect/mediastinal shift, and multifocal disease.
Article
Medicine, General & Internal
Michiel A. G. E. Bannier, Sophie Kienhorst, Quirijn Jobsis, Kim D. G. van de Kant, Frederik-Jan Van Schooten, Agnieszka Smolinska, Edward Dompeling
Summary: Exhaled breath analysis has the potential to diagnose various respiratory and non-respiratory diseases. This study found that inhaled corticosteroids can influence the volatile organic compounds in the exhaled breath of wheezing preschool children. Furthermore, the exhaled volatile organic compounds can predict the response to corticosteroid treatment in these children.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Respiratory System
Domenique Zomer, Jakko van Ingen, Regina Hofland, Dutch C. F. Registry Steering group Dutch CF Registry Steering Grp
Summary: A survey and retrospective data analysis from the Dutch CF Registry were conducted to assess the epidemiology and management of NTM isolation and disease in pwCF in the Netherlands. The study revealed an increasing prevalence of NTM isolation, poor treatment outcomes, and an association with declining lung function. The prevention and treatment of NTM pulmonary disease among pwCF in the Netherlands require increased attention.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Gastroenterology & Hepatology
D. J. M. Barnett, M. F. Endika, C. E. Klostermann, F. Gu, C. Thijs, A. Nauta, H. A. Schols, H. Smidt, I. C. W. Arts, J. Penders
Summary: The infant gut microbiota is influenced by antibiotic exposures and prebiotic oligosaccharides found in breast milk. This study analyzed the stool microbiota of 1023 one-month-old infants and found that breastfeeding and antibiotic exposure both decrease gut microbial diversity, but have different effects on microbiota composition. Other factors such as C-section, homebirth, siblings, and exposure to animals also impact microbiota composition. Understanding these factors can help protect and promote a healthy infant gut microbiota.
Review
Biochemistry & Molecular Biology
Robert van Vorstenbosch, Hao Ran Cheng, Daisy Jonkers, John Penders, Erik Schoon, Ad Masclee, Frederik-Jan van Schooten, Agnieszka Smolinska, Zlatan Mujagic
Summary: Colorectal cancer (CRC) is associated with changes in volatile metabolic profiles, making it possible for non-invasive detection. However, the origin of these volatile organic compounds (VOCs) and their relation to gut microbiome are still not fully understood. This systematic review provides a comprehensive overview of the current understanding on this topic. The analysis of seventy-one included studies revealed dysregulations in various matrices, such as feces, urine, breath, blood, tissue, and saliva, with short-chain fatty acids, amino acids, proteolytic fermentation products, and products related to tricarboxylic acid cycle and Warburg metabolism being the most frequently reported.
Article
Microbiology
Evy Maas, John Penders, Koen Venema
Summary: Most research on the human microbiome has focused on bacteria, with less attention given to fungi and their role in human health, particularly their modulation through diet. This study used a validated in vitro model of the colon to investigate the gut fungal community and its response to different dietary interventions. The results showed that the mycobiome had lower diversity and greater variability compared to the bacterial community, and that diet could influence its composition and diversity.
Article
Microbiology
Evy Maas, John Penders, Koen Venema
Summary: This study investigated the relationships between fungi and bacteria using a complex computer-controlled in vitro model of the colon. The results showed that cross-kingdom interactions exist between fungi and bacteria, and they can influence each other. These findings are important for understanding the role of the microbial community in the human gut.
Article
Microbiology
Evy Maas, John Penders, Koen Venema
Summary: Most studies on the human gut microbiota focus on bacteria, but recent research indicates that intestinal fungi are also important for maintaining health. This study analyzed the mycobiome of healthy individuals and its interaction with the bacterial component of the microbiome. The results showed a lower diversity of fungi compared to bacteria, with significant inter-individual variation. Positive correlations were observed between certain fungi and bacteria, including those associated with alleviating inflammatory bowel disease. Further research is needed to investigate the importance of these correlations and distinguish between gut colonizers and transient species.
Review
Immunology
Natalia Torow, Timothy W. Hand, Mathias W. Hornef
Summary: The mucosal immune system of neonates develops through phases influenced by environmental cues and evolutionary developmental programming. The response to exogenous stimuli during early life is tightly regulated, determining future immune responses to diet, microbiota, and pathogens. Early-life exposures, such as breastfeeding and environmental/microbial stimuli, play a role in shaping immunological and metabolic homeostasis and the risk of developing diseases like asthma/allergy and obesity.
Article
Cultural Studies
Alena Kamenshchikova, Petra F. G. Wolffs, Christian J. P. A. Hoebe, John Penders, Klasien Horstman
Summary: Complex phenomena, such as antimicrobial resistance (AMR), are often explained in biomedical sciences using analogies and metaphors. These metaphors play a crucial role in knowledge production and can shape scientific models of thought. Some metaphors, like 'AMR is an apocalypse' or 'antibiotics are weapons', are recognized immediately, but others, such as 'bacterial reservoirs' and 'bacterial colonies', are presented as literal and descriptive. However, these terms still carry historical links and can perpetuate thinking about bacteria as foreign actors.
SCIENCE AS CULTURE
(2023)
Article
Microbiology
Danyta I. Tedjo, Jennifer A. Wilbrink, Jos Boekhorst, Harro M. Timmerman, Simon W. Nienhuijs, Arnold Stronkhorst, Paul H. M. Savelkoul, Ad A. M. Masclee, John Penders, Daisy M. A. E. Jonkers
Summary: This study investigated the changes in fecal microbiota composition in obese individuals before and after sleeve gastrectomy (SG) and found a significant shift in microbiota composition after the surgery, but not towards a leaner profile. There were no correlations found between inflammatory markers, intestinal permeability, and changes in microbial profile.
Article
Pediatrics
M. van der Steen, P. L. Leroy, G. J. A. Driessen, M. A. G. E. Bannier
Summary: Multisystem inflammatory syndrome in children (MIS-C) is an inflammatory condition associated with SARS-CoV-2, characterized by various clinical manifestations. The lack of specificity in current definitions and diagnostic criteria can lead to confusion with other inflammatory pediatric diseases, emphasizing the importance of cautious diagnosis and treatment.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
