Article
Oncology
Hua Yin, Jingjing Hu, Zhiying Ye, Saijun Chen, Yunwen Chen
Summary: Long non-coding RNAs (lncRNAs) play a crucial role in colorectal cancer (CRC), with NNT-AS1 levels associated with clinical staging and potential as a biomarker. Additionally, NNT-AS1 exerts its biological effects in CRC cells via regulation of the microRNA-496/Ras-related protein Rap-2c axis.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Hyun Jun Park, Kyung-A Byun, Seyeon Oh, Hyoung Moon Kim, Moon Suk Chung, Kuk Hui Son, Kyunghee Byun
Summary: Nicotinamide nucleotide transhydrogenase (NNT) is involved in decreasing melanogenesis through modulation of cellular redox changes. The mixture of nicotinamide, vitamin C, and PDRN (NVP-mix) can decrease melanogenesis by increasing NNT expression and reducing mitochondrial oxidative stress.
Article
Biochemistry & Molecular Biology
Thiago Rentz, Gabriel G. Dorighello, Renata R. dos Santos, Lohanna M. Barreto, Israelle N. Freitas, Carolina M. Lazaro, Daniela S. Razolli, Patricia M. Cazita, Helena C. F. Oliveira
Summary: CETP activity decreases HDL-cholesterol concentrations, but CETP expression in macrophages can reduce cholesterol accumulation, inflammation, and increase antioxidant capacity. Transplantation experiments showed that CETP expression did not change vascular lesion areas but decreased macrophage and neutrophil content, mitigating inflammation. These findings help explain the failure of CETP inhibitors in reducing atherosclerotic events.
Article
Endocrinology & Metabolism
DongLiang Wang, Ying Zheng
Summary: This study investigated the role of NNT-AS1 in papillary thyroid cancer (PTC) progression, revealing its impact on cell proliferation, migration, invasion, and apoptosis. The study demonstrated a negative correlation between NNT-AS1 and miR-199a-5p in PTC cells, and their opposing effects on PTC cell functions.
Article
Biochemistry & Molecular Biology
Annelise Francisco, Tiago Rezende Figueira, Roger Frigerio Castilho
Summary: Proton-translocating NAD(P)(+) transhydrogenase, known as NNT, plays a crucial role in mitochondrial function and antioxidant pathways. Dysfunctions in NNT have been linked to various metabolic pathways and disease phenotypes, making it a potential target for new therapeutic strategies. Further research is needed to fully understand the role of NNT in physiological and pathological conditions.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Maria Favia, Anna Atlante
Summary: In cystic fibrosis cells, NNT activity is lower compared to healthy cells, leading to a reverse reaction that consumes NADPH to support NADH production and reduces the explosion of ROS from the damaged respiratory chain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Daniel J. Rawle, Thuy T. Le, Troy Dumenil, Cameron Bishop, Kexin Yan, Eri Nakayama, Phillip Bird, Andreas Suhrbier
Summary: Granzyme A is a protease secreted by cytotoxic lymphocytes, and its role in Chikungunya viral arthritis was studied. The presence of Nnt and C57BL/6N genetic background influenced the phenotype, rather than the loss of GZMA expression. Background issues related to Nnt and C57BL/6N have complicated the understanding of GZMA.
Review
Biochemistry & Molecular Biology
Jonathan M. Borkum
Summary: The study highlights the role of oxidative stress in triggering acute migraine attacks by impacting antioxidant defense mechanisms. It reveals the crucial role of intracellular NADPH in neurons, particularly the significance of isocitrate dehydrogenase and nicotinamide nucleotide transhydrogenase in this process.
NEUROCHEMICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Xiaoqian Li, Kun Qian, Yuehua Zhang, Yining Zhang, Yulan Liu, Chuntang Sun, Yang Jiao, Daojiang Yu, Fenghao Geng, Jianping Cao, Shuyu Zhang
Summary: This study reveals the critical role of USP47 in oxidative skin damage through regulating NNT degradation and mitochondrial homeostasis. Inhibition of NNT expression limits energy production ability and leads to accumulation of mitochondrial reactive oxygen species (ROS).
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Soo Jung Lee, Jae-Hwan Jeong, Jeeyeon Lee, Ho Yong Park, Jin Hyang Jung, Jieun Kang, Eun Ae Kim, Nora Jee-Young Park, Ji-Young Park, In Hee Lee, Yee Soo Chae
Summary: The study indicates that miR-496 and miR-137 may modulate the progression of triple negative breast cancer (TNBC) by targeting the Del-1 gene, potentially serving as new biomarkers for patients with TNBC.
Article
Oncology
Zhiyong Xiong, Wei Xiong, Wen Xiao, Changfei Yuan, Jian Shi, Yu Huang, Cheng Wang, Xiangui Meng, Zhixian Chen, Hongmei Yang, Ke Chen, Xiaoping Zhang
Summary: The study revealed a novel mechanism by which HIF2a decreased NNT level through a microRNA that suppressed tumor cell slimming, resulting in the progression of ccRCC. This mechanism provides a fresh perspective of lipid accumulation in ccRCC and may help target novel strategies for the treatment of tumors with abnormal lipid metabolism.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Shino Nemoto, Tetsuya Kubota, Hiroshi Ohno
Summary: This study investigates the genetic cause of phenotypic differences between B6J and B6N mice, identifying candidate genes with differential expression in metabolic tissues and providing comparative data on body weight, tissue weight, blood components, and energy balance. These findings have important implications for future research in related fields.
Article
Biochemistry & Molecular Biology
Jennifer Allouche, Inbal Rachmin, Kaustubh Adhikari, Luba M. Pardo, Ju Hee Lee, Alicia M. McConnell, Shinichiro Kato, Shaohua Fan, Akinori Kawakami, Yusuke Suita, Kazumasa Wakamatsu, Vivien Igras, Jianming Zhang, Paula P. Navarro, Camila Makhlouta Lugo, Haley R. Noonan, Kathleen A. Christie, Kaspar Itin, Nisma Mujahid, Jennifer A. Lo, Chong Hyun Won, Conor L. Evans, Qing Yu Weng, Hequn Wang, Sam Osseiran, Alyssa Lovas, Istvan Nemeth, Antonio Cozzio, Alexander A. Navarini, Jennifer J. Hsiao, Nhu Nguyen, Lajos Kemeny, Othon Iliopoulos, Carola Berking, Thomas Ruzicka, Rolando Gonzalez-Jose, Maria-Catira Bortolini, Samuel Canizales-Quinteros, Victor Acuna-Alonso, Carla Gallo, Giovanni Poletti, Gabriel Bedoya, Francisco Rothhammer, Shosuke Ito, Maria Vittoria Schiaffino, Luke H. Chao, Benjamin P. Kleinstiver, Sarah Tishkoff, Leonard Zon, Tamar Nijsten, Andres Ruiz-Linares, David E. Fisher, Elisabeth Roider
Summary: This study reveals a mechanism of skin pigmentation that is independent of UV light and MITF, involving the regulation of melanosome maturation through targeting the mitochondrial enzyme NNT. Inhibition of NNT leads to increased pigmentation, as shown in human skin and mice experiments, and genetic modifications of NNT affect melanocytic pigmentation in zebrafish. Analysis of human cohorts also suggests significant associations between skin color and various single-nucleotide polymorphisms within NNT.
Article
Genetics & Heredity
Tjasa Krasovec, Jaka Sikonja, Mojca Zerjav Tansek, Marusa Debeljak, Sasa Ilovar, Katarina Trebusak Podkrajsek, Sara Bertok, Tine Tesovnik, Jernej Kovac, Jasna Suput Omladic, Michaela F. Hartmann, Stefan A. Wudy, Magdalena Avbelj Stefanija, Tadej Battelino, Primoz Kotnik, Urh Groselj
Summary: This study presents the clinical and genetic characteristics of three family members with a novel pathogenic variant in the NNT gene, which causes primary adrenal insufficiency. These patients developed the disease at different ages and showed both adrenal and extra-adrenal manifestations.
Article
Genetics & Heredity
Miaomiao Li, Weibing Tian, Fengqi Wang, Chengyu Yang, Lu Zhang, Qian Tang, Shiguo Liu, Fang Wang
Summary: Thyroid dysgenesis (TD) is the most common neonatal disorder, with 80% of cases attributed to it. Research suggests that Nicotinamide nucleotide transhydrogenase (NNT) gene mutations may play a role in TD, with three potentially pathogenic mutations identified in NNT. These mutations have damaging effects on protein stability and cellular redox balance, providing new insights into the pathophysiology of thyroid and expanding the spectrum of pathogenic genes associated with TD. Further investigation into the pathogenic mechanism of NNT in TD is needed.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
