Review
Cell Biology
Laura Gerosa, Amir Mohammad Malvandi, Marco Malavolta, Mauro Provinciali, Giovanni Lombardi
Summary: The locomotor system, consisting of skeletal muscles and bones, plays a vital role in maintaining function and preventing frailty. As individuals age, chronic disorders of the locomotor system may arise, negatively impacting bone and muscle function. Senescent cells, which accumulate in muscle tissue with advancing age or under pathological conditions, impair muscle regeneration and contribute to muscle weakness. Additionally, senescence in the bone microenvironment affects bone turnover, increasing the risk of osteoporosis. Understanding the mechanisms underlying cellular senescence in musculoskeletal tissues may aid in developing effective biomarkers for early detection of tissue flaws.
AGEING RESEARCH REVIEWS
(2023)
Review
Medicine, Research & Experimental
Yingqian Zhu, Jianli Ge, Ce Huang, Hailiang Liu, Hua Jiang
Summary: Aging frailty is a complex geriatric syndrome characterized by disruption of physiological homeostasis and declining health status. Factors such as genome instability, DNA damage, and stem cell exhaustion contribute to the development of frailty with advancing age. Effective interventions are needed to improve the health status of frail patients.
Review
Cell & Tissue Engineering
Yaping Wang, Tianyun Gao, Bin Wang
Summary: Senescence is a hot topic due to the accumulation of senescent cells and inflammatory factors, leading to various senescence-related diseases. Stem cell-based therapy, particularly using mesenchymal stromal cells (MSCs), is considered a promising strategy to alleviate or cure these diseases.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Pharmacology & Pharmacy
Jeremy Boulestreau, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: Osteoarthritis is associated with a high number of senescent cells in joint tissues, which release senescence-associated secretory phenotype (SASP) factors contributing to the disease progression. Targeting senescent cells has shown improvement in OA features in mouse models. MSCs and MSC-EVs are promising treatments for OA, but their functions are affected by aging.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Zehuan Liao, Han Lin Yeo, Siaw Wen Wong, Yan Zhao
Summary: Cellular senescence is a complex process affecting various biological processes, with characteristics including senescence-associated phenotype and cell cycle arrest. Persistent senescence is associated with aging pathologies, while transient senescence is linked to beneficial programs.
Review
Biochemistry & Molecular Biology
Erika Csekes, Lucia Rackova
Summary: This article discusses the impact of skin aging and cellular senescence on the skin, as well as the role of natural polyphenols in preventing and delaying aging. It also summarizes the latest research on the anti-senescent mechanisms of polyphenols.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
C. Voskamp, L. A. Anderson, W. J. L. M. Koevoet, S. Barnhoorn, P. G. Mastroberardino, G. J. V. M. van Osch, R. Narcisi
Summary: TWIST1 influences the expansion of MSCs, and its silencing-induced senescence in MSCs is characterized by a specific SASP profile and metabolic state, different from irradiation-induced senescent MSCs.
EUROPEAN CELLS & MATERIALS
(2021)
Review
Cell Biology
Thamil Selvee Ramasamy, Yong Mei Yee, Ilyas M. Khan
Summary: Osteoarthritis is a common degenerative joint disease associated with aging, where damage to articular chondrocytes plays a key role. Understanding the complexity of cellular aging is crucial for developing new therapies targeting the specific causes of age-related functional decline in OA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Geriatrics & Gerontology
Serena Marcozzi, Giorgia Bigossi, Maria Elisa Giuliani, Robertina Giacconi, Francesco Piacenza, Maurizio Cardelli, Dario Brunetti, Agnese Segala, Alessandra Valerio, Enzo Nisoli, Fabrizia Lattanzio, Mauro Provinciali, Marco Malavolta
Summary: This study provides a comprehensive evaluation of the role of senescent cells in driving inflammation and frailty. The results indicate that the burden of senescent cells related to musculoskeletal and cerebral health has the strongest causal link to frailty. These findings are important for understanding the role of cellular senescence in frailty and developing personalized therapies.
Review
Cell Biology
Jing Yang, Mengmeng Liu, Dongchun Hong, Musheng Zeng, Xing Zhang
Summary: Cellular senescence in cancer presents a dual role, acting as both a preventative measure and a promoter of tumor development. Senescent cells contribute to oncogenesis through their secretory phenotype, both inhibiting tumor growth and creating an environment conducive to tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell & Tissue Engineering
Marco Tatullo
Summary: Aging is characterized by physiological changes that increase susceptibility to age-related diseases. This review summarizes the alterations affecting MSCs during aging and the role of inflammation in age-related syndromes.
Review
Biochemistry & Molecular Biology
Fernanda Hernandez-Gonzalez, Rosa Faner, Mauricio Rojas, Alvar Agusti, Manuel Serrano, Jacobo Sellares
Summary: Fibrosing interstitial lung diseases are chronic and fatal lung diseases characterized by the irreversible accumulation of scar tissue in the lung tissue. Cellular senescence, defined as a cell fate decision caused by unrepairable cellular damage, plays an important role in the initiation and progression of pulmonary fibrosis, likely by promoting molecular and cellular changes in chronic fibrosing processes. Targeting cellular senescence may be a potential therapeutic approach for treating fibrosing ILDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Mariann M. Gabrawy, Nick Khosravian, George S. Morcos, Tatiana V. Morozova, Meagan Jezek, Jeremy D. Walston, Wen Huang, Peter M. Abadir, Jeff Leips
Summary: Treatment with lisinopril, a renin-angiotensin system inhibitor, shows mixed results in humans due to genetic variation. Genes in the WNT signaling pathway are associated with physical performance and sensitivity to lisinopril treatment. These genes could be potential therapeutic targets for improving resiliency.
Article
Cell Biology
Minxue Jia, Khaled Sayed, Maria G. Kapetanaki, William Dion, Lorena Rosas, Saad Irfan, Eleanor Valenzi, Ana L. Mora, Robert A. Lafyatis, Mauricio Rojas, Bokai Zhu, Panayiotis V. Benos
Summary: The study of aging and its mechanisms, such as cellular senescence, has provided valuable insights into age-related pathologies. Through the analysis of transcriptional profiles, the lymphoid enhancer binding factor 1 (LEF1) has been identified as an important regulator of gene expression in lung cells, which is associated with aging and cellular senescence.
Review
Immunology
Dominique E. Martin, Blake L. Torrance, Laura Haynes, Jenna M. Bartley
Summary: Immunometabolism plays a crucial role in aging, affecting immune cell activation and effector functions through metabolic pathways. It has been found that aging can impact the networks controlling immune cell metabolism, but further research is needed to fully understand these effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Geriatrics & Gerontology
Emi Ampo, Ana Paula Mendes-Silva, Vanessa Goncalves, Jenna M. Bartley, George A. Kuchel, Breno S. Diniz
Summary: This study evaluated the levels of circulating cell-free mitochondrial DNA (ccf-mtDNA), a marker of cellular stress and damage, in older adults with late-life depression (LLD) and frailty. The coexistence of LLD and frailty was associated with higher levels of ccf-mtDNA, suggesting a common biological mechanism of cellular stress and mitochondrial dysfunction. This finding offers potential opportunities for future interventions guided by geroscience.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Loren M. DeVito, Nir Barzilai, Ana Maria Cuervo, Laura J. Niedernhofer, Sofiya Milman, Morgan Levine, Daniel Promislow, Luigi Ferrucci, George A. Kuchel, Joan Mannick, Jamie Justice, Mitzi M. Gonzales, James L. Kirkland, Pinchas Cohen, Judith Campisi
Summary: Geroscience posits that aging is malleable and by targeting the hallmarks of biological aging, age-related diseases can be alleviated and longevity extended. Experts have made significant advancements in understanding the mechanisms underlying biological aging and identified ways to target aging pathways. Proof-of-concept studies and early-stage clinical trials are underway to assess the feasibility of drug evaluation in geroscience.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Cell Biology
Erica C. Lorenzo, Blake L. Torrance, Spencer R. Keilich, Iman Al-Naggar, Andrew Harrison, Ming Xu, Jenna M. Bartley, Laura Haynes
Summary: The differentiation of CD4 T helper cells during influenza infection is affected by aging, with an increase in regulatory T cells (Treg) and higher levels of TGF-beta in the lungs of aged mice. Treatment with senolytic drugs in aged mice prior to infection can restore Th cell differentiation and promote a return to homeostasis by reducing the percentage of Treg cells and inducing a healing Type 2 phenotype. Senescent cells play a significant role in impacting Th cell differentiation through production of cytokines like TGF-beta.
Article
Cell Biology
Lichao Wang, Binsheng Wang, Nathan S. Gasek, Yueying Zhou, Rachel L. Cohn, Dominique E. Martin, Wulin Zuo, William F. Flynn, Chun Guo, Evan R. Jellison, Taewan Kim, Larissa G. P. Langhi Prata, Allyson K. Palmer, Ming Li, Christina L. Inman, Lauren S. Barber, Iman M. A. Al-Naggar, Yanjiao Zhou, Wenqiang Du, Kshitiz, George A. Kuchel, Alexander Meves, Tamar Tchkonia, James L. Kirkland, Paul Robson, Ming Xu
Summary: This study identifies a small population of p21 high-expressing cells that accumulate in adipose tissue with obesity and shows that intermittent clearance of these cells can prevent and alleviate insulin resistance. Inactivation of the NF-kB pathway within these cells attenuates insulin resistance. Additionally, a drug combination of dasatinib and quercetin can eliminate p21 high-expressing cells in human fat and mitigate insulin resistance.
Review
Cell Biology
Rachel L. Cohn, Nathan S. Gasek, George A. Kuchel, Ming Xu
Summary: Senescent cells play a significant role in aging and disease, and targeting them could slow down the aging process. The commonly used marker p16 has led to important discoveries, but new markers and investigating heterogeneity are crucial. Advanced technologies like single-cell RNA-seq can help uncover new markers and the urgent need to investigate senescence heterogeneity.
TRENDS IN CELL BIOLOGY
(2023)
Editorial Material
Oncology
Shree Bose, Margarida Barroso, Milan G. Chheda, Hans Clevers, Elena Elez, Salma Kaochar, Scott E. Kopetz, Xiao-Nan Li, Funda Meric-Bernstam, Clifford A. Meyer, Haiwei Mou, Kristen M. Naegle, Martin F. Pera, Zinaida Perova, Katerina A. Politi, Benjamin J. Raphael, Paul Robson, Rosalie C. Sears, Josep Tabernero, David A. Tuveson, Alana L. Welm, Bryan E. Welm, Christopher D. Willey, Konstantin Salnikow, Jeffrey H. Chuang, Xiling Shen
Summary: 3D patient tumor avatars hold great promise for precision medicine, but their clinical benefits need to be established through standardization and prospective trials. Innovative trial designs and integrated platforms combining diagnostics and therapeutics can accelerate the development of new treatments for refractory diseases.
Article
Biochemistry & Molecular Biology
Ravi S. Pandey, Mark P. Krebs, Mohan T. Bolisetty, Jeremy R. Charette, Jurgen K. Naggert, Paul Robson, Patsy M. Nishina, Gregory W. Carter
Summary: This study analyzed the transcriptome of mouse retinal pigment epithelium (RPE) using single-cell RNA sequencing, identifying six distinct cell populations and revealing cell heterogeneity within RPE. One cell population exhibited stem and/or progenitor characteristics. Analysis along a pseudotime axis showed a relative decrease in melanogenesis and SP gene expression and an increase in visual cycle gene expression during RPE maturation. Additional expression patterns were identified that may contribute to understanding RPE stem cell maintenance and cellular metabolic network evolution.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Correction
Cell Biology
Yuliana Tan, William F. Flynn, Santhosh Sivajothi, Diane Luo, Suleyman B. Bozal, Monica Dave, Anthony A. Luciano, Paul Robson, Danielle E. Luciano, Elise T. Courtois
NATURE CELL BIOLOGY
(2022)
Review
Biology
Allison M. M. Andrade, Mingda Sun, Nathan S. S. Gasek, Geneva R. R. Hargis, Roshanak Sharafieh, Ming Xu
Summary: Cellular senescence plays a significant role in aging, tissue and wound repair, tumor biology, and development. It is an irreversible growth arrest induced by internal and external stress mechanisms. Senescent cell populations are diverse and finding a specific biomarker for this state is challenging. Despite its involvement in wound healing and tissue repair, the mechanisms by which senescent cells modulate regenerative processes remain unclear.
Article
Nutrition & Dietetics
Chia-Ling Kuo, Ben Kirk, Meiruo Xiang, Luke C. C. Pilling, George A. A. Kuchel, Richard Kremer, Gustavo Duque
Summary: This study examined the relationship between vitamin D levels and leukocyte telomere length (LTL) in older participants. It found that low or extremely low vitamin D levels were associated with shorter LTL, as well as high vitamin D levels. However, these associations may be influenced by unmeasured confounders.
Article
Cell Biology
Patty J. Lee, Christopher C. Benz, Philip Blood, Katy Boerner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, David Furman, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Indra Heckenbach, Ziv-Bar Joseph, Pragati Katiyar, So-Jin Kim, Melanie Koenigshoff, George A. Kuchel, Haesung Lee, Jun Hee Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, Joao F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Morten Scheibye-Knudsen, Birgit Schilling, Pixu Shi, Jonathan C. Silverstein, Vidyani Suryadevara, Jichun Xie, Jinhua Wang, A. Ian Wong, Laura J. Niedernhofer, Siyuan (Steven) Wang, Hannah Anvari, Julia Balough, Christopher Benz, Joanna Bons, Boris Brenerman, William Evans, Akos Gerencser, Heather Gregory, Malene Hansen, Jamie Justice, Pankaj Kapahi, Natalia Murad, Amy O'Broin, Mary Ellen Pavone, Mark Powell, Gary Scott, Elisheva Shanes, Mahalakshmi Shankaran, Eric Verdin, Daniel Winer, Fei Wu, Andrew Adams, Philip D. Blood, Andreas Bueckle, Ivan Cao-Berg, Hao Chen, Michael Davis, Shane Filus, Yuhan Hao, Austin Hartman, Euxhen Hasanaj, Jesse Helfer, Bruce Herr, Ziv Bar Joseph, Gesmira Molla, Gloria Mou, Juan Puerto, Ellen M. Quardokus, Alexander J. Ropelewski, Matt Ruffalo, Rahul Satija, Melissa Schwenk, Robin Scibek, William Shirey, Max Sibilla, Joel Welling, Zhou Yuan, Richard Bonneau, Angela Christiano, Benjamin Izar, Vilas Menon, David M. Owens, Hemali Phatnani, Colin Smith, Yousin Suh, Andrew F. Teich, Valerie Bekker, Cliburn Chan, Elias Coutavas, Matthew G. Hartwig, Zhicheng Ji, Andrew B. Nixon, Zhixun Dou, Jayaraj Rajagopal, Nikolai Slavov, David Holmes, Diana Jurk, James L. Kirkland, Anthony Lagnado, Tamara Tchkonia, Kristin Abraham, Amanda Dibattista, Yih-Woei Fridell, T. Kevin Howcroft, Chamelli Jhappan, Viviana Perez Montes, Mercy Prabhudas, Haluk Resat, Veronica Taylor, Manoj Kumar, Francisco Cigarroa, Rachel Cohn, Tiffany M. Cortes, Elise Courtois, Jeffrey Chuang, Monica Dave, Sergii Domanskyi, Elizabeth Ann Lieser Enninga, Giray Naim Eryilmaz, Sara E. Espinoza, Jon Gelfond, James Kirkland, Chia-Ling Kuo, Julia S. Lehman, Cristina Aguayo-Mazzucato, Alexander Meves, Meenakshi Rani, Shane Sanders, Asa Thibodeau, Stefan G. Tullius, Duygu Ucar, Brian White, Qian Wu, Ming Xu, Seiji Yamaguchi, Naziheh Assarzadegan, Chun-Seok Cho, Irene Hwang, Yongha Hwang, Jingyue Xi, Oyedele A. Adeyi, Constantin F. Aliferis, Alessandro Bartolomucci, Xiao Dong, Mickayla J. DuFresne-To, Sayeed Ikramuddin, Steve G. Johnson, Andrew C. Nelson, Xavier S. Revelo, Claudia Trevilla-Garcia, John M. Sedivy, Elizabeth L. Thompson, Paul D. Robbins, Jinhua Wang, Katherine M. Aird, Jonathan K. Alder, Delphine Beaulieu, Marta Bueno, Jazmin Calyeca, Julian A. Chamucero-Millaris, Stephen Y. Chan, Dongjun Chung, Anthony Corbett, Vera Gorbunova, Kymberly M. Gowdy, Aditi Gurkar, Jeffrey C. Horowitz, Qianjiang Hu, Gagandeep Kaur, Timur O. Khaliullin, Robert Lafyatis, Serafina Lanna, Dongmei Li, Anjun Ma, Alison Morris, Thivanka M. Muthumalage, Victor Peters, Gloria S. Pryhuber, Brenda F. Reader, Lorena Rosas, John C. Sembrat, Sadiya Shaikh, Hangchuan Shi, Sean D. Stacey, Claudette St Croix, Cankun Wang, Qixin Wang, Andrew Watts, Liangcai Gu, Yiing Lin, Peter S. Rabinovitch, Mariya T. Sweetwyne, Maxim N. Artyomov, Samuel J. Ballentine, Milan G. Chheda, Sherri R. Davies, John F. DiPersio, Ryan C. Fields, James A. J. Fitzpatrick, Robert S. Fulton, Shin-ichiro Imai, Sanjay Jain, Tao Ju, Vladimir M. Kushnir, Daniel C. Link, Michael Ben Major, Stephen T. Oh, Daniel Rapp, Michael P. Rettig, Shelia A. Stewart, Deborah J. Veis, Kiran R. Vij, Michael C. Wendl, Matthew A. Wyczalkowski, Joseph E. Craft, Archibald Enninful, Negin Farzad, Peter Gershkovich, Stephanie Halene, Yuval Kluger, Jennifer VanOudenhove, Mina Xu, Junchen Yang, Mingyu Yang
Summary: Cells respond to stress by undergoing senescence, and the heterogeneity of senescent cells and their secretory phenotype need further characterization. The Cellular Senescence Network (SenNet) was established to create a map of senescent cells across the human lifespan and improve diagnostic and therapeutic approaches.
Meeting Abstract
Oncology
Kevin Johnson, Kevin Anderson, Djamel Nehar-Belaid, Frederick Varn, Amit Gujar, Elise Courtois, Paul Robson, Hyo-Eun Moon, Anna Golebiewska, Sun Ha Paek, Simone Niclou, Roel Verhaak
Article
Cell Biology
Jan Martinek, Jianan Lin, Kyung In Kim, Victor G. Wang, Te-Chia Wu, Michael Chiorazzi, Hannah Boruchov, Ananya Gulati, Shamreethaa Seeniraj, Lili Sun, Florentina Marches, Paul Robson, Anthony Rongvaux, Richard A. Flavell, Joshy George, Jeffrey H. Chuang, Jacques Banchereau, Karolina Palucka
Summary: Modulating immune function at the tumor site could improve patient outcomes. This study shows that tumor infiltrating T cells are predominantly associated with CD14(+) monocytes/macrophages rather than melanoma cells in metastatic melanoma patients. Transcriptional analysis reveals that stromal CD14(+) cells have a distinct signature compared to CD14(+) cells within tumor nests and the included LY75 gene may serve as a potential biomarker for predicting prolonged survival in metastatic cutaneous melanoma and other cancers. Reprogramming stromal macrophages to acquire dendritic cell (DC) function could offer a therapeutic opportunity for metastatic cancers.
CELL REPORTS MEDICINE
(2022)
Meeting Abstract
Endocrinology & Metabolism
Gabriel Alvares Borges, Angelo Guilatco, Sonya Royzenblat, Iyabode Ajayi, Claire Edwards, Ming Xu, Tamar Tchkonia, James Kirkland, Taxiarchis Kourelis, Matthew Drake, Megan Weivoda
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)