Article
Engineering, Environmental
Taotao Yang, Chao Xu, Changlu Liu, Yongqin Ye, Zhaowei Sun, Bin Wang, Zhiqiang Luo
Summary: The study found that crosslinking different conductive polymers with PEDOT:PSS as a conductive dopant can result in conductive hydrogels with higher conductivity and biocompatibility, suitable for bioelectronic device applications and in situ electrochemical sensing of bioactive molecules.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Hong Sun, Tao Li, Yingying An, Dingding Wang, Wei Yang, Haoran Sun, Hongdian Lu, Chunxiang Wei
Summary: Polydopamine-based hydrogels, inspired by mussels, can repair themselves autonomously but have reduced mechanical strength. By incorporating bimetallic ions, tissue-mimetic hydrogels with enhanced toughness, self-healing properties, and high conductivity are developed. A bioelectronic sensor is constructed to detect human motion, pulse, and voice.
Article
Materials Science, Multidisciplinary
Mushtaq A. Bhat, Reyaz A. Rather, Aabid H. Shalla
Summary: Conducting polymer hydrogels have shown potential in medical therapies, medical and bioelectronics, environmental pollution treatments, energy storage, and sensors. Among them, PEDOT-based conducting polymer hydrogels have attracted great interest and been applied in various fields such as bioelectronics, tissue engineering, drug delivery, and electrode purposes.
Article
Chemistry, Applied
Yohan Kim, Yiluo Hu, Jae-pil Jeong, Seunho Jung
Summary: The OSG/CS hydrogel prepared by aldehyde-amine Schiff-base reaction showed excellent thermal stability and mechanical strength, as well as high compressive stress, adhesive strength, and antibacterial effect. Furthermore, it exhibited a pH-controlled drug release pattern and good biocompatibility.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Xiaonan Liu, Yujie Zhang, Yijie Liu, Shengming Hua, Fanjun Meng, Qinglin Ma, Lingming Kong, Shihui Pan, Yuju Che
Summary: An injectable, self-healing and antibacterial supramolecular hydrogel with multiresponses was developed for wound dressing. The hydrogel was fabricated by mixing Pluronic F127, quaternized chitosan-graft-cyclodextrin, and polydopamine coated tunicate cellulose nanocrystals. The hydrogel exhibited changing crosslink density of network through the photoisomerization of azobenzene, and its antimicrobial property was enhanced by the incorporation of cellulose nanocrystals. The hydrogel showed superior wound healing performance, as confirmed by in vitro and in vivo experiments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Santiago Correa, Emily L. Meany, Emily C. Gale, John H. Klich, Olivia M. Saouaf, Aaron T. Mayer, Zunyu Xiao, Celine S. Liong, Ryanne A. Brown, Caitlin L. Maikawa, Abigail K. Grosskopf, Joseph L. Mann, Juliana Idoyaga, Eric A. Appel
Summary: This study explores the ability of a slow-releasing injectable hydrogel depot to reduce toxicities of immunostimulatory drugs and improve treatment efficacy. The hydrogel-based delivery system demonstrates improved local cytokine induction and shows enhanced therapeutic effects in a melanoma model.
Article
Engineering, Environmental
Maduru Suneetha, Oh Sun Moo, Soon Mo Choi, Sunmi Zo, Kummara Madhusudana Rao, Sung Soo Han
Summary: A new generation of hydrogel-based sensors in wearable devices have been developed with improved properties including stretchability, tensile strength, self-adhesiveness, and conductivity. The hydrogel demonstrated promising potential for flexible wearable devices in bioelectronic applications with self-healing, self-adhesive properties, and good biocompatibility.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Applied
Xueyu Jiang, Xuefeng Yang, Boguang Yang, Lina Zhang, Ang Lu
Summary: By utilizing reversible ketoester-type acylhydrazone linkages for the fabrication of novel cellulose-based hydrogel, high efficiency of self-healing performance and applications in physiological environments were achieved. The dynamic hydrogels possess tunable mechanical properties, pH responsiveness, injectability, and biocompatibility, showing immense potential for biomedical applications such as drug and cell delivery.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Konstantinos Safakas, Sofia-Falia Saravanou, Zacharoula Iatridi, Constantinos Tsitsilianis
Summary: In this article, polysaccharide-based graft copolymers with thermo-responsive grafting chains were designed to form thermo-responsive injectable hydrogels. The critical gelation temperature, T-gel, was controlled using an alginate-based thermo-responsive gelator with heterograft copolymer topology. Rheological investigation showed that the hydrogel exhibited temperature and shear responsiveness, making it suitable for biomedical applications.
Article
Chemistry, Multidisciplinary
[Anonymous]
Summary: Flexible PEDOT:PSS micropillar arrays were fabricated and their application in neural interfaces was investigated. The results demonstrated that these soft micropillars can support the adhesion, growth, and differentiation of cells, as well as influence the direction of neurite outgrowth.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Zeynep Cimen, Sena Babadag, Sedat Odabas, Sevde Altuntas, Gokhan Demirel, Gokcen Birlik Demirel
Summary: Injectable, self-healable, and pH-responsive hybrid hydrogels offer a promising potential for controlled and long-term drug release in cancer treatment. The gelation time is short, with excellent injectability and self-healing capability, alongside outstanding gelation stability. The hybrid hydrogels also exhibit efficient pH-dependent drug release and excellent biocompatibility with support for cell proliferation.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Polymer Science
Trevor Gilbert, Matthew A. Campea, Nahieli Preciado Rivera, Michael Majcher, Richard Alsop, Mouhanad Babi, Thomas Kalab, Jose Moran-Mirabal, Maikel Rheinstadter, Todd Hoare
Summary: In this study, injectable PNIPAM/PVP interpenetrating polymer networks were fabricated and characterized. The results show that the internal structure of the injectable IPNs can be controlled by adjusting the PVP molecular weight and degree of thiolation. The PNIPAM gelation drives the formation of domains, with PNIPAM mainly located in the PVP-rich domains and PVP entrapped in the PNIPAM-rich domain. Additionally, the structural reconfiguration of the IPNs can be achieved by heating above the volume phase transition temperature of the PNIPAM phase, which is influenced by the molecular weight and thiolation degree of the PVP precursor polymers.
Article
Materials Science, Biomaterials
Franco Furlani, Margherita Montanari, Nicola Sangiorgi, Emanuela Saracino, Elisabetta Campodoni, Alessandra Sanson, Valentina Benfenati, Anna Tampieri, Silvia Panseri, Monica Sandri
Summary: This work presents the development of electroconductive hydrogels as injectable matrices for neural tissue regeneration. The physical-chemical properties of the hydrogels can be finely tuned by the amount of conductive polymer and natural cross-linking agent used in the formulation. The resulting hydrogels exhibit enhanced adhesion and growth of primary cortical astrocytes, indicating potential applications in neurological therapies and brain tissue repair.
BIOMATERIALS SCIENCE
(2022)
Article
Materials Science, Biomaterials
Yingfan Chen, Xiangyu Liu, Mingying Yang, Weilian Sun, Chuanbin Mao
Summary: Peripheral nerve injury (PNI) leads to persistent abnormalities in sensory function. The current treatment methods for large nerve defects are not effective. In this study, a genetically engineered virus nanofiber was developed as an artificial nerve fiber graft, which promoted nerve regeneration and neurogenesis in a rat model. This phage-based biomaterial shows potential as a substitute for autologous nerve grafts (ANGs) in treating PNI.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Engineering, Biomedical
Alexandra N. Borelli, Mark W. Young, Bruce E. Kirkpatrick, Matthew W. Jaeschke, Sarah Mellett, Seth Porter, Michael R. Blatchley, Varsha V. Rao, Balaji V. Sridhar, Kristi S. Anseth
Summary: This image demonstrates the clustering ability of mesenchymal stromal cells within a stress-relaxing 3D environment.
ADVANCED HEALTHCARE MATERIALS
(2022)
