The Antitumor Efficacy of CpG Oligonucleotides is Improved by Encapsulation in Plant Virus‐Like Particles

Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47−mediated ‘don’t-eat-me’ signal

(2019) Mingen Liu et al.   NATURE IMMUNOLOGY

CD47 Blockade and Cowpea Mosaic Virus Nanoparticle In Situ Vaccination Triggers Phagocytosis and Tumor Killing

(2019) Chao Wang et al.   Advanced Healthcare Materials

Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics

(2019) Sokullu et al.   Pharmaceutics

Cowpea Mosaic Virus Immunotherapy Combined with Cyclophosphamide Reduces Breast Cancer Tumor Burden and Inhibits Lung Metastasis

(2019) Hui Cai et al.   Advanced Science

Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumours

(2018) Qin Dai et al.   ACS Nano

Talimogene laherparepvec: First in class oncolytic virotherapy

(2018) Robert M. Conry et al.   Human Vaccines & Immunotherapeutics

CpG Still Rocks! Update on an Accidental Drug

(2018) Arthur M. Krieg   Nucleic Acid Therapeutics

CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies

(2017) Nobutaka Hanagata   International Journal of Nanomedicine

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Design of virus-based nanomaterials for medicine, biotechnology, and energy

(2016) Amy M. Wen et al.   CHEMICAL SOCIETY REVIEWS

Self-Assembled DNA Immunonanoflowers as Multivalent CpG Nanoagents

(2015) Liqin Zhang et al.   ACS Applied Materials & Interfaces

Open-label phase 1b study of FOLFIRI plus cetuximab plus IMO-2055 in patients with colorectal cancer who have progressed following chemotherapy for advanced or metastatic disease

(2015) Emily Chan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer

(2015) P. H. Lizotte et al.   Nature Nanotechnology

Antitumor activity and safety of combination therapy with the Toll-like receptor 9 agonist IMO-2055, erlotinib, and bevacizumab in advanced or metastatic non-small cell lung cancer patients who have progressed following chemotherapy

(2014) David A. Smith et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Injectable, self-gelling, biodegradable, and immunomodulatory DNA hydrogel for antigen delivery

(2014) Makiya Nishikawa et al.   JOURNAL OF CONTROLLED RELEASE

Characterization of Viral Capsid Protein Self-Assembly around Short Single-Stranded RNA

(2014) Mauricio Comas-Garcia et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structure-based programming of lymph-node targeting in molecular vaccines

(2014) Haipeng Liu et al.   NATURE

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

(2014) Theerawut Chanmee et al.   Cancers

The Toll-like Receptor 9 Ligand, CpG Oligodeoxynucleotide, Attenuates Cardiac Dysfunction in Polymicrobial Sepsis, Involving Activation of Both Phosphoinositide 3 Kinase/Akt and Extracellular-Signal-Related Kinase Signaling

(2013) Ming Gao et al.   JOURNAL OF INFECTIOUS DISEASES

Gold Nanoparticle Delivery of Modified CpG Stimulates Macrophages and Inhibits Tumor Growth for Enhanced Immunotherapy

(2013) Adam Yuh Lin et al.   PLoS One

Reconstituted plant viral capsids can release genes to mammalian cells

(2013) Odisse Azizgolshani et al.   VIROLOGY

Self-Assembled Multivalent DNA Nanostructures for Noninvasive Intracellular Delivery of Immunostimulatory CpG Oligonucleotides

(2011) Jiang Li et al.   ACS Nano

Polyvalent Immunostimulatory Nanoagents with Self-Assembled CpG Oligonucleotide-Conjugated Gold Nanoparticles

(2011) Min Wei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Membrane Anchored Immunostimulatory Oligonucleotides for In Vivo Cell Modification and Localized Immunotherapy

(2011) Haipeng Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Toll-like receptor 9 (TLR9) agonists in the treatment of cancer

(2008) A M Krieg   ONCOGENE