Article
Nutrition & Dietetics
Silke Crommen, Karl Peter Rheinwalt, Andreas Plamper, Marie-Christine Simon, Daniela Rosler, Rolf Fimmers, Sarah Egert, Christine Metzner
Summary: The study found that supplementation with a specifically tailored probiotic and micronutrient mixture improved NAFLD-related markers more than a basic micronutrient mixture in obese patients following MGB surgery.
JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Jeanne Alard, Benoit Cudennec, Denise Boutillier, Veronique Peucelle, Amandine Descat, Raphael Decoin, Sarah Kuylle, Amin Jablaoui, Moez Rhimi, Isabelle Wolowczuk, Bruno Pot, Anne Tailleux, Emmanuelle Maguin, Sophie Holowacz, Corinne Grangette
Summary: This study identified potential probiotics that can be used for the management of obesity through both in vitro and in vivo approaches. Selected probiotic strains showed positive effects in limiting body weight gain and improving obesity-related metabolic dysfunction and inflammation in a murine model of diet-induced obesity. These protective effects were associated with changes in hypothalamic gene expression, gut microbiota composition, and bile acid profile.
Article
Biotechnology & Applied Microbiology
Naif ALSuhaymi, Ahmed Mohamed Darwish, Abd El-Nasser Khattab
Summary: Obesity is a chronic disease that leads to cardiovascular diseases, and this study evaluates the role of two potential probiotics as anti-obesity supplements. The findings show that Lactiplantibacillus plantarum Pro1 reduces inflammation and cholesterol levels in the liver, suggesting its potential as an anti-obesity supplement.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Skrypnik, Pawel Bogdanski, Magdalena Sobieska, Marcin Schmidt, Joanna Suliburska
Summary: Simultaneous oral multistrain probiotic and iron supplementation can enhance iron absorption in rats and show greater effectiveness in increasing tissue iron stores compared to exclusive probiotic or iron intake.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Chul Sang Lee, Mi Hyun Park, Byoung Kook Kim, Sae Hun Kim
Summary: Obesity is a major cause of metabolic diseases, and inhibiting adipogenic differentiation can prevent and suppress obesity. Oral administration of Lactobacillus strains can improve serum lipid profile and normalize gut microbiota, effectively preventing obesity and improving metabolic health.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Nutrition & Dietetics
Chorng-An Liao, Cheng-Hsieh Huang, Hsieh-Hsun Ho, Jui-Fen Chen, Yi-Wei Kuo, Jia-Hung Lin, Shin-Yu Tsai, Hui-Yun Tsai, Yao-Tsung Yeh
Summary: Obesity refers to the accumulation of excess body fat that negatively impacts health. Gut microbiota, which are regulated by energy metabolism, play a key role in body fat formation. Probiotic supplementation has been shown to improve metabolic syndrome and control body weight. This study found that three probiotic strains - AP-32, bv-77, and CP-9 - effectively reduced body weight gain and improved blood biochemistry in obese rats. A combination of the three strains had a greater effect than individual strains, and a higher dose of supplementation provided more significant benefits. This suggests that these probiotic strains may have potential in treating or controlling metabolic disorders.
Article
Dentistry, Oral Surgery & Medicine
Chiao-Wen Lin, Yi-Tzu Chen, Hsieh-Hsun Ho, Pei-Shan Hsieh, Yi-Wei Kuo, Jia-Hung Lin, Cheng-Ruei Liu, Yu-Fen Huang, Ching-Wei Chen, Chen-Hung Hsu, Wen-Yang Lin, Shun-Fa Yang
Summary: The study showed that oral probiotic lozenges significantly increased the population of Lactobacillus in the oral cavity and exhibited antibacterial activity within two weeks. IgA levels, Lactobacillus and Bifidobacterium abundances in the oral cavity were significantly increased in the experimental groups, leading to reduced plaque formation. Most participants experienced improved oral health and intestinal symptoms.
Article
Food Science & Technology
Moloko G. Mathipa-Mdakane, Mapitsi S. Thantsha
Summary: This article discusses the use of probiotics in controlling foodborne pathogens and introduces the method of creating pathogen-specific probiotic strains through pathogen gene engineering. However, choosing the right probiotics poses a challenge, and the selected probiotics must meet certain criteria. Lacticaseibacillus rhamnosus is a candidate that deserves further research.
Article
Nutrition & Dietetics
Giuseppe Derosa, Luigina Guasti, Angela D'Angelo, Chiara Martinotti, Maria Chiara Valentino, Sergio Di Matteo, Giacomo M. Bruno, Andrea M. Maresca, Giovanni V. Gaudio, Pamela Maffioli
Summary: This study aimed to evaluate the effectiveness of VSL#3(R) in improving hepatic parameters. The results showed that VSL#3(R) therapy reduced triglycerides and inflammatory status, and improved hepatic steatosis, with no difference between men and women.
FRONTIERS IN NUTRITION
(2022)
Article
Geriatrics & Gerontology
Asima Karim, Tahir Muhammad, M. Shahid Iqbal, Rizwan Qaisar
Summary: The aim of this study was to evaluate the effects of probiotics on sarcopenia and physical capacity in COPD patients. The results showed that probiotic treatment can reduce intestinal permeability, stabilize neuromuscular junction, and improve muscle strength and functional performance. In addition, probiotics treatment also decreased plasma levels of markers of systemic inflammation and oxidative stress. However, probiotics treatment did not significantly reduce the prevalence of sarcopenia.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Nutrition & Dietetics
Silvia Lopez-Escalera, Mari L. L. Lund, Gerben D. A. Hermes, Beatrice S. -Y. Choi, Kei Sakamoto, Anja Wellejus
Summary: Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder that is associated with various health issues and is expected to increase in prevalence. Disturbance of tight junction proteins can lead to increased gut permeability and the passage of harmful microbial components to the liver, triggering inflammation and cellular stress. Targeted probiotic supplements have been proposed as a preventive therapy to improve gut barrier function and promote beneficial effects on liver health.
Review
Food Science & Technology
Basavaprabhu Haranahalli Nataraj, Pradip V. Behare, Hariom Yadav, Anil Kumar Srivastava
Summary: Probiotics are widely studied and used dietary supplements that have gained consumer acceptance. However, emerging evidence suggests potential risks associated with probiotics, especially among immunocompromised individuals, emphasizing the need for careful and comprehensive safety studies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Giselle S. Escouto, Gabriela Z. Port, Cristiane V. Tovo, Sabrina A. Fernandes, Alessandra Peres, Gilson P. Dorneles, Vanessa P. Houde, Thibault V. Varin, Genevieve Pilon, Andre Marette, Caroline Buss
Summary: This study evaluated the effects of probiotic supplementation on hepatic fibrosis, inflammatory markers, metabolic markers, and gut microbiota in NASH patients. The results showed that patients who received probiotic supplementation for 6 months had improved APRI scores, but no significant differences were observed in liver fibrosis, steatosis, inflammatory activity, and gut microbiota between the probiotic and placebo groups.
JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Huong Thi Nguyen, Mingkun Gu, Pia Werlinger, Joo-Hyung Cho, Jinhua Cheng, Joo-Won Suh
Summary: The study found that Lactobacillus sakei MJM60958 (MJM60958) has inhibitory effects on non-alcoholic fatty liver disease (NAFLD), and it can influence the gut microbiota and alter the production of short-chain fatty acids. This suggests that MJM60958 has the potential to be a probiotic for the prevention and treatment of NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Ivana Hyrslova, Vladimir Drab, Jaromir Cihlar, Gabriela Krausova, Iva Mrvikova, Antonin Kana, Jiri Stetina, Sarka Musilova
Summary: This study isolated and characterized nine potential probiotic strains from infant feces and breast milk. The strains Lacticaseibacillus rhamnosus S1F and S6C, as well as Lactobacillus gasseri M8C, showed good tolerance to bile salts and adhesion properties, indicating their potential for application in the food industry.
FERMENTATION-BASEL
(2023)
Article
Medicine, General & Internal
Sergii Tkach, Andrii Dorofeyev, Iurii Kuzenko, Tetyana Falalyeyeva, Olena Tsyryuk, Oleksandr Kovalchuk, Nazarii Kobyliak, Ludovico Abenavoli, Luigi Boccuto
Summary: This study aimed to evaluate the clinical and microbiological efficacy, tolerability, and safety of fecal microbiota transplantation (FMT) in patients with mild-to-moderate ulcerative colitis (UC). The results showed that FMT as an add-on therapy performed better in improving symptoms and disease activity levels compared to standard-care treatment. Additionally, FMT was found to significantly improve gut microbiota composition.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Mariia Rudyk, Yevheniia Hurmach, Tetiana Serhiichuk, Iryna Akulenko, Larysa Skivka, Tetiana Berehova, Liudmyla Ostapchenko
Summary: The epidemic scope of obesity in many countries requires a shift in medicine towards personalized prevention. Obesity is characterized by chronic inflammation and sex-specific effects have been proven in morbidity, pathophysiology, comorbidity, outcomes, and prevention efficacy. Gut microbiota plays a key role in obesity and can affect phagocyte functions and inflammation. Probiotics show potential in preventing obesity, but the sex-specific effects are not yet known.
Article
Pharmacology & Pharmacy
Yuriy Tuharov, Daryna Krenytska, Tetiana Halenova, Larysa Kot, Nataliia Raksha, Olexii Savchuk, Larisa Prysiazhniuk, Ruzhena Matkivska, Tetyana Falalyeyeva, Liudmyla Ostapchenko
Summary: This study investigated the levels of MMPs and TIMP-1 in the plasma of patients with OA after recovery from COVID-19. The results suggest that COVID-19 can affect the proteolysis-antiproteolysis system in patients with OA, leading to further complications of existing musculoskeletal pathologies.
REVIEWS ON RECENT CLINICAL TRIALS
(2023)
Article
Pharmacology & Pharmacy
A. N. T. O. N. I. N. A. RACHKOVSKA, D. A. R. Y. N. A. KRENYTSKA, V. I. T. A. L. KARBOVSKYY, T. E. T. I. A. N. A. HALENOVA, N. A. T. A. L. I. I. A. RAKSHA, T. E. T. I. A. N. A. VOVK, O. L. E. X. SAVCHUK, D. M. Y. T. R. O. LIUBENKO, T. E. T. Y. A. N. A. FALALYEYEVA, L. I. U. D. M. Y. L. A. OSTAPCHENKO, L. U. D. O. V. I. C. O. ABENAVOLI
Summary: This study aimed to analyze the potential changes in the parameters of the hemostasis system in the post-COVID period in donors with different titers of anti-SARS-CoV-2 IgG. The results showed a slight increase in the concentration of fibrinogen, SFMCs, and D-dimers in some donor groups, which could lead to the development of hemostasis disorders. The appearance of protein fragments of different molecular weights in the fraction of SFMCs points to uncontrolled activation of biochemical processes involving molecules of fibrinogenic origin.
REVIEWS ON RECENT CLINICAL TRIALS
(2023)
Editorial Material
Immunology
Mariia Rudyk, Ganna Tolstanova, Liudmyla Ostapchenko, Larysa Skivka
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Medicine, General & Internal
Nataliia Raksha, Tetiana Halenova, Tetiana Vovk, Olexandra Kostyuk, Tatyana Synelnyk, Tatyana Andriichuk, Tetiana Maievska, Olexiy Savchuk, Ludmila Ostapchenko
Summary: This study aimed to investigate the ability of collagen peptides derived from a jellyfish of the Antarctic region to prevent obesity in rats fed a high-calorie diet. Collagen peptides were produced by pepsin hydrolysis of jellyfish-derived collagen. The results showed that rats treated with hydrolyzed jellyfish collagen peptides had a decreased body weight gain and body mass index, as well as improved metabolic parameters and decreased oxidative stress markers.
CROATIAN MEDICAL JOURNAL
(2023)
Article
Genetics & Heredity
A. Huet, Yu. Tugarov, K. Dvorshchenko, D. Grebinyk, O. Savchuk, O. Korotkyi, L. Ostapchenko
Summary: This study analyzed the gene expression of TGFB1, FOXO1, and COMP, as well as the generation of free radicals in the blood of patients with osteoarthritis after COVID-19. The results showed a significant decrease in the expression levels of TGFB1 and FOXO1, indicating disruption in cell redox state and signaling attenuation. Additionally, COMP gene expression was significantly decreased, suggesting a more intense activation of cell destructive processes and further pathology progression in patients with osteoarthritis after the SARS-CoV2 infection.
CYTOLOGY AND GENETICS
(2023)
Article
Biotechnology & Applied Microbiology
Olesia Kalmukova, Nataliia Raksha, Tetiana Vovk, Tetiana Halenova, Mykola Dzerzhynsky, Dinko Mitrecic, Olexiy Savchuk, Ludmila Ostapchenko
Summary: This study explores the effect of low-molecular-mass collagen fragments obtained from the scales of Antarctic wild marine fish on rats' adipose tissue in a high-calorie diet-induced obesity model. The results show that the treatment with low-molecular-mass collagen fragments reduces body mass, improves morphological parameters, and decreases inflammation in obese rats.
FOOD TECHNOLOGY AND BIOTECHNOLOGY
(2023)
Review
Microbiology
Nazarii Kobyliak, Maria Khomenko, Tetyana Falalyeyeva, Alexandra Fedchenko, Oleksii Savchuk, Yuliya Tseyslyer, Liudmyla Ostapchenko
Summary: Type 2 diabetes is a metabolic disease characterized by insulin resistance and beta-cell dysfunction. The gut microbiota has a direct impact on metabolism and metabolic diseases. There is current focus on the effects of probiotics on insulin resistance, glycemic control, and related factors, but there is a lack of evidence for their efficacy on beta-cell function.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Daryna Krenytska, Kateryna Strubchevska, Marko Kozyk, Tetiana Vovk, Tetiana Halenova, Larysa Kot, Nataliia Raksha, Olexii Savchuk, Tetyana Falalyeyeva, Olena Tsyryuk, Liudmyla Ostapchenko
Summary: The study aimed to evaluate the degree of inflammation and levels of pro-angiogenic and hypoxic factors, as well as heat shock proteins HSP60 and HSP70 in plasma, of patients with osteoarthritis (OA) after recovery from COVID-19. The results suggest the potential role pro-inflammatory cytokines and angiogenesis-related growth factors in the pathogenesis of both joint pathologies and long-term systemic post-COVID-19 disorders.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Nazarii Kobyliak, Oleh Dynnyk, Maryana Savytska, Oleksandr Solodovnyk, Oleksandr Zakomornyi, Oleksii Omelchenko, Anton Kushnir, Roman Titorenko
Summary: This study evaluates the accuracy and reproducibility of ultrasound steatometry with the Attenuation Coefficient measurement in assessing hepatic steatosis. The results show that this method has good correlation with MRI-PDFF and can provide valuable diagnostic information.
Article
Medicine, General & Internal
Marko Kozyk, Kateryna Strubchevska, Tetiana Marynenko, Alena Zlatska, Tetiana Halenova, Nataliia Raksha, Olexii Savchuk, Tetyana Falalyeyeva, Oleksandr Kovalchuk, Ludmyla Ostapchenko
Summary: Coronary artery disease (CAD) is a major cause of adult disability and mortality, and there is an urgent need to focus on new approaches for its prevention and treatment. This study tested the effects of peptides isolated from CAD patients' blood plasma on endothelial cell secretion using an in vitro model. The results showed that peptides from patients with myocardial infarction promoted vasoconstriction and a prothrombotic state, while peptides from patients with progressive unstable angina suppressed endothelin-1 secretion and increased the secretion of von Willebrand factor and tissue plasminogen activator.
MEDICINA-LITHUANIA
(2023)