Review
Chemistry, Multidisciplinary
Mustafa Nakipoglu, Aysen Tezcaner, Christopher H. Contag, Nasim Annabi, Nureddin Ashammakhi
Summary: Bioadhesives with antimicrobial properties enable easier and safer treatment of wounds. However, designing these biomaterials with the required properties can be challenging. Developing bioadhesives with tunable physical, chemical, and biological properties is crucial for future advancements.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xingguang Cai, Sacha Javor, Bee Ha Gan, Thilo Kohler, Jean-Louis Reymond
Summary: The pH-activity profiling shows that antimicrobial peptide dendrimers (AMPDs) are effective in killing Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0 but not at pH = 7.4, likely due to stronger electrostatic binding to bacterial cells at higher pH. This phenomenon could also apply to polymyxin B and other polycationic antimicrobials.
CHEMICAL COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Haofang Zhu, Guoming Xu, Yiyan He, Hongli Mao, Deling Kong, Kui Luo, Wenbo Tang, Rong Liu, Zhongwei Gu
Summary: In this study, a double-bioinspired hydrogel adhesive with a strong tissue adhesion and enhanced toughness was developed. The adhesive showed fast, strong, and durable adhesion to wet biological tissues. Compared to commercial bio-glues and traditional adhesives, the adhesive exhibited significantly better tissue adhesion both ex vivo and in vivo.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Bin Kong, Rui Liu, Yi Cheng, Yixuan Shang, Dagan Zhang, Hongcheng Gu, Yuanjin Zhao, Wei Xu
Summary: The developed bioadhesive patch shows strong adhesion to defect tissue and improves tissue repair without adjacent adhesion in a rat model with full-thickness perforation of the stomach wall. The responsive structural color can provide color-sensing monitoring to evaluate the adhesive and repair process, making it of great scientific significance and broad clinical application prospects.
Article
Engineering, Biomedical
Yiqian Huang, Wei Jing, Jianping Zeng, Yunxia Xue, Yan Zhang, Xueqiao Yu, Pengfei Wei, Bo Zhao, Jiahong Dong
Summary: Convenient and injectable poly(ethylene glycol) (PEG)-based adhesives have been developed for liver hemostasis, addressing the challenges faced by conventional tissue adhesives. These PEG-bioadhesives possess mechanical compliance to native tissues and tough tissue adhesion, promoting liver regeneration while effectively stopping bleeding. Animal experiments have shown that the PEG-bioadhesives outperform traditional tissue adhesives in terms of hemostasis.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Hossein Montazerian, Elham Davoodi, Avijit Baidya, Maryam Badv, Reihaneh Haghniaz, Arash Dalili, Abbas S. Milani, Mina Hoorfar, Nasim Annabi, Ali Khademhosseini, Paul S. Weiss
Summary: This review provides a biomacromolecular design roadmap for the development of tough adhesive surgical sealants. The intrinsic toughness and elasticity of polymers are achieved through the introduction of strong and dynamic inter- and intramolecular interactions, either through polymer chain design or the use of crosslink regulating additives. Efforts have also been made to promote underwater adhesion through covalent/noncovalent bonds and micro/macro-interlock mechanisms. The measurement and reporting requirements for fair comparisons of different materials and their properties are discussed.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Physical
Mahshid Shokri, Faezeh Dalili, Mahshid Kharaziha, Mohamadreza Baghaban Eslaminejad, Hossein Ahmadi Tafti
Summary: This review article discusses the recent state of the art in bone adhesives, with a specific focus on biomimetic adhesives, their action mechanisms, and upcoming perspective. The article introduces adhesive biomaterials with specific affinity to bone tissue and comprehensively overviews various types of synthetic and natural bioadhesives for bone tissue. It then describes bioinspired adhesives, highlighting relevant structures and examples of biomimetic adhesives mainly made of DOPA and the complex coacervates inspired by proteins secreted in mussel and sandcastle worms, respectively. Finally, the article overviews the challenges of current bioadhesives and the future research for the improvement of the properties of biomimetic adhesives for use as bone adhesives.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Ayca Bal-Ozturk, Berivan Cecen, Meltem Avci-Adali, Seda Nur Topkaya, Emine Alarcin, Gokcen Yasayan, Yi-Chen Ethan Li, Bunyamin Bulkurcuoglu, Ali Akpek, Huseyin Avci, Kun Shi, Su Ryon Shin, Shabir Hassan
Summary: Tissue adhesives serve as an interface to connect the surfaces of wound edges and prevent them from separation, offering new possibilities for wound closure. The chemical properties of these products play a crucial role in their commercial success in clinical applications.
Article
Materials Science, Biomaterials
Kai-Wolfgang Hintzen, Christian Simons, Kim Schaffrath, Gernot Roessler, Sandra Johnen, Felix Jakob, Peter Walter, Ulrich Schwaneberg, Tibor Lohmann
Summary: This study developed bioadhesive peptides for fixing epiretinal stimulating arrays, validated their biocompatibility through biological evaluation and cytotoxicity testing, and demonstrated their fixing capabilities in experiments.
BIOMATERIALS SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Qiang Miao, Jin-Long Sun, Fei Huang, Jing Wang, Pei Wang, Ya-Fei Zheng, Feng Wang, Chu-Fan Ma
Summary: The study constructed a sustained-release system of HHC-36 on the surface of titanium dioxide nanotubes using PDLLA and PLGA coatings. Results showed that the coated nanotubes effectively inhibited the proliferation of Staphylococcus aureus in vitro and exhibited biocompatibility and antibacterial properties in vivo. The findings suggest that HHC-36 coated titanium nanotubes could enhance the antibacterial potential of percutaneous implants, offering a novel and efficient strategy to prevent bacterial infections.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemical Research Methods
Jae Park, Yeonju Kim, Beomsoo Chun, Jungmok Seo
Summary: In recent years, the development of functional bioadhesives has overcome the limitations of traditional bioadhesives, providing more effective solutions for wound healing and biosignal monitoring. These bioadhesives with characteristics such as antimicrobial, cell infiltrative, and stimuli-responsive properties can adhere stably to tissue surfaces and promote tissue regeneration.
BIOTECHNOLOGY JOURNAL
(2021)
Article
Fisheries
Xitong Cen, Bing Liu, Gege Zhang, Huiru Liu, Gaoyou Yao, Maoxian He, Wenguang Liu
Summary: In this study, antimicrobial peptides with antibacterial activity were discovered in the giant Triton snail. These peptides showed significant inhibitory effects on both Gram-positive and Gram-negative bacteria, with the strongest effect observed against Staphylococcus aureus. This research provides important fundamental data for the prevention and treatment of aquatic animal diseases, promoting the sustainable growth of the aquaculture industry, and laying the foundation for the development of novel anti-infective drugs.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Chemistry, Physical
Nisal Wanasingha, Naba K. Dutta, Namita Roy Choudhury
Summary: Over the past two decades, significant milestones have been reached in the development of bioadhesives, capable of adhering to both dry and wet tissue. While these adhesives exhibit high adhesion strength, they often lack other properties required for versatile application. Novel bioadhesives must adapt from early limitations to meet current demands and set new milestones for the future.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Priyadarshi Chakraborty, Moran Aviv, Francesca Netti, Dana Cohen-Gerassi, Lihi Adler-Abramovich
Summary: Co-assembly of two different building blocks can harness both of their attributes and produce nanostructured macro-scale objects with improved physical properties and desired functional complexity.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Engineering, Biomedical
Wan-rong Wang, Jing Li, Jun-ting Gu, Bo-wen Hu, Wen Qin, Yi-na Zhu, Zhen-xing Guo, Yu-Xuan Ma, Franklin Tay, Kai Jiao, Lina Niu
Summary: Poor sealing of the titanium implant-soft tissue interface leads to bacterial invasion and inflammation, resulting in implant failure. To improve this, lactoferrin-derived amyloid is coated on the titanium surface to enhance cell integrin expression and provide antibacterial activity. The coated implants promote cell proliferation and adhesion, have a positive charge, and exhibit strong antibacterial activities.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Applied
Hongli Mao, Shijia Zhao, Yuxin He, Miao Feng, Lihuang Wu, Yiyan He, Zhongwei Gu
Summary: This study developed a polysaccharide-based hydrogel dressing with excellent properties, which accelerated wound healing and improved skin regeneration through in situ photocrosslinking.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Xiangming Kong, Miao Feng, Lihuang Wu, Yiyan He, Hongli Mao, Zhongwei Gu
Summary: The 10-year survival rate of patients with pancreatic cancer is still low due to incomplete surgery and lack of effective postoperative treatment. This study developed a biodegradable microdevice for local sustained drug delivery to effectively inhibit postoperative recurrence with minimal systemic toxicity.
Article
Engineering, Biomedical
Haofang Zhu, Guoming Xu, Yiyan He, Hongli Mao, Deling Kong, Kui Luo, Wenbo Tang, Rong Liu, Zhongwei Gu
Summary: In this study, a double-bioinspired hydrogel adhesive with a strong tissue adhesion and enhanced toughness was developed. The adhesive showed fast, strong, and durable adhesion to wet biological tissues. Compared to commercial bio-glues and traditional adhesives, the adhesive exhibited significantly better tissue adhesion both ex vivo and in vivo.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Lihuang Wu, Yuqi Wang, Xinyue Zhao, Hongli Mao, Zhongwei Gu
Summary: Poly(trimethylene carbonate) (PTMC), a representative of biodegradable aliphatic polycarbonates, degrades in vivo via surface erosion. This unique degradation behavior and the resulting nonacidic products make it competitive with aliphatic polyesters in clinical practice. The biodegradation mechanism of PTMC involves macrophage-mediated erosion, where macrophages fuse into giant cells and release proinflammatory cytokines, primarily secreting enzymes (lipase specifically) to erode PTMC extracellularly.
Review
Chemistry, Multidisciplinary
Haonan Li, Qiang Luo, Hu Zhang, Xuelei Ma, Zhongwei Gu, Qiyong Gong, Kui Luo
Summary: This review provides a comprehensive overview of the applications of nanomedicine-assisted radio-immunotherapy, including the underlying working principles, design strategies, concerns over clinical translation, and perspectives.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Xiaoqin Zhang, Xiaoming Wang, Zhiqian Li, Jun Du, Xueyang Xiao, Dayi Pan, Hu Zhang, Xiaohe Tian, Qiyong Gong, Zhongwei Gu, Kui Luo
Summary: A macromolecular contrast agent BLDCGd was developed for targeted liver cancer imaging. The contrast agent had a high molecular weight and small particle size, and exhibited significant signal enhancement at the tumor site. The study demonstrated the potential of BLDCGd as an effective and bio-safe MRI contrast agent for clinical diagnosis of liver cancer.
Article
Materials Science, Biomaterials
Lu Han, Yuqi Wang, Lihuang Wu, Zixiang Wu, Yiyan He, Hongli Mao, Zhongwei Gu
Summary: Smart materials, specifically biodegradable shape memory polymers (SMPs), have significant potential in various biomedical applications such as surgical sutures, implants, and stents. Poly(DL-lactide-co-trimethylene carbonate) (PDLLTC) is a promising SMP widely used in the field, but the relationship between its shape memory property and chemical structure requires further investigation. In this study, different compositions of PDLLTC copolymers were synthesized and their shape memory properties were studied. The results showed that the shape memory property is influenced by the chemical composition and polymeric chain segments. PDLLTC copolymer with a DLLA/TMC ratio of 75:25 (PDLLTC7525) exhibited excellent shape fixation and recovery ratio at human body temperature. Furthermore, PDLLTC7525-based self-morphing small-diameter vascular scaffolds, incorporating electrospun aligned gelatin/hyaluronic acid (Gel/HA) nanofibers on the inner layer, showed great potential for facilitating endothelial cell proliferation and adhesion. Thus, PDLLTC with customizable shape memory properties holds promise for SMP development and small-diameter vascular scaffold construction.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Qingtao Song, Xiaoyong Ding, Yilin Liu, Wenjuan Liu, Jing Li, Bohan Wang, Zhongwei Gu
Summary: We designed an active drug combination therapy and responsive drug release for Helicobacter pylori using self-propelled micromotors. These micromotors can penetrate the mucus layer, deliver amoxicillin and clarithromycin, and release them in a pH-responsive manner. The micromotors showed enhanced retention and distribution capability, and significantly improved antimicrobial efficiency compared to single-drug loaded micromotors. The optimized dosage ratio of amoxicillin and clarithromycin on the micromotors was determined to be 2:1.
APPLIED MATERIALS TODAY
(2023)
Article
Engineering, Biomedical
Zhilin Li, Hao Cai, Zhiqian Li, Long Ren, Xuelei Ma, Hongyan Zhu, Qiyong Gong, Hu Zhang, Zhongwei Gu, Kui Luo
Summary: To improve the response rate of immune checkpoint inhibitors in immunosuppressive cancers, a self-amplified biomimetic nanosystem was constructed to induce immunogenic cell death at tumor sites. The nanosystem effectively reverses the immunosuppressive tumor microenvironment, leading to distinctive inhibition of tumor growth and metastasis when combined with immune checkpoint inhibitors.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Lihuang Wu, Junhua Li, Yuqi Wang, Xinyue Zhao, Yiyan He, Hongli Mao, Wenbo Tang, Rong Liu, Kui Luo, Zhongwei Gu
Summary: Drug treatment is crucial for improving patient outcomes in both resectable and unresectable cancers. However, conventional systemic administrations are often unsatisfactory, and current drug delivery systems fail to meet clinical demands. This study introduces a microfabrication concept called HMPI and engineers biodegradable-polymer-based microdevices that can pre-program controlled drug release profiles. The designed microdevices show promising results in inhibiting tumor growth and recurrence, providing alternative treatments for postsurgical and unresectable tumor control.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Xiaoling Li, Zhenyu Duan, Zhiqian Li, Lei Gu, Yinggang Li, Qiyong Gong, Zhongwei Gu, Kui Luo
Summary: The advent of immune checkpoint inhibitors introduces a new era of anti-tumor immunity. However, the current anti-PD-L1 antibodies used in clinics can only target PD-L1 on the cell membrane, failing to diminish the cancer-promoting effects of intracellular PD-L1. Therefore, directly reducing the abundance of PD-L1 in cancer cells may be a potential strategy to overcome the limitations of current anti-PD-L1 antibodies.
Article
Engineering, Biomedical
Lei Gu, Zhenyu Duan, Xue Li, Xin Li, Yinggang Li, Xiaoling Li, Gang Xu, Peng Gao, Hu Zhang, Zhongwei Gu, Jie Chen, Qiyong Gong, Kui Luo
Summary: Emerging nanomedicines can eliminate cancer cells by promoting excessive intracellular reactive oxygen species (ROS) generation. However, tumor heterogeneity and poor penetration of nanomedicines often result in varying levels of ROS production, where low levels of ROS can actually promote tumor cell growth, reducing the effectiveness of these nanomedicines. In this study, a novel amphiphilic and block polymer-dendron conjugate-derived nanomedicine (GFLG-DP/Lap NPs) was developed, incorporating a photosensitizer (Ppa) for ROS therapy and Lapatinib (Lap) for molecular targeted therapy. By combining ROS therapy with Lap, the synergistic effect effectively kills cancer cells, even in deep tumor regions.
BIOACTIVE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Xiuli Zheng, Xiaohai Song, Guonian Zhu, Dayi Pan, Haonan Li, Jiankun Hu, Kai Xiao, Qiyong Gong, Zhongwei Gu, Kui Luo, Weimin Li
Summary: Lung cancer, the second most prevalent cancer and the leading cause of cancer-related death, is often accompanied by drug resistance. Nanomedicine, with its multifunctional and tunable physiochemical properties, holds great promise in overcoming drug resistance in lung cancer treatment.
ADVANCED MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Jiajun Qin, Ming Li, Ming Yuan, Xinglei Shi, Jiliang Song, Yiyan He, Hongli Mao, Deling Kong, Zhongwei Gu
Summary: The metal gallium shows great potential in fighting infections by disrupting bacterial iron metabolism. This study reports a novel dual-cross-linked alginate hydrogel containing gallium ions, which exhibits broad-spectrum antimicrobial activity and enhanced mechanical performance. It can effectively treat infected wounds and accelerate healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Biomaterials
Ke Zhou, Miao Feng, Hongli Mao, Zhongwei Gu
Summary: This study addresses the limitations of methacrylated hyaluronic acid (HAMA) in 3D bioprinting by developing a thiol-norbornene photoclick polysaccharide-based bioink (HC-HN). The HC-HN bioink exhibits improved viscoelastic properties, reduced accumulation of reactive oxygen species (ROS), and superior shape fidelity compared to HAMA. The bioink is employed to print a liver model in vitro, which shows enhanced functionality and drug sensitivity compared to 2D culture. Therefore, the HC-HN bioink expands the options for polysaccharide-based bioinks and broadens the opportunities for 3D bioprinting.
BIOMATERIALS SCIENCE
(2022)
