Article
Cell Biology
Jie Shen, Ruihuan Wang, Qing Wang, Minjuan Zhang, Chunyan Liu, Zhenxia Tao, Guohong Su
Summary: Bortezomib-loaded HMSNs (BTZ@HMSNs) system sustains the release of BTZ, inhibits lymphoma cell proliferation and migration, and promotes apoptosis. BTZ@HMSNs downregulate oncogenic genes in lymphoma development, activate p53 signaling, and reduce tumor volume in lymphoma mice model, demonstrating improved tumor-suppressing effect compared to free BTZ. HMSNs show promise as a strategy for delivering therapeutic agents for cancer treatment.
Review
Chemistry, Medicinal
Betzabeth Jaime-Escalante, Luz Maria Melgoza-Contreras, Gerardo Leyva-Gomez, Nestor Mendoza-Munoz
Summary: SBA-15 mesoporous silica is a suitable drug carrier material due to its structural characteristics and biocompatibility. Spray drying is an efficient method to obtain SBA-15 particles, and co-spray drying with drugs improves drug loading, dissolution, and stability. The resulting drug-loaded SBA-15 particles have defined size, high sphericity, and easy handling, making them suitable for pharmaceutical formulations.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Pharmacology & Pharmacy
Jun Wu, Xinyu Wang, Haiwen Li, Mingyue Qu, Wenbin Sun, Xu Yan, Zheng Zhao, Binbin Li
Summary: In this study, chitosan-coated PLGA microspheres with rough surface and hollow structure were successfully prepared using a modified method. These microspheres can be used as drug carriers to improve drug loading efficiency and anticancer effect, and reduce drug administration frequency. The chitosan-modified microspheres showed prolonged anticancer activity and promoted apoptosis, suggesting their potential application in liver cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Ceramics
Eva Krakor, Sven Saniternik, Isabel Gessner, Robert Frohnhoven, Michael Wilhelm, Marco Drexelius, Nurgul Tosun, Ines Neundorf, Sanjay Mathur
Summary: Intensive and overuse of antibiotics have led to a rise in antibiotic resistance globally, creating a demand for alternative treatments. Metal ions like copper, silver, and zinc have been used to inhibit microorganism growth for centuries. This study focuses on the synthesis of metal and oxide nanoparticles immobilized on hollow mesoporous silica capsules (HMSCs) for efficient antimicrobial effects against both Gram-positive and Gram-negative bacteria. The results show promising potential for metal-loaded capsules as antibacterial delivery vehicles, providing sustained bacterial inhibition over several hours.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Soroush Mirfakhraee, Reza Bafkary, Yalda H. Ardakani, Rassoul Dinarvand
Summary: In this study, hyaluronic acid-functionalized disulfide hollow mesoporous silica nanoparticles (HMSN-NH2-HA) were synthesized and characterized as an anticancer drug delivery system. The nanoparticles demonstrated controlled release and targeted delivery of DOX, showing potential application in cancer treatment.
JOURNAL OF NANOPARTICLE RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Jason William Grunberger, Hamidreza Ghandehari
Summary: Silica nanoparticles (SNPs) have versatile synthetic methods and tunable physicochemical properties, making them promising for biomedical applications. In this study, hollow mesoporous SNPs (HMSNPs) with different layer compositions were fabricated, and their degradation profiles were characterized in simulated body fluid. The results showed that the composition and number of layers influenced degradation rates, with particles containing more disulfide bridges being more responsive to enzymatic degradation. These findings suggest the potential utility of layer-by-layer HMSNPs for controlled drug delivery.
Article
Chemistry, Inorganic & Nuclear
Xiaofei Yang, Xuefang Chen, Jingyi Qiu, Meng Li, Hai Ming, Songtong Zhang, Tingting Zhang
Summary: A silicon/carbon hollow microsphere was successfully synthesized using recycled kerf loss silicon and lignin as raw materials. The micron kerf loss silicon provided nucleation sites for lignin, leading to uniform distribution of carbon on the silicon's surface. The composite exhibited excellent electrochemical properties as anode material for lithium-ion battery, showing high reversible capacity and capacity retention, demonstrating a cost-effective strategy for preparing high-capacity and high-cycling-behavior anode materials.
JOURNAL OF SOLID STATE CHEMISTRY
(2021)
Article
Chemistry, Physical
Md Aquib, Hang Zhang, Faisal Raza, Parikshit Banerjee, Rohit Bavi, Samuel Kesse, Kofi Oti Boakye-Yiadom, Mensura Sied Filli, Muhammad Asim Farooq, Bo Wang
Summary: Aminated mesoporous silica nanoparticles (AMPSNPs) were developed as a nanocarrier for disulfiram (DSF) delivery in cancer therapies. The optimized AMPSNPs showed excellent properties and compatibility, providing potential for effective drug delivery.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Pharmacology & Pharmacy
Csilla Bartos, Patricia Varga, Piroska Szabo-Revesz, Rita Ambrus
Summary: The study explores the absorption of NSAIDs through the nasal epithelium using chitosan-based microspheres prepared via spray-drying, with a focus on meloxicam delivery. The results demonstrate that non-cross-linked samples exhibit higher dissolution and permeation rates for meloxicam.
Review
Engineering, Biomedical
Yi Feng, Zhen Liao, Mengyue Li, Hanxi Zhang, Tingting Li, Xiang Qin, Shun Li, Chunhui Wu, Fengming You, Xiaoling Liao, Lulu Cai, Hong Yang, Yiyao Liu
Summary: In recent years, researchers have developed novel nanoparticles for diagnostic applications and therapeutic purposes. This review focuses on the synthesis of mesoporous silica nanoparticles (MSNs) for drug delivery and smart response applications, including the fabrication of ordered, hollow, core-shell structured, dendritic, and biodegradable MSNs. The review also discusses recent research progress in designing functional MSN materials with various controlled release mechanisms in anticancer therapy, as well as their bioimaging capabilities and potential as delivery vehicles.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shaoxin Deng, Cheng-Xing Cui, Lingyao Duan, Linfeng Hu, Xiaoxun Yang, Ji-Chao Wang, Ling-Bo Qu, Yuping Zhang
Summary: The article introduces a pH-responsive drug delivery system using in situ amino-functionalized hollow mesoporous silica nanoparticles as carriers, which can intelligently and targetedly release anticancer drugs in tumor microenvironments. The system shows efficient drug loadings and targeted release, with nearly 100% release of zorubicin hydrochloride at a buffer pH of 5.0, demonstrating great potential in anticancer therapy.
Review
Pharmacology & Pharmacy
Nisar Ul Khaliq, Juyeon Lee, Joohyeon Kim, Yejin Kim, Sohyeon Yu, Jisu Kim, Sangwoo Kim, Daekyung Sung, Hyungjun Kim
Summary: Cancer remains a major global health challenge, and traditional chemotherapy often leads to side effects and drug resistance, necessitating the development of alternative treatments like gene therapy. Mesoporous silica nanoparticles (MSNs) offer numerous advantages as gene delivery carriers, including high loading capacity, controlled drug release, and easy surface functionalization. They are biodegradable and biocompatible, making them promising candidates for drug delivery applications. Recent studies have reviewed the use of MSNs for delivering therapeutic nucleic acids to cancer cells and discussed their potential as a tool for cancer therapy. The major challenges and future interventions of MSNs as gene delivery carriers for cancer therapy are also discussed.
Article
Chemistry, Multidisciplinary
Gi Dae Park, Yun Chan Kang, Jung Sang Cho
Summary: Phase-pure ZnMn2O4 nanopowders and their aggregated microsphere powders were successfully obtained by a simple spray drying process followed by post-annealing. The optimized post-annealing temperature of 800 degrees C resulted in ZnMn2O4 nanopowders with high capacity and good cycle performance. The aggregated ZnMn2O4 microsphere exhibited improved cycle stability, with a capacity retention of 84% after the second cycle.
Article
Chemistry, Inorganic & Nuclear
Selvakumari Ulagesan, Madhappan Santhamoorthy, Thi Phan Vy Phan, Krishnapandi Alagumalai, Kokila Thirupathi, Seong-Cheol Kim, Taek-Jeong Nam, Youn-Hee Choi
Summary: In this study, a mesoporous silica material containing amidoxime ligand groups was successfully synthesized through surface modification. The resulting SBA-15@AMI NPs exhibited a high concentration of amidoxime ligands on the surface, making them suitable for pH-responsive drug delivery applications in cancer therapy.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Margot Van der Verren, Vit Vykoukal, Ales Styskalik, Ali Shan Malik, Carmela Aprile, Damien P. Debecker
Summary: Supported gold nanoparticles have a significant impact on catalysis and can selectively oxidize bio-based platform molecules. The addition of a gold stabilizer during synthesis improves the dispersion of gold, resulting in enhanced catalyst performance.
ACS APPLIED NANO MATERIALS
(2022)