Article
Biophysics
Furqan A. Maulvi, Parth D. Soni, Pooja J. Patel, Ankita R. Desai, Ditixa T. Desai, Manish R. Shukla, Shailesh A. Shah, Dinesh O. Shah, Mark D. P. Willcox
Summary: The research used graphene oxide (GO) to control the release of bimatoprost from contact lenses in order to improve drug uptake, lens swelling, and transmittance. Although GO did not enhance bimatoprost uptake, it improved the in vitro release profile of the drug.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Engineering, Biomedical
Qiong Li, Cheng Ma, Yingpeng Ma, Yiping Ma, Yan Mao, Zelan Meng
Summary: The study investigated the effect of gold nanoparticles (GNPs) on bimatoprost loading/uptake and release kinetics from contact lenses. The presence of GNPs significantly improved drug uptake and sustained release of bimatoprost, without affecting the critical properties of the lenses for therapeutic application.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Ophthalmology
Stephen A. DiPasquale, Biaggio Uricoli, Matthew C. DiCerbo, Thea L. Brown, Mark E. Byrne
Summary: This study demonstrates the potential of therapeutic contact lenses for in vitro controlled and extended release of post-ocular surgery therapeutics, providing a promising alternative to eye drops for the treatment of uveitis and corneal inflammation, pain, and infection.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Review
Environmental Sciences
Shalini Sanyal, Venkatesh Ravula
Summary: Pesticide exposure leads to deterioration of ocular health and various eye conditions such as irritation, tear overproduction, surface abrasions, and decreased visual acuity. Eye tissues absorb pesticides more quickly and are more susceptible to damage. Current methods of mitigating pesticide-induced toxicity, such as topical eye drops, have limited efficacy due to low bioavailability and short duration. Contact lenses and nanoparticle-based drug delivery systems show promise in increasing bioavailability and prolonging drug effects. This review focuses on the futuristic aspects of using contact lenses for drug delivery and corneal protection from ocular toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Applied
Dandan Liu, Yipeng Zang, Ziwei Hu, Chenrui Yu, Zhenxing Han, Mengmeng Wang, Maodong Xu, Xiaofeng Zhao, Wenjin Yue, Guangjun Nie
Summary: KH-570@HEMA hydrogel was synthesized to balance vision correction and drug sustained release in drug-loaded soft contact lens. The hydrogel composition was optimized using conditional maximum method, achieving high transmittance, oxygen permeability and wettability. Molecular imprinting technique improved the loading capacity and release time, potentially solving the issue of drug-loaded SCLs.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Article
Biotechnology & Applied Microbiology
Simin Masoudi, Mark Willcox
Summary: The efficacy of extracting lipids from contact lenses varies for different lipid classes and lens materials. Differences in the amount and time of lipid desorption probably resulted from the strength of the bond between lipid and lens polymer and the depth of adsorption of lipid in the polymer.
Article
Engineering, Biomedical
Dongkai Zhu, Yangping Liu, Jeremy L. Gilbert
Summary: Adhesion properties of silicone hydrogel contact lenses are crucial for their performance and comfort in the eye. This study developed a new testing method to study adhesive interactions of different silicone contact lenses under dehydrating conditions, highlighting the importance of hydration state on adhesion.
ACTA BIOMATERIALIA
(2021)
Article
Pharmacology & Pharmacy
Diana Silva, Herminio C. de Sousa, Maria Helena Gil, Luis F. Santos, Madalena Salema Oom, Carmen Alvarez-Lorenzo, Benilde Saramago, Ana Paula Serro
Summary: This study developed a molecularly imprinted silicone-based hydrogel for the manufacturing of contact lenses that can efficiently load and sustainably release the antibiotic moxifloxacin hydrochloride (MXF). The modified hydrogel showed promising results in treating ocular infections, with no cytotoxicity or ocular irritancy effects detected.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Engineering, Biomedical
Liana Wuchte, Stephen DiPasquale, Ashlyn Masterson, Abigail Vance, Jonathan Goff, Barry Arkles, Santy Sulaiman, Mark Byrne
Summary: Contact lenses are a successful biomaterial in global market, especially silicone hydrogel contact lenses. This study investigates the influence of silicone macromers on the properties of silicone hydrogel lenses. The findings suggest that fluorine-containing silicone macromers allow for a wider range of successful compositions, and asymmetric siloxane macromers have potential to meet critical lens properties.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Engineering, Biomedical
Yan Fu, Yang Luo, Xi Chen, Yao Tong, Yabin Zhu, Lu Yang
Summary: Atropine is commonly used to treat myopia, but its aqueous solution is unstable. This study developed an atropine-eluting contact lens to improve drug release and control myopia effectively. Experimental results showed the safety and effectiveness of this lens in reducing side effects and delaying the progress of myopia.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Polymer Science
Chen-Ying Su, Lung-Kun Yeh, Tzu-Wei Fan, Chi-Chun Lai, Hsu-Wei Fang
Summary: The study analyzed how tear albumin affects the friction coefficient of contact lenses, concluding that albumin provided lubrication for silicone hydrogel lenses regardless of concentration, while it acted as a lubricant for hydrogel lenses only at normal concentration. The results did not correspond to albumin deposition amount or surface roughness, but a proposed model explained how albumin might act as a lubricant on the surface of some contact lenses.
Article
Biophysics
Nguyen-Phuong-Dung Tran, Ming-Chien Yang, Phuong Lan Tran-Nguyen
Summary: Silicone hydrogel lenses were prepared by copolymerizing PDMS-PEGMA macromer (PGP) with various substances, showing higher water uptake ability and oxygen permeability. They also exhibited good optical transparency, anti-protein deposition, and non-cytotoxicity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Engineering, Biomedical
Yunli Xu, Hongyi Li
Summary: In this study, a novel drug-loaded contact lens was developed for the treatment of glaucoma. The contact lens, which contained brimonidine-loaded silica nanoparticles, demonstrated controlled drug release without altering the optophysical properties of the lens. The experimental results showed that the contact lens had good biocompatibility and effective drug release.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Article
Engineering, Biomedical
Tomasz Sulinski, Natalia Nowak, Jedrzej Szymanski, Jacek Pniewski
Summary: This paper describes the surface differences of a range of silicone-hydrogel lenses using reflectance confocal microscopy, and reveals that light reflection is correlated with material parameters such as water content and surface modulus. The proposed analysis method allows for differentiation between lenses with and without surface modifications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Pharmacology & Pharmacy
Chenfei Tian, Lu Zeng, Le Tang, Jingni Yu, Mei Ren
Summary: In this study, timolol-loaded nanostructured lipid carriers (NLCs) were prepared and evaluated for enhanced timolol uptake and sustained release in contact lenses for the management of glaucoma. NLC-laden lenses showed improved drug uptake and sustained release compared to conventional soaked lenses, leading to potential clinical benefits for patients with glaucoma.