期刊
CURRENT MEDICAL SCIENCE
卷 39, 期 5, 页码 741-747出版社
SPRINGER
DOI: 10.1007/s11596-019-2100-9
关键词
blood pressure; blood pressure variability; meta-analysis; stroke; systematic review; visit-to-visit systolic blood pressure
资金
- National Natural Science Foundation of China [81760221, 81660209]
- National Science & Technology Foundational Resource Investigation Program of China [2018FY100900]
- Major Program of the Natural Science Foundation of Jiangxi Province [2016ACB20015]
Visit-to-visit variability in systolic blood pressure (SBP) may have an important additional role in increasing the risk of vascular complications, including stroke. We conducted a meta-analysis to assess the relationship between visit-to-visit SBP variability (SBPV) and stroke risk. PubMed, EMBASE, and the Cochrane library databases were searched for cohort studies with data on visit-to-visit SBPV and stroke risk. Studies that reported adjusted relative risks (RRs) with 95% CIs of stroke associated with SBPV were included. Fourteen cohort studies met the inclusion criteria and were included in our meta-analysis. After adjustment for age, sex, and existing vascular risk factors, the analysis showed that the risk of stroke in patients with SBPV was significantly increased compared with patients with a small baseline SBPV [SD (RR=1.20, 95% CI=(1.07-1.35), P=0.0005), CV (RR=1.12, 95% CI=(1.00-1.26), P=0.008)]. In addition, follow-up variations of more than 5 years were associated with a higher risk of stroke than those of less than 5 years [RR=1.08, 95% CI=(1.04-1.11)]. Visit-to-visit SBPV was associated with an increased risk of stroke, especially in terms of the time of variation. Taken together, SBPV data may be useful as a preventative diagnostic method in the management of stroke.
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