Article
Biochemistry & Molecular Biology
Sung Bae Kim, Hyun Yeoul Ryu, Woo Nam, So Min Lee, Mi Ran Jang, Youn Gil Kwak, Gyoo Il Kang, Kyung Seok Song, Jae Won Lee, Efthimios M. C. Skoulakis, Annamaria Morelli
Summary: This study investigated the neuroprotective effects of Dendropanax morbifera leaves and stems (DMLS) water extract on scopolamine-induced memory impairment in mice. The results revealed that DMLS protected neuronal cells from neurotoxicity and reduced oxidative stress. Animal studies showed that oral ingestion of DMLS improved memory impairment and enhanced memory abilities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hien Thi Hoang, Jae-Seok Park, Seong-Hyeon Kim, Ju-Young Moon, Young-Chul Lee
Summary: Recently, utilizing natural bioactive compounds for active ingredients in cosmetics has become a growing worldwide trend. In order to optimize the safety of natural ingredients, choosing an environmentally friendly extraction method also plays an important role. This study investigated an eco-friendly extraction technique for Dendropanax morbifera using microwave treatment, which resulted in higher yields and enhanced antioxidant properties of the extract. Moreover, the extract exhibited extraordinary antioxidant, anti-aging, and skin-whitening activities, indicating its potential as a cosmeceutical ingredient for comprehensive skin protection.
Article
Nutrition & Dietetics
Ji-Hye Song, Hyunhee Kim, Minseok Jeong, Min Jung Kong, Hyo-Kyoung Choi, Woojin Jun, Yongjae Kim, Kyung-Chul Choi
Summary: Metabolic syndrome is a global health issue, with obesity being closely related to various diseases. D. morbifera is rich in antioxidant nutrients, reduces bad cholesterol and triglycerides, and is beneficial for cardiovascular diseases, hypertension, hyperlipidemia, and diabetes. Treatment with D. morbifera extract effectively reduces weight and body fat, increases HDL cholesterol, and can be used to develop anti-obesity functional foods and products.
Article
Integrative & Complementary Medicine
Dongho Lee, Jin-Kyoung Kim, Yongjae Han, Kwang Il Park
Summary: Dendropanax morbifera is a traditional medicine used in China and Korea to treat intestinal disorders, urosis, and chronic glomerulonephritis. Recent studies have shown that its ethanol extract can reduce uric acid levels in patients with hyperuricemia.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Chemistry, Physical
Wenying You, Jong Chan Ahn, Vinothini Boopathi, Lakshminarayanan Arunkumar, Esrat Jahan Rupa, Reshmi Akter, Byoung Man Kong, Geun Sik Lee, Deok Chun Yang, Se Chan Kang, Jingjing Liu
Summary: The green synthesis of metal nanoparticles from medicinal plants, particularly using Dendropanax morbifera (DM) as a capping agent for zinc ions and co-loading it with tryptophan, shows promising results in reducing lipid accumulation in adipocytes and combating obesity. This novel method demonstrates low toxicity and stable formulation, providing opportunities for further research in treating obesity and associated disorders.
Article
Food Science & Technology
Mun-Ock Kim, Myung-Ji Kang, Su-Ui Lee, Doo-Young Kim, Hyun-Jae Jang, Ju Hyeon An, Hyun-Sun Lee, Hyung Won Ryu, Sei-Ryang Oh
Summary: Extracts from Dendropanax morbifera leaves showed strong inhibitory activity against triglyceride biosynthesis. Through bioactivity-guided fractionation, three polyacetylene derivatives were identified as the active compounds. The study aimed to protect the active ingredients in the development and distribution of functional foods containing D. morbifera.
Article
Nutrition & Dietetics
Yong-Joo Park, Dong-Min Kim, Hye-Been Choi, Mi-Ho Jeong, Seung-Hwan Kwon, Ha-Ryong Kim, Jong-Hwan Kwak, Kyu-Hyuck Chung
Summary: In this study, the researchers found that dendropanoxide (DPX) extracted from Dendropanax morbifera has anti-fibrotic effects on hepatic fibrosis by inhibiting the activation of hepatic stellate cells (HSCs). DPX was able to suppress the expression of fibrotic markers and deposition of extracellular matrix in a mouse model of hepatic fibrosis induced by carbon tetrachloride. The researchers also demonstrated that DPX inhibits HSC activation by inhibiting autophagy.
Article
Horticulture
Ming Zhang, Ting Bu, Shuilin Liu, Sooah Kim
Summary: The study optimized the extraction method for caffeic acid from Dendropanax morbifera leaves and evaluated the polyphenolic content and antioxidant capacity of the extracts. Results indicated that the extracts exhibited potential antioxidant activity, suggesting they could be a good source for functional food and medicinal applications.
Article
Environmental Sciences
Hao Wang, Glen M. Abel, Daniel R. Storm, Zhengui Xia
Summary: Cadmium (Cd) is a toxic heavy metal that is a significant public health concern due to its potential neurotoxic effects on cognition in both humans and animals. Exposure to Cd during adolescence can impair short-term spatial memory and contextual fear memory in mice, while also affecting key processes of hippocampal neurogenesis.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Nutrition & Dietetics
Andreia de Toledo, Kaori Nomoto, Eiichi Hirano, Chihiro Tohda
Summary: Human placental extract and animal-derived placental extracts have a wide range of biological activities, with potential effects on neuronal functioning. Horse placental extract JBP-F-02 may promote neurogenesis and has the potential to prevent dementia, as suggested by this study.
Article
Plant Sciences
Jorelle Linda Kamda Damo, Razvan Stefan Boiangiu, Ion Brinza, Lea Blondelle Kenko Djoumessi, Roland Nhouma Rebe, Balbine Nkwingwa Kamleu, Simon Desire Nyayi Guedang, Guillaume Woumitna Camdi, Parfait Bouvourne, Eglantine Wado Keugong, Herve Herve Abaissou Ngatanko, Oana Cioanca, Monica Hancianu, Harquin Simplice Foyet, Lucian Hritcu
Summary: The present study investigated the potential benefits of Guiera senegalensis in improving scopolamine-induced memory impairment and brain oxidative stress in zebrafish. The results showed that Guiera senegalensis treatment reduced oxidative stress and acetylcholinesterase activity. These findings suggest that Guiera senegalensis could be a natural alternative treatment for cognitive disorders associated with Alzheimer's disease.
Article
Nutrition & Dietetics
Muhammad Awais, Reshmi Akter, Vinothini Boopathi, Jong Chan Ahn, Jung Hyeok Lee, Ramya Mathiyalagan, Gi-Young Kwak, Mamoona Rauf, Deok Chun Yang, Geun Sik Lee, Yeon-Ju Kim, Seok-Kyu Jung
Summary: In this study, an in-depth investigation was conducted on Dendropanax morbifera samples collected from three regions in Korea. The results showed that ultrasound-assisted extraction method yielded a higher content of polyphenols compared to the Soxhlet method. The anti-obesity effects of the plant samples were found to be related to their polyphenol contents.
FRONTIERS IN NUTRITION
(2023)
Article
Food Science & Technology
Tomasz Piechowiak, Natalia matlok, Maciej Balawejder
Summary: Young shoots of Pinus sylvestris L. are a good source of pro-healthy substances, mainly flavonoids and ascorbic acid. The ultrasound-assisted extraction of phytochemicals from young pine shoots was optimized in this study. The extracted bioactive components showed antioxidant and inhibitory activities.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kayoung Ko, Yejin Ahn, Ga Yeong Cheon, Hyung Joo Suh, Yun Jae Cho, Sung-Soo Park, Ki-Bae Hong
Summary: Dendropanax morbiferus extract (DE) can improve sleep quality and quantity by regulating neurotransmitter content and related receptor expression, along with its high antioxidant activity, and may have a therapeutic effect on sleep disorders.
Article
Nutrition & Dietetics
Ahreum Lee, Yuki Sugiura, Ik-Hyun Cho, Noriko Setou, Eugene Koh, Gyun Jee Song, Seungheun Lee, Hyun-Jeong Yang
Summary: Studies demonstrate that Dendropanax trifidus (DT) sap exhibits hypoglycemic effects and contains higher levels of certain components compared to Acer saccharum (AS) sap.
Article
Biochemistry & Molecular Biology
Hyo Young Jung, Hyun Jung Kwon, Woosuk Kim, Kyu Ri Hahn, Seung Myung Moon, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang
Summary: Phosphoglycerate mutase 5 (PGAM5), a glycolytic enzyme, has been found to play a significant role in oxidative stress and ischemic damage. In this study, the authors investigated the effects of PGAM5 on HT22 hippocampal cells and gerbil hippocampus, demonstrating its neuroprotective effects and its ability to alleviate oxidative stress and ischemia-induced neuronal death.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Kyu Ri Hahn, Hyun Jung Kwon, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang
Summary: In this study, the researchers synthesized the Tat-CHIP fusion protein and successfully delivered it into brain cells. The results showed that Tat-CHIP has antioxidant and neuroprotective effects, making it a potential therapeutic agent against ischemic damage.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Civil
Huihui Li, Lifeng Li, Doo-Yeol Yoo, Meng Ye, Cong Zhou, Xudong Shao
Summary: This paper proposed a novel non-prismatic prestressed CSW-UHPC composite box girder to enhance the cracking resistance and reduce the dead weight of highway bridges. Experimental and numerical analyses showed that the shear lag effect of the UHPC flanges in the stress concentration region was more pronounced than in the non-stress concentration region, and the boundary conditions and loading forms significantly influenced the shear lag behavior.
ARCHIVES OF CIVIL AND MECHANICAL ENGINEERING
(2023)
Article
Engineering, Civil
Meng Ye, Lifeng Li, Doo-Yeol Yoo, Lianhua Wang, Huihui Li, Xudong Shao
Summary: This study focuses on the use of ultrahigh-performance concrete (UHPC) in precast segmental beams to enhance bridge performance and durability. The shear behavior of the dry-jointed segmental beams was investigated through testing various specimens with different joint types and shear span-to-depth ratios. The results showed that shear capacity, stiffness, and cracking load of the dry-jointed segmental beams were lower than those of the monolithic specimen, and the number of shear keys also influenced the shear behavior. The study also evaluated UHPC design codes and proposed a simplified strut-and-tie model for estimating shear strength.
ARCHIVES OF CIVIL AND MECHANICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Kyu Ri Hahn, Hyun Jung Kwon, Woosuk Kim, Hyo Young Jung, In Koo Hwang, Dae Won Kim, Yeo Sung Yoon
Summary: This study investigated the neuroprotective effects of SOD1 against cuprizone-induced demyelination and adult hippocampal neurogenesis in C57BL/6 mice. It was found that the fusion protein PEP-1-SOD1 could alleviate the damage caused by cuprizone in terms of demyelination and neurogenesis in the hippocampus.
NEUROCHEMICAL RESEARCH
(2023)
Article
Engineering, Civil
Soonho Kim, Yun Sik Jang, Taekgeun Oh, Seung Kyun Lee, Doo-Yeol Yoo
Summary: With the increasing use of wireless electronic devices, electromagnetic pollution has become a serious threat. This study investigates the advantages of adding carbon fibers to strain-hardening cementitious composites (SHCCs) to enhance their mechanical and electrical properties as electromagnetic shielding materials. The results show that the addition of carbon fibers improves the tensile performance, energy absorption capacity, electrical conductivity, and EMI shielding effectiveness of the SHCCs. This study provides a basis for evaluating the EMI shielding effectiveness of damaged structures.
ARCHIVES OF CIVIL AND MECHANICAL ENGINEERING
(2023)
Article
Construction & Building Technology
Gi Woong Kim, Taekgeun Oh, Seung Kyun Lee, Seung Won Lee, Nemkumar Banthia, Eunjong Yu, Doo-Yeol Yoo
Summary: The effects of steel and polyethylene (PE) fiber hybrid reinforcement on the mechanical performance of cementless ultra-high performance alkali-activated concrete (UHP-AAC) were studied. The compressive and tensile strengths were reduced when steel fibers were replaced with PE fibers. The best performance was observed in the hybrid specimens with a medium-grade fine aggregate-to-binder (FA/B) ratio.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Construction & Building Technology
Rongzhen Piao, Taekgeun Oh, Gi Woong Kim, Hong-Joon Choi, Nemkumar Banthia, Doo- Yeol Yoo
Summary: This study investigates the effect of silicon dioxide nanoparticles (nano-SiO2) on the microstructure and mechanical properties of eco-friendly, cementless ultra-high-performance fiber-reinforced alkali-activated concrete (UHP-FRAAC). The results showed that the addition of nano-SiO2 improves the packing density of UHP-AAC and generates abundant C-(A-)S-H gels to increase its density. The optimal dosage of nano-SiO2 in UHP-FRAAC was suggested to be 2% by mass of silica fume.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Construction & Building Technology
Booki Chun, Taekgeun Oh, Hong-Joon Choi, Seung Kyun Lee, Nemkumar Banthia, Doo-Yeol Yoo
Summary: This study investigates the self-healing capacity of ultra-rapid-hardening fiber-reinforced cementitious composites. Different lengths of polyethylene (PE) fibers were incorporated with different volume fractions. The fiber reinforcing index was proportional to the tensile performance, with the length of the PE fiber being more dominant. Specimens with 2% medium-length fibers showed the most appropriate self-healing behavior.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Hyun Jung Kwon, Kyu Ri Hahn, Sung Min Nam, Yeo Sung Yoon, Seung Myung Moon, In Koo Hwang, Dae Won Kim
Summary: Purpurin has potent anti-oxidant and anti-inflammatory effects in brain damage. This study shows that purpurin can ameliorate the aging phenotypes induced by D-galactose and improve memory impairment in mice.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Chemistry, Physical
Haowei Li, Jun Li, Xiaoyu Wang, Caiyue Xie, Yifei Wang, Xifeng Ding
Summary: A-type cation-deficient perovskite material has been explored as a prospective cathode for PCFCs, which can reduce polarization resistance and enhance hydration capability. This research provides an effective methodology for designing high-performance cathodes to enhance the efficiency of PCFCs.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Veterinary Sciences
Dae Young Yoo, Woosuk Kim, Hyo Young Jung, In Koo Hwang
Summary: The expression of somatostatin (SST) in the hippocampus of rats increases during postnatal development but decreases after P21. This study suggests that SST is closely associated with the differentiation of neuroblasts in the hippocampus during postnatal development.
VETERINARY SCIENCES
(2023)
Article
Construction & Building Technology
Joo Ha Lee, Doo-Yeol Yoo
Summary: This study aims to design a high-performance fiber-reinforced cementitious composite (HPFRCC) material for reinforcing masonry walls and assess its impact on in-plane shear performance. The study found that HPFRCC significantly enhances the shear strength and energy dissipation capacity of masonry walls.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Construction & Building Technology
Gi Woong Kim, Taekgeun Oh, Booki Chun, Seung Won Lee, Chung-Chan Hung, Doo-Yeol Yoo
Summary: By modifying the surface of steel fibers with an EDTA-electrolyte solution, the mechanical performance of UHP-AAC was improved, leading to higher fiber bond strength and tensile strength. The best tensile performance was achieved when straight steel fibers were surface-refined by the EDTA-electrolyte solution for 6 hours. The Weibull distribution model was used to predict crack width, and it was found that the surface treatment using EDTA solution had marginal influence on the median microcrack width of UHP-AAC, while straight and twisted fibers produced wider cracks.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Construction & Building Technology
Jiale Zhou, Peng Yu, Doo-Yeol Yoo, Lie Yu, Lu Ke
Summary: This study investigates the effect of different types of stirrup and cross-sectional dimensions on the torsional behaviors of ultra-high-performance fiber-reinforced concrete hollow beams. The results show that the inclusion of flanges substantially influences the torsional strength of the beams, attributed to the section torsional plastic resistance moment and UHPFRC tensile capacity in flanges.
DEVELOPMENTS IN THE BUILT ENVIRONMENT
(2023)