Article
Plant Sciences
Yuanru Zheng, Chunyang Tian, Chunlin Fan, Nishan Xu, Junjie Xiao, Xiaoyang Zhao, Zibin Lu, Huihui Cao, Junshan Liu, Linzhong Yu
Summary: This study found that Sheng-Mai Yin has significant anti-inflammatory effects, potentially achieved through inhibiting the NF-kappa B and STAT3 signal pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Jing-Ya Li, Chun-Chun Zhao, Jian-Fei Peng, Meng Zhang, Liang Wang, Gang Yin, Peng Zhou
Summary: This study demonstrates that Sheng Mai Yin can alleviate diabetic cardiomyopathy (DCM) by regulating the NLRP3/caspase-1 signaling pathway, providing a potential therapeutic approach. By reducing blood glucose and lipid levels, improving heart function, alleviating histopathological changes and myocardial fibrosis, Sheng Mai Yin can improve the condition of DCM.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Agriculture, Multidisciplinary
M. F. Nagoor Meeran, Sheikh Azimullah, Hebaallah Hashiesh Mamoudh, Charu Sharma, Sanjay Kumar, Sameer N. Goyal, Shreesh Ojha
Summary: This study evaluated the cardioprotective effects of nerolidol against chronic cardiotoxicity induced by doxorubicin in rats. Nerolidol demonstrated significant protection against doxorubicin-induced cardiac dysfunction, oxidative stress, and inflammation, possibly through its potent antioxidant properties.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yiyang Wang, Jia Liao, Yuanliang Luo, Mengsi Li, Xingyu Su, Bo Yu, Jiashuo Teng, Huadong Wang, Xiuxiu Lv
Summary: This study aimed to determine the therapeutic effect of berberine (Ber) on DOX-induced cardiomyopathy and explore the underlying mechanism. The results showed that Ber effectively prevented cardiac dysfunction and fibrosis, reduced oxidative stress, and restored mitochondrial function in DOX-treated rats and cells. The protective effect of Ber was mediated by the activation of the Nrf2 pathway. These findings suggest that Ber is a potential therapeutic agent for DOX-induced cardiotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Jianheng Pan, Zhanhong Cao, Chunqiu Fang, Yuting Lei, Jiaming Sun, Xiaowei Huang, Dong Han
Summary: Huangqi Shengmai Yin (HSY) was found to inhibit isoprenaline (ISO)-induced myocardial collagen deposition in rats, leading to improved cardiac function and protection of myocardium by reducing apoptosis and collagen deposition. This suggests that HSY could be a potential therapeutic agent for ameliorating myocardial fibrosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shasha Zheng, Hong Huang, Yizhuo Li, Ye Wang, Yawei Zheng, Junya Liang, Siqi Zhang, Ming Liu, Zhuyuan Fang
Summary: Atherosclerosis is a major cause of mortality and morbidity worldwide, and the traditional Chinese medicine Yin-xing-tong-mai decoction has been shown to attenuate atherosclerosis by activating the PPAR gamma-LXR alpha-ABCA1/ABCG1 pathway, highlighting the important role of Chinese medicine in treating atherosclerosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Plant Sciences
Shuqing Shi, Yajiao Wang, Xuesong Zhang, Xintian Shou, Bingxuan Zhang, Yumeng Li, Huaqin Wu, Qingqiao Song, Yuanhui Hu
Summary: This study aimed to investigate the molecular mechanisms and potential targets of the Chinese herbal formula Qi-Po-Sheng-Mai Granule (QPSM) for atrial fibrillation (AF). Through pharmacology and single nucleus RNA sequencing (snRNA-Seq), it was found that QPSM can maintain calcium homeostasis in cardiomyocytes by regulating calcium transporters, thereby reducing the inducibility and duration of AF.
Article
Plant Sciences
Xiaosong Zhang, Yaqian Jia, Ziwen Yuan, Yanqiao Wen, Yahui Zhang, Jianmin Ren, Peng Ji, Wanling Yao, Yongli Hua, Yanming Wei
Summary: This study comprehensively investigated the pharmacological effect and molecular mechanisms of Sheng Mai San (SMS) on heat stress-induced liver injury using a combination of pharmacodynamics, targeted metabolomics, and molecular biology technology. The results demonstrated that SMS alleviates liver dysfunction and pathological damage caused by heat stress through regulating energy metabolism, suppressing inflammation and oxidative injury, and promoting mitophagy. These findings support the use of SMS in treating liver injury induced by heat stress.
Article
Multidisciplinary Sciences
Yazhu Hou, Zixun He, Yixiao Han, Tongyan Zhang, Shuai Wang, Xianliang Wang, Jingyuan Mao
Summary: New optimized Sheng-Mai-San (NO-SMS) has been shown to be significantly effective in improving cardiac function, increasing exercise tolerance, and slowing the progression of myocardial fibrosis in heart failure patients. This study investigates the relationship between NO-SMS and cardiomyocyte apoptosis through in vivo and in vitro experiments.
Article
Biochemistry & Molecular Biology
Xipeng Sun, Li Zhou, Yonglong Han, Quanjun Yang, Xingxia Li, Bo Xin, Mengyi Chi, Yaxian Wang, Cheng Guo
Summary: This study found that scutellarin has a protective effect against chronic cardiotoxicity induced by doxorubicin, possibly by reducing oxidative stress, myocardial fibrosis, apoptosis, and autophagy.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Pharmacology & Pharmacy
Yuan-Yuan Yu, Qiu-Ping Liu, Meng-Ting Li, Pei An, Yu-Ying Chen, Xin Luan, Chao Lv, Hong Zhang
Summary: HZQMY showed anti-DR effects by inhibiting proliferation and promoting mitochondria-related apoptosis of HRCECs exposed to high glucose possibly through regulating P38 and NF-kappa B signaling pathway. The constituents of HZQMY were analyzed by LC-MS/MS and 27 main chemical components were identified. Proteomic analysis suggested HSPA4, MAPK3, ENO1, EEF2 and ERPS as candidate targets involved in the mechanism of HZQMY in HRCECs.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Lanxuan Wei, David Abraham, Voon Ong
Summary: IL-17 is a pro-inflammatory cytokine that plays an important role in host defense. It activates transcription and stabilizes mRNAs through multiple pathways, mainly acting on stromal cells to promote the secretion of other immunomodulatory factors and support the growth and differentiation of immune cells. IL-17 has a dual role in immune reactions and inflammatory diseases, and it also plays a significant role in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yong Fu, Jun Shi, Hong Qian, Chaoyi Qin, Lulu Liu, Jiayu Shen, Hao Ma, Lang Ma, Bin Liao, Yingqiang Guo
Summary: This study investigated the therapeutic effect of peritoneal matrix-loaded pirfenidone nanodroplets (NDs) on myocardial infarction (MI) fibrosis. The results showed that the nanodroplets achieved a slow drug release and inhibited cardiac fibroblasts transformation and collagen synthesis. Combining the peritoneal matrix with pirfenidone nanodroplets showed excellent therapeutic effects on fibrosis in MI rats. This study confirmed the feasibility and synergistic effectiveness of the approach and highlighted the potential application of nanomedicine in other biomedical fields.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Maoyi Yang, Zhipeng Hu, Rensong Yue
Summary: This meta-analysis summarizes the applications of Sheng-Mai Injection (SMI) in diabetes mellitus (DM) and its related complications. The results showed that SMI can significantly improve blood glucose control and renal function in DM patients, but has no effect on neurological function.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Review
Biochemistry & Molecular Biology
Satoshi Kubota, Kazumi Kawata, Takako Hattori, Takashi Nishida
Summary: CCN2 and CCN3, as members of the cellular communication network factor family, promote the harmonized development of various tissues and organs through interaction with multiple biomolecules in the microenvironment. Despite their structural similarities, they have contrasting molecular functions and temporospatial emergence. CCN2 promotes cell growth, while CCN3 restrains it, but these two proteins collaborate together to fulfill their mission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)