Article
Cardiac & Cardiovascular Systems
Majid Valizadeh, Erfan Tasdighi, Maryam Barzin, Ramyar Hariri, Maryam Mahdavi, Pooneh Dehghan, Amin Momeni Moghaddam, Fereidoun Azizi, Farhad Hosseinpanah
Summary: This study investigated the association of MetS and metabolic phenotypes with a high CIMT in early adulthood. The results showed that the presence of MetS and certain metabolic phenotypes were associated with an increased risk of high CIMT.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Nutrition & Dietetics
Lukasz Szczerbinski, Gladys Wojciechowska, Adam Olichwier, Mark A. Taylor, Urszula Puchta, Paulina Konopka, Adam Paszko, Anna Citko, Joanna Goscik, Oliver Fiehn, Sili Fan, Anna Wasilewska, Katarzyna Taranta-Janusz, Adam Kretowski
Summary: Obesity rates among children are increasing rapidly worldwide, leading to pressure on healthcare systems. This study utilized untargeted metabolomics to investigate the metabolic signatures of childhood obesity and found clear differences between obese and normal-weight children. Alterations in lipid metabolism were found to be correlated with the pathogenesis and metabolic consequences of obesity in the serum metabolome. The identified metabolites could potentially be used as biomarkers and contribute to the study of obesity pathomechanisms.
Article
Pharmacology & Pharmacy
Giulia Fiore, Martina Chiara Pascuzzi, Elisabetta Di Profio, Antonio Corsello, Marta Agostinelli, Alice La Mendola, Chiara Milanta, Cristina Campoy, Valeria Calcaterra, Gianvincenzo Zuccotti, Elvira Verduci
Summary: Obesity is a common chronic disease in children worldwide and has a significant burden on society. Metabolically unhealthy obesity (MUO) can occur in children from an early age, and new therapeutic strategies are being investigated. This review focuses on bioactive compounds and their potential benefits in treating obesity, including omega-3, docosahexaenoic acid, vitamin D, biotics, polysaccharide macromolecules, polyphenols, inositols, alpha lipoic acid, and bromelaine. The review highlights the most studied compounds, such as omega-3 and vitamin D, and explores the emerging interest in the gut-brain axis and its connection to metabolic health and microbiota. However, more research is needed to fully understand the efficacy and dosage requirements, especially in pediatric patients.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Brianna F. Moore, Katherine A. Sauder, Allison L. B. Shapiro, Tessa Crume, Gregory L. Kinney, Dana Dabelea
Summary: The study assessed the impact of fetal exposure to cannabis on adiposity and glucose-insulin traits in early life. The results suggest that fetal exposure to cannabis may be associated with increased adiposity and fasting glucose in childhood.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Pediatrics
Mieczyslaw Litwin, Zbigniew Kulaga
Summary: Primary hypertension is the main form of arterial hypertension in adolescents, closely related to metabolic syndrome and visceral obesity. Metabolic syndrome is also observed in adolescents with primary hypertension. Obesity and metabolic abnormalities can increase the risk of hypertension and target organ damage.
PEDIATRIC NEPHROLOGY
(2021)
Article
Endocrinology & Metabolism
Ibrahim Kartal, Abdurrahman Alacam, Ayhan Dagdemir, Cengiz Kara, Oguz Salih Dincer, Canan Albayrak, Murat Elli
Summary: This study found that the prevalence of metabolic syndrome is higher in children with leukemia and lymphoma after treatment, and it begins to increase with the initiation of treatment and continues to increase over time. Family history is significantly associated with metabolic syndrome.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Endocrinology & Metabolism
Alvaro Gonzalez-Dominguez, Thalia Belmonte, Raul Gonzalez-Dominguez
Summary: The incidence of childhood obesity and metabolic syndrome has become a major public health concern in developed countries. Oxidative stress, along with inflammation, insulin disturbances, and dyslipidemia, plays a crucial role in the development of obesity-related complications. Understanding the molecular basis of oxidative dysregulations and the involvement of miRNAs can lead to new approaches for the diagnosis, prevention, and treatment of childhood obesity and associated disorders. This literature review focuses on the association between childhood obesity, metabolic syndrome, and miRNAs, with particular emphasis on the role of miRNAs in modulating obesity-related pathogenic events, especially oxidative stress.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Review
Health Care Sciences & Services
Alberto Romano, Ester Del Vescovo, Serena Rivetti, Silvia Triarico, Giorgio Attina, Stefano Mastrangelo, Palma Maurizi, Antonio Ruggiero
Summary: The improvement in childhood cancer treatments has increased survival rates, but has also resulted in long-term side effects, with metabolic syndrome being one of the most frequent and leading to high mortality. Therefore, early diagnosis strategies are necessary.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Fayaz Ahmad Mir, Ehsan Ullah, Raghvendra Mall, Ahmad Iskandarani, Tareq A. Samra, Farhan Cyprian, Aijaz Parray, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Abdul-Badi Abou-Samra
Summary: This study found differential expression of serum metabolites and pathways between Arabic subjects with obesity and metabolic syndrome compared to subjects with obesity only. Lipids, including sphingomyelin, were significantly decreased in the group with metabolic syndrome. Non-lipid metabolites, such as quinolinate, kynurenine, and tryptophan, were also decreased in the group with metabolic syndrome. Metabolites and pathways associated with chronic inflammation were found to be dysregulated in subjects with metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Nami Mohammadian Khonsari, Ehsan Shahrestanaki, Amir Ehsani, Sara Asadi, Leily Sokoty, Sahar Mohammadpoor Nami, Benyamin Hakak-Zargar, Mostafa Qorbani
Summary: This systematic review and meta-analysis found a significant association between childhood and adolescent obesity and increased incidence and mortality of cancers in adulthood. The risk of cancer was higher in women compared to men. Therefore, preventing childhood obesity can reduce the burden of cancer in adulthood.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hyunjin Park, Seunghee Jun, Hye-Ah Lee, Hae Soon Kim, Young Sun Hong, Hyesook Park
Summary: The prevalence of obesity and metabolic syndrome (MetS) in the pediatric population has increased globally. This study evaluated the impact of childhood obesity and sarcopenic obesity on the risk of MetS in adolescence using cohort study data. Overweight and obesity were defined based on body mass index (BMI) percentiles, and sarcopenic obesity was defined using body composition data. The results showed that overweight and sarcopenic obese individuals have a higher overall risk of MetS components compared to normal people. Both overweight and sarcopenic obesity remained significantly associated with MetS indicators, even after adjusting for covariates. The study emphasizes the importance of early detection of childhood obesity and effective public health interventions.
Article
Endocrinology & Metabolism
Noel T. Mueller, Mingyu Zhang, Sheryl L. Rifas-Shiman, Emily Oken, Marie-France Hivert, Jorge Chavarro
Summary: Cesarean delivery is associated with higher childhood BMI-z, but this association is not significant when cesarean delivery is preceded by spontaneous labor.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Qi Zhu, Yawei Xing, Yunfeng Fu, Xiaqin Chen, Langyi Guan, Foqiang Liao, Xiaodong Zhou
Summary: This study used Mendelian randomization analysis to assess the causal effect of MetS on cholelithiasis. The results showed that MetS increased the risk of cholelithiasis, especially in MetS patients with abdominal obesity. Control and treatment of MetS can effectively reduce the risk of gallstone formation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pediatrics
Jana Brauchmann, Susann Weihrauch-Blueher, Stefan Ehehalt, Susanna Wiegand
KLINISCHE PADIATRIE
(2018)
Review
Endocrinology & Metabolism
Susann Weihrauch-Bluether, Matthias Richter, Martin S. Staege
METABOLISM-CLINICAL AND EXPERIMENTAL
(2018)
Review
Endocrinology & Metabolism
Susann Weihrauch-Blueher, Kartin Kromeyer-Hauschild, Christine Graf, Kurt Widhalm, Ulrike Korsten-Reck, Birgit Joedicke, Jana Markert, Manfred James Mueller, Anja Moss, Martin Wabitsch, Susanna Wiegand
Article
Endocrinology & Metabolism
Susann Weihrauch-Blueher, Peter Schwarz, Jan-Henning Klusmann
METABOLISM-CLINICAL AND EXPERIMENTAL
(2019)
Article
Endocrinology & Metabolism
Laura J. Gray, Emer M. Brady, Olatz Albaina, Charlotte L. Edwardson, Deirdre Harrington, Kamlesh Khunti, Joanne Miksza, Joao Filipe Raposo, Ellesha Smith, Andriani Vazeou, Itziar Vergara, Susann Weihrauch-Blueher, Melanie J. Davies
BMC ENDOCRINE DISORDERS
(2019)
Review
Endocrinology & Metabolism
Patrick Timpel, Lorenz Harst, Doreen Reifegerste, Susann Weihrauch-Blueher, Peter E. H. Schwarz
Article
Endocrinology & Metabolism
Eric Goepel, Denise Rockstroh, Heike Pfaeffle, Marina Schlicke, Susanne Bechtold-Dalla Pozza, Marie-Helene Gannage-Yared, Zoran Gucev, Angelika Mohn, Eva-Maria Harmel, Julia Volkmann, Susann Weihrauch-Blueher, Ruth Gausche, Holger Bogatsch, Christoph Beger, Juergen Klammt, Roland Pfaeffle
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Endocrinology & Metabolism
Paul Weihe, Julia Spielmann, Heike Kielstein, Jan Henning-Klusmann, Susann Weihrauch-Blueher
CURRENT OBESITY REPORTS
(2020)
Article
Pediatrics
Deirdre M. Harrington, Emer M. Brady, Susann Weihrauch-Bluher, Charlotte L. Edwardson, Laura J. Gray, Michelle Hadjiconstantinou, Janet Jarvis, Kamlesh Khunti, Itziar Vergara, Irati Erreguerena, Rogerio T. Ribeiro, Jacqui Troughton, Andriani Vazeou, Melanie J. Davies
Summary: The development of a family-based interactive lifestyle intervention for adolescents at risk of T2D involved a multidisciplinary team from different countries collaborating to gather potential program topics and theoretical frameworks. Through two iterative cycles of piloting, feedback, and refinement, stakeholders were involved in decision-making regarding content and delivery, leading to the creation of an eight-session program tailored to local languages and adaptations. This approach could provide a flexible intervention method for 'at risk' groups and their families.
Review
Pediatrics
Holger Till, Oliver Mann, Georg Singer, Susann Weihrauch-Blueher
Summary: Despite increasing prevalence of severe morbid obesity in children and adolescents, management requires a lifelong multidisciplinary approach including lifestyle changes and medication. Metabolic bariatric surgery (MBS) has evolved from controversy to being included in distinct recommendations, with significant improvement seen in resolving major co-morbidities.
Article
Endocrinology & Metabolism
Charlotte Loh, Paul Weihe, Nicole Kuplin, Kerstin Placzek, Susann Weihrauch-Blueher
Summary: The study analyzed the impact of the COVID-19 lockdown on children with diabetes mellitus, showing that the lockdown resulted in younger age and more severe DKA symptoms in children with new-onset diabetes, leading to longer hospital stays.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Pediatrics
Susann Weihrauch-Bluher, Susanna Wiegand, Paul Weihe, Nicole Prinz, Daniel Weghuber, Georg Leipold, Almut Dannemann, Lara Bergjohann, Thomas Reinehr, Reinhard W. Holl
Summary: This study investigated the associations between BMI-SDS/WHtR and serum uric acid (sUA)/gamma-glutamyl-transferase (GGT) levels, as well as cardiometabolic risk markers in children with obesity, considering factors such as sex, pubertal development, and weight loss/type of patient care. The findings suggest that abdominal obesity may contribute to hyperuricemia and hepatic involvement in prepubertal children. Even moderate weight loss has beneficial effects on cardiometabolic risk profile and glucose homeostasis.
Article
Pediatrics
Julia M. M. Goeldel, Clemens Kamrath, Kirsten Minden, Susanna Wiegand, Stefanie Lanzinger, Claudia Sengler, Susann Weihrauch-Blueher, Reinhard W. W. Holl, Sascha R. R. Tittel, Petra Warschburger
Summary: This study investigates the access to healthcare for children and adolescents with three common chronic diseases (T1D, obesity, or JIA) during the COVID-19 pandemic in Germany. The results show that overall satisfaction with healthcare was high and the proportion of canceled appointments was relatively small. Only a few parents reported obstacles to health services during the pandemic. Therefore, it seems that access to healthcare was largely preserved for this population in Germany.
Review
Endocrinology & Metabolism
Susann Weihrauch-Blueher, Susanna Wiegand
CURRENT OBESITY REPORTS
(2018)