Article
Multidisciplinary Sciences
Jongyun Myeong, Cheon-Gyu Park, Byung-Chang Suh, Bertil Hille
Summary: Our study investigated the possible segregation of plasma membrane phosphoinositide metabolism in different lipid domains, revealing distinct characteristics of L-o and L-d domains. Phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate were found in both L-o and L-d domains, with lipid exchange between these domains occurring much slower than predicted by free diffusion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Pharmacology & Pharmacy
Masahiko Terauchi, Atsushi Tamura, Yoshinori Arisaka, Hiroki Masuda, Tetsuya Yoda, Nobuhiko Yui
Summary: Research on regenerative treatment of oral tissues using cyclodextrin-based pharmaceutics and polyelectrolyte complexation shows great potential in enhancing the effectiveness and stability of treatments. These advanced techniques contribute to the progression of successful oral tissue regeneration.
Article
Neurosciences
Danielle A. Becktel, Jacob C. Zbesko, Jennifer B. Frye, Amanda G. Chung, Megan Hayes, Kylie Calderon, Jeffrey W. Grover, Anna Li, Frankie G. Garcia, Marco A. Tavera-Garcia, Rick G. Schnellmann, Hsin-Jung Joyce Wu, Thuy-Vi V. Nguyen, Kristian P. Doyle
Summary: This study suggests that systemic treatment with HP beta CD after stroke can attenuate chronic inflammation, prevent neurodegeneration, and improve cognitive function.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Orthopedics
Jan A. P. Geurts, Tom A. G. van Vugt, Jacobus J. C. Arts
Summary: Chronic osteomyelitis poses challenges in treatment due to bone infection and bacterial biofilm eradication. Novel biomaterials with unique properties are increasingly used to combat infection in this context, with ongoing debate about focusing on bone regeneration or antimicrobial properties.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Spectroscopy
Zifan Hou, Dandan Sun, Guanjun Wang, Jie Ma
Summary: This article introduces a β-cyclodextrin-based optical fiber microfiber biosensor for detecting cholesterol concentration, and demonstrates it experimentally.The β-cyclodextrin is immobilized on the fiber surface to form an inclusion complex with cholesterol, causing a change in surface refractive index and resulting in a macroscopic wavelength drift in the interference spectrum. The sensor has a high refractive index sensitivity of 1251 nm/RIU and a low temperature sensitivity of -0.019 nm/℃. It can rapidly detect cholesterol in the concentration range of 0.001 to 1 mM with a sensitivity of 12.7 nm/(mM) in the low concentration range of 0.001 to 0.05 mM. Characterization by infrared spectroscopy confirms the ability of the sensor to detect cholesterol. The biosensor has advantages of high sensitivity and good selectivity, showing great potential in biomedical applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Physical
Shankar Pandey, Yuan Xiang, Dirk Friedrich, Yongsheng Leng, Hanbin Mao
Summary: The study used optical tweezers to directly investigate the intermolecular mechanical force of nonspecific interactions between cholesterols, revealing that the IMMF of cholesterol dimers is orientation-dependent. Quantification of changes in free energy showed that cyclodextrins can easily solubilize cholesterols.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Jessica Y. Idowu, Bruno Hagenbuch
Summary: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), which are associated with obesity, are characterized by increased levels of free cholesterol in the liver. This study found that adding cholesterol impaired the function of two hepatic uptake transporters, while removing cholesterol increased their capacities. Furthermore, adding or removing cholesterol affected the localization of these transporters within lipid rafts. These findings suggest that the free cholesterol content in the liver can affect bile acid and drug uptake, potentially leading to altered drug disposition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Nigel Unwin
Summary: This study reveals the arrangement of phospholipids and cholesterol in the cell membrane using cryoelectron microscopy. It shows that these lipids exhibit distinct properties in different layers of the membrane, with a particular close-packed linear structure formed in the inner layer with higher cholesterol concentration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Yusei Yamada, Madoka Fukaura-Nishizawa, Asami Nishiyama, Akira Ishii, Tatsuya Kawata, Aina Shirakawa, Mayuko Tanaka, Yuki Kondo, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Takahiro Seki, Yuki Kurauchi, Hiroshi Katsuki, Katsumi Higaki, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
Summary: This study found that cyclodextrins can be used to treat Niemann-Pick disease type C (NPC), but concerns about ototoxicity exist. By optimizing the molecular structure of cyclodextrins, this study suggests a way to overcome this dilemma.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Yusei Yamada, Madoka Fukaura-Nishizawa, Asami Nishiyama, Akira Ishii, Tatsuya Kawata, Aina Shirakawa, Mayuko Tanaka, Yuki Kondo, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Takahiro Seki, Yuki Kurauchi, Hiroshi Katsuki, Katsumi Higaki, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
Summary: This study investigates the relationship between the formation of cyclodextrin (CD) and unesterified cholesterol (UC) complexes and their therapeutic effectiveness. The findings suggest that the solubility and molecular mechanisms of CD influence the formation and complexation capability of these complexes. The ability of CD derivatives to form 1:1 and 2:1 complexes is correlated with their therapeutic efficacy and toxicity, respectively. These findings highlight the importance of optimizing the molecular structure of CDs to overcome current treatment dilemmas.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Alexandra N. Edelbrock, Tristan D. Clemons, Stacey M. Chin, Joshua J. W. Roan, Eric P. Bruckner, Zaida Alvarez, Jack F. Edelbrock, Kristen S. Wek, Samuel I. Stupp
Summary: The study reports a supramolecular system where interactions between peptide amphiphiles and beta-cyclodextrin with adamantane lead to the formation of a mechanically robust hydrogel with highly porous architecture, which can be 3D printed and exhibits significant bioactivity towards neurons. This nanostructured hydrogel based on supramolecular assembly has potential applications in neuronal research and biomaterial design.
Article
Biochemistry & Molecular Biology
Olga S. C. Snip, Menno Hoekstra, Yiheng Zhang, Janine J. Geerling, Miranda Van Eck
Summary: 2-Hydroxypropyl-beta-cyclodextrin (2HP beta CD) can solubilize cholesterol and reverse atherosclerotic lesions, but its potential to induce regression of established lesions is still controversial.
Article
Reproductive Biology
Maria Jose Contreras, Maria Elena Arias, Mauricio Silva, Paulina Cabrera, Ricardo Felmer
Summary: Cryopreservation of stallion semen is less efficient due to the susceptibility of stallion sperm to freezing damage. The addition of membrane stabilizers to the freezing medium can reduce membrane disruption and cell damage, improving sperm quality and in vitro capacitation.
Article
Chemistry, Analytical
Wenxiang Xiao, Zhenzhen Yang, Jing Liu, ZhenCheng Chen, Hua Li
Summary: In this study, mercapto-beta-cyclodextrin capped gold nanoclusters were used as fluorescent probes for the determination of cholesterol. The probe showed a linear response to cholesterol with a satisfactory detection limit. The method successfully detected cholesterol in real serum samples without interference from common coexisting components.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Antonino Puglisi, Simone Bassini, Erik Reimhult
Summary: Cholesterol plays a crucial role in major cardiovascular and neurodegenerative diseases, and cyclodextrins have shown promising therapeutic efficacy in sequestering and mobilising cholesterol. A new approach involves core-shell superparamagnetic iron oxide nanoparticles functionalised with cyclodextrins, which can specifically cleave off from the nanoparticles' shell at a slightly acidic pH to mobilise cholesterol out of the lysosome. This platform shows potential in removing cholesterol from the lysosomal compartment.
FRONTIERS IN CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Susana Santos Braga, Firas El-Saleh, Karyna Lysenko, Filipe A. Almeida Paz
Summary: This study investigated the interaction between gamma-cyclodextrin and efavirenz in both solution and solid state. The 3:2 host-to-guest stoichiometry was found to be the optimal condition for isolating a solid inclusion compound. The effect of gamma-cyclodextrin on the solubility of efavirenz was examined using the isotherm method.
Editorial Material
Biochemistry & Molecular Biology
Susana Santos Braga
Article
Chemistry, Medicinal
Jessica S. Barbosa, Filipe A. Almeida Paz, Susana Santos Braga
Summary: This review provides an overview of the contributions of bisphosphonates to human health, starting with their chemistry and clinical uses, and then discussing pharmacology, administration methods, and the latest research efforts to expand their use. In addition, it highlights innovative routes and strategies of administration, as well as new drug candidates for anti-infectious purposes.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Susana Santos Braga, Jessica S. Barbosa, Nadia E. Santos, Firas El-Saleh, Filipe A. Almeida Paz
Summary: Cyclodextrins play various roles in vaccines against viruses and antiviral therapeutics, including solubilizing and stabilizing antiviral drugs, serving as adjuvants in vaccine development, and acting as pharmaceutical active ingredients. Although still in its early stages, the promising results indicate potential applications in treating viral infections and other pathologies.
Review
Biochemistry & Molecular Biology
Mariana Monteiro, Andreia F. R. Silva, Daniela Resende, Susana S. Braga, Manuel A. Coimbra, Artur M. S. Silva, Susana M. Cardoso
Summary: Oleuropein and hydroxytyrosol, as health-promoting agents, face challenges in food applications such as degradation and undesired sensory properties. Strategies to overcome these setbacks include encapsulation in delivery systems and covalent and non-covalent complexation. More research is needed to investigate their impact on sensory properties and bioactivity, as well as limitations in the food industry scale.
Article
Nanoscience & Nanotechnology
Jessica S. Barbosa, Miguel Pinto, Sandra Barreiro, Carlos Fernandes, Ricardo F. Mendes, Pedro Lavrador, Vitor M. Gaspar, Joao F. Mano, Fernanda Borges, Fernando Remiao, Susana S. Braga, Filipe A. Almeida Paz
Summary: The study presents an all-in-one combination therapy for osteoporosis by incorporating four antiosteoporotic components into coordination complexes. These compounds have the potential to effectively manage chronic bone diseases, warranting further research on their therapeutic properties.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Susana Santos Braga, Filipe A. Almeida Paz
Summary: Metal-Organic Frameworks (MOFs), as a class of coordination compounds, have high versatility and loading ability, making them attractive for drug delivery. This review summarizes the early use of cyclodextrin-coated and cyclodextrin-based MOFs in the treatment of bone-related diseases, including cyclodextrin-coated MOFs, cyclodextrin-based MOFs, and cross-linked derivatives of CD-MOFs. The review highlights their applications in delivering bisphosphonates, osteoporotic regulating drugs, and non-steroidal anti-inflammatory drugs for osteoarthritis management, as well as their recent use in dentistry.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Marcelo D. Catarino, Beatriz S. Baia Costa, Ana Rita Circuncisao, Artur M. S. Silva, Susana M. Cardoso, Susana Santos Braga
Summary: In this study, the interaction between gamma-cyclodextrin (gamma-CD) and phloroglucinol was investigated, resulting in the formation of a solid inclusion compound. The solid-state characterization confirmed the formation of the compound, and the evaluation of its antioxidant potential showed improved activity at the end of the digestion process.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Nadia E. Santos, Flavio Figueira, Miguel Neto, Filipe A. Almeida Paz, Susana Santos Braga, Joana C. Mendes
Summary: Diamond-based electrodes and biosensors have unique properties suitable for analytics. They can detect various types of biological molecules and utilize different detection methods based on the type of analyte.
APPLIED SCIENCES-BASEL
(2022)
Correction
Pharmacology & Pharmacy
Susana Santos Braga, Jessica S. Barbosa, Nadia E. Santos, Firas El-Saleh, Filipe A. Almeida Paz
Article
Food Science & Technology
Andreia F. R. Silva, Mariana Monteiro, Rute Nunes, Ana Baiao, Susana S. Braga, Bruno Sarmento, Manuel A. Coimbra, Artur M. S. Silva, Susana M. Cardoso
Summary: This study evaluated the impact of two delivery systems on the stability, antioxidant activity, bio-accessibility, and bioavailability of trans-resveratrol integrated into a bread matrix. The results showed that bread itself can effectively deliver trans-resveratrol without the need for additional delivery systems.
Review
Chemistry, Medicinal
Marcelo D. Catarino, Sonia M. G. Pires, Sonia Silva, Filipa Costa, Susana S. Braga, Diana C. G. A. Pinto, Artur M. S. Silva, Susana M. Cardoso
Summary: Fucales, an order of Phaeophyceae, are common littoral seaweeds in temperate and subtropical coastal regions. They have been utilized as food, feed, and medicine in human culture. These seaweeds are also a valuable source of bioactive compounds, with phlorotannins being of particular interest due to their health benefits. However, the identification and characterization of phlorotannins face challenges due to their complex structures and lack of standards.
Review
Chemistry, Medicinal
Marcelo D. Catarino, Rita Silva-Reis, Amina Chouh, Sonia Silva, Susana S. Braga, Artur M. S. Silva, Susana M. Cardoso
Summary: This article provides an overview of Sargassum seaweeds, one of the largest and most diverse genus of brown seaweeds, comprising around 400 taxonomically accepted species. Many species of this genus have long been used in human culture for food, feed, and folk medicine. Besides their high nutritional value, these seaweeds are also rich in natural antioxidant compounds, such as polyphenols, carotenoids, meroterpenoids, and phytosterols. These compounds have important applications in various fields, including agriculture, food, and health, and can be used for product preservation, cosmetics, and crop production improvement.
Review
Biochemistry & Molecular Biology
Nadia E. Santos, Joana C. Mendes, Susana Santos Braga
Summary: Diamond shows great potential in the biomedical field due to its biocompatibility, strength, and electrical conductivity. It can be synthesized in the lab using various methods and exists in different morphologies from microcrystalline to ultrananocrystalline diamond. This review summarizes relevant studies on cell adhesion, cell growth, and differentiation on diamond surfaces, and discusses how morphologies and surface termination can affect cell behavior. The review also presents a perspective on the use of diamond as a biointerface based on the results of cell adhesion and biocompatibility.
Review
Pharmacology & Pharmacy
Susana Santos Braga
Summary: Cyclodextrins play a significant role in oral hygiene compositions and have a wide range of potential applications in dentistry, including dental repair techniques and treatment of long-lasting diseases.
