Article
Chemistry, Multidisciplinary
Yaqi Zhu, Yang Tian, Tingting Zheng
Summary: A tri-modal paper device based on flower-like CuSe was developed for monitoring Alzheimer's disease-related miRNA by integrating colorimetric, photothermal, and surface-enhanced Raman scattering approaches. The presented tri-modal strategy effectively eliminates false-negative signals at the early stage of Alzheimer's disease.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Caterina Visconte, Chiara Fenoglio, Maria Serpente, Paola Muti, Andrea Sacconi, Marta Rigoni, Andrea Arighi, Vittoria Borracci, Marina Arcaro, Beatrice Arosio, Evelyn Ferri, Maria Teresa Golia, Elio Scarpini, Daniela Galimberti
Summary: This study isolated total EVs from plasma and characterized the miRNA contents in AD patients. The results showed widespread deregulation of specific miRNAs in plasma EVs, some of which were already known to be associated with neurological pathologies. Further validation analysis confirmed the upregulation of certain miRNAs in prodromal AD patients, suggesting their involvement in the early progression of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neuroimaging
Kejal Kantarci, Bradley F. Boeve, Scott A. Przybelski, Timothy G. Lesnick, Qin Chen, Julie Fields, Christopher G. Schwarz, Matthew L. Senjem, Jeffrey L. Gunte, Clifford R. Jack, Paul Min, Manoj Jain, Toji Migayawa, Rodolfo Savica, Jonathan Graff-Radford, Hugo Botha, David T. Jones, David S. Knopman, Neill Graff-Radford, Tanis J. Ferman, Ronald C. Petersen, Val J. Lowe
Summary: Patients with mild cognitive impairment (MCI) who progressed to probable dementia with Lewy bodies (DLB) show hypometabolism in the parieto-occipital cortex extending into temporal lobes, substantia nigra, and thalamus. In comparison to those who progressed to Alzheimer's disease (AD) dementia, MCI-DLB patients exhibit preserved medial temporal and posterior cingulate metabolism, along with greater hypometabolism in the substantia nigra. The CIS ratio and medial temporal to substantia nigra ratio are identified as useful in distinguishing prodromal DLB from AD.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
Shorena Janelidze, Divya Bali, Nicholas J. Ashton, Nicolas R. Barthelemy, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Yingxin He, Anna Orduna Dolado, Gallen Triana-Baltzer, Michael J. Pontecorvo, Henrik Zetterberg, Hartmuth Kolb, Manu Vandijck, Kaj Blennow, Randall J. Bateman, Oskar Hansson
Summary: Plasma phospho-tau species, especially p-tau217, show promise as blood-based biomarkers for Alzheimer's disease. This study compared the performance of different assays for p-tau181, p-tau217, and p-tau231 in detecting abnormal A beta status and predicting progression to Alzheimer's dementia. The mass spectrometry-based p-tau217 (p-tau217(WashU)) demonstrated the best performance, while several immunoassays, including p-tau217(Lilly), p-tau217(Janss), p-tau181(ADx), and p-tau181(WashU), showed high accuracy in both outcomes.
Article
Clinical Neurology
Annalise Rahman-Filipiak, Corey Bolton, Joshua D. Grill, Ayda Rostamzadeh, Nathaniel Chin, Judith Heidebrink, Sarah Getz, Nicole R. Fowler, Allyson Rosen, Jennifer Lingler, Ellen Wijsman, Lindsay Clark
Summary: The development of biomarkers for Alzheimer's disease (AD) has allowed researchers to improve sample homogeneity and test candidate treatments earlier in the disease. However, it is unknown to what extent standardized methods for disclosing biomarker testing results to research participants are implemented in trials.
ALZHEIMERS & DEMENTIA
(2023)
Article
Cell Biology
Wanting Liu, Lisa Wing Chi Au, Jill Abrigo, Yishan Luo, Adrian Wong, Bonnie Yin Ka Lam, Xiang Fan, Pauline Wing Lam Kwan, Hon Wing Ma, Anthea Yee Tung Ng, Sirong Chen, Eric Yim Lung Leung, Chi Lai Ho, Simon Ho Man Wong, Winnie C. W. Chu, Ho Ko, Alexander Yuk Lun Lau, Lin Shi, Vincent Chung Tong Mok
Summary: AD-RAI shows potential in detecting early Alzheimer's disease, particularly in the prodromal stage.
Article
Clinical Neurology
Xinyang Feng, Frank A. Provenzano, Scott A. Small
Summary: A deep learning approach using structural MRI outperforms other neuroimaging methods in detecting neurodegeneration and accurately classifying Alzheimer's disease. The model also performs better than biomarkers of amyloid and tau pathology, offering potential advantages in reducing patient burden, risk, and cost.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Longfei Jia, Min Zhu, Jianwei Yang, Yana Pang, Qi Wang, Ying Li, Tingting Li, Fangyu Li, Qigeng Wang, Yan Li, Yiping Wei
Summary: This study suggests that a panel of microRNAs in serum can serve as a promising substitute for traditional measurement of P-tau/A beta 42 in CSF as an effective biomarker of Alzheimer's disease (AD), successfully differentiating AD from other dementias.
Article
Clinical Neurology
Hiroyuki Watanabe, Sakura Hikida, Manabu Ikeda, Etsuro Mori
Summary: This study aimed to determine the characteristics of aphasic mild cognitive impairment (aphasic MCI), which is characterized by a progressive and relatively prominent language impairment compared with other cognitive impairments, in the prodromal phase of dementia with Lewy bodies (DLB). The clinical diagnosis of probable prodromal DLB accounted for more than 30% of cases in the aphasic MCI cohort, and language impairment was not very uncommon in prodromal DLB. Patients with cholinesterase inhibitor therapy showed improvement in general cognitive function, including language function.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Alice Tisserand, Benjamin Cretin, Mary Mondino, Anne Botzung, Lea Sanna, Catherine Demuynck, Pierre Anthony, Candice Muller, Olivier Bousiges, Nathalie Philippi, Frederic Blanc
Summary: This study aimed to investigate the association between photophobia and dementia with Lewy bodies (DLB). The study found that photophobia was more frequent in DLB patients and was associated with decreased gray matter in the right precentral cortex and the eyelid motor region. This finding is important for understanding the pathological mechanism of DLB.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Ricardo Titze-de-Almeida, Simoneide Souza Titze-de-Almeida, Gabriel Ginani Ferreira, Andrezza Paula Brito Silva, Pedro Renato de Paula Brandao, Wolfgang H. Oertel, Carlos H. Schenck, Raimundo Nonato Delgado Rodrigues
Summary: The flow of gene expression is a tightly controlled cell process, with microRNAs playing a crucial role in maintaining healthy cell physiology. Aberrant expressions of microRNAs are associated with Parkinson's disease pathogenesis, while REM-sleep behavior disorder may serve as a valuable phenotype for disease prediction.
Article
Neurosciences
Fatemah Sakr, Martin Dyrba, Anja Braeuer, Stefan Teipel
Summary: This study found that lipid alterations can be observed in the early stages of Alzheimer's disease and that a specific lipidomic signature in blood may provide insights into an individual's metabolic status and predict the risk of clinical progression.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Adam S. Bernstein, Steven Z. Rapcsak, Michael Hornberger, Manojkumar Saranathan
Summary: Using a novel MRI-based thalamic segmentation technique, this study found significant atrophy in specific thalamic nuclei in late MCI and AD patients compared to healthy controls, supporting the role of thalamic nuclei in the progression of AD. Additionally, early MCI patients also showed smaller volumes in certain thalamic nuclei, indicating early changes in the thalamus during the MCI stage.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Daniella Castro Araujo, Adriano Alonso Veloso, Karina Braga Gomes, Leonardo Cruz de Souza, Nivio Ziviani, Paulo Caramelli
Summary: This study aimed to develop a machine learning-based blood panel to predict the risk of progression from mild cognitive impairment (MCI) to dementia due to Alzheimer's disease (AD). By using ADNI data, researchers created a panel composed of 12 plasma proteins and successfully predicted the risk of MCI patients converting to AD dementia within a four-year time frame.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Nigel L. Kravatz, Dristi Adhikari, Emmeline Ayers, Joe Verghese
Summary: The study found that there are functional limitations in complex everyday tasks during the prodromal stages of MCR, which can assist in risk prognostication.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Immunology
Felipe Perez-Garcia, Sonia Vazquez-Moron, Ivan Burgueno-Garcia, Maria Jose Munoz-Gomez, Maria Ascension Zea-Sevilla, Miguel Calero, Isidoro Martinez, Alberto Rabano, Salvador Resino
Summary: The presence of hepatitis E virus antibodies is associated with a higher risk of central nervous system neurodegenerative disorders and neuropathological injury in older people.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biotechnology & Applied Microbiology
Stephen F. Madden, Mattia Cremona, Angela M. Farrelly, Weng Hei Low, Jean McBryan
Summary: This study presents a novel proteomic timecourse dataset, profiling potential drug targets in tamoxifen-treated MCF7 cells. It identifies a biphasic response to tamoxifen and identifies key molecular mechanisms during the growth-impeded phase.
CANCER GENE THERAPY
(2023)
Article
Oncology
Hajrah Khawaja, Rebecca Briggs, Cheryl H. Latimer, Mustasin Rassel, Dary Griffin, Lyndsey Hanson, Alberto Bardelli, Frederica Di Nicolantonio, Simon S. McDade, Christopher J. Scott, Shauna Lambe, Manisha Maurya, Andreas U. Lindner, Jochen H. M. Prehn, Jose Sousa, Chris Winnington, Melissa J. LaBonte, Sarah Ross, Sandra Van Schaeybroeck
Summary: Novel covalent inhibitors of KRASG12C have shown limited response rates in patients with KRASG12C-mutant colorectal cancer. In this study, researchers found that the combination of AZ'1569 and a Bcl-xL inhibitor led to a dramatic and universal apoptosis, suggesting a potential therapeutic strategy for patients with KRAS G12C-mutant colorectal cancer.
MOLECULAR CANCER THERAPEUTICS
(2023)
Article
Clinical Neurology
Diana Ortega-Cruz, Alicia Uceda-Heras, Juan Eugenio Iglesias, Maria Ascension Zea-Sevilla, Bryan Strange, Alberto Rabano
Summary: This study aimed to characterize features of early hippocampal sclerosis of aging (HS) to refine its understanding within combined pathology. The HS staging system developed showed significant correlation with disease duration, cognitive performance, and combined neuropathologies, especially with limbic-predominant age-related TAR DNA-binding protein 43 (TDP-43) encephalopathy (LATE). In vivo MRI demonstrated focal hippocampal gray matter loss as a function of HS staging.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Pablo Garcia-Gonzalez, Itziar de Rojas, Sonia Moreno-Grau, Laura Montrreal, Raquel Puerta, Emilio Alarcon-Martin, Ines Quintela, Adela Orellana, Victor Andrade, Pamela V. Martino Adami, Stefanie Heilmann-Heimbach, Pilar Gomez-Garre, Maria Teresa Perinan, Ignacio Alvarez, Monica Diez-Fairen, Raul Nunez Llaves, Claudia Olive Roig, Guillermo Garcia-Ribas, Manuel Menendez-Gonzalez, Carmen Martinez, Miquel Aguilar, Mariateresa Buongiorno, Emilio Franco-Macias, Maria Eugenia Saez, Amanda Cano, Maria J. Bullido, Luis Miguel Real, Eloy Rodriguez-Rodriguez, Jose Luis Royo, Victoria Alvarez, Pau Pastor, Gerard Pinol-Ripoll, Pablo Mir, Miguel Calero Lara, Miguel Medina Padilla, Pascual Sanchez-Juan, Angel Carracedo, Sergi Valero, Isabel Hernandez, Lluis Tarraga, Alfredo Ramirez, Merce Boada, Agustin Ruiz
Summary: Mosaic loss of chromosome Y (mLOY) is a common somatic event associated with Alzheimer's disease (AD) and can be age-confounded in genome-wide association studies. This study used Mendelian randomisation to construct an age-independent mLOY polygenic risk score (mloy-PRS) and found that higher genetic risk for mLOY was associated with faster progression to AD in men with mild cognitive impairment. The study suggests that mLOY is involved in AD pathogenesis and shows associations with cerebrospinal fluid biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Florian Pichot, Marion C. Hogg, Virginie Marchand, Valerie Bourguignon, Elisabeth Jirstrom, Cliona Farrell, Hesham A. Gibriel, Jochen H. M. Prehn, Yuri Motorin, Mark Helm
Summary: Modification of tRNA is crucial for generating RNA expression diversity. In this study, the stoichiometry of incompletely modified sites in human tRNAs was investigated, and it was found that up to 75% of sites can be incompletely modified. The modification patterns of tRNA populations can provide information to differentiate different cell lines.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Oncology
Cha Len Lee, Mattia Cremona, Angela Farrelly, Julie A. Workman, Sean Kennedy, Razia Aslam, Aoife Carr, Stephen Madden, Brian O'Neill, Bryan T. Hennessy, Sinead Toomey
Summary: Background studies have shown the effectiveness of Palbociclib, Gedatolisib, and PD0325901 in treating colorectal cancer (CRC), but single agent therapies often face resistance. This study compares the anti-proliferative effects of combinations of Gedatolisib and Palbociclib, and Gedatolisib and PD0325901 in different CRC cell lines, and examines their impact on signaling pathway proteins. The results demonstrate that the combination of Palbociclib and Gedatolisib is superior and has synergistic anti-proliferative effects in both wild-type and mutated CRC cell lines. The phosphorylation of S6rp may serve as a promising biomarker for the responsiveness to this combination therapy.
CANCER BIOLOGY & THERAPY
(2023)
Article
Multidisciplinary Sciences
Sandra Roche, Patricia Gaule, Deirdre Winrow, Nupur Mukherjee, Fiona O'Neill, Neil T. T. Conlon, Justine Meiller, Denis M. M. Collins, Alexandra Canonici, Mohammed Ibrahim Fawsi, Alejandra Estepa-Fernandez, Stephen F. F. Madden, John Crown, Norma O'Donovan, Alex J. J. Eustace
Summary: Triple Negative Breast Cancer (TNBC), a subtype of breast cancer, has fewer successful therapeutic therapies than other types of breast cancer. Insulin-like growth factor receptor 1 (IGF1R) and the Insulin receptor (IR) are associated with poor outcomes in TNBC. However, inhibiting both IR/IGF1R is not an effective therapeutic approach to treat TNBC.
Correction
Multidisciplinary Sciences
Itziar de Rojas, Sonia Moreno-Grau, Niccolo Tesi, Benjamin Grenier-Boley, Victor Andrade, Iris Jansen, Nancy L. Pedersen, Najada Stringa, Anna Zettergren, Isabel Hernandez, Laura Montrreal, Carmen Antunez, Anna Antonell, Rick M. Tankard, Joshua Bis, Rebecca Sims, Celine Bellenguez, Ines Quintela, Antonio Gonzalez-Perez, Miguel Calero, Emilio Franco-Macias, Juan Macias, Rafael Blesa, Laura Cervera-Carles, Manuel Menendez-Gonzalez, Ana C. Frank-Garcia, Jose Luis W. Royo, Fermin Moreno, Raquel Huerto Vilas, Miquel Baquero, Monica Diez-Fairen, Carmen Lage, Sebastian Garcia-Madrona, Pablo Garcia-Gonzalez, Emilio Alarcon-Martin, Sergi Valero, Oscar Sotolongo-Grau, Abbe Ullgren, Adam C. Naj, Afina W. Lemstra, Alba Benaque, Alba Perez-Cordon, Alberto L. Benussi, Alberto Rabano, Alessandro Padovani, Alessio Squassina, Alexandre de Mendonca, Alfonso M. Arias Pastor, Almar A. L. Kok, Alun Meggy, Ana Belen Pastor, Ana Espinosa, Anais Corma-Gomez, Angel Martin Montes, Angela Sanabria, Anita W. DeStefano, Anja Schneider, Annakaisa Haapasalo, Anne Kinhult Stahlbom, Anne Tybjaerg-Hansen, Annette M. Hartmann, Annika Spottke, Arturo Corbaton-Anchuelo, Arvid B. Rongve, Barbara Borroni, Beatrice Arosio, Benedetta Nacmias, Borge G. Nordestgaard, Brian W. Kunkle, Camille Charbonnier, Carla Abdelnour, Carlo Masullo, Carmen Martinez Rodriguez, Carmen Munoz-Fernandez, Carole Dufouil, Caroline Graff, Catarina Ferreira, Caterina Chillotti, Chandra A. Reynolds, Chiara Fenoglio, Christine Van Broeckhoven, Christopher Clark, Claudia Pisanu, Claudia L. Satizabal, Clive Holmes, Dolores Buiza-Rueda, Dag Aarsland, Dan Rujescu, Daniel Alcolea, Daniela Galimberti, David Wallon, Davide Seripa, Edna Grunblatt, Efthimios Dardiotis, Emrah Duezel, Elio Scarpini, Elisa Conti, Elisa Rubino, Ellen Gelpi, Eloy Rodriguez-Rodriguez, Emmanuelle Duron, Eric Boerwinkle, Evelyn Ferri, Fabrizio Tagliavini, Fahri Kuecuekali, Florence Pasquier, Florentino Sanchez-Garcia, Francesca Mangialasche, Frank Jessen, Gael Nicolas, Geir Selbaek, Gemma K. Ortega, Genevieve Chene, Georgios Hadjigeorgiou, Giacomina Rossi, Gianfranco Spalletta, Giorgio Giaccone, Giulia Grande, Giuliano Binetti, Goran Papenberg, Harald Hampel, Henri Bailly, Henrik Zetterberg, Hilkka Soininen, Ida Karlsson, Ignacio Alvarez, Ildebrando Appollonio, Ina Giegling, Ingmar Skoog, Ingvild Saltvedt, Innocenzo Rainero, Irene Rosas Allende, Jakub Hort, Janine Diehl-Schmid, Jasper Van Dongen, Jean-Sebastien Vidal, Jenni Lehtisalo, Jens Wiltfang, Jesper Qvist Thomassen, Johannes Kornhuber, Jonathan A. Haines, Jonathan Vogelgsang, Juan Pineda, Juan Fortea, Julius Popp, Juergen Deckert, Katharina Buerger, Kevin Morgan, Klaus Fliessbach, Kristel Sleegers, Laura Molina-Porcel, Lena Kilander, Leonie Weinhold, Lindsay Farrer, Li-San Wang, Luca Kleineidam, Lucia A. Farotti, Lucilla Parnetti, Lucio Tremolizzo, Lucrezia Hausner, Luisa Benussi, Lutz Froelich, M. Arfan Ikram, M. Candida Deniz-Naranjo, Magda Tsolaki, Maitee Rosende-Roca, Malin Lowenmark, Marc Hulsman, Marco Spallazzi, Margaret H. Pericak-Vance, Margaret Esiri, Maria Bernal Sanchez-Arjona, Maria Carolina Dalmasso, Maria Teresa T. Martinez-Larrad, Marina Arcaro, Markus Noethen, Marta Fernandez-Fuertes, Martin Dichgans, Martin Ingelsson, Martin Herrmann, Martin Scherer, Martin Vyhnalek, Mary M. Kosmidis, Mary M. Yannakoulia, Matthias Schmid, Michael J. Ewers, Michael T. Heneka, Michael Wagner, Michela Scamosci, Miia Kivipelto, Mikko Hiltunen, Miren Zulaica, Montserrat Alegret, Myriam Fornage, Natalia Roberto, Natasja van Schoor, Nazib Seidu, Nerisa Banaj, Nicola Armstrong, Nikolaos Scarmeas, Norbert A. Scherbaum, Oliver Goldhardt, Oliver Hanon, Oliver Peters, Olivia Anna Skrobot, Olivier Quenez, Ondrej Lerch, Paola Bossu, Paolo Caffarra, Paolo Dionigi Rossi, Paraskevi Sakka, Patrizia Mecocci, Per Hoffmann, Peter Holmans, Peter A. Fischer, Peter Riederer, Qiong Yang, Rachel Marshall, Rajesh N. Kalaria, Richard Mayeux, Rik Vandenberghe, Roberta Cecchetti, Roberta Ghidoni, Ruth Frikke-Schmidt, Sandro Sorbi, Sara Haegg, Sebastiaan Engelborghs, Seppo Helisalmi, Sigrid Botne Sando, Silke Kern, Silvana Archetti, Silvia Boschi, Silvia Fostinelli, Silvia Gil, Silvia Mendoza, Simon Mead, Simona Ciccone, Srdjan Djurovic, Stefanie Heilmann-Heimbach, Steffi Riedel-Heller, Teemu Kuulasmaa, Teodoro del Ser, Thibaud Lebouvier, Thomas Polak, Tiia Ngandu, Timo Grimmer, Valentina Bessi, Valentina Escott-Price, Vilmantas Giedraitis, Vincent Deramecourt, Wolfgang Maier, Xueqiu Jian, Yolande A. L. Pijnenburg, Patrick Gavin Kehoe, Guillermo Garcia-Ribas, Pascual Sanchez-Juan, Pau Pastor, Jordi Perez-Tur, Gerard Pinol-Ripoll, Adolfo Lopez De Munain, Jose Maria Garcia-Alberca, Maria J. Bullido, Victoria Alvarez, Alberto Lleo, Luis M. Real, Pablo Mir Miguel Medina, Philip Scheltens, Henne Holstege, Marta Marquie, Maria Eugenia Saez, Angel Carracedo, Philippe Amouyel, Gerard D. Schellenberg, Julie Williams, Sudha Seshadri, CorneliaM. Van Duijn, Karen A. Mather, Raquel Sanchez-Valle, Manuel Serrano-Rios, Adelina Orellana, Lluis Tarraga, Kaj Blennow, Ole A. Andreassen, Danielle Posthuma, Jordi Clarimon, Merce Boada, Wiesje M. Van der Flier, Alfredo Ramirez, Jean-Charles Lambert, Sven J. Van der Lee, Agustin Ruiz
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Diana Ortega-Cruz, Juan Eugenio Iglesias, Alberto Rabano, Bryan A. Strange
Summary: This study discovered that hippocampal sclerosis of aging (HS) plays an important role in dementia neuropathology. Longitudinal MRI analysis of 64 dementia patients revealed that HS-associated hippocampal volume changes can be detected more than 10 years before death, independent of age and Alzheimer's disease (AD) pathology, and driven by atrophy in CA1 and subiculum. These findings suggest that these MRI findings can aid in differentiation between HS and AD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Oncology
Nicola Gaynor, Alfonso Blanco, Stephen F. Madden, Barry Moran, Jean M. Fletcher, Damien Kaukonen, Javier Sanchez Ramirez, Alex J. Eustace, Martina S. J. McDermott, Alexandra Canonici, Sinead Toomey, Ausra Teiserskiene, Bryan T. Hennessy, Norma O'Donovan, John Crown, Denis M. Collins
Summary: This study investigated the alterations in phenotype, genotype, and cytotoxic capacity of circulating immune cells in patients with HER2+ breast cancer after neo-adjuvant treatment. The results showed changes in cytotoxicity and immune cell populations after treatment, and suggested that Pembrolizumab may be a potential biomarker of treatment response in ex vivo ADCC assays.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Nicola Cosgrove, Alex J. Eustace, Peter O'Donovan, Stephen F. Madden, Bruce Moran, John Crown, Brian Moulton, Patrick G. Morris, Liam Grogan, Oscar Breathnach, Colm Power, Michael Allen, Janice M. Walshe, Arnold D. Hill, Anna Blumel, Darren O'Connor, Sudipto Das, Malgorzata Milewska, Joanna Fay, Elaine Kay, Sinead Toomey, Bryan T. Hennessy, Simon J. Furney
Summary: This study suggests that age, estrogen receptor status, and level of immune cell infiltration may play important roles in predicting the response to neoadjuvant therapy in HER2-positive breast cancer. Clonal evolution analysis reveals the presence of therapy resistant subclones. APOBEC-associated mutagenesis may mediate the immunogenic phenotype in HER2-negative/HER2-positive subtype.
Meeting Abstract
Oncology
Dalal AlSultan, Alex J. Eustace, Stephen F. Madden, John Crown
Article
Endocrinology & Metabolism
N. Ng, H. A. Y. Gibriel, L. Halang, E. Jirstrom, J. A. Ioana, M. Burke, M. M. Byrne, J. H. M. Prehn
Summary: This study investigated the levels of tiRNA 5'ValCAC (alone and in combination with miR-23b-3p) in serum samples from healthy controls, type 1 diabetes, type 2 diabetes, and MIDD subjects. The results showed reduced levels of 5'ValCAC in MIDD and type 2 diabetes subjects compared to controls, and higher levels of miR-23b-3p in type 2 diabetes subjects. Receiver Operating Characteristic analysis demonstrated the potential of 5'ValCAC and miR-23b-3p as MIDD biomarkers, with the combination showing excellent separation from type 2 diabetes subjects.
