Article
Pharmacology & Pharmacy
Jian Chen, Xian Lin, Kangdi Liu, Juan He, Xin Li, Chuchu Zhang, Yongxing Deng, Lianxiang Luo, Cheng Tao, Qingwen Wang
Summary: This study demonstrated that a novel compound CT2-3 inhibits the abnormal functions of RA-fibroblastlike synoviocytes (RA-FLSs) by inducing cell cycle arrest and apoptosis through modulating the PI3K/AKT pathway, offering a potential lead compound for the development of novel anti-RA drugs.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Immunology
Zewen Wu, Dan Ma, Helin Yang, Jinfang Gao, Gailian Zhang, Ke Xu, Liyun Zhang
Summary: Fibroblast-like synoviocytes (FLS) play a crucial role in the pathophysiology of rheumatoid arthritis (RA) and have become the main focus of research. Advances in technology, such as high-throughput sequencing, have made it possible to identify different FLS subsets, allowing for a detailed study of RA pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Yirixiati Aihaiti, Xiadiye Tuerhong, Haishi Zheng, YongSong Cai, Mingyi Yang, Peng Xu
Summary: PRDX4 is up-regulated in synovial tissue of RA patients and regulates the tumor cell-like characteristics of RA-FLS through activation of the PI3K/Akt signaling pathway.
CLINICAL IMMUNOLOGY
(2022)
Review
Cell Biology
Qianwei Li, Yuehong Chen, Huan Liu, Yunru Tian, Geng Yin, Qibing Xie
Summary: This review thoroughly explores the pathological and physiological characteristics of three crucial glycolytic enzymes in RA, delving into their putative regulatory mechanisms and shedding light on their significance in RAFLS. Furthermore, the review offers an up-to-date overview of emerging small-molecule candidate drugs designed to target these glycolytic enzymes and the upstream signaling pathways that regulate them. By enhancing our understanding of the pathogenic mechanisms of RA and highlighting the pivotal role of glycolytic enzymes, this study contributes to the development of innovative anti-rheumatic therapies.
INFLAMMATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Mei Meng, Zhenggang Yue, Lu Chang, Yanru Liu, Jinhang Hu, Zhongxing Song, Zhishu Tang, Rui Zhou, Changli Wang
Summary: PS VII inhibits the proliferation and induces apoptosis of RA-FLS and MH7A cells by regulating the mitochondrial apoptotic pathway and the JNK and p38 MAPK pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Lianhua He, Huijie Luan, Juan He, Miaomiao Zhang, Qingxia Qin, Yiping Hu, Yueming Cai, Desheng Sun, Yu Shi, Qingwen Wang
Summary: Shikonin has anti-inflammatory and immunomodulatory activities and has been shown to reduce arthritis incidence and inflammation in collagen-induced arthritis mice. It also inhibits the invasion, adhesion, and migration of fibroblast-like synoviocytes, as well as the expression of inflammatory cytokines. Shikonin targets suppressor of cytokine signaling 1 and blocks the Janus kinase/signal transducer and activator of transcription signaling pathway, making it a promising candidate for the treatment of rheumatoid arthritis.
Article
Chemistry, Multidisciplinary
Yuan Liu, Peishi Rao, Hongyan Qian, Yesi Shi, Shiju Chen, Jingying Lan, Dan Mu, Rongjuan Chen, Xinwei Zhang, Chaoqiong Deng, Gang Liu, Guixiu Shi
Summary: Fibroblast-like synoviocytes (FLS) are the main cell component in inflamed joints of patients with rheumatoid arthritis (RA) and interact with infiltrating T cells. Under normal conditions, FLS have inhibitory effects on T cells, but in RA, FLS exhibit a proinflammatory phenotype. The signals that control FLS heterogeneity are still unclear.
Article
Plant Sciences
Nan Li, Xiaojuan Li, Lijuan Deng, Haixin Yang, Zhaohui Gong, Qiang Wang, Dongmei Pan, Shan Zeng, Jiaxu Chen
Summary: This study found that 6-shogaol inhibits proliferation, migration, and invasion, and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes (FLSs). It also reduces the production of inflammatory cytokines and matrix metalloproteinases (MMPs). Molecular mechanism analysis revealed that 6-shogaol inhibits the PI3K/AKT/NF-kappa B pathway by activating PPAR-gamma. Treatment with 6-shogaol ameliorated joint destruction in a mouse model of collagen-induced arthritis (CIA). Therefore, 6-shogaol may be a potential natural drug for future rheumatoid arthritis treatments.
Article
Pharmacology & Pharmacy
Xiao-Feng Li, Sha Wu, Qi Yan, Yuan-Yuan Wu, He Chen, Su-Qin Yin, Xin Chen, Hua Wang, Jun Li
Summary: The study reveals that PTEN methylation promotes inflammation and activation in fibroblast-like synoviocytes (FLS) in the pathogenesis of rheumatoid arthritis (RA). Inhibiting methylation can reduce inflammation and alleviate joint swelling, potentially serving as an effective treatment strategy for RA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Mingcheng Huang, Keping Wu, Shan Zeng, Wenfen Liu, Tianjiao Cui, Zhiqing Chen, Lian Lin, Dongying Chen, Hui Ouyang
Summary: The study demonstrated that punicalagin has anti-inflammatory and anti-bone destruction effects in rheumatoid arthritis by inhibiting the proliferation and migration of FLSs and modulating NF-kappa B pathways.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
M. Vomero, M. Caliste, C. Barbati, M. Speziali, A. I. Celia, F. Ucci, C. Ciancarella, E. Putro, T. Colasanti, G. Buoncuore, E. Corsiero, M. Bombardieri, F. R. Spinelli, F. Ceccarelli, F. Conti, C. Alessandri
Summary: The study demonstrates that tofacitinib has the ability to modulate autophagy in fibroblast-like synoviocytes, contributing to its effectiveness in treating patients with rheumatoid arthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Weihong Xu, Lu Ye, Huaxiang Wu
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with increasing incidence globally. The study revealed that miR-4423-3p is downregulated in RA patients and targets MMP13 to inhibit cell proliferation, migration, and invasion while promoting apoptosis in HFLS-RA cells.
Article
Oncology
Jian Chen, Xian Lin, Juan He, Dandan Liu, Lianhua He, Miaomiao Zhang, Huijie Luan, Yiping Hu, Cheng Tao, Qingwen Wang
Summary: The study found that ATT has potential therapeutic effects on RA by suppressing proliferation, migration, and invasion of RA-FLSs, as well as inducing apoptosis. ATT achieves therapeutic potential for RA by modulating the METTL3/ICAM2/PI3K/AKT/p300 feedback loop.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Environmental Sciences
Qingliang Meng, Zhike Wen, Wanting Meng, Hua Bian, Huimin Gu, Ruiting Zuo, Junping Zhan, Huilian Wang, Xiyun Miao, Wei Fan, Zipeng Zhou, Fuzeng Zheng, Liying Wang, Xiao Su, Junfu Ma
Summary: Blimp1 inhibits the activation of FLSs induced by CD4(+) T cells by promoting the secretion of IL-10 in CD4(+) T cells.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Immunology
Yanhua Zuo, Huaheng Xu, Yanxia Li, Zongfang Zhang, Ran Tao, Manxiang Wang
Summary: Synovial samples from RA patients and normal controls were used to isolate FLSs. Increased expression of circ_0007707 was observed in synovial samples from RA patients and FLS-RA cells. Circ_0007707 silencing inhibited cell proliferation, induced cell apoptosis, and decreased cell inflammatory response in FLS-RA cells. Mechanistically, circ_0007707 mediated cell apoptosis and inflammatory response in FLS-RA cells through the miR-27b-3p/PDE3B axis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wei Peng, Yunhui Chen, Steve Tumilty, Lizhou Liu, Ling Luo, Haiyan Yin, Yongmei Xie
Summary: Neurodegenerative diseases (NDDs) are neurological disorders characterized by neuronal degeneration and apoptosis. Paeoniflorin, a natural compound extracted from the root of Paeonia lactiflora pall, has been found to have potential therapeutic effects on NDDs by modulating cellular Ca2+/ROS homeostasis.
CURRENT OPINION IN PHARMACOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Ruolan Li, Feng Lu, Xue Sun, Liying He, HuXinyue Duan, Wei Peng, ChunJie Wu
Summary: The study successfully developed hydroxy-alpha-sanshool liposomes (HAS-LPs) that can improve learning and memory disorders in an Alzheimer's disease (AD) model, suggesting potential clinical applications for these nanoparticles.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Cell Biology
Dandan Tang, Qing Zhang, Huxinyue Duan, Xun Ye, Jia Liu, Wei Peng, Chunjie Wu
Summary: This article comprehensively summarizes the pharmacological effects and potential molecular mechanisms of polydatin in protecting and treating liver disorders through regulation of oxidative stress. Polydatin has shown significant protective and curative effects on liver diseases associated with oxidative stress through various molecular mechanisms. However, further clinical investigations are needed to confirm the clinical treatment effect of polydatin in liver diseases related to regulation of oxidative stress.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cell Biology
Jia Liu, Qing Zhang, Yuanyuan Chen, Lingyu Wang, Ting Tao, Qiang Ren, Xiuping Chen, Yunhui Chen
Summary: This study investigated the protective effect and potential mechanisms of Cinnamomi Ramulus (CR) on rheumatoid arthritis (RA) using multiple approaches. The results showed that CR could ameliorate RA symptoms, inhibit inflammation and oxidative damage, possibly through regulating the TNF and IL-17 signaling pathways.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Multidisciplinary Sciences
Bingke Bai, Chang Liu, Chengzhong Zhang, Xuhui He, Hongrui Wang, Wei Peng, Chengjian Zheng
Summary: This review summarizes the structural diversities, biological activities, and promising biosynthetic potentials of terpenoids isolated from Trichoderma species. Trichoderma terpenoids exhibit important antibacterial, antifungal, inhibitory, and cytotoxic activities, making Trichoderma species valuable microbial resources for drug discovery and environmentally friendly agrochemicals development. The abundance of novel skeletons, bioactivities, and biosynthetic potentials present new opportunities for drug and agrochemicals discovery, genome mining, and enzymology exploration from Trichoderma species.
JOURNAL OF ADVANCED RESEARCH
(2023)
Editorial Material
Pharmacology & Pharmacy
Yunhui Chen, Charles Hsu, Xiuping Chen, Heng Zhang, Wei Peng
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Lijie Wang, Xiaoling Gou, Yin Ding, Jingye Liu, Yue Wang, Yaqian Wang, Jing Zhang, Leilei Du, Wei Peng, Gang Fan
Summary: Globally, metabolic diseases are a significant public health issue, and herbal medicines derived from plants are widely used in their treatment due to their efficacy and minimal side effects. Recent research has shown that the gut microbiota plays a key role in the therapeutic effects of herbal medicines on metabolic diseases. Mechanisms involved include effects on gut microbial composition, intestinal barrier, inflammation, and microbial metabolites. These findings highlight the importance of the interaction between herbal medicines and gut microbiota in the treatment of metabolic diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qi Liang, Jing-Wen Wang, Yu-Ru Bai, Ruo-Lan Li, Chun-Jie Wu, Wei Peng
Summary: TRPV1 and TRPA1 channels have beneficial effects in ameliorating postoperative ileus, making natural herbs a potential therapeutic option. Activation of these channels enhances gastrointestinal motility and relieves pain.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Ruo-Lan Li, Hu-Xinyue Duan, Ling-Yu Wang, Qi Liang, Chunjie Wu, Wei Peng
Summary: Neurodegenerative diseases are a global threat and burden on the social economy due to neuronal degeneration and apoptosis. The current drugs for these diseases have side effects, necessitating the urgent discovery of safe and effective alternatives. Zanthoxylum bungeanum Maxim. (ZBM) has a long medicinal history in China and is rich in amides. This review highlights the potential therapeutic role of amides from ZBM in neurodegenerative diseases, specifically in Alzheimer's, Parkinson's, and depression, through antioxidant and anti-inflammatory effects on the TRPV1, TRPA1, and PI3K/AKT signaling pathways. The review also discusses the physical and chemical properties of these amides.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Integrative & Complementary Medicine
Lian Zhong, Qing Zhang, Wei Peng, Yongxiang Gao, Daneng Wei, Xufeng Pu, Huan Xu, Chunjie Wu
Summary: This systematic review and meta-analysis evaluated the effect and safety of Guizhi-Shaoyao-Zhimu decoction (GSZD) for treating rheumatoid arthritis (RA). The results showed that GSZD was more likely to achieve clinical efficacy and significantly improve physical signs compared to conventional drugs. Additionally, GSZD exhibited a reduced incidence of adverse events compared to the control group.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Chengxun He, Ke Wang, Jun Xia, Die Qian, Juan Guo, Lian Zhong, Dandan Tang, Xiuping Chen, Wei Peng, Yunhui Chen, Yong Tang
Summary: MELNs can mitigate the progression of type 2 diabetes in the HFD/STZ mouse model. The underlying molecular mechanism is related to the PI3K/Akt/GLUT4/GSK-3 beta signaling pathway.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Yunhui Chen, Yongmei Xie, Cailu Lin, Wei Peng
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Qi Liang, Ruo-Lan Li, Dan-Dan Tang, Ting Zhang, Lian Zhong, Chun-Jie Wu, Wei Peng
Summary: This review summarizes the potential roles of targeting T2Rs with bitter compounds for the treatment of respiratory diseases. It also discusses the potential of ABC transmembrane transporter proteins in delivering bitter compounds to combat drug resistance. The findings provide a reference for future studies on bitter receptor therapy for respiratory diseases.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Biochemical Research Methods
Meiyan Li, Dandan Tang, Runchun Xu, Sirong Zhang, Yu Chen, Wei Peng
Summary: This study aims to investigate the quality markers of Yiqi Tongluo capsule (YTC) and optimize its extraction process based on these markers. The results identified 8 compounds with protective effects on cardiomyocytes, which were considered as the quality markers of YTC. The optimized extraction process was established and the HPLC fingerprint of optimized YTC was successfully developed.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Plant Sciences
Qing Zhang, Cheng-Xun He, Ling-Yu Wang, Die Qian, Dan-Dan Tang, Sheng-Nan Jiang, Wen-Wen Chen, Chun-Jie Wu, Wei Peng
Summary: The study found that hydroxy-alpha-sanshool (HAS) can promote browning of white adipose tissue (WAT) through the regulation of the AMPK/SIRT-1/PPAR gamma signaling pathway, which helps combat obesity.