Article
Biochemistry & Molecular Biology
Laila Yasmim dos Santos Silva, Andrezza da Silva Ramos, Debora Nogueira Cavalcante, Valdely Ferreira Kinupp, Joao Vitor da Silva Rodrigues, Bianca Muniz Lacerda Ventura, Tiago Antonio de Oliveira Mendes, Edgar Aparecido Sanches, Pedro Henrique Campelo, Jaqueline de Araujo Bezerra
Summary: The consumption of edible flowers, such as Hibiscus acetosella Welw. Ex Hiern, is beneficial for human health due to their rich bioactive compounds, high antioxidant activity, and absence of cytotoxicity. These flowers are particularly valuable for their high content of organic acids and phenolic compounds, including myricetin, quercetin derivatives, kaempferol, and anthocyanins. Therefore, they have great potential as nutraceuticals in the healthy food industry.
Review
Biochemistry & Molecular Biology
Josemar Goncalves Oliveira Filho, Mariana Buranelo Egea
Summary: Edible packaging is a biodegradable and non-toxic alternative to traditional food packaging. The new generation of edible food packaging incorporates functional ingredients for consumer health benefits. Curcumin, a bioactive compound, is being studied for its potential use in edible packaging development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Oluwafemi Adeleke Ojo, Temiloluwa Rhoda Adeyemo, Damilare Rotimi, Gaber El-Saber Batiha, Gomaa Mostafa-Hedeab, Matthew Eboseremen Iyobhebhe, Tobiloba Christiana Elebiyo, Bukola Atunwa, Adebola Busola Ojo, Clara Mariana Goncalves Lima, Carlos Adam Conte-Junior
Summary: Colorectal cancer is a common and recurring disease, ranking as the second leading cause of death worldwide. Curcumin, a natural compound, has demonstrated significant anti-cancer properties against colorectal cancer, including inhibiting cell proliferation, stopping the cell cycle, and anti-angiogenesis. It plays a crucial role in the treatment and prevention of CRC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Luis Estrada-Gil, Juan C. Contreras-Esquivel, Carolina Flores-Gallegos, Alejandro Zugasti-Cruz, Mayela Govea-Salas, Marco A. Mata-Gomez, Raul Rodriguez-Herrera, Juan A. Ascacio-Valdes
Summary: Rambutan, a tropical fruit from Asia, is extensively produced in Mexico. The peel of Mexican rambutan, which makes up around 45% of the fruit's weight, is usually discarded as waste. However, this study showed that the hybrid technology extraction method yielded the highest polyphenolic content from Mexican rambutan peel. The chemical analysis revealed three major compounds, which exhibited excellent results in biological assays, demonstrating antioxidant and prebiotic activities.
Article
Multidisciplinary Sciences
Malgorzata Kubczak, Ainur B. Khassenova, Bartosz Skalski, Sylwia Michlewska, Marzena Wielanek, Maria Sklodowska, Araylim N. Aralbayeva, Zhanar S. Nabiyeva, Maira K. Murzakhmetova, Maria Zamaraeva, Maria Bryszewska, Maksim Ionov
Summary: Ethanol extracts from the leaves and twigs of Hippophae rhamnoides L. were found to be rich in bioactive compounds with potent antioxidant properties. These extracts showed low toxicity on human cells and may serve as an important source for the food, pharmaceutical and cosmetic industries.
SCIENTIFIC REPORTS
(2022)
Review
Nanoscience & Nanotechnology
Andrea M. Araya-Sibaja, Norma J. Salazar-Lopez, Krissia Wilhelm Romero, Jose R. Vega-Baudrit, J. Abraham Dominguez-Avila, Carlos A. Velazquez Contreras, Ramon E. Robles-Zepeda, Mirtha Navarro-Hoyos, Gustavo A. Gonzalez-Aguilar
Summary: Curcumin, as a safe phenolic compound for human consumption, has potential as an anticancer agent, but its low bioavailability and fast metabolism can be improved through nanosystems. Loading curcumin into nanosystems enhances its effects and can result in synergistic effects when co-administered with other molecules.
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2021)
Review
Food Science & Technology
Thamila Dib, Haibo Pan, Shiguo Chen
Summary: This review highlights the recent advances in pectin-based nanoencapsulation techniques for the enrichment of bioactive components. The entrapment and release properties of curcumin in pectin-based nanoparticles, as well as the improvement of carrier properties through the addition of natural polymers, are of particular interest.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Giulio Bresciani, Jan Vanco, Tiziana Funaioli, Stefano Zacchini, Tomas Malina, Guido Pampaloni, Zdenek Dvorak, Zdenek Travnicek, Fabio Marchetti
Summary: Diruthenacyclopentenone complexes were synthesized and characterized. The complexes exhibited stronger cytotoxicity than cisplatin against various cancer cell lines, with the 17α-estradiol derived complex showing the highest activity. Further studies revealed that some complexes affected the cell cycle, apoptosis, oxidative stress, and autophagy.
INORGANIC CHEMISTRY
(2023)
Review
Environmental Sciences
Muhammad Idrees Khan, Abdelhakim Bouyahya, Naoufal E. L. Hachlafi, Naoual El Menyiy, Muhammad Akram, Sabira Sultana, Gokhan Zengin, Lilya Ponomareva, Mohammad Ali Shariati, Oluwafemi Adeleke Ojo, Stefano Dall'Acqua, Tobiloba Christiana Elebiyo
Summary: This article introduces the role of medicinal plants and their bioactive compounds in the treatment of breast cancer. It is found that compounds in natural products have anti-cancer effects on breast cancer cells, and they work through various mechanisms, including inhibiting apoptotic pathways, blocking the cell cycle, and activating autophagy. In addition, they also exhibit anti-angiogenesis and anti-metastatic effects. However, the chemopreventive effects of different compounds on breast cancer vary.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Nutrition & Dietetics
Shu Chyi Wong, Muhamad Noor Alfarizal Kamarudin, Rakesh Naidu
Summary: Glioblastoma (GBM) is the most malignant brain tumor with limited treatment options. Curcumin, a phytochemical, shows promise as a potential anticancer agent by targeting multiple pathways in GBM cells.
Article
Pharmacology & Pharmacy
Ahmed Elfadadny, Rokaia F. Ragab, Rania Hamada, Soad K. Al Jaouni, Junjiang Fu, Shaker A. Mousa, Ali H. El-Far
Summary: Cancer is a major cause of death worldwide, and finding effective and safe treatments is crucial. Doxorubicin is a commonly used chemotherapy drug, but it has limitations such as cardiotoxicity and drug resistance. Research has shown that combining natural bioactive compounds with doxorubicin could enhance its effectiveness and reduce adverse effects.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kacper Szewczyk, Aleksandra Chojnacka, Magdalena Gornicka
Summary: Tocopherols and tocotrienols are natural compounds of plant origin, mainly sourced from vegetable oils and nuts. While alpha-tocopherol has the highest tissue concentration in the vitamin E family, current research suggests that tocotrienols may have greater antioxidant potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Natalia Zurek, Karolina Pycia, Agata Pawlowska, Leszek Potocki, Ireneusz Tomasz Kapusta
Summary: The aim of this study was to evaluate the biological potential of the polyphenolic fraction from J. regia leaves collected in Poland. The phenolic profile was determined and the antioxidant, anticancer, antibacterial, and antifungal effects were assessed. The preparation demonstrated high iron chelating ability and radical capturing ability. It showed the most significant effects on DLD-1, Caco-2, and MCF-7 cell lines in terms of anticancer activity, and had the highest susceptibility against K. pneumoniae, S. pyogenes, and S. aureus in terms of antibacterial activity. Depending on the needs, this preparation can be widely used in the design of functional food and/or cosmetics industry.
Review
Biochemistry & Molecular Biology
Francesca Cuomo, Silvio Iacovino, Pasquale Sacco, Antonella De Leonardis, Andrea Ceglie, Francesco Lopez
Summary: This review presents recent advances in the delivery of bioactive phenolic compounds mediated by colloid systems. The focus is on the progress made in this field in recent years. The structural and dynamic aspects of different colloid delivery systems, as well as the interactions with two bioactive constituents, are discussed. Two case studies are presented, one representing hydrophobic phenolic compounds and the other representing hydrophilic compounds.
Review
Biochemistry & Molecular Biology
Arshad Husain Rahmani, Ahmad Almatroudi, Khaled S. S. Allemailem, Wanian M. M. Alwanian, Basmah F. F. Alharbi, Faris Alrumaihi, Amjad Ali Khan, Saleh A. A. Almatroodi
Summary: Cancer is a global health concern, and current cancer treatments often cause adverse complications. Myricetin, a natural antioxidant found in medicinal plants, has shown potential in cancer prevention and management through its anti-inflammatory and hepato-protective properties. It also has the ability to modulate cell signaling molecules and enhance the effectiveness of other anticancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Education, Scientific Disciplines
Srinivasan Ramamurthy, Hui Meng Er, Vishna Devi Nadarajah, Ammu Kutty Radhakrishnan
Summary: This study found that medical students show a significant increase in orientation towards lifelong learning with academic progression, especially clinical students showing significant improvements in seeking information skills and attention to learning opportunities. Problem-based learning, flipped classroom, guided reading, projects, and experiential learning activities are perceived to be effective in promoting lifelong learning skills.
Review
Neurosciences
Win Ning Chen, Mohd Farooq Shaikh, Saatheeyavaane Bhuvanendran, Abhijit Date, Mohammad Tahir Ansari, Ammu Kutty Radhakrishnan, Iekhsan Othman
Summary: This systematic review summarizes the evidence of neuroprotective potential of Poloxamer 188 (P188) in CNS disorders. The search from relevant databases resulted in 11 articles that met the inclusion criteria. These articles described the protective effects of P188 in neurotoxicity, traumatic brain injury, and various diseases, demonstrating the potential of P188 as a neuroprotective agent.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Razali Mohamed Salleh, Garry Kuan, Mohd Noorazlan Ab Aziz, Mohamad Rahizam Abd Rahim, Tandiyo Rahayu, Sulaiman Sulaiman, Donny Wira Yudha Kusuma, A. M. G. C. P. Adikari, Muhammad Syafiq Mohd Razam, Ammu K. Radhakrishnan, Mahenderan Appukutty
Summary: The study found that daily probiotic consumption had significant positive effects on university badminton players, including reducing competitive anxiety and perceived stress levels, as well as improving aerobic capacity.
Article
Nutrition & Dietetics
Hemavathy Subramaiam, Wan-Loy Chu, Ammu Kutty Radhakrishnan, Srikumar Chakravarthi, Kanga Rani Selvaduray, Yih-Yih Kok
Summary: Nutritional supplements gamma-tocotrienol and Spirulina were evaluated for immune-enhancing and anticancer effects in a mouse model of breast cancer. While individual supplementation with each showed immune modulation effects, the combination did not demonstrate synergistic anticancer effects in this study model.
Article
Nutrition & Dietetics
Kasthuri Bai Magalingam, Sushela Devi Somanath, Shadab Md, Nagaraja Haleagrahara, Ju-Yen Fu, Kanga Rani Selvaduray, Ammu Kutty Radhakrishnan
Summary: This study demonstrates the neuroprotective effects of T3 and its analogues against oxidative damage in Parkinson's disease, with TRF showing significant protection of dopamine neurons. Gamma-T3 was most effective in attenuating apoptosis, while alpha-T3 showed the most efficient antioxidant effects.
NUTRITION RESEARCH
(2022)
Review
Nutrition & Dietetics
Ali Qusay Khalid, Saatheeyavaane Bhuvanendran, Kasthuri Bai Magalingam, Premdass Ramdas, Mangala Kumari, Ammu Kutty Radhakrishnan
Summary: The research in the past decade has shown that tocotrienols have potent anti-cancer properties, particularly in the field of oncology, and may have important therapeutic effects on various cancers such as colorectal cancer. Bioactive natural compounds like tocotrienols show promise in preventing tumor and cancer progression. Studies on tocotrienols and human CRC cells have focused on exploring their modulation of gene expression and encoded proteins, as well as their mechanisms in intervening cancer progression.
Article
Biochemistry & Molecular Biology
Kasthuri Bai Magalingam, Sushela Devi Somanath, Premdass Ramdas, Nagaraja Haleagrahara, Ammu Kutty Radhakrishnan
Summary: This study investigated the protein expression changes in SH-SY5Y cells induced by 6-OHDA and their role in Parkinson's disease. The results suggest that abnormal neuronal development and ribosome pathway may play important roles in the neurodegeneration of PD, while heat shock proteins and histone release are also involved in the pathogenesis of PD.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Rathimalar Ayakannu, Nor Azizan Abdullah, Vijaya Lechimi Raj, Ammu K. Radhakrishnan, Chong Kin Liam
Summary: This study explored the clinical characteristics, cytokine profile, and plasma IgE levels in Malaysian asthma patients. The results showed that asthmatics had higher levels of plasma IgE and cytokines compared to controls. However, there was no significant association between cytokine levels and asthma severity or clinical symptoms.
MOLECULAR IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Dina El-Rabie Osman, Brandon Wee Siang Phon, Muhamad Noor Alfarizal Kamarudin, Stephen Navendran Ponnampalam, Ammu Kutty Radhakrishnan, Saatheeyavaane Bhuvanendran
Summary: This paper systematically reviews and describes the roles of various biomarkers regulated by lipid-soluble vitamins in the pathophysiology of GBM. The results suggest that retinoids activate cell differentiation, vitamin D modulates cell cycle biomarkers, and vitamin E derivatives modulate apoptosis-related biomarkers.
Article
Nutrition & Dietetics
Kasthuri Bai Magalingam, Premdass Ramdas, Sushela Devi Somanath, Kanga Rani Selvaduray, Saatheeyavaane Bhuvanendran, Ammu Kutty Radhakrishnan
Summary: This study investigated the proteomic changes in human neural cells induced by TRF, a palm oil-derived vitamin E fraction, using a label-free LC-MS/MS approach. The results showed that TRF and levodopa, a drug used in Parkinson's disease treatment, regulated the expression of a number of proteins involved in crucial pathways such as ubiquitin-proteasome, calcium signaling, protein processing in the endoplasmic reticulum, mitochondrial pathway, and axonal transport system. Overall, TRF is an important functional food that affects protein expression in human neuronal cells.
Article
Biology
Brandon Wee Siang Phon, Saatheeyavaane Bhuvanendran, Qasim Ayub, Ammu Kutty Radhakrishnan, Muhamad Noor Alfarizal Kamarudin
Summary: This study investigated the suitability of 3D cultures as cell-based models for GBM by leveraging genomic data. Genes related to pathways such as epithelial-to-mesenchymal transition, angiogenesis/migration, hypoxia, stemness, and the Wnt signalling pathway were found to be upregulated in both brain samples from GBM patients and 3D GBM cells. These findings support the use of 3D GBM cultures as reliable preclinical models for studying GBM.
Review
Biology
Dexter Hoi Long Leung, Brandon Wee Siang Phon, Mageswary Sivalingam, Ammu Kutty Radhakrishnan, Muhamad Noor Alfarizal Kamarudin
Summary: In this scoping review, we identified a range of lncRNAs that play a regulatory role in GBM cells by modulating EMT markers, transcription factors, and the affiliated signalling pathways associated with MES transition. These findings provide an update on the complex interplays between lncRNAs, EMT markers, TFs, and signalling pathways in GBM cell studies.
Article
Biotechnology & Applied Microbiology
Jayasree S. Kanathasan, Uma Devi Palanisamy, Ammu K. Radhakrishnan, Srikumar Chakravarthi, Tan Boon Thong, Varghese Swamy
Summary: This study investigates the targeting potential of pSi NPs functionalized with two types of peptides and finds that the linear peptide-pSi NP conjugate has better stability and higher binding efficiency under tumor conditions. In vivo studies show a higher accumulation of linear peptide-conjugated pSi NPs in the tumor site. These results suggest that the linear peptide-pSi NP formulation is a potential drug-delivery platform and fluorescence bioimaging agent.
Article
Oncology
Sarmini Munisamy, Ammu Kutty Radhakrishnan, Premdass Ramdas, Priscilla Josephine Samuel, Vivek Ajit Singh
Summary: The study found that CD4(+) T-cells and certain cytokines levels were significantly reduced in sarcoma patients compared to healthy controls. Additionally, five genes were found to be dysregulated in sarcoma patients.
