Article
Plant Sciences
Dongpeng Wang, Jufeng Duan, Xiao-Jing Chen, Kaiqi Liu, Yingying Guo, Run Shi, Sha Li, Ming Liu, Lijun Zhao, Bei Li, Hongtao Liu, Minglun Li, Yibin Feng, Hongliang Li, Xuanbin Wang
Summary: This study compared the pharmacokinetic characteristics of emodin alone and emodin in Zhiheshouwu, and found that the other anthraquinones in Zhiheshouwu can change the pharmacokinetic characteristics of emodin and participate in its complex effects on liver cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shixiao Wang, Xiang Kong, Ning Chen, Pengwei Hu, Hamza Boucetta, Zhaoliang Hu, Xin Xu, Pei Zhang, Xiang Zhan, Ming Chang, Rui Cheng, Wei Wu, Min Song, Yuting Lu, Taijun Hang
Summary: A comparative sub-acute toxicity study in mice revealed that the hepatotoxicity of Polygoni Multiflori Radix (PM) in mice mainly came from the integrative contribution of TSG, EMG and emodin.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ya-Qin Yang, Fan-Ying Meng, Xin Liu, Mei Zhang, Wen Gu, Hong-Li Yan, Jie Yu, Xing-Xin Yang
Summary: This study elucidated the effects of Polygoni Multilori Radix Preparata (PMRP) in regulating mitochondria dysfunction and alleviating glucolipid metabolic disorders (GLMD) using mitochondrial metabonomics. The results showed that PMRP could improve liver mitochondrial function by regulating metabolic pathways, indicating its potential as a promising nutrient for alleviating GLMD-associated diseases.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wenhao Cheng, Siyang Wu, Zheng Yuan, Weiyu Hu, Xin Yu, Nianxin Kang, Qiutao Wang, Mingying Zhu, Kexin Xia, Wei Yang, Chen Kang, Shuofeng Zhang, Yingfei Li
Summary: Through a multicompound pharmacokinetic analysis, the tissue distribution and excretion characteristics of Radix Polygoni Multiflori (RPM) components were investigated. The findings showed that the active ingredients of RPM were quickly absorbed after oral administration and had high tissue distribution in the liver and kidney. These components were key contributors to the effectiveness and toxicity of RPM on the liver and kidney.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Reshmi Akter, Dong Uk Yang, Jong Chan Ahn, Muhammad Awais, Jinnatun Nahar, Zelika Mega Ramadhania, Jong Yun Kim, Gyong Jai Lee, Gi-Young Kwak, Dong Wook Lee, Byoung Man Kong, Deok Chun Yang, Seok-Kyu Jung
Summary: Postmenopausal women experience various symptoms due to estrogen deprivation, including inflammation and increased oxidative stress. The use of estrogen replacement therapy (ERT) is limited due to adverse effects and high costs, emphasizing the urgent need for affordable herbal-based treatments. This study investigated the estrogen-like properties of methanol extracts from Cynanchum wilfordii (CW) and Poligonum multiflorum (PM) and explored their mechanism of action through in vitro assays.
Article
Pharmacology & Pharmacy
Li Kang, Dan Li, Xin Jiang, Yao Zhang, Minhong Pan, Yixin Hu, Luqin Si, Yongjun Zhang, Jiangeng Huang
Summary: This study demonstrates for the first time that Polygoni Multiflori Radix (PMR) and its major anthraquinones have hepatotoxic effects in mice by altering bile acid homeostasis through the regulation of bile acid efflux transporters. These findings provide a theoretical basis for the quality control and safe use of PMR in clinical practice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Xiaoyang Wang, Shengying Lin, Roy Wai-Lun Tang, Hung Chun Lee, Ho-Hin Chan, Sheyne S. A. Choi, Ka Wing Leung, Sarah E. Webb, Andrew L. Miller, Karl Wah-Keung Tsim
Summary: In this study, a multi-component testing platform was used to identify potential therapeutic agents for COVID-19 among herbal extracts from traditional Chinese medicine. The water and ethanol extracts of Polygoni Multiflori Radix were found to effectively inhibit the binding and entry of SARS-CoV-2, with the water extract being more effective. The active component EGCG was identified in both extracts. These findings suggest that Polygoni Multiflori Radix may have potential as a treatment for COVID-19.
Article
Medicine, Research & Experimental
Yongjie Xu, Haizhi Li, Gang Chen, Liying Zhu, Hairong Lin, Changyudong Huang, Sijia Wei, Tingting Yang, Wen Qian, Xing Li, Shuyun Zhao, Wei Pan
Summary: This study found that Radix Polygoni Multiflori (RPM) can improve the cognitive function of diabetic rats by inhibiting the expression of HDAC4, suppressing the activation of the JNK pathway, and reducing neuronal apoptosis. Additionally, the inhibitory effects of RPM and Emodin on HAT and HDAC were identified for the first time in this study.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Guangfei Wei, Yichuan Liang, Guozhuang Zhang, Zhaoyu Zhang, Yongqing Zhang, Shilin Chen, Linlin Dong
Summary: This study investigated the presence of fungi on the surface of Polygonum multiflorum Thunb and found that it is easily contaminated by toxigenic fungi and mycotoxins, posing a health risk for consumers. The results also showed that sampling location and processing can influence the assembly and network complexity of the surface microbiome of Polygonum multiflorum Thunb.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2024)
Article
Engineering, Chemical
Ji-Hyun Kim, Ji Hyun Kim, Mei Tong He, Su Cheol Kim, Kyung Pan Hwa, Kye Man Cho, Eun Ju Cho
Summary: This study provides new evidence on the therapeutic effect of PPM and TSG during cognitive impairment in mice, showing significant improvement in memory loss and cognitive dysfunction through regulation of cholinergic function, brain-derived neurotrophic factor, and neural apoptosis. Further research is needed to support the clinical application of PPM and TSG for Alzheimer's disease prevention and treatment.
Article
Medicine, Research & Experimental
Guoqin Zhang, Jianhua Sun, Meiqi Liu, Zhixiang Tian, Zicheng Ma, Bingyu Hao, Jintang Ning, Xiaoliang Ren, Meng Wang, Ping Wang, Jiunian Li, Hailin Li, Jian Ni, Yi Liu
Summary: In this study, the mechanism of PM-induced idiosyncratic inflammatory liver injury was investigated in zebrafish and rat models. The results showed that toxic components of PM increased absorption and metabolism slowed down under inflammatory stress, leading to liver injury via the FXR-SHP axis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Xu Wang, Guode Zhao, Chengguo Ju, Lingwen Dong, Yuyang Liu, Zifang Ding, Weiwei Li, Ying Peng, Jiang Zheng
Summary: This study aimed to elucidate the mechanism underlying the reduced hepatotoxicity of Polygoni Multiflori Radix (PMR) after processing. It was found that processed PMR contained lower levels of emodin-8-O-beta-D-glucoside (EG). Processed PMR showed fewer adverse effects and less hepatic protein adduction compared to raw PMR. Effective hydrolysis of EG to emodin (EMD) occurred in the intestinal epithelial cells during absorption. Cytosolic broad-specificity beta-glucosidase, lactase phlorizin hydrolase, and intestinal flora participated in the hydrolysis of EG. Circulating EMD resulting from the deglycosylation of EG exerted hepatotoxic effects. The reduction of EG content due to processing is a key factor in the detoxification of PMR.
Article
Chemistry, Multidisciplinary
Xueting Wang, Jianbo Yang, Xianlong Cheng, Ying Wang, Huiyu Gao, Yunfei Song, Feng Wei, Shuangcheng Ma
Summary: In this study, compounds from PMR were extracted using three solvents of different polarities and analyzed by UHPLC-Q-ToF MS/MS. A total of 152 compounds were detected and identified, including anthraquinones, stilbene derivatives, flavonoids, naphthalene compounds, and other compounds. Eight compounds were reported for the first time in PMR-related literature, and eight compounds were potentially new compounds.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Yonghui Rui, Xiaohua Ou, Jiahui Li, Keke Luo, Wenjing Deng, Xiaoxia Gao, Mengling He, Hongyi Zhang, Hanjing Yan
Summary: This study conducted a comparative analysis of metabolites to understand the relationship between the geographical origin of Polygoni Multiflori Radix (PMR) samples and their medicinal properties. Metabolomic profiling was found to be an effective means of differentiating between PMR samples from different geographic regions within China. Catechins were identified as important markers of the geographic origin of PMR samples.
PHARMACOGNOSY MAGAZINE
(2022)
Article
Biochemistry & Molecular Biology
Fengye Wu, Yunlin Li, Wenya Liu, Ran Xiao, Benxing Yao, Mingzhe Gao, Di Xu, Junsong Wang
Summary: This study compared the similarities and differences between raw and processed Radix Polygoni Multiflori in the treatment of vascular dementia. The results showed that both forms effectively reduced cognitive impairment and histological alterations, and they achieved this by regulating metabolic pathways and reducing oxidative stress.