Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet

T Cells and Cancer: How Metabolism Shapes Immunity

(2016) Barbara Molon et al.   Frontiers in Immunology

Metabolic therapy: A new paradigm for managing malignant brain cancer

(2015) Thomas N. Seyfried et al.   CANCER LETTERS

Nutrient Competition: A New Axis of Tumor Immunosuppression

(2015) Madhusudhanan Sukumar et al.   CELL

Concepts of immunotherapy for glioma

(2015) Mira A. Patel et al.   JOURNAL OF NEURO-ONCOLOGY

Immunosuppressive mechanisms in glioblastoma: Fig. 1.

(2015) Edjah K. Nduom et al.   NEURO-ONCOLOGY

Fatty acid metabolism in the regulation of T cell function

(2015) Matthias Lochner et al.   TRENDS IN IMMUNOLOGY

Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model

(2015) D. A. Reardon et al.   Cancer Immunology Research

Immunotherapeutic Advancements for Glioblastoma

(2015) Leonel Ampie et al.   Frontiers in Oncology

The Ketogenic Diet Alters the Hypoxic Response and Affects Expression of Proteins Associated with Angiogenesis, Invasive Potential and Vascular Permeability in a Mouse Glioma Model

(2015) Eric C. Woolf et al.   PLoS One

NF-κB enhances hypoxia-driven T-cell immunosuppression via upregulation of adenosine A2A receptors

(2014) Laurie Bruzzese et al.   CELLULAR SIGNALLING

Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors

(2014) D. A. Wainwright et al.   CLINICAL CANCER RESEARCH

The ketogenic diet for the treatment of malignant glioma

(2014) Eric C. Woolf et al.   JOURNAL OF LIPID RESEARCH

Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma

(2014) Anna Sophie Berghoff et al.   NEURO-ONCOLOGY

Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages

(2013) O. Bloch et al.   CLINICAL CANCER RESEARCH

Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas

(2013) Jing Zeng et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell–mediated glioma rejection

(2013) Johannes vom Berg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic level

(2013) Justyna Kmiecik et al.   JOURNAL OF NEUROIMMUNOLOGY

Using the molecular classification of glioblastoma to inform personalized treatment

(2013) Adriana Olar et al.   JOURNAL OF PATHOLOGY

Standards of care for treatment of recurrent glioblastoma—are we there yet?

(2012) Michael Weller et al.   NEURO-ONCOLOGY

The Ketogenic Diet Is an Effective Adjuvant to Radiation Therapy for the Treatment of Malignant Glioma

(2012) Mohammed G. Abdelwahab et al.   PLoS One

Hypoxia Potentiates Glioma-Mediated Immunosuppression

(2011) Jun Wei et al.   PLoS One

Intracellular metabolic pathways control immune tolerance

(2011) Claudio Procaccini et al.   TRENDS IN IMMUNOLOGY

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Distinct effects of human glioblastoma immunoregulatory molecules programmed cell death ligand-1 (PDL-1) and indoleamine 2,3-dioxygenase (IDO) on tumour-specific T cell functions

(2010) Tony Avril et al.   JOURNAL OF NEUROIMMUNOLOGY

The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma

(2010) Phillip Stafford et al.   Nutrition & Metabolism

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial

(2008) Elizabeth G Neal et al.   LANCET NEUROLOGY