Article
Public, Environmental & Occupational Health
Andri Wilberg Orrason, Hans Garmo, Johan Styrke, Paul W. Dickman, Par Stattin
Summary: Net survival, measured in different frameworks, such as relative survival and cause-specific survival, was compared in men with prostate cancer. The study found biases in estimates of survival rates for different age groups and risk categories, emphasizing the importance of evaluating underlying assumptions for each method.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Oncology
Laure Tron, Mathieu Fauvernier, Anne-Marie Bouvier, Michel Robaszkiewicz, Veronique Bouvier, Melanie Cariou, Valerie Jooste, Olivier Dejardin, Laurent Remontet, Arnaud Alves, Florence Molinie, Guy Launoy
Summary: The study found a negative impact of the social environment on net survival of digestive cancers, especially for esophagus, stomach, bile ducts, colon, and rectum. The research offers new perspectives for addressing social inequalities in digestive cancer survival, highlighting the importance of understanding and targeting key follow-up periods to implementing actions.
Review
Oncology
Camila Macedo Lima Nagamine, Barbara Niegia Garcia de Goulart, Patricia Klarmann Ziegelmann
Summary: This scoping review examines the use and justifications of the Pohar Perme Estimator (PPE) in estimating net survival in oncology. The review finds that PPE is recognized as the gold standard for estimating net survival and is valued for its unbiased estimates and comparability among different populations. No limitations of using PPE are identified. The review concludes that PPE should be more widely used in oncology, especially for population-based studies with long follow-up time.
Article
Medicine, Research & Experimental
Yelda A. Leal, Javier Torres, Ricardo Gamboa, Alejandra Mantilla-Morales, Patricia Pina-Sanchez, Oscar Arrieta, Laura Bonifaz, Abelardo Meneses, Celida Duque, Marion Pineros
Summary: This article presents the first results of the Merida population-based cancer registry in Mexico over a four-year period. The main incident cancers were prostate and breast cancer, while cervical cancer had high incidence rates among women. Further exploration is needed for lymphomas and liver cancer data.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Oncology
Asa Akesson, Claudia Adok, Pernilla Dahm-Kahler
Summary: This study investigated the recurrences and survival of endometrioid endometrial cancer (EC) and found a low overall recurrence rate, with only a small portion of recurrences limited to the vaginal area, which had a better prognosis compared to other sites of recurrence. Age, FIGO stage, and adjuvant treatment were identified as independent prognostic factors for recurrence.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Marcela Guevara, Amaia Molinuevo, Diego Salmeron, Rafael Marcos-Gragera, Maria Carulla, Maria-Dolores Chirlaque, Marta Rodriguez Camblor, Araceli Aleman, Dolores Rojas, Ana Vizcaino Batlles, Matilde Chico, Rosario Jimenez Chillaron, Arantza Lopez de Munain, Visitacion de Castro, Maria-Jose Sanchez, Enrique Ramalle-Gomara, Paula Franch, Jaume Galceran, Eva Ardanaz
Summary: The study found that cancer survival rates among adult patients in Spain showed an increasing trend from 2002 to 2013, especially in patients under 75 years old, with higher survival rates in women than in men. Among middle-aged men, prostate cancer had the highest survival rate, and among women, thyroid cancer had the highest survival rate.
Article
Oncology
Diana R. Withrow, Brian D. Nicholson, Eva J. A. Morris, Melisa L. Wong, Sophie Pilleron
Summary: Cancer survival rates have improved since the 1990s, but there are differences in survival rates between age groups, particularly for older adults. This study aimed to quantify age-related differences in survival rates for 10 common cancer types by stage at diagnosis. The results showed that cancers with very high (>95%) or very low (<40%) 1-year survival rates tended to have smaller age-related differences in survival.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Sean McPhail, Ruth Swann, Shane A. Johnson, Matthew E. Barclay, Hazem Abd Elkader, Riaz Alvi, Andriana Barisic, Oliver Bucher, Gavin R. C. Clark, Nicola Creighton, Bolette Danckert, Cheryl A. Denny, David W. Donnelly, Jeff J. Dowden, Norah Finn, Colin R. Fox, Sharon Fung, Anna T. Gavin, Elba Gomez Navas, Steven Habbous, Jihee Han, Dyfed W. Huws, Christopher G. C. A. Jackson, Henry Jensen, Bethany Kaposhi, S. Eshwar Kumar, Alana L. Little, Shuang Lu, Carol A. McClure, Bjorn Moller, Grace Musto, Yngvar Nilssen, Nathalie Saint-Jacques, Sabuj Sarker, Luc te Marvelde, Rebecca S. Thomas, Robert J. S. Thomas, Catherine S. Thomson, Ryan R. Woods, Bin Zhang, Georgios Lyratzopoulos
Summary: This study analyzed data from 14 jurisdictions in six high-income countries and found significant variations in the rate of emergency cancer diagnoses across different regions and cancer types. Older age and advanced stage at diagnosis were consistently associated with an increased risk of emergency presentation. Furthermore, emergency presenters had a significantly higher risk of 12-month mortality compared to non-emergency presenters. The study also identified negative associations between the percentage of emergency presentations and one-year survival for certain types of cancer.
Article
Oncology
Saeed Nemati, Elnaz Saeedi, Fereshte Lotfi, Azin Nahvijou, Elham Mohebbi, Zahra Ravankhah, Abbas Rezaeianzadeh, Majid Yaghoobi-Ashrafi, Habbiballah Pirnejad, Arash Golpazir, Roya Dolatkhah, Saba Alvand, Seyed Vahid Ahmadi-Tabatabaei, Maria Cheraghi, Elisabete Weiderpass, Freddie Bray, Michel P. Coleman, Arash Etemadi, Ardeshir Khosravi, Farid Najafi, Mohammad Ali Mohagheghi, Gholamreza Roshandel, Reza Malekzadeh, Kazem Zendehdel
Summary: A national cancer survival study in Iran revealed that Iranian cancer patients have relatively low 5-year survival rates compared to high-income countries. Breast and prostate cancers had the highest survival rates, while pancreatic, lung, liver, stomach, and esophageal cancers had very low survival rates.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Ahmed Bedir, Sneha Mehrotra, Jessica Gnuechtel, Dirk Vordermark, Daniel Medenwald
Summary: The study demonstrated that advancements in diagnostic and treatment strategies have led to improved survival outcomes for patients with stage III non-small cell lung cancer. Combining radiotherapy and chemotherapy showed the most significant benefit in terms of survival. However, further research is needed to evaluate the impact of current immunotherapy integration on survival rates.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Anne-Marie Bouvier, Valerie Jooste, Maria Jose Sanchez-Perez, Maria Jose Bento, Jessica Rocha Rodrigues, Rafael Marcos-Gragera, Maria Carmen Carmona-Garcia, Miguel Angel Luque-Fernandez, Pamela Minicozzi, Veronique Bouvier, Kaire Innos, Milena Sant
Summary: A study comparing the management and prognosis of metastatic colorectal cancers in Europe found significant differences among countries, partly explained by heterogeneity in the application of European guidelines. Further population-based studies are needed to clarify these differences.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Oncology
Mariana Brandao, Diogo Martins-Branco, Claudia De Angelis, Peter Vuylsteke, Richard D. Gelber, Nancy Van Damme, Lien van Walle, Arlindo R. Ferreira, Matteo Lambertini, Francesca Poggio, Didier Verhoeven, Annelore Barbeaux, Francois P. Duhoux, Hans Wildiers, Carmela Caballero, Ahmad Awada, Martine Piccart-Gebhart, Kevin Punie, Evandro de Azambuja
Summary: Among patients with de novo metastatic breast cancer who received systemic treatment and survived for nine months or more, those who underwent surgery of the primary tumor within nine months of diagnosis had longer overall survival compared to those who did not.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Public, Environmental & Occupational Health
Andreas Stang, Richard Knowlton, Jan Rekowski, Susan T. Gershman, Sandro Galea
Summary: Cigarette smoking is causally linked with increased mortality in cancer patients, with higher smoking prevalence in those diagnosed with cancer. Smokers at the time of diagnosis had higher mortality rates than former smokers, suggesting the importance of smoking cessation programs in improving cancer outcomes.
ANNALS OF EPIDEMIOLOGY
(2021)
Article
Oncology
Walter Mazzucco, Francesco Vitale, Sergio Mazzola, Rosalba Amodio, Maurizio Zarcone, Davide Alba, Claudia Marotta, Rosanna Cusimano, Claudia Allemani
Summary: The study examined survival rates of HCC patients based on their level of access to care and age, finding that patients with easier access to care had higher 5-year survival rates during 2006-2015. The results suggest a correlation between access to care and improved survival outcomes for HCC patients.
Article
Oncology
Marieke Pape, Steven C. Kuijper, Pauline A. J. Vissers, Jelle P. Ruurda, Karen J. Neelis, Hanneke W. M. van Laarhoven, Rob H. A. Verhoeven
Summary: Conditional relative survival (CRS) estimates the 3-year relative survival for patients with esophageal or gastric cancer based on their survival after treatment. The study found that the probability of surviving an additional 3 years varied for different stages of cancer and treatment methods.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Mathematical & Computational Biology
Dimitra-Kleio Kipourou, Maja Pohar Perme, Bernard Rachet, Aurelien Belot
Summary: Net survival is a crucial measure in population-based cancer studies for population comparison purposes. However, alternative measures, such as crude probability of death and number of life years lost due to different causes, can provide additional insights into prognosis, treatment choice, and control strategy development. This study extended the pseudo-observation approach to model these measures in the absence of cause of death information. The approach performed well in estimating regression parameters and was demonstrated using cervical cancer data.
Article
Public, Environmental & Occupational Health
Manuela Quaresma, James R. Carpenter, Adrian Turculet, Bernard Rachet
Summary: The study found that geographical disparities in colon cancer survival in London disappeared once controlled for hospitals, with disparities appearing to be augmented between hospitals. Poorer survival in some hospitals was mostly associated with higher proportions of emergency diagnoses, while these hospitals' performance was generally as expected for non-emergency diagnoses.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Article
Multidisciplinary Sciences
Ananya Malhotra, Bernard Rachet, Audrey Bonaventure, Stephen P. Pereira, Laura M. Woods
Summary: This study made progress in early detection of high-risk pancreatic cancer patients using machine learning, predicting the likelihood of patients developing pancreatic cancer before diagnosis. By combining the algorithm with existing biomarker tests, more tumors could be diagnosed earlier, potentially increasing survival rates for patients.
Article
Health Care Sciences & Services
Luis Antunes, Denisa Mendonca, Maria Jose Bento, Edmund Njeru Njagi, Aurelien Belot, Bernard Rachet
Summary: Missing data is a common issue in epidemiological databases, and multiple imputation has become a popular method for addressing it. By extending a new approach to reduce incompatibility between imputation and substantive models, the study validated the effectiveness of the method through simulation studies.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2021)
Article
Oncology
Thi-Van-Trinh Tran, Camille Maringe, Sara Benitez Majano, Bernard Rachet, Marie-Christine Boutron-Ruault, Neige Journy
Summary: This study found that hypothyroidism was not associated with overall breast cancer risk, but risk decreased more than 10 years after diagnosis. There was no association with hyperthyroidism overall, but breast cancer risk was elevated among women with treated hyperthyroidism.
Article
Oncology
Aimilia Exarchakou, Dimitra-Kleio Kipourou, Aurelien Belot, Bernard Rachet
Summary: This study investigates the impact of socio-economic inequalities on cancer survival in England. The results show that more deprived patients, particularly young individuals with more lethal cancers, lose more life-years.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Sara Benitez Majano, Georgios Lyratzopoulos, Bernard Rachet, Niek J. de Wit, Cristina Renzi
Summary: Cancer patients with comorbidities, especially cardiovascular disease, are less likely to be promptly investigated for colorectal cancer and have a higher risk of emergency presentation. Comorbidity can be a risk factor for diagnostic delay and may help prioritize patients for prompt assessment.
BRITISH JOURNAL OF CANCER
(2022)
Article
Mathematical & Computational Biology
Matthew J. Smith, Mohammad A. Mansournia, Camille Maringe, Paul N. Zivich, Stephen R. Cole, Clemence Leyrat, Aurelien Belot, Bernard Rachet, Miguel A. Luque-Fernandez
Summary: The main purpose of medical studies is to estimate treatment effects, but sometimes randomization is not possible; observational studies are used in such cases. Challenges in observational studies include confounding, which is typically controlled by adjusting measured confounders; recent advances in causal inference have focused on addressing confounding. However, a lack of computational tutorials has caused some confusion for researchers using these methods.
STATISTICS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Matthew James Smith, Edmund Njeru Njagi, Aurelien Belot, Clemence Leyrat, Audrey Bonaventure, Sara Benitez Majano, Bernard Rachet, Miguel Angel Luque Fernandez
Summary: Overall, this study showed that multimorbidity, deprivation, and their combination are strong and independent predictors of an increased short-term mortality risk among patients with DLBCL and FL in England. Public health measures targeting the reduction of multimorbidity among the most deprived patients with DLBCL and FL are needed to reduce the short-term mortality gap.
Article
Oncology
Matthew James Smith, Aurelien Belot, Matteo Quartagno, Miguel Angel Luque Fernandez, Audrey Bonaventure, Susan Gachau, Sara Benitez Majano, Bernard Rachet, Edmund Njeru Njagi
Summary: Our study found that regardless of comorbidity status, patients with DLBCL or FL in the most deprived areas in England had a higher excess mortality hazard compared to the least deprived patients. This highlights the need for improvement in the National Health Service framework to enhance survival rates for DLBCL and FL patients in the most deprived areas of England.
Article
Oncology
S. F. Lee, B. A. Vellayappan, L. C. Wong, C. L. Chiang, S. K. Chan, E. Y-F Wan, I. C-K Wong, P. C. Lambert, B. Rachet, A. K. Ng, M. A. Luque-Fernandez
Summary: In an Asian population-based cohort, it was found that incident cardiovascular diseases (CVDs) can occur soon after treatment for diffuse large B-cell lymphoma (DLBCL) and continue to occur throughout survivorship. Age, hypertension, diabetes, and baseline use of aspirin were associated with an increased risk of incident CVD. In a subgroup of higher-risk patients, the time in the CVD state was relatively short, with other causes of death surpassing DLBCL-related death after about 5 years.
Article
Oncology
Marissa C. van Maaren, Bernard Rachet, Gabe S. Sonke, Audrey Mauguen, Virginie Rondeau, Sabine Siesling, Aurelien Belot
Summary: This study investigates the relationship between socioeconomic status (SES), recurrent events, and mortality in breast cancer patients under the age of 40. The results show that high SES is associated with lower recurrence risks and better prognosis after recurrence over a 10-year period, compared to low SES.
CANCER EPIDEMIOLOGY
(2022)
Article
Health Care Sciences & Services
Elizabeth Beaulieu, Anne Spanjaart, Ashley Roes, Bernard Rachet, Stephane Dalle, Marie Jose Kersten, Delphine Maucort-Boulch, Mohammad S. Jalali
Summary: Purpose System science provides tools for understanding the complexity of factors affecting quality of life. Cancer immunotherapy patients' health-related quality of life is influenced by various factors, and a systems-level model can aid in understanding this complexity. In this study, a causal loop diagram (CLD) was developed for cancer immunotherapy patients' quality of life, providing visualization of how changes in the system can impact their quality of life. This study highlights the value of a systems perspective in quality-of-life research.
QUALITY OF LIFE RESEARCH
(2022)
Article
Oncology
Kueshivi Midodji Atsou, Bernard Rachet, Edouard Cornet, Marie-Lorraine Chretien, Cedric Rossi, Laurent Remontet, Laurent Roche, Roch Giorgi, Sophie Gauthier, Stephanie Girard, Johann Bockle, Stephane Kroudia Wasse, Helene Rachou, Laila Bouzid, Jean-Marc Poncet, Sebastien Orazio, Alain Monnereau, Xavier Troussard, Morgane Mounier, Marc Maynadie
Summary: This study examines the care pathways of acute myeloblastic leukemia patients in France and found that different pathways could lead to unequal access to treatment, resulting in excess mortality. Referral from a general practitioner to a specialized hematology unit is the most common care pathway. Age, medical condition, diagnostic evaluations, and the type of hospital also influence whether patients can receive treatment at a specialized hematology unit.
Article
Oncology
Laure Tron, Laurent Remontet, Mathieu Fauvernier, Bernard Rachet, Aurelien Belot, Ludivine Launay, Ophelie Merville, Florence Molinie, Olivier Dejardin, Guy Launoy
Summary: The study found that the social gradient in cancer net survival could be partially explained by socially-determined co-morbidities, and using simulated deprivation-specific life tables reduced the social gradient. However, the lack of deprivation-specific life tables in the original data overestimated the social gradient in cancer net survival, leading to potential inaccuracies in conclusions. This highlights the importance of creating proper deprivation-specific life tables for accurate analysis of social inequalities in cancer net survival.
