Article
Food Science & Technology
Priyanka Priyanka, Prem Raj Meena, Dharma Raj, Anuj Rana, Akshay Dhanokar, K. Siddaardha Duggirala, Arvind Pratap Singh
Summary: This study systematically examined various plant-origin foods for the presence of Extraintestinal pathogenic Escherichia coli (ExPEC) and specific putative ExPEC pathotypes. The findings revealed the presence of ExPEC isolates and specific putative ExPEC pathotypes such as Uropa-thogenic E. coli and Septicemia-associated E. coli. The study also highlighted the presence of multidrug resistance in these ExPEC pathotypes, posing a potential threat to human health and food safety.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2023)
Article
Infectious Diseases
Guadalupe Miranda-Novales, Karen Flores-Moreno, Yolanda Lopez-Vidal, Samuel Ponce de Leon-Rosales
Summary: This study evaluated the antimicrobial susceptibility patterns of Escherichia coli and Klebsiella pneumoniae, and found that multidrug-resistant bacteria represented 61% of all isolates.
Article
Immunology
Thijs ten Doesschate, Sander Kuiper, Cees van Nieuwkoop, Robert-Jan Hassing, Tom Ketels, Suzan P. van Mens, Wouter van den Bijllaardt, Akke K. van der Bij, Suzanne E. Geerlings, Ad Koster, Evert L. Koldewijn, Judith Branger, Andy I. M. Hoepelman, Cornelis H. van Werkhoven, Marc J. M. Bonten
Summary: Fosfomycin is noninferior to ciprofloxacin as oral step-down treatment for febrile urinary tract infections (fUTIs) caused by E. coli in women, but its use is associated with more gastrointestinal events.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Microbiology
Victoria Ballen, Yaiza Gabasa, Carlos Ratia, Melany Sanchez, Sara Soto
Summary: This study characterized 376 extraintestinal pathogenic E. coli strains collected from hospitals in Catalonia, Spain, between 2016 and 2017. The strains showed high resistance to several antibiotics and varied biofilm formation ability. Various virulence and antimicrobial resistance genes were detected, including the colibactin-encoding genes associated with colorectal cancer. The study also investigated the relationship between colibactin and biofilm formation.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria Maisto, Fortuna Iannuzzo, Ettore Novellino, Elisabetta Schiano, Vincenzo Piccolo, Gian Carlo Tenore
Summary: Urinary tract infections (UTIs) are a common bacterial infection, especially in women. The main etiological agents are E. coli, Pseudomonas aeruginosa, and Proteus mirabilis. Due to the increase in antimicrobial resistance, there is a need for natural alternatives for UTI treatment. This review summarizes the potential therapeutic effects of natural polyphenol-based nutraceuticals and foods through in vitro and in vivo studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Kazuma Sakaeda, Takuya Sadahira, Yuki Maruyama, Takehiro Iwata, Masami Watanabe, Koichiro Wada, Motoo Araki
Summary: We conducted a molecular biological analysis of ESBL-producing E. coli strains and their sensitivity to FMOX. Most of the strains belonged to the ST-131 sequence type and had CTX-M genotypes. The isolated strains were sensitive to FMOX in drug susceptibility tests. FMOX showed efficacy for perioperative prophylactic administration in urologic surgery and for therapeutic administration for urinary tract infections.
Article
Public, Environmental & Occupational Health
Erastus H. Haindongo, Binta Funtua, Boni Singu, Marius Hedimbi, Francis Kalemeera, Jana Hamman, Olli Vainio, Antti J. Hakanen, Jaana Vuopio
Summary: This study aimed to describe the national antimicrobial resistance situation of major bacterial uropathogens in females within the 14 Namibian regions. High resistance to ampicillin, quinolones, and sulfamethoxazole-trimethoprim among E. coli was reported, with concerning rates of resistance to third-generation cephalosporins at 22%.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Review
Infectious Diseases
Iain J. Abbott, Trisha N. Peel, Kelly A. Cairns, Andrew J. Stewardson
Summary: This article highlights the key clinical decisions involved in the diagnosis and treatment of urinary tract infections (UTIs) in adult women, emphasizing the importance of clinical effectiveness and antimicrobial stewardship in the post-antimicrobial era. The article discusses the diagnosis and treatment of UTIs, as well as emerging areas of research in this field.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Microbiology
Valerio M. Sora, Gabriele Meroni, Piera A. Martino, Alessio Soggiu, Luigi Bonizzi, Alfonso Zecconi
Summary: The One Health approach highlights the importance of antimicrobial resistance in both public health and food animal production, with specific focus on the ExPEC strains of E. coli which may transfer resistance genes to other pathogenic bacteria, posing a serious threat to public health globally.
Article
Multidisciplinary Sciences
Yu-Hsin Tang, Po-Liang Lu, Ho-Yin Huang, Ying-Chi Lin
Summary: The study found that in hospitalized diabetic patients with UTIs, beta-lactams were more effective than fluoroquinolones, especially when the resistance rate to fluoroquinolones was higher.
Article
Microbiology
Jullia A. S. Nascimento, Fernanda F. Santos, Jose F. Santos-Neto, Liana O. Trovao, Tiago B. Valiatti, Isabel C. Pinaffi, Monica A. M. Vieira, Rosa M. Silva, Ivan N. Falsetti, Ana C. M. Santos, Tania A. T. Gomes
Summary: This study evaluated E. coli isolates from 172 outpatient with UTI and found that phylogroup B2 strains were predominant, along with the presence of various virulence factors associated with diarrheagenic and extraintestinal pathogenic E. coli. Some strains showed uropathogenic potential, including a few classified as hybrid strains. These hybrid strains interacted with renal and bladder cells, highlighting their uropathogenic capabilities.
Review
Biochemistry & Molecular Biology
Yang Zhou, Zuying Zhou, Lin Zheng, Zipeng Gong, Yueting Li, Yang Jin, Yong Huang, Mingyan Chi
Summary: Urinary tract infections (UTIs) are common bacterial infections caused by various pathogens, with uropathogenic Escherichia coli (UPEC) being the most prevalent causative agent. UPEC has shown adaptive evolution in invading the urinary tract and surviving inside cells. Despite the success of antibiotic therapy, the increasing antimicrobial resistance and high recurrence rates pose challenges to its efficacy. Thus, there is a need to explore alternative treatment options, such as vaccines and medicinal plants, that target multiple pathogenic mechanisms of UPEC to combat antibiotic resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Isabella F. S. Figueiredo, Lorena G. Araujo, Raissa G. Assuncao, Itaynara L. Dutra, Johnny R. Nascimento, Fabricia S. Rego, Carolina S. Rolim, Leylane S. R. Alves, Mariana A. Frazao, Samilly F. Cadete, Luis Claudio N. da Silva, Joicy C. de Sa, Eduardo M. de Sousa, Waldir P. Elias, Flavia R. F. Nascimento, Afonso G. Abreu
Summary: The study showed that cinnamaldehyde has potential in treating sepsis by reducing inflammation, increasing cell production in bone marrow and spleen, and improving survival rates in animals.
Article
Infectious Diseases
Qinghai Wang, Kai Zhao, Chen Guo, Hong Li, Tao Huang, Jianlei Ji, Xiaoxia Sun, Yanwei Cao, Zhen Dong, Hongyang Wang
Summary: This study investigated the antibiotic resistance and virulence genes of Escherichia coli strains in UTI patients after kidney transplantation from deceased donors. The findings showed that E. coli strains exhibited resistance to multiple antibiotics and carried numerous virulence genes, with hospital-acquired strains showing higher resistance compared to community-acquired strains.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Microbiology
Cheng-Yen Kao, Yen-Zheng Zhang, Deng-Chi Yang, Pek Kee Chen, Ching-Hao Teng, Wei-Hung Lin, Ming-Cheng Wang
Summary: This study investigated the characteristics of host and bacteria in recurrent urinary tract infections (RUTI) caused by genetically identical or different Escherichia coli strains. The results showed that E. coli strains in RUTI were more virulent and important for the development of RUTI in patients who were younger, without anatomical/functional defects or immune dysfunction. Prior antibiotic therapy, especially fluoroquinolones, could induce subsequent antimicrobial resistance in genetically highly-related E. coli RUTI.
Article
Multidisciplinary Sciences
Irene Anna Lambraki, Melanie Cousins, Tiscar Graells, Anais Leger, Patrik Henriksson, Stephan Harbarth, Max Troell, Didier Wernli, Peter Sogaard Jorgensen, Andrew P. Desbois, Carolee A. Carson, Elizabeth Jane Parmley, Shannon Elizabeth Majowicz
Summary: This study identified the factors influencing antimicrobial resistance (AMR) in the European food system and places for intervention through two workshops. The findings highlight the complexity of the AMR problem and the challenge in finding long-term solutions. The study also identifies relevant leverage points in the system for intervention.
Article
Biodiversity Conservation
Diana Sinclair, Craig Stephen, E. Jane Parmley, Andria Jones-Bitton, Zvonimir Poljak, Claire M. Jardine
Summary: This study aims to investigate and compare how wildlife health data and information are shared in the conservation and animal health fields in Ontario, Canada. The results demonstrate that there is more sharing of data and information between people from different institutions, highlighting opportunities for improved networking between wildlife conservation and health practitioners in Ontario.
HUMAN DIMENSIONS OF WILDLIFE
(2023)
Article
Public, Environmental & Occupational Health
H. M. O'Grady, R. Harrison, K. Snedeker, L. Trufen, P. Yue, L. Ward, A. Fifen, P. Jamieson, A. Weiss, J. Coulthard, T. Lynch, M. A. Croken, V. Li, K. Pabbaraju, A. Wong, H. Y. Zhou, T. C. Dingle, K. Hellmer, B. M. Berenger, K. Fonseca, Y-C. Lin, D. Evans, J. M. Conly
Summary: An epidemiological investigation was conducted on a Delta variant COVID-19 outbreak in two wards, revealing factors such as hand transmission, suboptimal PPE compliance, and multi-bedded rooms as significant risk factors for nosocomial infection. The outbreak was resolved rapidly within 3 weeks through basic measures and temporary restrictions on patient and staff movement.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Microbiology
Irene Anna Lambraki, Mohan Vishnumurthy Chadag, Melanie Cousins, Tiscar Graells, Anais Leger, Patrik John Gustav Henriksson, Max Fredrik Troell, Stephan Harbarth, Didier Wernli, Peter Sogaard Jorgensen, Carolee Anne Carson, Elizabeth Jane Parmley, Shannon E. E. Majowicz
Summary: By integrating the perspectives of experts from the region, this study identified factors influencing antimicrobial resistance (AMR) in the food system of Southeast Asia and pinpointed potential places for intervention. The causal loop diagram constructed based on the experts' insights illustrated the complexity of AMR in the region and highlighted the need for comprehensive, multi-pronged interventions across multiple sectors.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Samira Mubareka, John Amuasi, Arinjay Banerjee, Helene Carabin, Joe Copper Jack, Claire Jardine, Bogdan Jaroszewicz, Greg Keefe, Jonathon Kotwa, Susan Kutz, Deborah McGregor, Anne Mease, Lily Nicholson, Katarzyna Nowak, Brad Pickering, Maureen G. Reed, Johanne Saint-Charles, Katarzyna Simonienko, Trevor Smith, J. Scott Weese, E. Jane Parmley
Summary: Given the global impact of COVID-19 pandemic, outbreaks of avian influenza, and other zoonotic pathogen activity, there is an urgent need for a deeper understanding of the human-animal-environment interface and factors influencing the emergence, spread, and impact of zoonotic diseases. We propose a One Health approach and Action Plan for Canada, focusing on strategy and governance, technical leadership, equity, education, and research. A paradigm shift is needed to restore balance with the natural world and recognize the intrinsic value of all living species for the health of all.
Article
Public, Environmental & Occupational Health
Courtney A. A. Primeau, Jennifer E. E. McWhirter, Carolee Carson, Scott A. A. McEwen, E. Jane Parmley
Summary: The study aimed to explore the perceptions and understanding of medical and veterinary students regarding antimicrobial resistance (AMR) and to identify effective communication materials for these groups. The findings showed that students recognized the importance of AMR and identified antimicrobial use as a key driver. They also emphasized the need for tailored communication materials based on the target audience's needs.
Article
Infectious Diseases
Ashley N. Williams, Matthew A. Croxen, Walter H. B. Demczuk, Irene Martin, Gregory J. Tyrrell
Summary: Genomic analysis was used to characterize fourteen adult invasive serotype VIII isolates from 2009 to 2021 in Alberta. The study found an emerging trend of invasive GBS serotype VIII, mainly caused by ST42, and identified the susceptibility and resistance patterns of these isolates. The presence of potential vaccine targets in the isolate genomes highlights the importance of continued surveillance and characterization for outbreak prevention, vaccine development, and understanding the global epidemiology of this rare serotype.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Veterinary Sciences
Meagan King, Jolene Giacinti, Sara Dubois, Stephane Lair, E. Jane Parmley, Claire M. Jardine
Summary: The health and welfare of wild animals are becoming increasingly important, but there is limited large-scale data on the causes of wildlife morbidity and mortality across time, space, and taxa. This study analyzed data from the Canadian Wildlife Health Cooperative (CWHC) and wildlife rehabilitation centers (WRCs) to identify the main causes of morbidity and mortality for Canadian wildlife and assess the usefulness of these data sources in understanding wildlife health.
JOURNAL OF WILDLIFE DISEASES
(2023)
Review
Veterinary Sciences
S. D. Pearce, E. J. Parmley, C. B. Winder, J. M. Sargeant, M. Prashad, M. Ringelberg, M. Felker, D. F. Kelton
Summary: A review and meta-analysis were conducted to evaluate the efficacy of internal teat sealants (ITS) in preventing new infections and mastitis in dairy cattle. The results showed that ITS significantly reduced the incidence of new infections and mastitis. Sufficient evidence currently exists to support the practical use of ITS, and further research should focus on improving its application.
PREVENTIVE VETERINARY MEDICINE
(2023)
Review
Medicine, General & Internal
Kamal Raj Acharya, Jhoana P. Romero-Leiton, Elizabeth Jane Parmley, Bouchra Nasri
Summary: Antimicrobial resistance is a complex problem that requires collaboration among different disciplines in animal, human, and environment sectors. Mathematical and statistical models have been used to understand the development, emergence, dissemination, prediction, and forecasting of antimicrobial resistance. This study aims to identify and synthesize knowledge on mathematical and statistical models of antimicrobial resistance among bacteria in animals, humans, and the environment.
Article
Public, Environmental & Occupational Health
Jenine Leal, Heidi M. M. O'Grady, Logan Armstrong, Devika Dixit, Zoha Khawaja, Kate Snedeker, Jennifer Ellison, Joyce Erebor, Peter Jamieson, Amanda Weiss, Daniel Salcedo, Kimberley Roberts, Karen Wiens, Matthew A. A. Croxen, Byron M. M. Berenger, Kanti Pabbaraju, Yi-Chan Lin, David Evans, John M. M. Conly
Summary: This study investigated a nosocomial outbreak of COVID-19 in three cardiac wards of a tertiary teaching hospital in Calgary, Canada. The results showed that exposure in a multi-bedded room was the strongest independent risk factor for nosocomial COVID-19 transmission.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Review
Clinical Neurology
Andrea E. Portt, Christa Orchard, Hong Chen, Erjia Ge, Christine Lay, Peter M. Smith
Summary: This study systematically reviewed the association between air pollution and migraine. The findings showed a positive correlation between carbon monoxide, nitrogen dioxide, ozone, and particulate matter with migraine risk.
Article
Environmental Sciences
Didier Wernli, Peter Sogaard Jorgensen, E. Jane Parmley, Shannon E. Majowicz, Irene Lambraki, Carolee A. Carson, Melanie Cousins, Tiscar Graells, Patrik J. G. Henriksson, Anais Leger, Stephan Harbarth, Max Troell
Summary: Social-ecological resilience is crucial in understanding and addressing the challenges posed by antimicrobial resistance. It provides a framework to comprehend the impacts, diversity of strategies, and conditions of intervention success or failure. Resilience thinking is essential for human societies to cope, adapt, and transform in the face of growing global antimicrobial resistance.
LANCET PLANETARY HEALTH
(2023)
Article
Environmental Sciences
Jena Webb, Sergio Raez-Villanueva, Paul Carriere, Audrey -Anne Beauchamp, Isaac Bell, Angela Day, Sarah Elton, Mathieu Feagan, Jolene Giacinti, Jean Paul Kabemba Lukusa, Celia Kingsbury, Paola A. Torres-Slimming, Martin Bunch, Katie Clow, Maya K. Gislason, Margot W. Parkes, E. Jane Parmley, Blake Poland, Cathy Vaillancourt
Summary: This paper presents the work and insights from the Canadian Community of Practice in Ecosystem Approaches to Health (CoPEH-Canada) and 15 years of land-based, transdisciplinary, learner-centered, transformative learning and training. The learning approaches have included cognitive, psychomotor, and affective learning, which are essential for enacting structural changes and reestablishing healthier relationships with nature and each other. The development of teaching techniques and resources, integration of different approaches and ways of knowing, and the creation of a networked Community of Practice highlight the importance of ecohealth teaching and learning in informing planetary health education approaches.
LANCET PLANETARY HEALTH
(2023)
Article
Medicine, General & Internal
Leyla Asadi, Matthew Croxen, Courtney Heffernan, Mannat Dhillon, Catherine Paulsen, Mary Lou Egedahl, Greg Tyrrell, Alexander Doroshenko, Richard Long
Summary: This study used a comprehensive dataset and new high-resolution techniques to accurately estimate the true transmission risk of smear-negative tuberculosis cases, finding that their infectiousness is approximately 50% lower than previously thought.