The Future of PSMA-Targeted Radionuclide Therapy: An Overview of Recent Preclinical Research
出版年份 2019 全文链接
标题
The Future of PSMA-Targeted Radionuclide Therapy: An Overview of Recent Preclinical Research
作者
关键词
-
出版物
Pharmaceutics
Volume 11, Issue 11, Pages 560
出版商
MDPI AG
发表日期
2019-10-31
DOI
10.3390/pharmaceutics11110560
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cancer statistics, 2019
- (2019) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Development and dosimetry of 203Pb/212Pb-labelled PSMA ligands: bringing “the lead” into PSMA-targeted alpha therapy?
- (2019) José Carlos dos Santos et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- PSMA expression in the Hi-Myc model; extended utility of a representative model of prostate adenocarcinoma for biological insight and as a drug discovery tool
- (2019) Brian W. Simons et al. PROSTATE
- Targeted Radionuclide Therapy: New Advances for Improvement of Patient Management and Response
- (2019) Javian Malcolm et al. Cancers
- Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progression
- (2019) Fu-Ju Chou et al. EBioMedicine
- Dosimetry of 177Lu-PSMA-617 after Mannitol Infusion and Glutamate Tablet Administration: Preliminary Results of EUDRACT/RSO 2016-002732-32 IRST Protocol
- (2019) Anna Sarnelli et al. MOLECULES
- Preclinical evaluation and pilot clinical study of Al18F-PSMA-BCH for prostate cancer imaging
- (2019) Teli Liu et al. JOURNAL OF NUCLEAR MEDICINE
- First clinico-pathological evidence of a non PSMA-related uptake mechanism for 68Ga-PSMA-11 in salivary glands.
- (2019) Niels J. Rupp et al. JOURNAL OF NUCLEAR MEDICINE
- Recent Advances in Prostate-Specific Membrane Antigen-Based Radiopharmaceuticals
- (2019) Wei Diao et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Terbium-161 for PSMA-targeted radionuclide therapy of prostate cancer
- (2019) Cristina Müller et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- PSMA-Targeted Radiopharmaceuticals for Imaging and Therapy
- (2019) Hans-Jürgen Wester et al. SEMINARS IN NUCLEAR MEDICINE
- Preclinical evaluation of 203/212Pb-labeled low-molecular-weight compounds for targeted radiopharmaceutical therapy of prostate cancer
- (2019) Sangeeta Ray Banerjee et al. JOURNAL OF NUCLEAR MEDICINE
- Radiosensitization by enzalutamide for human prostate cancer is mediated through the DNA damage repair pathway
- (2019) Konjeti R. Sekhar et al. PLoS One
- Enhancing PSMA-uptake with androgen deprivation therapy – a new way to detect prostate cancer metastases?
- (2019) Conrad Leitsmann et al. International Braz J Urol
- Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer
- (2019) Ayman Abouzayed et al. Pharmaceutics
- Tumor Uptake of Triazine Dendrimers Decorated with Four, Sixteen, and Sixty-Four PSMA-Targeted Ligands: Passive versus Active Tumor Targeting
- (2019) Jongdoo Lim et al. Biomolecules
- Radioligand Therapy of Prostate Cancer with a Long-Lasting Prostate-Specific Membrane Antigen Targeting Agent 90Y-DOTA-EB-MCG
- (2018) Zhantong Wang et al. BIOCONJUGATE CHEMISTRY
- Theranostics of prostate cancer: from molecular imaging to precision molecular radiotherapy targeting the prostate specific membrane antigen
- (2018) Harshad R Kulkarni et al. BRITISH JOURNAL OF RADIOLOGY
- Trifunctional PSMA-targeting constructs for prostate cancer with unprecedented localization to LNCaP tumors
- (2018) James Kelly et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Targeting PSMA by radioligands in non-prostate disease—current status and future perspectives
- (2018) Philipp Backhaus et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Salivary gland toxicity of PSMA Radioligand Therapy: relevance and preventive strategies
- (2018) Thomas Langbein et al. JOURNAL OF NUCLEAR MEDICINE
- Targeted α-Therapy of Metastatic Castration-Resistant Prostate Cancer with225Ac-PSMA-617: Swimmer-Plot Analysis Suggests Efficacy Regarding Duration of Tumor Control
- (2018) Clemens Kratochwil et al. JOURNAL OF NUCLEAR MEDICINE
- [ 177 Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study
- (2018) Michael S Hofman et al. LANCET ONCOLOGY
- Targeting prostate cancer: Prostate-specific membrane antigen based diagnosis and therapy
- (2018) Till Wüstemann et al. MEDICINAL RESEARCH REVIEWS
- Albumin-Binding PSMA Ligands: Optimization of the Tissue Distribution Profile
- (2018) Martina Benešová et al. MOLECULAR PHARMACEUTICS
- Molar Activity of Ga-68 Labeled PSMA Inhibitor Conjugates Determines PET Imaging Results
- (2018) Alexander Wurzer et al. MOLECULAR PHARMACEUTICS
- Preclinical Development of Novel PSMA-Targeting Radioligands: Modulation of Albumin-Binding Properties To Improve Prostate Cancer Therapy
- (2018) Christoph A. Umbricht et al. MOLECULAR PHARMACEUTICS
- Effects of Linker Modification on Tumor-to-Kidney Contrast of 68Ga-Labeled PSMA-Targeted Imaging Probes
- (2018) Hsiou-Ting Kuo et al. MOLECULAR PHARMACEUTICS
- Prostate-specific membrane antigen for prostate cancer theranostics
- (2018) Frédéric Arsenault et al. Current Opinion in Supportive and Palliative Care
- Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018
- (2018) J. Ferlay et al. EUROPEAN JOURNAL OF CANCER
- Initial clinical experience performing sialendoscopy for salivary gland protection in patients undergoing 225Ac-PSMA-617 RLT
- (2018) Hendrik Rathke et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- 225Ac-PSMA-617 in chemotherapy-naive patients with advanced prostate cancer: a pilot study
- (2018) Mike Sathekge et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Monosodium glutamate reduces68Ga-PSMA-11 uptake in salivary glands and kidneys in preclinical prostate cancer model
- (2018) Etienne Rousseau et al. JOURNAL OF NUCLEAR MEDICINE
- Enhancing treatment efficacy of 177Lu-PSMA-617 with the conjugation of an albumin-binding motif: preclinical dosimetry and endoradiotherapy studies
- (2018) Hsiou-Ting Kuo et al. MOLECULAR PHARMACEUTICS
- A Single Dose of 225Ac-RPS-074 Induces a Complete Tumor Response in a LNCaP Xenograft Model
- (2018) James M. Kelly et al. JOURNAL OF NUCLEAR MEDICINE
- Albumin-Binding PSMA Ligands: Implications for Expanding the Therapeutic Window
- (2018) James M. Kelly et al. JOURNAL OF NUCLEAR MEDICINE
- Synthesis and preclinical evaluation of the 177Lu-DOTA-PSMA(inhibitor)-Lys3-bombesin heterodimer designed as a radiotheranostic probe for prostate cancer
- (2018) Alondra Escudero-Castellanos et al. NUCLEAR MEDICINE COMMUNICATIONS
- Preclinical evaluation of PSMA expression in response to androgen receptor blockade for theranostics in prostate cancer
- (2018) Katharina Lückerath et al. EJNMMI Research
- New Prostate Cancer Targets for Diagnosis, Imaging, and Therapy: Focus on Prostate-Specific Membrane Antigen
- (2018) Alessia Cimadamore et al. Frontiers in Oncology
- Reduction of 68Ga-PSMA renal uptake with mannitol infusion: preliminary results
- (2017) Federica Matteucci et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Repeated PSMA-targeting radioligand therapy of metastatic prostate cancer with 131I-MIP-1095
- (2017) Ali Afshar-Oromieh et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Current status of theranostics in prostate cancer
- (2017) Irene Virgolini et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent
- (2017) Nicolas Mottet et al. EUROPEAN UROLOGY
- Targeted α Therapies for the Treatment of Bone Metastases
- (2017) Fable Zustovich et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Will GRPR Compete with PSMA as a Target in Prostate Cancer?
- (2017) Andrei Iagaru JOURNAL OF NUCLEAR MEDICINE
- Prostate-Specific Membrane Antigen Ligands for Imaging and Therapy
- (2017) Matthias Eiber et al. JOURNAL OF NUCLEAR MEDICINE
- Dual-Target Binding Ligands with Modulated Pharmacokinetics for Endoradiotherapy of Prostate Cancer
- (2017) James M. Kelly et al. JOURNAL OF NUCLEAR MEDICINE
- Targeted α-Therapy of Metastatic Castration-Resistant Prostate Cancer with225Ac-PSMA-617: Dosimetry Estimate and Empiric Dose Finding
- (2017) Clemens Kratochwil et al. JOURNAL OF NUCLEAR MEDICINE
- Glu-Ureido–Based Inhibitors of Prostate-Specific Membrane Antigen: Lessons Learned During the Development of a Novel Class of Low-Molecular-Weight Theranostic Radiotracers
- (2017) Klaus Kopka et al. JOURNAL OF NUCLEAR MEDICINE
- Targeted radionuclide therapy in combined-modality regimens
- (2017) Martin R Gill et al. LANCET ONCOLOGY
- 99m Tc-MIP-1404-SPECT/CT for the detection of PSMA-positive lesions in 225 patients with biochemical recurrence of prostate cancer
- (2017) Christian Schmidkonz et al. PROSTATE
- Should Low Molecular Weight PSMA Targeted Ligands Get Bigger and Use Albumin Ligands for PSMA Targeting?
- (2017) Steve S. Huang et al. Theranostics
- 177Lu-Labeled Phosphoramidate-Based PSMA Inhibitors: The Effect of an Albumin Binder on Biodistribution and Therapeutic Efficacy in Prostate Tumor-Bearing Mice
- (2017) Cindy J. Choy et al. Theranostics
- 44Sc-PSMA-617 for radiotheragnostics in tandem with 177Lu-PSMA-617—preclinical investigations in comparison with 68Ga-PSMA-11 and 68Ga-PSMA-617
- (2017) Christoph A. Umbricht et al. EJNMMI Research
- Preclinical Comparative Study of 68Ga-Labeled DOTA, NOTA, and HBED-CC Chelated Radiotracers for Targeting PSMA
- (2016) Sangeeta Ray Banerjee et al. BIOCONJUGATE CHEMISTRY
- Novel Bispecific PSMA/GRPr Targeting Radioligands with Optimized Pharmacokinetics for Improved PET Imaging of Prostate Cancer
- (2016) C. Liolios et al. BIOCONJUGATE CHEMISTRY
- Prostate-Specific Membrane Antigen–Directed Therapy for Metastatic Castration-Resistant Prostate Cancer
- (2016) Min Yuen Teo et al. CANCER JOURNAL
- Design, synthesis and biological evaluation of PSMA/hepsin-targeted heterobivalent ligands
- (2016) Milan Subedi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA)
- (2016) Pavel Majer et al. JOURNAL OF MEDICINAL CHEMISTRY
- Linker Modification Strategies To Control the Prostate-Specific Membrane Antigen (PSMA)-Targeting and Pharmacokinetic Properties of DOTA-Conjugated PSMA Inhibitors
- (2016) Martina Benešová et al. JOURNAL OF MEDICINAL CHEMISTRY
- (2S)-2-(3-(1-Carboxy-5-(4-211At-Astatobenzamido)Pentyl)Ureido)-Pentanedioic Acid for PSMA-Targeted -Particle Radiopharmaceutical Therapy
- (2016) A. P. Kiess et al. JOURNAL OF NUCLEAR MEDICINE
- German Multicenter Study Investigating 177 Lu-PSMA-617 Radioligand Therapy in Advanced Prostate Cancer Patients
- (2016) Kambiz Rahbar et al. JOURNAL OF NUCLEAR MEDICINE
- The Rise of PSMA Ligands for Diagnosis and Therapy of Prostate Cancer
- (2016) A. Afshar-Oromieh et al. JOURNAL OF NUCLEAR MEDICINE
- PSMA-Targeted Radionuclide Therapy of Metastatic Castration-Resistant Prostate Cancer with 177Lu-Labeled PSMA-617
- (2016) C. Kratochwil et al. JOURNAL OF NUCLEAR MEDICINE
- Preclinical Evaluation and First Patient Application of 99m Tc-PSMA-I&S for SPECT Imaging and Radioguided Surgery in Prostate Cancer
- (2016) Stephanie Robu et al. JOURNAL OF NUCLEAR MEDICINE
- Preliminary evaluation of prostate-targeted radiotherapy using131I-MIP-1095 in combination with radiosensitising chemotherapeutic drugs
- (2016) Mathias Tesson et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Systemic Radioligand Therapy with 177Lu Labeled Prostate Specific Membrane Antigen Ligand for Imaging and Therapy in Patients with Metastatic Castration Resistant Prostate Cancer
- (2016) Matthias M. Heck et al. JOURNAL OF UROLOGY
- Radiolabeled enzyme inhibitors and binding agents targeting PSMA: Effective theranostic tools for imaging and therapy of prostate cancer
- (2016) Maroor Raghavan Ambikalmajan Pillai et al. NUCLEAR MEDICINE AND BIOLOGY
- Comparison between Three Promising ß-emitting Radionuclides, 67Cu, 47Sc and 161Tb, with Emphasis on Doses Delivered to Minimal Residual Disease
- (2016) Christophe Champion et al. Theranostics
- Towards Personalized Treatment of Prostate Cancer: PSMA I&T, a Promising Prostate-Specific Membrane Antigen-Targeted Theranostic Agent
- (2016) Kristell L.S. Chatalic et al. Theranostics
- Design of Internalizing PSMA-specific Glu-ureido-based Radiotherapeuticals
- (2016) Till Wüstemann et al. Theranostics
- Cancer of the prostate: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
- (2015) C. Parker et al. ANNALS OF ONCOLOGY
- Structure and Enzymatic Activities of Human Serum Albumin
- (2015) Yu Wang et al. CURRENT PHARMACEUTICAL DESIGN
- PMPA for Nephroprotection in PSMA-Targeted Radionuclide Therapy of Prostate Cancer
- (2015) C. Kratochwil et al. JOURNAL OF NUCLEAR MEDICINE
- Auger Radiopharmaceutical Therapy Targeting Prostate-Specific Membrane Antigen
- (2015) A. P. Kiess et al. JOURNAL OF NUCLEAR MEDICINE
- Preclinical Evaluation of a Tailor-Made DOTA-Conjugated PSMA Inhibitor with Optimized Linker Moiety for Imaging and Endoradiotherapy of Prostate Cancer
- (2015) M. Bene ova et al. JOURNAL OF NUCLEAR MEDICINE
- 68Ga- and 177Lu-Labeled PSMA I&T: Optimization of a PSMA-Targeted Theranostic Concept and First Proof-of-Concept Human Studies
- (2015) M. Weineisen et al. JOURNAL OF NUCLEAR MEDICINE
- Alterations in androgen deprivation enhanced prostate-specific membrane antigen (PSMA) expression in prostate cancer cells as a target for diagnostics and therapy
- (2015) B. Meller et al. EJNMMI Research
- Heterobivalent Agents Targeting PSMA and Integrin-αvβ3
- (2014) Hassan M. Shallal et al. BIOCONJUGATE CHEMISTRY
- Hormone and Radiotherapy versus Hormone or Radiotherapy Alone for Non-metastatic Prostate Cancer: A Systematic Review with Meta-analyses
- (2014) M. Schmidt-Hansen et al. CLINICAL ONCOLOGY
- Synthesis and biological evaluation of copper-64 radiolabeled [DUPA-6-Ahx-(NODAGA)-5-Ava-BBN(7-14)NH2], a novel bivalent targeting vector having affinity for two distinct biomarkers (GRPr/PSMA) of prostate cancer
- (2014) Rajendra Prasad Bandari et al. NUCLEAR MEDICINE AND BIOLOGY
- DNA Double Strand Breaks as Predictor of Efficacy of the Alpha-Particle Emitter Ac-225 and the Electron Emitter Lu-177 for Somatostatin Receptor Targeted Radiotherapy
- (2014) Franziska Graf et al. PLoS One
- Improving the biodistribution of PSMA-targeting tracers with a highly negatively charged linker
- (2014) Steve S. Huang et al. PROSTATE
- Preclinical evaluation of a bispecific low-molecular heterodimer targeting both PSMA and GRPR for improved PET imaging and therapy of prostate cancer
- (2014) Matthias Eder et al. PROSTATE
- Unraveling the mysteries of serum albumin—more than just a serum protein
- (2014) Angelica M. Merlot et al. Frontiers in Physiology
- Serum albumin: Accuracy and clinical use
- (2013) Ilenia Infusino et al. CLINICA CHIMICA ACTA
- Effect of Chelators on the Pharmacokinetics of 99mTc-Labeled Imaging Agents for the Prostate-Specific Membrane Antigen (PSMA)
- (2013) Sangeeta Ray Banerjee et al. JOURNAL OF MEDICINAL CHEMISTRY
- First-in-Man Evaluation of 2 High-Affinity PSMA-Avid Small Molecules for Imaging Prostate Cancer
- (2013) J. A. Barrett et al. JOURNAL OF NUCLEAR MEDICINE
- 99mTc-Labeled Small-Molecule Inhibitors of Prostate-Specific Membrane Antigen for Molecular Imaging of Prostate Cancer
- (2013) S. M. Hillier et al. JOURNAL OF NUCLEAR MEDICINE
- A Hormone-DNA Repair Circuit Governs the Response to Genotoxic Insult
- (2013) J. F. Goodwin et al. Cancer Discovery
- Radiosensitization in prostate cancer: mechanisms and targets
- (2013) Diego A Palacios et al. BMC Urology
- Prolonged androgen deprivation leads to downregulation of androgen receptor and prostate-specific membrane antigen in prostate cancer cells
- (2012) TIANCHENG LIU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- DOTA Conjugate with an Albumin-Binding Entity Enables the First Folic Acid-Targeted 177Lu-Radionuclide Tumor Therapy in Mice
- (2012) C. Muller et al. JOURNAL OF NUCLEAR MEDICINE
- A dimerized urea-based inhibitor of the prostate-specific membrane antigen for 68Ga-PET imaging of prostate cancer
- (2012) Martin Schäfer et al. EJNMMI Research
- Radiotherapy and Short-Term Androgen Deprivation for Localized Prostate Cancer
- (2011) Christopher U. Jones et al. NEW ENGLAND JOURNAL OF MEDICINE
- Preclinical Evaluation of Novel Glutamate-Urea-Lysine Analogues That Target Prostate-Specific Membrane Antigen as Molecular Imaging Pharmaceuticals for Prostate Cancer
- (2009) S. M. Hillier et al. CANCER RESEARCH
- Expression of the gastrin-releasing peptide receptor, the prostate stem cell antigen and the prostate-specific membrane antigen in lymph node and bone metastases of prostate cancer
- (2009) Hildo J.K. Ananias et al. PROSTATE
- Therapeutic Radionuclides: Biophysical and Radiobiologic Principles
- (2008) Amin I. Kassis SEMINARS IN NUCLEAR MEDICINE
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