Article
Pharmacology & Pharmacy
Fiorenza Rancan, Jana Jurisch, Cemre Guenday, Emre Tuereli, Ulrike Blume-Peytavi, Annika Vogt, Christoph Schaudinn, Nazende Guenday-Tuereli
Summary: The study found that surfactants significantly improved the penetration of PLGA particles in wound tissue and enhanced the antimicrobial efficacy of antibiotics, offering a potential safe and effective option for topical antimicrobial management of chronic wound infections.
Article
Chemistry, Multidisciplinary
Baixing Chen, Luis Ponce Benavente, Marco Chitto, Jacek K. Wychowaniec, Virginia Post, Matteo D'Este, Caroline Constant, Stephan Zeiter, Wenli Feng, Mercedes Gonzalez Moreno, Andrej Trampuz, Jeroen Wagemans, Jolien Onsea, R. Geoff Richards, Rob Lavigne, T. Fintan Moriarty, Willem-Jan Metsemakers
Summary: The study aimed to develop a dual antibiotic-phage delivery system using a hydrogel and alginate microbeads to treat multi-drug resistant Pseudomonas aeruginosa infection. The results showed that the combination of phages and meropenem had enhanced antibacterial activity against bacterial biofilms. The dual delivery system reduced the development of phage resistance and exposure to the immune system.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Immunology
Derek Fleming, Brandon Niese, Whitni Redman, Emily Vanderpool, Vernita Gordon, Kendra P. Rumbaugh
Summary: The absence of the exopolysaccharides Pel and Psl in Pseudomonas aeruginosa did not significantly affect the severity or wound closure rates of wound infections in a mouse model. However, the size and distribution of biofilm aggregates in the wound tissue were different, and the mutants' ability to survive antibiotic treatment was impaired.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Laia Fernandez-Barat, Nil Vazquez Burgos, Victoria Alcaraz, Leticia Bueno-Freire, Ruben Lopez-Aladid, Roberto Cabrera, Albert Gabarrus, Andrea Palomeque, Patricia Oscanoa, Adrian Ceccato, Ana Motos, Rosanel Amaro, Thierry Bernardi, Christian Provot, Alba Soler-Comas, Laura Munoz, Jordi Vila, Antoni Torres
Summary: The aim of this study was to validate and identify additional applications of the BioFilm Ring Test (BRT) for Pseudomonas aeruginosa (PA) isolates from patients with bronchiectasis (BE), and evaluate its relationship with antimicrobial stewardship. The results showed that a BPI value below 14.75 at 5 hours predicted the mucoid PA phenotype. In conclusion, the BRT has the potential to reveal biofilm features with clinical implications.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Erik Gerner, Sofia Almqvist, Peter Thomsen, Maria Werthen, Margarita Trobos
Summary: Inhibition of quorum sensing by sodium salicylate in Pseudomonas aeruginosa strains influences biofilm formation and tolerance to silver, making biofilms more susceptible to silver and reducing levels of virulence factors associated with biofilm development. This suggests that sodium salicylate allows antiseptics to become more readily available to cells by reducing cell aggregation in biofilms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Keren Zhou, Vinay Kammarchedu, Derrick Butler, Pouya Soltan Khamsi, Aida Ebrahimi
Summary: This study developed a flexible electrochemical sensor based on phenazines for early diagnosis of P. aeruginosa infection and stable monitoring of phenazine generation in biofilms.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Infectious Diseases
Frieder Schaumburg, Jonathan Vas Nunes, Giulia Moennink, Abdul-Mac Falama, James Bangura, Hanna Matheron, Amara Conteh, Maxwell Sesay, Aminata Sesay, Martin P. Grobusch
Summary: Based on a microbiological study on chronic wound infections in Sierra Leone, high antimicrobial resistance rates were found in bacteria, suggesting that empirical systemic antibiotic therapy should not be used unless patients show signs of systemic infections, supporting the strategy of local wound care.
Article
Infectious Diseases
Feifei Yang, Chunhong Liu, Jian Ji, Wenjun Cao, Baixing Ding, Xiaogang Xu
Summary: The Pseudomonas aeruginosa strains isolated from patients with aural infections showed low rates of resistance to most antibiotics but high resistance rates to quinolones. These strains exhibited strong biofilm formation ability and low susceptibility to biofilm eradication, indicating the need for more effective drugs and treatment methods to combat these infections.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Microbiology
Yixin Zhang, Xiaolong Liu, Huamei Wen, Zhongle Cheng, Yanyu Zhang, Haichuan Zhang, Zhongwen Mi, Xinjiong Fan
Summary: Pseudomonas aeruginosa can form biofilms at burn wound sites, causing infection and treatment failure. Previous in vitro studies have shown that a combination of the quorum-quenching enzyme AidH(A147G) and the extracellular matrix hydrolase PslG effectively inhibits biofilm formation and enhances antibiotic effects. This study aimed to evaluate the efficacy of this enzyme combination in conjunction with tobramycin for treating P. aeruginosa-infected burn wounds. The results showed that simultaneous treatment with these enzymes and antibiotics reduced tissue damage severity, bacterial load, and inflammatory markers, indicating it as a potentially effective treatment for P. aeruginosa biofilm infections of burn wounds.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Sara Masihzadeh, Mansour Amin, Zahra Farshadzadeh
Summary: This study investigated the antibiofilm activity of the WLBU2 peptide against Pseudomonas aeruginosa isolates. Results showed that WLBU2 exhibited strong inhibitory and eradication potency against MDR and carbapenem-resistant strains of P. aeruginosa, both in vitro and in vivo.
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Microbiology
Sang Phan, Cafrey He Feng, Raymond Huang, Zeng X. Lee, Yer Moua, Olivia J. Phung, Justin R. Lenhard
Summary: Pseudomonas aeruginosa is commonly found in chronic wound infections worldwide, except in South America, where it is less prevalent. It is the second most common organism in each continent, with Staphylococcus aureus being the most abundant pathogen overall. In Southeast Asia nations including India and Malaysia, P. aeruginosa is the most frequently isolated organism in chronic wound infections. The presence of P. aeruginosa in diabetic foot infections is lower in North America, Europe, and Africa compared to other types of chronic wound infections. The isolation of P. aeruginosa using the Levine wound swab technique may not be a reliable predictor of the patient's clinical course.
Review
Microbiology
Xuejie Li, Nixuan Gu, Teng Yi Huang, Feifeng Zhong, Gongyong Peng
Summary: Pseudomonas aeruginosa (P. aeruginosa) is a gram-negative pathogenic microorganism known for its virulence factors, biofilm forming capability, and antimicrobial resistance. Despite being underestimated, it is a foodborne pathogen that can be found in various food groups. Chemical preservatives used to suppress microbial growth in food can pose food safety concerns. Therefore, finding effective and natural alternative antimicrobial agents for food processing is crucial. This review focuses on recent advances in food safety related to P. aeruginosa, including antimicrobial resistance, virulence factors, and prevention measures.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Yun-Qi Song, Su Min Kyung, Suji Kim, Gun Kim, So Yeong Lee, Han Sang Yoo
Summary: Pseudomonas aeruginosa is a major pathogen in nosocomial infections, which are difficult to handle due to its biofilm-forming ability and carbapenem resistance. Antimicrobial peptides, such as RP557, have shown effectiveness in inhibiting biofilms. Our study assessed the effectiveness of RP557 on carbapenem-resistant P. aeruginosa planktonic cells and biofilms, providing a potential treatment option for carbapenem-resistant P. aeruginosa infection. This treatment could be helpful in managing severe nosocomial infections caused by carbapenem-resistant bacteria and improving patients' survival rates.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Mario Gajdacs, Zoltan Barath, Krisztina Karpati, Dora Szabo, Donatella Usai, Stefania Zanetti, Matthew Gavino Donadu
Summary: The study found a relationship between biofilm formation and expression of virulence factors with multidrug resistance in Pseudomonas aeruginosa. However, there were no significant differences in virulence factor expression between multidrug-resistant and non-multidrug-resistant isolates, and no correlations were seen between the rate of biofilm formation, pigment production, or motility. Understanding the interplay between drug resistance mechanisms, biofilm formation, and virulence is crucial for managing chronic bacterial infections.
Article
Dermatology
Brett King, Arash Mostaghimi, Yutaka Shimomura, Abraham Zlotogorski, Gwang-Seong Choi, Ulrike Blume-Peytavi, Thierry Passeron, Katrin Holzwarth, Yves Dutronc, Jill McCollam, Fan Emily Yang, Sarah Stanley, Wen-Shuo Wu, Rodney Sinclair
Summary: This study analyzed the safety data of baricitinib in patients with severe alopecia areata from two clinical trials. The results showed that the safety profile of baricitinib was consistent and no deaths were reported.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Mona Prendke, Varvara Kanti-Schmidt, Doris Wilborn, Kathrin Hillmann, Rashmi Singh, Annika Vogt, Jan Kottner, Ulrike Blume-Peytavi
Summary: Alopecia areata (AA) is an autoimmune-mediated non-scarring hair loss that has a stigmatizing effect and can severely impact psychosocial well-being. Previous research has shown a correlation between AA and bullying, reduced quality of life, and psychiatric comorbidities. This review aims to systematically describe the quality of life among children and adolescents affected by AA, as no previous systematic evaluation has been performed on this population.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Chemistry, Applied
Eric S. Johnson, Debora W. Chang, James R. Schwartz, Ulrike Blume-Peytavi, James P. Henry, Tamara L. Caterino, Allison L. Talley
Summary: Formulation technologies have been developed to increase the delivery efficiency of the scalp benefit agent piroctone olamine (PO) in shampoos, resulting in enhanced anti-dandruff efficacy.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2023)
Article
Immunology
F. Rancan, K. Rajes, P. Sidiropoulou, S. Hadam, X. Guo, F. Zabihi, U. Mirastschijski, E. Ruehl, R. Haag, U. Blume-Peytavi, A. Vogt
Summary: Rapamycin, a potential anti-proliferative drug, has limitations in topical treatment of skin disorders due to its high molecular weight and lipophilicity. This study demonstrated that oxidation-sensitive CMS nanocarriers improved drug delivery to the skin and showed mTOR inhibitory activity in an inflammatory ex vivo human skin model. The osCMS formulations achieved higher anti-inflammatory effects and downregulated mTOR activity, suggesting their potential use in topical anti-inflammatory therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Jan Kottner, Alexandra Fastner, Dimitra-Aikaterini Lintzeri, Christopher E. M. Griffiths, Ulrike Blume-Peytavi
Summary: Ageing is accompanied by physical and physiological changes in the skin, which require proper care and monitoring to prevent or manage dermatological diseases. This scoping review aims to describe and summarize the available evidence on screening, diagnosis, and management of skin conditions in older people living at home, as currently there is no organized body of evidence in this area.
Article
Nanoscience & Nanotechnology
Marco Contardi, Marta Fadda, Valerio Isa, Yohan D. Louis, Andrea Madaschi, Sara Vencato, Enrico Montalbetti, Laura Bertolacci, Luca Ceseracciu, Davide Seveso, Silvia Lavorano, Paolo Galli, Athanassia Athanassiou, Simone Montano
Summary: A new strategy of delivering antioxidants to coral has been proposed to mitigate the effects of thermal stress. Biocomposite films containing curcumin as a natural antioxidant have shown promising results in improving coral health and preventing bleaching. This research suggests the potential of combining natural antioxidants and biocomposites to mitigate coral bleaching events.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Dermatology
Rashmi Singh, Doris Wilborn, Dimitra-Aikaterini Lintzeri, Ulrike Blume-Peytavi
Summary: Cicatricial alopecia can have a significant impact on emotional well-being, social functioning, and overall quality of life. This review aimed to systematically describe the health-related quality of life in adults with primary cicatricial alopecia and its subtypes. The findings from thirteen observational cross-sectional and one single-arm study showed that more than 70% of patients experience impaired quality of life. The study suggests the importance of integrating psychosocial interventions with cicatricial alopecia treatments, and calls for further research to address the unmet mental health needs of this patient population.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marco Contardi, Maria Summa, Martina Lenzuni, Luigi Miracoli, Franco Bertora, Maurizio Diaz Mendez, Athanassia Athanassiou, Rosalia Bertorelli
Summary: This study demonstrates that the combination of Alginate/PVPI-based wound dressing and electrical neurostimulation devices can be a new approach to improve chronic wound treatment in diabetic patients.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Fiorenza Rancan, Jana Jurisch, Sabrina Hadam, Annika Vogt, Ulrike Blume-Peytavi, Ilker S. Bayer, Marco Contardi, Christoph Schaudinn
Summary: Bacterial infections pose a constant challenge in wound management, especially with the increasing prevalence of chronic wounds due to an aging population. This study investigated the antimicrobial activity of polyvinylpyrrolidone foils loaded with ciprofloxacin in ex vivo human wounds infected with methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. The treatment effectively countered the infections and their associated effects.
Article
Dermatology
Sergio Vano-Galvan, Ulrike Blume-Peytavi, Paul Farrant, Pascal Reygagne, Erin Johansson, Catherine Reed, Simran Marwaha, Frederick Durand, Bianca Maria Piraccini
Summary: This study compares the assessment of AA severity between doctors and patients in Europe and explores the burden of AA reported by patients. The data indicates a significant impact of AA beyond hair loss, particularly for patients with severe AA. The study highlights the importance of aligning physician and patient assessments in developing appropriate treatment strategies.
DERMATOLOGY AND THERAPY
(2023)
Review
Dermatology
Doris Wilborn, Ruhul Amin, Jan Kottner, Ulrike Blume-Peytavi
Summary: This scoping review aimed to obtain an overview of skin care activities in neonates and infants. The study found that there are various preferences, traditions, and behaviors regarding skin care, with a focus on prevention of skin diseases, maintaining skin barrier function, and improving overall health. The results highlight the need to develop core outcome sets in the field of skin care for healthy skin in this age group.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2023)
Article
Chemistry, Analytical
Despoina Kossyvaki, Matteo Bustreo, Marco Contardi, Athanassia Athanassiou, Despina Fragouli
Summary: This study presents the ability of highly porous colorimetric indicators to sense volatile and biogenic amine vapors in real time. The results show that the porous fiber mats loaded with curcumin can detect amine vapors at low concentrations, showing distinct color changes that are reversible. Additionally, the curcumin-loaded fibers demonstrate strong antioxidant activity.
