Review
Endocrinology & Metabolism
Jordan Mattke, Srividya Vasu, Carly M. M. Darden, Kenjiro Kumano, Michael C. C. Lawrence, Bashoo Naziruddin
Summary: Exosomes play a crucial role in studying diagnostic markers for islet cell viability and function in islet transplantation. They may have an impact on the success of islet transplantation and could potentially be used as a therapeutic tool.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Agnieszka Bielska, Magdalena Niemira, Adam Kretowski
Summary: Type 2 diabetes and its complications pose a serious threat to patients' life and health worldwide, especially vascular complications. MicroRNAs are considered potential biomarkers for detecting diabetes-related complications and may facilitate the development of more effective therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Joanna Jarosz-Popek, Marta Wolska, Aleksandra Gasecka, Pamela Czajka, Daniel Jakubik, Lucia Sharif, Taqwa Adem, Wei-Ling Liu, Dagmara Mirowska-Guzel, Marek Postula, Ceren Eyileten
Summary: Diabetes mellitus is a complex and global health problem, with increasing complications affecting the nervous system. Studies suggest that miRNAs and lncRNAs play crucial roles in modulating signaling pathways, making them potential biomarkers and treatment options for neurodegenerative diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Ceren Eyileten, Zofia Wicik, Disha Keshwani, Faisal Aziz, Felix Aberer, Peter N. Pferschy, Norbert J. Tripolt, Caren Sourij, Barbara Prietl, Florian Pruller, Dirk von Lewinski, Salvatore De Rosa, Jolanta M. Siller-Matula, Marek Postula, Harald Sourij
Summary: Hypoglycemia was found to influence the expression of miRNAs related to diabetes and platelet activation. These findings suggest that miRNAs could potentially serve as biomarkers for platelet activation in patients with diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mai-Huong Thi Nguyen, Yueh-Hsia Luo, An-Lun Li, Jen-Chieh Tsai, Kun-Lin Wu, Pei-Jung Chung, Nianhan Ma
Summary: Immune checkpoint inhibitors show promise in cancer treatment, but resistance in melanoma patients hinders their effectiveness. Recent studies explore the role of miRNAs in immune response and tumor microenvironment, suggesting their potential as key players in immunotherapy.
Article
Endocrinology & Metabolism
Tian Fang, Gong Xue, Wu Jianjun, Long Wei, Zhang Xiaomeng, Yang Fan
Summary: This study integrated transcriptome data and lncRNA regulatory association data of human pancreatic islet-derived exosome to construct a ceRNA network. It identified potential markers and mechanisms of diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michal Marczyk, Joanna Polanska, Andrzej Wojcik, Lovisa Lundholm
Summary: This study aimed to test miRNA biomarkers in leukocytes of breast cancer patients undergoing external beam radiotherapy. The results showed that while miR-744-5p showed promise as a stable miRNA marker, most tested miRNAs displayed individual signal variability and temporal patterns, potentially excluding them as sensitive biomarkers of radiation response in this setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Mohadeseh Fathi, Soudeh Ghafouri-Fard, Atefe Abak, Mohammad Taheri
Summary: Pancreatic cancer is a deadly disease with genetic aberrations and epigenetic alterations playing a role in its development. Certain miRNAs act as oncomiRs, promoting cell proliferation, while others function as tumor suppressors, regulating cell growth and cycle transitions. The use of miRNAs as non-invasive markers for diagnosing and prognosticating pancreatic cancer shows promise in research.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Elena Flowers, Kesava Asam, Isabel Elaine Allen, Alka M. M. Kanaya, Bradley E. E. Aouizerat
Summary: MicroRNAs (miRNAs) are important regulators of risk for type 2 diabetes (T2D). This study identified novel sets of miRNAs associated with T2D risk and their gene and pathway targets. Different factors of miRNAs were found to target pathways with distinct biological themes. Further exploration of these pathways may provide insights into T2D subtypes and novel therapeutic targets.
MOLECULAR MEDICINE REPORTS
(2022)
Review
Endocrinology & Metabolism
Xiyao Yang, Na Wu
Summary: This review summarizes the roles and potential of exosomal miRNAs and circulating miRNAs in GDM. Changes in the expression and secretion of exosomal miRNAs can be used as diagnostic and prognostic markers for GDM. Additionally, exosomal miRNAs can target metabolic pathways, leading to insulin resistance.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Endocrinology & Metabolism
Agnieszka Bielska, Magdalena Niemira, Witold Bauer, Iwona Sidorkiewicz, Anna Szalkowska, Anna Skwarska, Justyna Raczkowska, Damian Ostrowski, Kamil Gugala, Slawomir Dobrzycki, Adam Kretowski
Summary: The increasing morbidity and mortality of type 2 diabetic mellitus (T2DM) patients with ischemic heart disease (IHD) highlight the urgent need to identify early biomarkers for IHD development in diabetic individuals. This study suggests that circulating serum-derived micro RNAs (miRNAs) may serve as potential biomarkers for early diagnosis of IHD in T2DM patients. Six miRNAs were significantly upregulated in T2DM IHD patients and were associated with multiple signaling pathways. These miRNAs showed high diagnostic value, indicating their potential as biomarkers for early IHD detection in diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri, Normohammad Arefian
Summary: Sepsis results from inflammatory response to microbial agents and can lead to multiple organ system failure. Non-coding RNAs such as lncRNAs, miRNAs, and circRNAs have been found to play a role in the pathogenesis of sepsis-related complications.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Soudeh Ghafouri-Fard, Yadollah Poornajaf, Farzaneh Dashti, Bashdar Mahmud Hussen, Mohammad Taheri, Elena Jamali
Summary: Interferons (IFNs) are essential proteins in regulating immune responses during microbial infections and have significant roles in autoimmune disorders. Non-coding RNAs can influence the expression and activities of IFNs, particularly in the context of cancer. Additionally, non-coding RNAs may contribute to the pathogenesis of various diseases, including neuropsychiatric conditions and systemic sclerosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Chao Li, Peng Dou, Tianxiang Wang, Xin Lu, Guowang Xu, Xiaohui Lin
Summary: Studying miRNA synergy and identifying miRNA synergistic modules can help understand complex diseases such as cancers. A new method called DDRM combines knowledge databases and miRNA data to define disease-related modules and construct a weighted miRNA synergistic network. Experiments on TCGA datasets showed that DDRM can accurately distinguish cancer samples from normal samples and outperforms previous methods. Validation on prostate cancer data also demonstrated superior performance. Hence, combining miRNA synergy networks and miRNA data is significant for studying disease mechanisms.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Jacek Kabzinski, Monika Maczynska, Ireneusz Majsterek
Summary: This article discusses the potential use of microRNAs in the diagnosis of head and neck squamous cell carcinoma, highlighting their application in radiotherapy and immunotherapy, as well as addressing the challenges and future research directions in developing this promising technology.
Article
Endocrinology & Metabolism
Prathab Balaji Saravanan, Srividya Vasu, Gumpei Yoshimatsu, Carly M. Darden, Xuan Wang, Jinghua Gu, Michael C. Lawrence, Bashoo Naziruddin
Article
Gastroenterology & Hepatology
Michael C. Lawrence, Carly M. Darden, Srividya Vasu, Kenjiro Kumano, Jinghua Gu, Xuan Wang, Jinyan Chan, Zhaohui Xu, Benjamin F. Lemoine, Phuong Nguyen, Cynthia Smitherman, Bashoo Naziruddin, Giuliano Testa
LIVER TRANSPLANTATION
(2019)
Article
Endocrinology & Metabolism
Kenjiro Kumano, Michael C. Lawrence, Nicholas Onaca, Marlon F. Levy, Bashoo Naziruddin
ACTA DIABETOLOGICA
(2020)
Article
Gastroenterology & Hepatology
Kenjiro Kumano, Morihito Takita, Srividya Vasu, Carly Darden, Michael Lawrence, Ernest Beecherl, Amar Gupta, Nicholas Onaca, Bashoo Naziruddin
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2020)
Article
Immunology
Kenjiro Kumano, Srividya Vasu, Yang Liu, Su-Tang Lo, Aditi Mulgaonkar, Jenelle Pennington, Carly M. Darden, Xiankai Sun, Michael C. Lawrence, Bashoo Naziruddin
Article
Multidisciplinary Sciences
Kenjiro Kumano, Mazhar A. Kanak, Prathab Balaji Saravanan, J. P. Blanck, Yang Liu, Srividya Vasu, Michael Lawrence, Bashoo Naziruddin
Summary: Withaferin A may reduce inflammation and prolong allograft survival by inhibiting dendritic cell maturation and T-cell proliferation.
SCIENTIFIC REPORTS
(2021)
Review
Endocrinology & Metabolism
Jordan Mattke, Srividya Vasu, Carly M. M. Darden, Kenjiro Kumano, Michael C. C. Lawrence, Bashoo Naziruddin
Summary: Exosomes play a crucial role in studying diagnostic markers for islet cell viability and function in islet transplantation. They may have an impact on the success of islet transplantation and could potentially be used as a therapeutic tool.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yang Liu, Srividya Vasu, Kenjiro Kumano, Jeffrey A. SoRelle, Michael C. Lawrence, Bashoo Naziruddin
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Gastroenterology & Hepatology
Hiroki Sato, Ryuichi Yoshida, Kazuya Yasui, Yuzo Umeda, Kazuhiro Yoshida, Tomokazu Fuji, Kenjiro Kumano, Kosei Takagi, Takahito Yagi, Toshiyoshi Fujiwara
Summary: This study reviewed the medical records of PDAC patients who underwent curative resection and found that recurrence after surgery is still a critical issue. The results suggest that a multimodal approach may improve the clinical outcomes of patients with recurrent PDAC.
Article
Multidisciplinary Sciences
Carly M. Darden, Srividya Vasu, Jordan Mattke, Yang Liu, Christopher J. Rhodes, Bashoo Naziruddin, Michael C. Lawrence
Summary: The study reveals that calcineurin and PI3K/AKT signaling pathways play important roles in maintaining beta-cell function, but prolonged exposure to stress or perturbation of these pathways may lead to beta-cell dedifferentiation and dysfunction.
Article
Surgery
Carly Darden, Kenjiro Kumano, Yang Liu, Asim Mohamed, Jordan Mattke, Michael Lawrence, Amar Gupta, Ernest Beecherl, Seung Hee S. Lee, Bashoo Naziruddin
Summary: Pancreatic calcification in patients with chronic pancreatitis is a risk factor for diabetes development, poor islet yield, and metabolic outcomes after total pancreatectomy with islet autotransplantation (TPIAT). Our study investigated the association between calcification pattern and outcomes in 200 consecutive TPIAT procedures. The diffuse calcification group showed the greatest changes in outcomes, with higher preoperative hemoglobin A1c levels and lower stimulated C-peptide levels. Despite being a sign of diabetes risk, patients in the diffuse calcification group experienced exceptional pain relief.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Cell & Tissue Engineering
Srividya Vasu, Jiemin M. Yang, James Hodges, Maisam A. Abu-El-Haija, David B. Adams, Appakalai N. Balamurugan, Greg J. Beilman, Srinath Chinnakotla, Darwin L. Conwell, Martin L. Freeman, Timothy B. Gardner, Betul Hatipoglu, Varvara Kirchner, Luis F. Lara, Katherine A. Morgan, Jaimie D. Nathan, Andrew Posselt, Timothy L. Pruett, Sarah J. Schwarzenberg, Vikesh K. Singh, Martin Wijkstrom, Piotr Witkowski, Bashoo Naziruddin, Melena D. Bellin
Summary: The study investigated the associations between circulating miRNAs and patient, disease, and islet isolation characteristics in TPIAT patients. The results revealed different miRNAs were associated with genetic risk, toxic/metabolic diseases, exocrine insufficiency, and islet autotransplant outcomes.
CELL TRANSPLANTATION
(2021)
Article
Cell & Tissue Engineering
Gumpei Yoshimatsu, Mazhar A. Kanak, Srividya Vasu, Kenjiro Kumano, Michael Lawrence, Nicholas Onaca, Morihito Takita, Marlon F. Levy, Bashoo Naziruddin
CELL TRANSPLANTATION
(2020)