ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity

Targeting PI3K signaling in cancer: Challenges and advances

(2019) Maria Chiara De Santis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

ATM in DNA repair in cancer

(2019) Mei Hua Jin et al.   PHARMACOLOGY & THERAPEUTICS

Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions

(2019) Tian Liu et al.   Cancers

Hopes and failures in front-line ovarian cancer therapy

(2019) Irina Tsibulak et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Biomarkers of platinum resistance in ovarian cancer: what can we use to improve treatment

(2018) Belinda van Zyl et al.   ENDOCRINE-RELATED CANCER

Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells

(2017) Kirti S. Prabhu et al.   PLoS One

The PTEN protein: cellular localization and post-translational regulation

(2016) N. R. Leslie et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

ATM Mutations in Cancer: Therapeutic Implications

(2016) M. Choi et al.   MOLECULAR CANCER THERAPEUTICS

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion

(2016) Ashish Juvekar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of ATM Activation

(2015) Tanya T. Paull   Annual Review of Biochemistry

ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells

(2015) Jing-Hong Chen et al.   Autophagy

Targeting the DNA Damage Response in Cancer

(2015) Mark J. O’Connor   MOLECULAR CELL

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

PTEN

(2014) Carolyn A. Worby et al.   Annual Review of Biochemistry

The Double Life of p85

(2014) Carlotta Costa et al.   CANCER CELL

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2

(2014) Feng Rao et al.   MOLECULAR CELL

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

PTEN function: the long and the short of it

(2014) Benjamin D. Hopkins et al.   TRENDS IN BIOCHEMICAL SCIENCES

ATM pathway is essential for ionizing radiation-induced autophagy

(2013) Nan Liang et al.   CELLULAR SIGNALLING

The multiple layers of non-genetic regulation of PTEN tumour suppressor activity

(2013) Nádia C. Correia et al.   EUROPEAN JOURNAL OF CANCER

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATM kinase activity modulates ITCH E3-ubiquitin ligase activity

(2013) S Santini et al.   ONCOGENE

ATM signalling and cancer

(2013) C A Cremona et al.   ONCOGENE

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

(2013) D. N. Tripathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress

(2013) C. Bassi et al.   SCIENCE

PTEN in DNA damage repair

(2012) Mei Ming et al.   CANCER LETTERS

ATM and the Molecular Pathogenesis of Ataxia Telangiectasia

(2011) Peter J. McKinnon   Annual Review of Pathology-Mechanisms of Disease

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

(2011) Roya Babaei-Jadidi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

(2011) Lilach Moyal et al.   MOLECULAR CELL

High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

(2011) Lydia W.T. Cheung et al.   Cancer Discovery

Mechanism of p53 stabilization by ATM after DNA damage

(2010) Qian Cheng et al.   CELL CYCLE

Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase

(2010) R. B. Chagpar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Kinase CK2 in Health and Disease

(2009) J. H. Trembley et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

X-linked Inhibitor of Apoptosis Protein (XIAP) Regulates PTEN Ubiquitination, Content, and Compartmentalization

(2009) Céline Van Themsche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTEN and the PI3-Kinase Pathway in Cancer

(2008) Nader Chalhoub et al.   Annual Review of Pathology-Mechanisms of Disease

ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells

(2008) Marie-Jo Halaby et al.   CELLULAR SIGNALLING

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR

(2008) Melanie Winter et al.   NATURE CELL BIOLOGY