Article
Oncology
Chun-Chieh Huang, I-Chieh Chuang, Yu-Li Su, Hao-Lun Luo, Ya-Chun Chang, Jo-Ying Chen, Chang-Chun Hsiao, Eng-Yen Huang
Summary: This study investigated the role of tumor galectin-1 and galectin-3 in patients with lung adenocarcinoma after radiation therapy. The results showed that overexpression of tumor galectin-1 was associated with worse locoregional progression-free survival, while galectin-3 overexpression had no significant effect on survival outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Diyoly Ayona, Sandra Madariaga Zarza, Ludovic Landemarre, Benoit Roubinet, Philippe Decloquement, Didier Raoult, Pierre-Edouard Fournier, Benoit Desnues
Summary: Tropheryma whipplei is an actinobacterium that causes various infections in humans, including Whipple's disease. The bacterium's complex surface glycoproteins contain different sugars, and they interact with Galectin-1 and Galectin-3 to promote infection.
Review
Endocrinology & Metabolism
Deborah Simao Souza, Carla Macheroni, Gustavo Jose Silva Pereira, Carolina Meloni Vicente, Catarina Segreti Porto
Summary: Prostate cancer is the most common cancer among men worldwide, and hormone-related factors, such as androgens, estrogens, and their receptors, play a crucial role in its development and progression. Galectin-3, a family of proteins, is involved in various stages of tumor development and progression, but its expression regulation is still poorly understood. This review focuses on the interplay between Galectin-3 and estrogen receptor signaling pathways in prostate cancer cells and proposes a molecular mechanism involving ER, Galectin-3, and beta-catenin in the modulation of nuclear transcriptional events. Further understanding of the role of Galectin-3 and ER in prostate cancer could lead to the discovery of new drug targets to treat castration-resistant prostate cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Iwona Radziejewska
Summary: MUC1 mucin and galectin-3 with high affinity to T disaccharide are both overexpressed in human cancers, supporting cancer development and metastasis. Inhibiting their interactions may reduce tumor progression and metastasis. This review aims to summarize the relationship between MUC1 and galectin-3.
Article
Oncology
Qiong Wu, Jiali Ma, Jue Wei, Wenying Meng, Yugang Wang, Min Shi
Summary: FOXD1-AS1 aggravates gastric cancer progression and chemoresistance by promoting FOXD1 translation through the PIK3CA/PI3K/AKT/mTOR signaling pathway. These findings offer a potential novel target for treating gastric cancer patients, especially those with cisplatin resistance.
MOLECULAR ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Duncan C. Humphries, Ross Mills, Ross Dobie, Neil C. Henderson, Tariq Sethi, Alison C. Mackinnon
Summary: Selective depletion of Gal-3 in myeloid cells leads to reduced neutrophil recruitment into the interstitium, resulting in decreased pulmonary inflammation after acute lung injury. This suggests that targeting Gal-3 could be a promising new therapy for lung inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Shaheen A. Farhadi, Renjie Liu, Matthew W. Becker, Edward A. Phelps, Gregory A. Hudalla
Summary: Galectin-3 exhibits dynamic oligomerization and promiscuous binding, affecting cell behavior by influencing signaling pathways. Synthetic Gal3 constructs with defined valency can physically regulate extracellular signaling activity and cell death induction. Changes in multivalency impact caspase activation, membrane glycoprotein engagement, and intracellular pathway activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Duncan C. Humphries, Ross Mills, Cecilia Boz, Brian J. McHugh, Nikhil Hirani, Adriano G. Rossi, Anders Pedersen, Hans T. Schambye, Robert J. Slack, Hakon Leffler, Ulf J. Nilsson, Wei Wang, Tariq Sethi, Alison C. Mackinnon
Summary: This study investigates the role of Gal-3 in acute lung injury (ALI) and evaluates the potential protective role of GB0139, a Gal-3 inhibitor. The results show that Gal-3 plays a pro-inflammatory role in the early stages of lung injury and GB0139 can reduce inflammation severity and has potential as a treatment approach for ALI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yuxin Ma, Jingchao Han, Xi Luo
Summary: FOXD1-AS1 upregulates FOXD1 expression to promote OSCC malignant phenotypes through interacting with miR-369-3p and ADAR.
Article
Biochemistry & Molecular Biology
Fei Fei, Mingfeng Zhang, Somayeh S. Tarighat, Eun Ji Joo, Lu Yang, Nora Heisterkamp
Summary: Galectin-1 and Galectin-3 have a complicated joint contribution to BCP-ALL survival, with stromal Galectin-3 playing an important role in maintaining BCP-ALL fitness during chemotherapy exposure, while stromal Galectin-1 does not significantly contribute to drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Hao Liu, Lu Zhang, Zhen Liu, Jinyua Lin, Xiaojing He, Siyi Wu, Yi Qin, Chen Zhao, Youyuan Guo, Fei Lin
Summary: Lung ischemia-reperfusion injury (LIRI) is a complex aseptic inflammatory response, in which macrophages and the lectin Galectin-3 (Gal3) play important roles. Gal3 has been shown to interact with triggering receptor expressed on myeloid cell 2 (TREM2) in macrophages in Alzheimer's disease. This study aimed to investigate the relationship among Gal3, TREM2, and macrophage polarization in LIRI.
Article
Oncology
Yufei Long, Tuotuo Chong, Xiaoming Lyu, Lujia Chen, Xiaomin Luo, Oluwasijibomi Damola Faleti, Simin Deng, Fei Wang, Mingliang He, Zhipeng Qian, Hongli Zhao, Wenyan Zhou, Xia Guo, Ceshi Chen, Xin Li
Summary: In this study, a FOXD1-dependent RalA-ANXA2-Src complex that promotes CTC formation via activating ERK1/2 signal in BC was discovered. FOXD1 may serve as a prognostic factor in evaluating BC metastasis risks. This signaling cascade is druggable and effective for overcoming early stages of BC CTC formation.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Medicine, Research & Experimental
Emily Capone, Stefano Iacobelli, Gianluca Sala
Summary: LGALS3BP, a secreted protein expressed in most human cells, has been identified as a potential therapeutic target for cancer treatment. Studies have shown that LGALS3BP plays a significant role in cancer, potentially impacting prognosis and functionality.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yuanshe Huang, Lai Zhang, Tianlei Liu, E. Liang
Summary: The expression of FOXD1 is upregulated in prostate cancer, and its high expression is associated with clinical stage and survival. It regulates the expression of LMNB1 to promote viability, migration, and invasion of prostate cancer cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Tingting Shi, Koji Fujita, Joji Tani, Masanori Atsukawa, Tsutomu Masaki
Summary: Immunochemotherapy is gaining popularity, with new developments expected in cancer immunity mechanisms. Apoptosis maintains tissue homeostasis, and disruption of this process can contribute to carcinogenesis. Galectins, a type of lectin, regulate cell growth and signal transduction by interacting with sugar chains on cell surfaces. Galectin-9 induces apoptosis of T lymphocytes and cancer cells, but its detailed pharmacokinetics, cell receptors, and intracellular pathways are still not fully understood. In this article, the effects of galectin-9 on gastrointestinal cancers and its mechanisms are reviewed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yu-Chan Chang, Chien-Hsiu Li, Ming-Hsien Chan, Chih-Yeu Fang, Zhi-Xuan Zhang, Chi-Long Chen, Michael Hsiao
Summary: RAB3C plays a key role in the progression of colorectal cancer (CRC) and its overexpression is associated with drug resistance. RAB3C-induced dystrophin expression promotes vesicle formation and packaging. The RAB3C-dystrophin axis is positively correlated with PIK3CA genetic alterations in CRC patients, providing potential therapeutic options for CRC treatment.
MOLECULAR ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chien-Hsiu Li, Ming-Hsien Chan, Yu-Chan Chang, Michael Hsiao
Summary: Gold nanotechnology has revolutionized molecular biology applications, particularly in diagnosing and treating at the molecular and cellular levels. The combination of plasmonic resonance, biochemistry, and optoelectronic engineering has enhanced molecule detection and increased the possibility of analyzing atoms. Gold nanoparticles offer superior analytical properties that can be utilized for drug screening, gene sequencing, and detecting physiological functions.
Article
Oncology
Yu-Chan Chang, Ming-Hsien Chan, Yi-Fang Yang, Chien-Hsiu Li, Michael Hsiao
Summary: The glucose transporter family (GLUT) consists of fourteen members and is responsible for glucose homeostasis and transport. Different GLUTs have unique kinetics and distribution, playing important roles in human physiology. GLUT4 mediates insulin-dependent glucose uptake and dysfunction of GLUT4 is associated with insulin resistance, chronic diseases, inflammation, and cancer.
Article
Cell Biology
Chien-Hsiu Li, Chih-Yeu Fang, Ming-Hsien Chan, Chi-Long Chen, Yu-Chan Chang, Michael Hsiao
Summary: Based on large cohort survival analyses, this study found that FSTL3 is associated with a significantly worse prognosis in colorectal cancer (CRC) at the RNA and protein levels. Further analysis also showed that FSTL3 expression levels in the cytosol are significantly associated with poor overall and disease-free survival. Molecular simulation analysis revealed that FSTL3 participates in multiple cell motility signalling pathways to control CRC metastasis via the TGF-beta 1/TWIST1 axis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Yu-Ching Wen, Van Thi Ngoc Tram, Wei-Hao Chen, Chien-Hsiu Li, Hsiu-Lien Yeh, Phan Vu Thuy Dung, Kuo-Ching Jiang, Han-Ru Li, Jiaoti Huang, Michael Hsiao, Wei-Yu Chen, Yen-Nien Liu
Summary: Current treatment options for prostate cancer focus on targeting androgen receptor (AR) signaling, but inhibiting AR may promote the development of neuroendocrine prostate cancer (NEPC). Understanding the regulatory mechanisms of AR is crucial for the clinical management of NEPC. This study revealed the tumor-suppressive role of AR and identified its downregulation of CHRM4 expression. CHRM4 overexpression drives neuroendocrine differentiation in prostate cancer cells and is associated with immunosuppressive cytokine responses in the tumor microenvironment (TME). Targeting CHRM4 and evaluating IFNA17 secretion as a prognostic biomarker could be potential therapeutic strategies for NEPC.
CELL DEATH & DISEASE
(2023)
Article
Materials Science, Multidisciplinary
Aishwarya Satpathy, Wen-Tse Huang, Ming-Hsien Chan, Ting-Yi Su, Mikolaj Kaminski, Natalia Majewska, Sebastian Mahlik, Grzegorz Leniec, Slawomir M. Kaczmarek, Michael Hsiao, Ru-Shi Liu
Summary: In the biomedical field, fluorescence imaging in the NIR-II region is growing rapidly due to its advantages of reduced autofluorescence and low photon scattering. This work integrates the ZnGa2O4 spinel oxide system into mesoporous silica and utilizes energy transfer from Cr3+ to Ni2+ to achieve high emission intensity in the NIR-II region. By establishing emission in the NIR-II and NIR-I regions, it enables improved clarity and increased penetration depth for bioimaging purposes.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Pathology
Chien-Hsiu Li, Chih-Yeu Fang, Ming-Hsien Chan, Pei-Jung Lu, Luo-Ping Ger, Jan-Show Chu, Yu-Chan Chang, Chi-Long Chen, Michael Hsiao
Summary: The study examined the relationship between JAM family members and different types of cancer using The Cancer Genome Atlas dataset. It found that mRNA levels of F11R in tumors were inversely correlated to the expression of JAM-2 and JAM-3, specifically in breast cancer (BCa), and this was associated with poor prognosis. The study also revealed that F11R expression significantly increased in HER2-enriched and basal-like BCa tumors.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yu-Chen Chen, Chia-Ying Chen, Tai-Wei Chiang, Ming-Hsien Chan, Michael Hsiao, Huei-Mien Ke, Isheng Jason Tsai, Trees-Juen Chuang
Summary: The study developed a bioinformatics pipeline, NCLscan-hybrid, to detect trans-spliced RNAs (ts-RNAs) and distinguish them from circular RNAs (circRNAs). The pipeline integrates short and long RNA-seq reads, minimizing false positives and proposing out-of-circle and rolling-circle long reads.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jhih-Kai Pan, Wen-Der Lin, Yao-Lung Kuo, Yu-Chia Chen, Zhu-Jun Loh, Forn-Chia Lin, Hui-Chuan Cheng, Michael Hsiao, Pei-Jung Lu
Summary: Through proteomic analysis, high expression of ICAM2 was found in leptomeningeal metastatic TNBC cells, promoting spinal cord colonization and causing poor survival outcomes. Two-way demonstration showed that high levels of ICAM2 promoted BCB adhesion, migration, and stemness abilities, determining the specificity of LM in vivo. The study suggests that targeting ICAM2 is a potential therapeutic strategy for LM in TNBC.
Article
Chemistry, Multidisciplinary
Loan Thi Ngo, Wen-Tse Huang, Ming-Hsien Chan, Ting-Yi Su, Chien-Hsiu Li, Michael Hsiao, Ru-Shi Liu
Summary: This study investigates the neurotoxicity of all-inorganic lead halide perovskite quantum dots (PeQDs) using Caenorhabditis elegans as a model organism. The results show that PeQDs accumulate mainly in the alimentary system and head region, causing a decrease in locomotor behaviors, pharyngeal pumping, brood decline, short lifespan, and abnormal issues in reproduction. Excessive reactive oxygen species formation is also observed. The neurotoxicity of PeQDs is explained by gene expression. This study provides an insight into the neurotoxicity of PeQDs and inspires the development of nontoxic PeQDs.
Article
Multidisciplinary Sciences
Chi-Ling Chiang, Yifan Ma, Ya-Chin Hou, Junjie Pan, Sin-Yu Chen, Ming-Hsien Chien, Zhi-Xuan Zhang, Wei-Hsiang Hsu, Xinyu Wang, Jingjing Zhang, Hong Li, Lili Sun, Shannon Fallen, Inyoul Lee, Xing-Yu Chen, Yeh-Shiu Chu, Chi Zhang, Tai-Shan Cheng, Wen Jiang, Betty Y. S. Kim, Eduardo Reategui, Robert Lee, Yuan Yuan, Hsiao-Chun Liu, Kai Wang, Michael Hsiao, Chi-Ying F. Huang, Yan-Shen Shan, Andrew S. Lee, L. James Lee
Summary: This study reports a dual targeted extracellular vesicle (dtEV) that can effectively suppress large PDAC tumors. The dtEV carries high loads of therapeutic RNA and is delivered to target cells through electroporation. When used in combination with the chemotherapy drug Gemcitabine, the dtEVs can inhibit tumor growth and prolong animal survival.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yi-Ru Pan, Chiao-En Wu, Shih-Ming Jung, Shih-Chiang Huang, Sheng-Hsuan Lin, Wen-Chi Chou, Yu-Chan Chang, Ming-Huang Chen, Tsai-Hsien Hung, Alice L. Yu, Wen-Kuan Huang, Chun-Nan Yeh
Summary: Cholangiocarcinoma (CCA) is a type of cancer with aggressive behavior and poor prognosis. Gemcitabine (GEM)-based chemotherapy, the first-line treatment for advanced CCA, has a low response rate. Investigating treatments to overcome GEM resistance in advanced CCA is crucial. MUC4, a member of the mucin (MUC) family, is upregulated in gemcitabine-resistant (GR) CCA cells and mediates GEM resistance by activating AKT signaling. AKT inhibitors combined with GEM or afatinib show potential in overcoming GEM resistance in CCA.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)