Article
Pharmacology & Pharmacy
Chenyang Shi, Jiaxin Li, Guorong Fan, Yu Liu
Summary: This study proposes a synergistic antitumour strategy by simultaneously blocking VEGF and CD47 signalling to enhance the therapeutic effect of bevacizumab on advanced gastric cancer. The results demonstrate that this strategy can reverse immune-related resistance, enhance antitumour effects, and inhibit tumour metastasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Flavie Courtaut, Alessandra Scagliarini, Virginie Aires, Clarisse Cornebise, Jean-Paul Pais de Barros, Celine Olmiere, Dominique Delmas
Summary: The study explores potential targets for combating age-related macular degeneration and finds that a new nutritional supplement, Resvega, may effectively inhibit VEGF secretion, making it a promising complementary treatment against AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Hamid A. Bakshi, Gerry A. Quinn, Mohamed M. Nasef, Vijay Mishra, Alaa A. A. Aljabali, Mohamed El-Tanani, Angel Serrano-Aroca, Mateus Webba Da Silva, Paul A. McCarron, Murtaza M. Tambuwala
Summary: Crocin derived from Himalayan crocus inhibits the growth of colon cancer cells by targeting NF-kB and blocking TNF-alpha/NF-kappa B/VEGF pathways, thus suppressing angiogenesis and colorectal cancer cell metastasis.
Review
Biochemistry & Molecular Biology
Alessandro Zucchi, Francesco Claps, Antonio Luigi Pastore, Alessandro Perotti, Andrea Biagini, Luana Sallicandro, Rosaria Gentile, Concetta Caglioti, Federico Palazzetti, Bernard Fioretti
Summary: Bladder cancer is a common urinary system tumor, especially in males. Surgery and intravesical instillations can eliminate it, but recurrences and progression are frequent. Therefore, adjuvant therapy should be considered. Resveratrol has shown potential as an adjuvant therapy for bladder cancer, with anti-proliferative effects at high concentrations and anti-angiogenic action at low concentrations. This review examines the standard therapeutic approach to bladder cancer, preclinical studies on resveratrol in bladder cancer xenotransplantation models, and discusses molecular signals, particularly the STAT3 pathway and angiogenic growth factor modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Peace Mabeta, Vanessa Steenkamp
Summary: The VEGF/VEGFR axis plays a crucial role in angiogenesis and tumor vascularization. Current therapies targeting VEGF and its receptors have shown limited effectiveness and undesirable off-target effects. Recent studies have identified VEGF splice variants that modulate angiogenesis, and their expression is regulated by cues within the tumor microenvironment. These variants challenge the established norm of VEGF signaling and their aberrant expression has been observed in several cancers, highlighting the need for further research on their role in cancer and their impact on antiangiogenic therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Fanrui Meng, Yukai Cao, Han Su, Tianyan Liu, Limin Tian, Yu Zhang, Jiarui Yang, Wei Xiao, Deshan Li
Summary: This study demonstrates that rNDV-VEGF-Trap significantly inhibits the growth and migration of tumor cells through anti-angiogenesis and apoptosis. It also reduces tumor volume and weight, suggesting its potential as a candidate for carcinoma therapy, especially for colon cancer.
Article
Chemistry, Medicinal
Donghwa Kim, Sang Won Choi, Jihee Cho, Jae-Hui Been, Kyoungsun Choi, Wenzhe Jiang, Jaeho Han, Jedo Oh, Changmin Park, Soongyu Choi, Songyi Seo, Koung Li Kim, Wonhee Suh, Sang Kook Lee, Sanghee Kim
Summary: Diabetic retinopathy is a leading cause of blindness associated with excessive angiogenesis. Researchers have developed a novel antiangiogenesis agent by modifying the structure of wondonin marine natural products, resulting in improved bioactivity and selectivity. This compound, 31, shows potential as a lead for developing small-molecule drugs to treat diabetic retinopathy and to uncover new mechanisms of angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Yinan Yang, Wencong Tian, Lei Yang, Qiong Zhang, Mengmeng Zhu, Yuansheng Liu, Jing Li, Liang Yang, Jie Liu, Yanna Shen, Zhi Qi
Summary: The study revealed that GEM could decrease VEGF-B expression in PaCa, and the combination of RSV and GEM increased cell death and apoptosis, inhibiting tumor growth. The VEGF-B signaling pathway plays a crucial role in the development of PaCa, and the combination of RSV and GEM shows promise as a clinical therapy for PaCa.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Oncology
Domenico Ribatti, Antonio Giovanni Solimando, Francesco Pezzella
Summary: Several anti-angiogenic drugs are approved for cancer treatment, but resistance and adverse effects may occur. Combining multiple anti-angiogenic molecules or using them in combination with other treatment regimens is indicated as alternative therapeutic strategies to overcome resistance. Comprehensive omics profiling is crucial for increasing clinical benefits and overcoming resistance to anti-angiogenic therapies.
Review
Chemistry, Medicinal
Anurag Mathur, Abha Meena, Suaib Luqman
Summary: Monoterpenoids, a subclass of terpenoids, have been extensively studied for their antitumor properties, including antiproliferative, apoptotic, antiangiogenic, and antimetastatic effects. This review focuses on the effects of specific monoterpenoids on metastasis and relevant signaling pathways. Monoterpenoids exhibit complexity as natural products that regulate metastatic proteins through various signaling pathways. However, limited clinical trials hinder the drug usage of monoterpenoids in preventing cancer metastasis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Randa Sghaier, Maude Perus, Clarisse Cornebise, Flavie Courtaut, Alessandra Scagliarini, Celine Olmiere, Virginie Aires, Francois Hermetet, Dominique Delmas
Summary: This study investigated the impact of a nutraceutical formulation called Resvega (R), composed of omega-3 fatty acids and resveratrol, on the secretion of VEGF-A and the prolongation of anti-angiogenic effect. The results showed that Resvega (R) inhibits VEGF-A secretion by modulating the PI3K-AKT-mTOR and NF kappa B signaling pathways. Furthermore, Resvega (R) can affect the activity of the IKK complex and NF kappa B signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yunlong Yang, Yihai Cao
Summary: Metastasis, the leading cause of cancer-associated mortality, is still poorly understood. Both blood and lymphatic vasculatures play crucial roles in distal metastasis, with VEGF being a key angiogenic factor. Anti-VEGF drugs have been widely used in clinical treatment of various cancers, but their impact on cancer metastasis and systemic disease is largely unknown.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Cell Biology
Yingming Jiang, Jintuan Huang, Zhenze Huang, Weiyao Li, Rongchang Tan, Tuoyang Li, Zijian Chen, Xiaocheng Tang, Yandong Zhao, Jun Qiu, Chujun Li, Hao Chen, Zuli Yang
Summary: This study found that ADAMTS12 plays a role in promoting tumor development and angiogenic activity in gastric cancer. High expression of ADAMTS12 is associated with chemoresistance and worse overall survival outcomes.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Longhai Li, Kai Jiang, Dongpeng Li, Dongxiao Li, Zitong Fan, Guosheng Dai, Sheng Tu, Xiangyu Liu, Guangyou Wei
Summary: The study finds that high expression of CXCL7 is correlated with VEGF expression and poor prognosis in CRC patients. The combined expression of CXCL7 and VEGF can better predict patients' survival time.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Klaudia Katarzyna Brogowska, Monika Zajkowska, Barbara Mroczko
Summary: Breast cancer is the most common and lethal malignancy in women. Its development is influenced by factors such as age, genetic mutations, and body weight. Currently, there is a lack of sensitive and specific screening tests, but researchers are exploring new diagnostic biomarkers. The VEGF family of proteins and their receptors play a significant role in the pathogenesis of breast cancer and could potentially be used as diagnostic biomarkers and therapeutic targets.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Wei-Hui Hu, Huai-You Wang, Xiang-Peng Kong, Qing-Ping Xiong, Karman Ka-Man Poon, Li Xu, Ran Duan, Gallant Kar-Lun Chan, Tina Ting-Xia Dong, Karl Wah-Keung Tsim
Article
Plant Sciences
Yun Huang, Kenneth Kin Leung Kwan, Ka Wing Leung, Ping Yao, Huaiyou Wang, Tina Tingxia Dong, Karl Wah Keung Tsim
JOURNAL OF GINSENG RESEARCH
(2019)
Article
Integrative & Complementary Medicine
Guowei Gong, Baohui Qi, Yan T. Liang, Tina T. X. Dong, Huai Y. Wang, Karl W. K. Tsim, Yuzhong Zheng
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Agriculture, Multidisciplinary
Wei-Hui Hu, Ran Duan, Yi-Teng Xia, Qng-Ping Xiong, Huai-You Wang, Gallant Kar-Lun Chan, Si-Yue Liu, Tina Ting-Xia Dong, Qi-Wei Qin, Karl Wah-Keung Tsim
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Plant Sciences
Yun Huang, Ping Yao, Ka Wing Leung, Huaiyou Wang, Xiang Peng Kong, Tina Ting Xia Dong, Yicun Chen, Qi-Wei Qin, Karl Wah Keung Tsim
Article
Microbiology
Xiao-Yong Zhang, Hui-Li Hao, Stanley Chun Kwan Lau, Huai-You Wang, Yu Han, Li-Mei Dong, Ri-Ming Huang
ARCHIVES OF MICROBIOLOGY
(2019)
Article
Chemistry, Analytical
Huai-You Wang, Cheng Wang, Lin-Xiu Guo, Yun-Feng Zheng, Wei-Hui Hu, Tina T. X. Dong, Tie-Jie Wang, Karl W. K. Tsim
JOURNAL OF SEPARATION SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Huai-You Wang, Shu-Chen Guo, Zhi-Tian Peng, Cheng Wang, Ran Duan, Tina T. X. Dong, Karl W. K. Tsim
Article
Neurosciences
Kelly Y. C. Lam, Qi-Yun Wu, Wei-Hui Hu, Ping Yao, Huai-You Wang, Tina T. X. Dong, Karl W. K. Tsim
NEUROSCIENCE LETTERS
(2019)
Article
Pharmacology & Pharmacy
Lin-Xiu Guo, Huai-You Wang, Xue-Duan Liu, Jia-Yi Zheng, Qi Tang, Xin-Nan Wang, Jian-Qun Liu, Hua-Qun Yin, Bo Miao, Yi-Li Liang, Li-Fang Liu, Gui-Zhong Xin
PHARMACOLOGICAL RESEARCH
(2019)
Article
Chemistry, Analytical
Huai-You Wang, Cheng Wang, Shu-Chen Guo, Zhi-Cong Chen, Zhi-Tian Peng, Ran Duan, Tina T. X. Dong, Karl W. K. Tsim
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2019)
Article
Food Science & Technology
Huai-You Wang, Lin-Xiu Guo, Wei-Hui Hu, Zhi-Tian Peng, Cheng Wang, Zhi-Cong Chen, Etta Y. L. Liu, Tina T. X. Dong, Tie-Jie Wang, Karl W. K. Tsim
JOURNAL OF FUNCTIONAL FOODS
(2019)
Article
Chemistry, Applied
Zhi-Tian Peng, Ying-Jie Xia, Takuya Yashiro, Xiong Gao, Tina Ting-Xia Dong, Karl Wah-Keung Tsim, Huai-You Wang
Summary: Two new phenylpropanoids and one new isoflavone glycoside, along with nine known compounds, were isolated from Ceratonia siliqua L. pods. Their chemical structures were determined and compared with literature data. In addition, compounds 4, 5, and 12 exhibited inhibitory activity against acetylcholinesterase.
NATURAL PRODUCT RESEARCH
(2023)
Article
Multidisciplinary Sciences
Xiaoying Ding, Huaiyou Wang, Hengyang Li, Tao Wang, Shenghui Hao, Wenjie Li, Chengyue Wang, Lei Wang, Yuguang Zheng, Qi An, Long Guo, Dan Zhang
Summary: In this study, response surface methodology (RSM) and artificial neural network (ANN) were used to predict and validate the optimal processing method of Schizonepetae Herba Carbonisata (SHC). The highest overall desirability (OD) value of the total flavonoids content (TFC), total tannin content (TTC), and adsorption capacity (AC) were used as response values. The optimal processing technology processing time lasted 10 min at a processing temperature of 178 degrees C and the herbs/machine had a volume of 77 g/5 L.
Article
Food Science & Technology
Yan Jin, Caroline Yang Wang, Weihui Hu, Yun Huang, Miranda Li Xu, Huaiyou Wang, Xiangpeng Kong, Yicun Chen, Tina Tingxia Dong, Qiwei Qin, Karl Wah Keung Tsim
FOOD QUALITY AND SAFETY
(2019)