Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer’s disease

Learning induces transient upregulation of brevican in the auditory cortex during consolidation of long-term memories

(2019) Hartmut Niekisch et al.   JOURNAL OF NEUROSCIENCE

Performance of Fully Automated Plasma Assays as Screening Tests for Alzheimer Disease–Related β-Amyloid Status

(2019) Sebastian Palmqvist et al.   JAMA Neurology

National Institute on Aging – Alzheimer's Association Research Framework lays the groundwork for deeper understanding of Alzheimer's disease

(2018) David S. Knopman et al.   Alzheimers & Dementia

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease

(2018) Shorena Janelidze et al.   NEUROLOGY

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Caspase-8, association with Alzheimer’s Disease and functional analysis of rare variants

(2017) Jan Rehker et al.   PLoS One

Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

(2017) Sebastian Palmqvist et al.   Nature Communications

A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort

(2017) Steve Pedrini et al.   Scientific Reports

Urokinase-type Plasminogen Activator (uPA) Binding to the uPA Receptor (uPAR) Promotes Axonal Regeneration in the Central Nervous System

(2016) Paola Merino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

(2016) Bob Olsson et al.   LANCET NEUROLOGY

Plasma tau in Alzheimer disease

(2016) Niklas Mattsson et al.   NEUROLOGY

Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis

(2016) Niklas Mattsson et al.   Nature Communications

A targeted proteomic multiplex CSF assay identifies increased malate dehydrogenase and other neurodegenerative biomarkers in individuals with Alzheimer’s disease pathology

(2016) R W Paterson et al.   Translational Psychiatry

CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios: better diagnostic markers of Alzheimer disease

(2016) Shorena Janelidze et al.   Annals of Clinical and Translational Neurology

GWAS of longitudinal amyloid accumulation on18F-florbetapir PET in Alzheimer’s disease implicates microglial activation geneIL1RAP

(2015) Vijay K Ramanan et al.   BRAIN

Chitinase 3-like 1: prognostic biomarker in clinically isolated syndromes

(2015) Ester Cantó et al.   BRAIN

Different definitions of neurodegeneration produce similar amyloid/neurodegeneration biomarker group findings

(2015) Clifford R. Jack et al.   BRAIN

Amyloid   Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases

(2015) M. Brkic et al.   JOURNAL OF NEUROSCIENCE

Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease

(2015) Daniel Alcolea et al.   NEUROBIOLOGY OF AGING

Advanced glycation end products are mitogenic signals and trigger cell cycle reentry of neurons in Alzheimer's disease brain

(2015) Angela Kuhla et al.   NEUROBIOLOGY OF AGING

The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease

(2015) Megan M. Varnum et al.   NEUROBIOLOGY OF AGING

Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease

(2015) Daniel Alcolea et al.   NEUROLOGY

Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke

(2015) A P Shabanzadeh et al.   Cell Death & Disease

Plasma proteins predict conversion to dementia from prodromal disease

(2014) Abdul Hye et al.   Alzheimers & Dementia

A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death

(2014) Monica K Wetzel-Smith et al.   NATURE MEDICINE

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Homogenous 96-Plex PEA Immunoassay Exhibiting High Sensitivity, Specificity, and Excellent Scalability

(2014) Erika Assarsson et al.   PLoS One

OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice

(2014) M. Shimamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accuracy of Brain Amyloid Detection in Clinical Practice Using Cerebrospinal Fluid β-Amyloid 42

(2014) Sebastian Palmqvist et al.   JAMA Neurology

SPARC Regulates Microgliosis and Functional Recovery following Cortical Ischemia

(2013) S. M. Lloyd-Burton et al.   JOURNAL OF NEUROSCIENCE

Tissue plasminogen activator arrests Alzheimer's disease pathogenesis

(2013) Shin Bi Oh et al.   NEUROBIOLOGY OF AGING

Genetic Susceptibility for Alzheimer Disease Neuritic Plaque Pathology

(2013) Joshua M. Shulman et al.   JAMA Neurology

Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease

(2012) James D. Doecke   ARCHIVES OF NEUROLOGY

CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings

(2012) T. T. Seppala et al.   NEUROLOGY

Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease

(2012) M. Watabe-Rudolph et al.   NEUROLOGY

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease

(2011) Seo-Hyun Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The BMP Coreceptor RGMb Promotes While the Endogenous BMP Antagonist Noggin Reduces Neurite Outgrowth and Peripheral Nerve Regeneration by Modulating BMP Signaling

(2011) C. H. E. Ma et al.   JOURNAL OF NEUROSCIENCE

Advanced glycation end product level, diabetes, and accelerated cognitive aging

(2011) K. Yaffe et al.   NEUROLOGY

Cerebrospinal Fluid Microglial Markers in Alzheimer’s Disease: Elevated Chitotriosidase Activity but Lack of Diagnostic Utility

(2011) Niklas Mattsson et al.   NEUROMOLECULAR MEDICINE

A Blood-Based Screening Tool for Alzheimer's Disease That Spans Serum and Plasma: Findings from TARC and ADNI

(2011) Sid E. O'Bryant et al.   PLoS One

YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease

(2010) Rebecca Craig-Schapiro et al.   BIOLOGICAL PSYCHIATRY

A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB

(2009) Anna C. Need et al.   HUMAN MOLECULAR GENETICS

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ-Degrading Enzymes in Alzheimer's Disease

(2008) James Scott Miners et al.   BRAIN PATHOLOGY