Article
Pediatrics
Christina Taylan, Anne Schaaf, Corina Dorn, Claus Peter Schmitt, Sebastian Loos, Nele Kanzelmeyer, Lars Pape, Dominik Mueller, Lutz T. Weber, Julia Thumfart
Summary: This study retrospectively analyzed the treatment of therapeutic apheresis in 298 children and adolescents. The results showed that therapeutic apheresis is a safe treatment procedure in this population, and immunoadsorption has fewer complications compared to plasma exchange.
FRONTIERS IN PEDIATRICS
(2022)
Review
Urology & Nephrology
Yi-Yuan Chen, Xin Sun, Wei Huang, Fang-Fang He, Chun Zhang
Summary: Therapeutic apheresis, including techniques such as plasma exchange, double-filtration plasmapheresis, immunoadsorption, and low-density lipoprotein apheresis, has become an important treatment option for kidney diseases. While plasma exchange remains the leading therapy, there is growing evidence supporting the potential benefits of double-filtration plasmapheresis and immunoadsorption. More research, particularly randomized controlled trials, is needed. Additionally, low-density lipoprotein apheresis is an important supplementary therapy for certain kidney diseases. This review aims to compare and determine the optimal therapeutic regimens for specific kidney diseases.
Article
Multidisciplinary Sciences
Insha Zahoor, Hamid Suhail, Indrani Datta, Mohammad Ejaz Ahmed, Laila M. Poisson, Jeffrey Waters, Faraz Rashid, Rui Bin, Jaspreet Singh, Mirela Cerghet, Ashok Kumar, Md Nasrul Hoda, Ramandeep Rattan, Ashutosh K. Mangalam, Shailendra Giri
Summary: Metabolic aberrations were found to impact the pathogenesis of relapsing-remitting multiple sclerosis, with changes in multiple metabolic pathways identified in patient samples. Enhanced glycolysis in immune cells of MS patients was observed, and treatment with a glycolytic inhibitor showed promising effects in ameliorating disease progression by promoting an antiinflammatory phenotype. This study highlights the potential of blood-based metabolomic approaches in identifying therapeutic targets for developing new treatment strategies for multiple sclerosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cardiac & Cardiovascular Systems
Wolfgang Ries, Jan Torzewski, Franz Heigl, Christian Pfluecke, Sebastian Kelle, Harald Darius, Hueseyin Ince, Steffen Mitzner, Peter Nordbeck, Christian Butter, Horst Skarabis, Ahmed Sheriff, Christoph D. Garlichs
Summary: This study aimed to investigate the relationship between CRP levels, myocardial infarct size and function, and the safety and efficacy of CRP apheresis in STEMI patients. The results showed significant differences in the correlation between CRP concentration and infarct size, as well as LV function, between the CRP apheresis group and the control group. CRP apheresis effectively reduced CRP levels without relevant side effects and has the potential to interfere with deleterious aspects of STEMI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Clinical Neurology
Rita Rodrigues, Raquel Rocha, Goncalo Bonifacio, Daniela Ferro, Francisco Sabenca, Ana Isabel Goncalves, Filipe Correia, Joaquim Pinheiro, Jose Leal Loureiro, Rui Pedro Guerreiro, Jose Vale, Maria Jose Sa, Andreia Costa
Summary: Therapeutic inertia (TI) is a common issue in the management of RRMS patients in Portugal, with approximately 1 in 5 patients exhibiting TI. Factors such as absence of relapses, current use of disease-modifying therapies (DMT), absence of adverse events, and care level of the treatment center are associated with TI. Further studies are needed to explore the impact of these factors on therapeutic decisions in RRMS patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Review
Critical Care Medicine
Sherif Hanafy Mahmoud, Jessica Buhler, Eric Chu, Suzie A. Chen, Theresa Human
Summary: Therapeutic plasma exchange (TPE) is an extracorporeal process used to remove pathologic targets from the plasma, including in autoimmune disorders. TPE is increasingly used in neurointensive care and can remove drugs, potentially causing unintended consequences.
NEUROCRITICAL CARE
(2021)
Article
Immunology
Steffen Pfeuffer, Leoni Rolfes, Timo Wirth, Falk Steffen, Marc Pawlitzki, Andreas Schulte-Mecklenbeck, Catharina C. Gross, Marcus Brand, Stefan Bittner, Tobias Ruck, Luisa Klotz, Heinz Wiendl, Sven G. Meuth
Summary: Immunoadsorption demonstrated better outcomes compared to double-dose methylprednisolone for treating steroid-refractory acute multiple sclerosis relapses, and modulation of B cell function may be a potential mechanism of action for immunoadsorption.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Alyssa A. Toorop, Zoe Y. G. J. van Lierop, Liza M. Y. Gelissen, Elske Hoitsma, Esther M. P. E. Zeinstra, Luuk C. van Rooij, Caspar E. P. van Munster, Anke Vennegoor, Jop P. Mostert, Beatrijs H. A. Wokke, Nynke F. Kalkers, Erwin L. J. Hoogervorst, Jeroen J. J. van Eijk, Christiaan M. Roosendaal, Jolijn J. Kragt, Marijke Eurelings, Jessie van Genugten, Jessica Nielsen, Lgf Sinnige, Mark E. Kloosterziel, Edo P. J. Arnoldus, Gert W. van Dijk, Willem H. Bouvy, Mark H. J. Wessels, Lynn Boonkamp, Eva M. M. Strijbis, Bob W. van Oosten, Brigit A. De Jong, Birgit Lissenberg-Witte, Frederik Barkhof, Bastiaan Moraal, Charlotte E. Teunissen, Theo Rispens, Bernard M. J. Uitdehaag, Joep Killestein, Zoe L. E. van Kempen
Summary: Personalized extended interval dosing of natalizumab effectively controls disease activity in multiple sclerosis and can safely extend treatment intervals through therapeutic drug monitoring.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Xiaojuan Liu, Ming Xia, Di Liu, Haiyang Liu, Chengyuan Tang, Guochun Chen, Yu Liu, Fang Yuan, Hong Liu
Summary: This study evaluates the efficacy and safety of protein A immunoadsorption (PAIA) and therapeutic plasma exchange (TPE) for ANCA-associated vasculitis (AAV) patients with severe renal involvement. The results show that PAIA treatment effectively removes MPO-ANCA and IgG, and is superior to TPE in clearing MPO-ANCA. Furthermore, PAIA treatment has an advantage in reducing mortality. Higher serum creatinine, lower serum albumin or hemoglobin levels, age >60, and failure to achieve remission at 6 months independently predict the risk of end-stage renal disease (ESRD) or death in AAV patients.
ANNALS OF MEDICINE
(2023)
Article
Immunology
Stephanie N. Blandford, Neva J. Fudge, Chris P. Corkum, Craig S. Moore
Summary: Extracellular vesicles (EVs) secreted from cells have emerged as potential biomarkers for neurological conditions, including multiple sclerosis (MS). This study found that immune cell-derived EVs were significantly increased in the plasma of untreated RRMS patients, despite limited changes in circulating immune cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Chiara Zanetta, Massimo Filippi, Lucia Moiola
Summary: Fingolimod has been approved for the treatment of relapsing MS in both adults and children. Real-world data from Italy confirms its effectiveness in pediatric patients with active disease, supporting its use as a therapeutic strategy for pediatric MS.
NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Maria-Eleftheria Evangelopoulos, Georgios Koutsis, Fotini Boufidou, Manolis Markianos
Summary: Cholesterol levels may be associated with disease characteristics in multiple sclerosis, particularly with demyelination and immune response. This study found lower levels of plasma and cerebrospinal fluid cholesterol in patients with multiple sclerosis. Patients with positive oligoclonal bands had even lower cerebrospinal fluid cholesterol levels, which may be related to disease progression and enhanced humoral immune response.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Hematology
Erwin Strasser
Summary: Background: Therapeutic plasma exchange (TPE) is a widely used apheresis technology for the treatment of neurological disorders such as myasthenia gravis and Guillain-Barre syndrome. There is strong evidence from randomized controlled trials that TPE is effective and safe in these conditions. TPE is often combined with immunosuppressive therapy for optimal outcomes.
TRANSFUSION MEDICINE AND HEMOTHERAPY
(2023)
Article
Clinical Neurology
Kimitoshi Kimura, Youwei Lin, Hiromi Yamaguchi, Wakiro Sato, Daiki Takewaki, Misako Minote, Yoshimitsu Doi, Tomoko Okamoto, Ryosuke Takahashi, Takayuki Kondo, Takashi Yamamura
Summary: This study found that the frequency of IFN-gamma(+) Th1 cells was persistently higher in plasma exchange responders compared to nonresponders. The frequency of Th1 cells before treatment was highly predictive of a beneficial response, with an AUC of 0.902. Plasma exchange treatment decreased inflammation-related gene expressions in Th1 cells and positively correlated with the frequency of CD11c(+) B cells.
ANNALS OF NEUROLOGY
(2021)
Article
Clinical Neurology
Ahmed Abdelhak, Christian Cordano, W. John Boscardin, Eduardo Caverzasi, Jens Kuhle, Brandon Chan, Jeffrey M. Gelfand, Hao H. Yiu, Frederike C. Oertel, Alexandra Beaudry-Richard, Shivany Condor Montes, Jorge R. Oksenberg, Argentina Lario Lago, Adam Boxer, Julio C. Rojas-Martinez, Fanny M. Elahi, Jonah R. Chan, Ari J. Green
Summary: Treatment with the remyelinating agent clemastine in MS patients with no evidence of disease activity or progression was associated with a reduction of blood NfL, suggesting that neuroprotection is achievable and measurable with therapeutic remyelination.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Cardiac & Cardiovascular Systems
A. G. Bejinariu, M. Schilling, P. Mueller, L. Clasen, S. Gerguri, S. Angendohr, S. Katsianos, J. Schmidt, C. Brinkmeyer, S. G. Meuth, M. Kelm, H. Makimoto
Summary: The total atrial conduction time (TACT) measured by echocardiography can predict the risk of atrial fibrillation (AF) and stroke; adding TACT to the revised Framingham stroke risk profile (rFSRP) significantly improves the prediction of stroke incidence.
Article
Clinical Neurology
Harald Hefter, Dietmar Rosenthal, Alexander Jansen, Raphaela Brauns, Beyza Urer, Hans Bigalke, Hans-Peter Hartung, Sven G. Meuth, John-Ih Lee, Philipp Albrecht, Sara Samadzadeh
Summary: The study found that frequent injections of a complex protein-containing BoNT/A preparation are associated with a significantly higher risk of developing neutralizing antibodies (NABs) compared to injections with a complex protein-free BoNT/A preparation.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Isabel Lutfullin, Maria Eveslage, Stefan Bittner, Gisela Antony, Martina Flaskamp, Felix Luessi, Anke Salmen, Barbara Gisevius, Luisa Klotz, Catharina Korsukewitz, Achim Berthele, Sergiu Groppa, Florian Then Bergh, Brigitte Wildemann, Antonios Bayas, Hayrettin Tumani, Sven G. Meuth, Corinna Trebst, Uwe K. Zettl, Friedemann Paul, Christoph Heesen, Tania Kuempfel, Ralf Gold, Bernhard Hemmer, Frauke Zipp, Heinz Wiendl, Jan D. Luenemann
Summary: Obesity is associated with higher disease severity and poorer outcome in newly diagnosed patients with multiple sclerosis. The presence of obesity at disease onset is linked to higher disability at baseline and at follow-up periods of 2, 4, and 6 years. Obesity management could potentially improve the clinical outcome of multiple sclerosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Paul Disse, Isabel Aymanns, Nadine Ritter, Stefan Peischard, Lisanne Korn, Heinz Wiendl, Matthias Pawlowski, Stjepana Kovac, Sven G. Meuth, Thomas Budde, Nathalie Strutz-Seebohm, Bernhard Wunsch, Guiscard Seebohm
Summary: N-Methyl-D-aspartate receptors (NMDARs) are crucial for brain learning and information processing. Dysfunction of NMDARs can contribute to neurodegeneration and drug addiction. Developing selective NMDAR modulators is a promising approach for treating these diseases. We established a hiPSC-derived neural cell system to investigate the effects of NMDAR modulators and pharmaceuticals on human neurons.
BIOLOGICAL CHEMISTRY
(2023)
Review
Clinical Neurology
Yvonne Reiss, Sebastian Bauer, Bastian David, Kavi Devraj, Elif Fidan, Elke Hattingen, Stefan Liebner, Nico Melzer, Sven G. Meuth, Felix Rosenow, Theodor Rueber, Laurent M. Willems, Karl H. Plate
Summary: The blood-brain barrier (BBB) is a crucial physiological barrier that maintains the brain microenvironment necessary for proper neuronal function. Dysfunction of the BBB is a characteristic of neurological diseases including ischemia, brain tumors, neurodegenerative diseases, infections, and autoimmune neuroinflammatory disorders. Additionally, BBB dysfunction is involved in epilepsy, a brain disorder characterized by synchronized neuronal activity and seizures. While antiseizure drugs targeting neuronal hyperexcitability are not always effective, drugs specifically targeting the neurovasculature in epilepsy patients have not been explored. Understanding the mechanism of BBB compromise in epilepsy is important for its therapeutic potential.
Review
Clinical Neurology
Christoph Mueller, Saskia Elben, Gregory S. Day, Pedro Alves, Julien Hebert, David F. Tang-Wai, Olga Holtmann, Raffaele Iorio, Daniela Perani, Maarten J. Titulaer, Niels Hansen, Thorsten Bartsch, Andreas Johnen, Zslot Illes, Leah Borm, Alice G. Willison, Heinz Wiendl, Sven G. Meuth, Stjepana Kovac, Jens Boelte, Nico Melzer
Summary: This study aims to investigate whether autoimmune limbic encephalitis (ALE) with different associated autoantibodies (AABs) exhibit distinct neuropsychological manifestations and respond differently to immunotherapy. The results show that ALE patients with AABs against LGI1, CASPR2, and GAD65 commonly have memory deficits, along with deficits in attention, executive functions, and psychological function. However, there is currently no definite evidence supporting the notion that different AAB-types of ALE have distinct neuropsychological manifestations and respond differently to immunotherapy.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Biochemistry & Molecular Biology
Mercedeh Farhat Sabet, Sumanta Barman, Mathias Beller, Sven G. Meuth, Nico Melzer, Orhan Aktas, Norbert Goebels, Tim Prozorovski
Summary: Anti-NMDA receptor encephalitis is often associated with demyelinating disorders. Antibodies against the GluN1 subunit of the NMDA receptor reduce glutamatergic transmission and affect myelin formation. These antibodies have a toxic effect on mature neurons, leading to neuronal damage and myelin loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Saskia Rauber, Christina B. Schroeter, Christine Strippel, Christopher Nelke, Tillmann Ruland, Andre Dik, Kristin S. Golombeck, Liesa Regner-Nelke, Manuela Paunovic, Daniela Esser, Christian Muench, Felix Rosenow, Martijn van Duijn, Antonia Henes, Tobias Ruck, Ido Amit, Frank Leypoldt, Maarten J. Titulaer, Heinz Wiendl, Sven G. Meuth, Gerd Meyer zu Horste, Nico Melzer
Summary: Autoimmune encephalitis (AE) is a group of non-infectious inflammatory conditions of the central nervous system caused by an imbalanced immune response. Analysis of cerebrospinal fluid (CSF) protein profiles in AE patients with different autoantibodies revealed dysregulation in the complement system, imbalance between pro-inflammatory and anti-inflammatory proteins, dysregulation of proteins involved in synaptic transmission and neurodegeneration, as well as elevated levels of proteases and reduced protease inhibitors. Furthermore, distinct protein profiles were found in different AE subtypes, which may aid in identifying disease-specific biomarkers.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Clinical Neurology
Marie Madlener, Christine Strippel, Franziska S. Thaler, Kathrin Doppler, Klaus P. Wandinger, Jan Lewerenz, Marius Ringelstein, Rosa Roessling, Til Menge, Jonathan Wickel, Christoph Kellingshaus, Sigrid Mues, Andrea Kraft, Andreas Linsa, Simone C. Tauber, Florian Then Berg, Stefan T. Gerner, Asterios Paliantonis, Alexander Finke, Josef Priller, Ingo Schirotzek, Marie Suesse, Kurt W. Suehs, Christian Urbanek, Makbule Senel, Claudia Sommer, Tania Kuempfel, Harald Pruess, Gereon R. Fink, Frank Leypoldt, Nico Melzer, Michael P. Malter
Summary: This study investigated 101 patients with suspected autoimmune neurological syndromes (AINS) associated with glutamic acid decarboxylase (GAD) antibodies. The results showed that immunotherapy had moderate effectiveness in these patients, and serum GAD antibody levels and intrathecal GAD antibody synthesis did not predict clinical characteristics or treatment outcomes.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Christina B. Schroeter, Christopher Nelke, Marcus Schewe, Lucas Spohler, Alexander M. Herrmann, Thomas Muentefering, Niklas Huntemann, Maria Kuzikov, Philip Gribbon, Sarah Albrecht, Stefanie Bock, Petra Hundehege, Lea Christine Neelsen, Thomas Baukrowitz, Guiscard Seebohm, Bernhard Wuensch, Stefan Bittner, Tobias Ruck, Thomas Budde, Sven G. Meuth
Summary: This study identifies and validates three new activators of TREK1 channel, namely E1, B3, and A2. These compounds reduce levels of adhesion molecules on human brain and muscle endothelial cells without affecting cell viability. Among them, A2 has the strongest effect on adhesion molecules but lacks TREK1 activation in neuronal cells. This study provides new activators that might be employed to pharmacologically modulate TREK1 activity.
BIOLOGICAL CHEMISTRY
(2023)
Article
Immunology
Louisa Mueller-Miny, Michael Heming, Tobias Lautwein, Tobias Ruck, I-Na Lu, Heinz Wiendl, Gerd Meyer Zu Hoerste
Summary: This study aims to investigate the immediate effects of peripheral leukocyte depletion on cerebrospinal fluid (CSF) leukocytes. Using single cell RNA-sequencing, the researchers found that after peripheral leukocyte depletion with alemtuzumab, pDCs were still present in the CSF but depleted from the blood. This suggests partial decoupling between the CSF and blood compartments, highlighting the limited accessibility of the CNS to peripheral treatments.
JOURNAL OF NEUROIMMUNOLOGY
(2023)
Article
Clinical Neurology
Chi D. L. Nguyen, Aura Cecilia Jimenez-Moreno, Monika Merker, Charles Joseph Bowers, Nikoletta Nikolenko, Andreas Hentschel, Thomas Muentefering, Angus Isham, Tobias Ruck, Matthias Vorgerd, Vera Dobelmann, Genevieve Gourdon, Ulrike Schara-Schmidt, Andrea Gangfuss, Charlotte Schroeder, Albert Sickmann, Claudia Gross, Grainne Gorman, Werner Stenzel, Laxmikanth Kollipara, Denisa Hathazi, Sally Spendiff, Cynthia Gagnon, Corinna Preusse, Elise Duchesne, Hanns Lochmueller, Andreas Roos
Summary: This study aimed to identify a blood biomarker for patients with myotonic dystrophy type 1 (DM1). The results showed that Periostin may serve as a novel biomarker for DM1, correlating with disease severity, cardiac dysfunction, and fibrosis.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Daniel Weiss, Henrik Lang, Christian Rubbert, Kai Jannusch, Marius Kaschner, Vivien Lorena Ivan, Julian Caspers, Bernd Turowski, Robin Jansen, John-Ih Lee, Tobias Ruck, Sven Guenther Meuth, Michael Gliem
Summary: The study investigated whether computed tomography perfusion (CT-P) parameters could be used to differentiate between different etiologies of internal carotid artery (ICA) occlusion, and found that CT-P parameters, specifically mean transit time (MTT), can distinguish between embolic and macroangiopathic occlusions.
CLINICAL NEURORADIOLOGY
(2023)
Article
Immunology
Amelie Semmler, Anna Katharina Mundorf, Anna Sabrina Kuechler, Karin Schulze-Bosse, Harald Heidecke, Kai Schulze-Forster, Matthias Schott, Markus Uhrberg, Sandra Weinhold, Karl J. Lackner, Marc Pawlitzki, Sven Guenther Meuth, Fritz Boege, Jana Ruhrlaender
Summary: SARS-CoV-2 mRNA vaccination may lead to chronic fatigue/dysautonomia known as post-acute COVID-19 vaccination syndrome (PACVS). Receptor autoantibodies and interleukin-6 (IL-6) were identified as somatic correlates of PACVS. Diagnostic blood markers, including increased Angiotensin II type 1 receptor antibodies, decreased alpha-2B adrenergic receptor antibodies, and elevated IL-6, can distinguish PACVS from normal post-vaccination state.
