Article
Cell Biology
Ying-Ren Chen, Chih-Sung Liang, Hsin Chu, Joachim Voss, Xiao Linda Kang, Grant O'Connell, Hsiu-Ju Jen, Doresses Liu, Shu-Tai Shen Hsiao, Kuei-Ru Chou
Summary: Blood-based biomarkers have shown high diagnostic accuracy for detecting Alzheimer's disease, with plasma A beta 42, A beta oligomer, and plasma tau demonstrating good sensitivity and specificity. However, evidence for detecting amnestic mild cognitive impairment using blood-based biomarkers is still limited. Ultra-high sensitive technology can help explain the heterogeneity in diagnostic performance.
AGEING RESEARCH REVIEWS
(2021)
Article
Medicine, General & Internal
Yu-Kai Lin, Chih-Sung Liang, Chia-Kuang Tsai, Chia-Lin Tsai, Jiunn-Tay Lee, Yueh-Feng Sung, Chung-Hsing Chou, Hung-Sheng Shang, Bing-Heng Yang, Guan-Yu Lin, Ming-Wei Su, Fu-Chi Yang
Summary: This study assessed the potential of 36 trace elements in predicting cognitive decline in patients with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease (AD). The study found that disease severity was linked to lower plasma levels of certain trace elements, and baseline levels of certain trace elements were associated with the rate of cognitive decline.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Yuting Nie, Changbiao Chu, Qi Qin, Huixin Shen, Lulu Wen, Yi Tang, Miao Qu
Summary: This study identified significant differences in lipid metabolism between Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) patients compared to normal controls (NC). Three sphingomyelin (SPH) biomarkers were found to effectively distinguish AD and aMCI patients from NC. Additionally, AD patients exhibited elevated oxidative stress, and there were complex interactions between lipid metabolites and oxidative stress.
Article
Neurosciences
Xiaotong Wei, Xiaotong Du, Yingying Xie, Xinjun Suo, Xiaoxi He, Hao Ding, Yu Zhang, Yi Ji, Chao Chai, Meng Liang, Chunshui Yu, Yong Liu, Wen Qin
Summary: By mapping the region-specific nonlinear atrophic trajectory of the whole cerebrum from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD), this study found that the atrophic trajectory is quadratic accelerated, especially in the superior temporal pole, caudate, and hippocampus. Furthermore, the study revealed that APOE ε4 carriers and younger patients had faster atrophic rates in specific regions. Lastly, the identified region-specific biomarkers were able to predict AD conversion within 10 years.
Article
Clinical Neurology
Hatice Eraslan Boz, Koray Kocoglu, Muege Akkoyun, Isil Yagmur Tufekci, Merve Ekin, Guelden Akdal
Summary: The study found that visual search impairment exists in early stages of both AD and aMCI, highlighting the importance of addressing visual processes in the Alzheimer's continuum.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Huei-Chun Liu, Hsin-Hsien Chen, Chia-Shin Ho, Jui-Feng Chang, Chia-Chun Lin, Ming-Jang Chiu, Ta-Fu Chen, Chaur-Jong Hu, Sui-Hing Yan, Yu Sun, Shieh-Yueh Yang
Summary: The study found that increasing the number of repeated tests can reduce the coefficients of variation (CVs) in measuring plasma biomarkers associated with Alzheimer's disease, ensuring reliable results.
NEUROLOGY AND THERAPY
(2021)
Article
Neurosciences
Marina Botello-Marabotto, M. Carmen Martinez-Bisbal, Miguel Calero, Andrea Bernardos, Ana B. Pastor, Miguel Medina, Ramon Martinez-Manez
Summary: This study employed 1H NMR spectroscopy to conduct a metabolomic study in serum samples from patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively healthy controls (HC). The aim was to search for potential metabolite biomarkers. The results highlight the potential of 1H NMR metabolomics to support the diagnosis of dementia in a less invasive way, and provide a starting point for the study of potential biomarkers to identify MCI or HC subjects at risk of developing AD in the future.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Xiaomei Zhong, Ben Chen, Le Hou, Qiang Wang, Meiling Liu, Mingfeng Yang, Min Zhang, Huarong Zhou, Zhangying Wu, Si Zhang, Gaohong Lin, Yuping Ning
Summary: This study aimed to compare temporal variability in the spontaneous fluctuations of activity and connectivity between amnestic MCI (aMCI) and nonamnestic MCI (naMCI). The results showed that both aMCI and naMCI patients exhibited abnormal brain activity and connectivity. The variability in dALFF, dReHo, and hippocampal dFC was different between aMCI and naMCI patients and was associated with cognitive scores. The dReHo of the superior parietal lobule and dFC of the hippocampus-cerebellum contributed to the memory heterogeneity of MCI subtypes.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Geriatrics & Gerontology
Eun Jin Yoon, Jun-Young Lee, Seyul Kwak, Yu Kyeong Kim
Summary: Mild behavioral impairment (MBI) is a neurobehavioral syndrome associated with a higher risk of progression to Alzheimer's disease (AD) in individuals with amnestic mild cognitive impairment (MCI). The presence of multiple MBI domains is also associated with cortical thinning in specific brain regions.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Haichao Zhao, Jian Cheng, Tao Liu, Jiyang Jiang, Forrest Koch, Perminder S. Sachdev, Peter J. Basser, Wei Wen
Summary: White matter abnormalities, such as orientational changes in specific fiber tracts, were found to be prominent in Alzheimer's disease patients compared to cognitively normal individuals. In contrast, individuals with amnestic mild cognitive impairment showed subtle changes in specific fiber tracts that were associated with cognitive performance. These findings suggest that white matter fiber orientation information could offer valuable insights into the pathology of neurodegenerative diseases like Alzheimer's disease.
HUMAN BRAIN MAPPING
(2021)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Article
Clinical Neurology
Alexa Pichet Binette, Sebastian Palmqvist, Divya Bali, Gill Farrar, Christopher J. Buckley, David A. Wolk, Henrik Zetterberg, Kaj Blennow, Shorena Janelidze, Oskar Hansson
Summary: This study found that the combination of plasma p-tau217 and a brief cognitive composite score is strongly associated with the risk of progression to AD dementia in MCI patients. These findings suggest that these measures could be key components of future prognostic algorithms for early AD.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Neurosciences
Erin E. Sundermann, Lisa L. Barnes, Mark W. Bondi, David A. Bennett, David P. Salmon, Pauline M. Maki
Summary: This study found that sex-adjusted norms improve diagnostic accuracy for aMCI, avoiding diagnostic errors. The risk of false negative in women and false positive in men is significantly higher than expected.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Yirong He, Qiongling Li, Zhenrong Fu, Debin Zeng, Ying Han, Shuyu Li
Summary: Using connectome gradient mapping, we investigated the altered topological organization in amnestic mild cognitive impairment and Alzheimer's disease. Our results showed that Alzheimer's disease patients exhibited a more distributed and significant suppression of the neocortical hierarchy gradient, while this alteration was limited to limbic areas in amnestic mild cognitive impairment patients. Furthermore, we found that gradient dispersion was associated with cognitive scores in both patient groups, providing new evidence for altered brain hierarchy in these conditions.
Article
Clinical Neurology
Dan Li, Yue-Yi Yu, Nan Hu, Min Zhang, Li Liu, Li-Mei Fan, Shi-Shuang Ruan, Fen Wang
Summary: This study compared the reliability and validity of the color-picture version of BNT (CP-BNT) and the black-and-white version of BNT (BW-BNT) in differentiating amnestic mild cognitive impairment (aMCI) or mild Alzheimer's disease (AD) from cognitive normals. The results showed that CP-BNT outperformed BW-BNT in terms of diagnostic accuracy and reliability.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychiatry
Tien-Wei Hsu, Ya-Mei Bai, Shih-Jen Tsai, Tzeng-Ji Chen, Chih-Sung Liang, Mu-Hong Chen
Summary: Few studies have investigated the parental risk of major psychiatric disorders among patients with comorbid autism spectrum disorder and attention deficit hyperactivity disorder. This study found that the parents of patients with autism spectrum disorder-only had a different incidence of major psychiatric disorders compared to the parents of patients with attention deficit hyperactivity disorder-only and dual-diagnosis.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Dian-Jeng Li, Mu-Hong Chen, Ya-Mei Bai, Shih-Jen Tsai, Chih-Ming Cheng, Tung-Ping Su, Tzeng-Ji Chen, Ta-Chuan Yeh, Chih-Sung Liang
Summary: This study found that offspring of parents with bipolar disorder have a higher risk of exposure to prescription opioids and developing pain disorders.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Oncology
Tien-Wei Hsu, Chih-Sung Liang, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen
Summary: Evidence suggests that childhood and adolescent cancer survivors have an increased long-term risk of major psychiatric disorders. However, it remains unclear whether these associations vary for different types of cancers.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Psychiatry
Dian-Jeng Li, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Chih-Sung Liang, Mu-Hong Chen
Summary: This study aimed to investigate the association between a history of premenstrual dysphoric disorder (PMDD) and the subsequent risk of major affective disorders. The results showed that women with PMDD had a higher risk of developing unipolar depression and bipolar disorder compared to those without PMDD.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Review
Dermatology
Chia-Ling Yu, Po-Yi Chou, Chih-Sung Liang, Li-Huei Chiang, Tzu-Yu Wang, Yu-Kang Tu, Ching-Chi Chi
Summary: This study conducted a systematic review and meta-analysis, finding no evidence of an association between isotretinoin use and inflammatory bowel disease (IBD). Therefore, isotretinoin should not be withheld due to unnecessary concerns for the development of IBD.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Review
Neurosciences
Liu Shu-Tsen, Lin Sheng-Che, Chang Jane Pei-Chen, Yang Kai-Jie, Chu Che-Sheng, Yang Chia-Chun, Liang Chih-Sung, Sun Ching-Fang, Wang Shao-Cheng, Senthil Kumaran Satyanarayanan, Su Kuan-Pin
Summary: There is growing evidence that COVID-19 is associated with increased risks of psychiatric sequelae, including depression, anxiety, cognitive impairments, sleep disturbance, and fatigue. This review provides timely updates on clinical research findings and identifies potential key targets for developing effective treatment strategies for long COVID. Additionally, the Formosa Long COVID Multicenter Study (FOCuS) applies the inflammation theory to the pathogenesis and treatment of post-COVID depression and anxiety.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Psychology, Developmental
Shih-Jen Tsai, Wen-Han Chang, Chih-Ming Cheng, Chih-Sung Liang, Ya-Mei Bai, Ju-Wei Hsu, Kai-Lin Huang, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen
Summary: Evidence suggests that autistic individuals have increased risks of mortality, including natural-cause, suicide, and accident mortalities. A study conducted in Taiwan found that autistic individuals had higher likelihoods of all-cause mortality, natural-cause mortality, and suicide mortality compared with non-autistic individuals. Autistic males were more likely to die by suicide, and autistic females were more likely to die of accident compared with non-autistic individuals.
Correction
Dermatology
Chia-Ling Yu, Po-Yi Chou, Chih-Sung Liang, Li-Huei Chiang, Tzu-Yu Wang, Yu-Kang Tu, Ching-Chi Chi
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Letter
Dermatology
Chia-Ling Yu, Po-Yi Chou, Chih-Sung Liang, Li-Huei Chiang, Tzu-Yu Wang, Yu-Kang Tu, Ching-Chi Chi
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Article
Psychiatry
Che-Sheng Chu, Shu-Li Cheng, Ya-Mei Bai, Tung-Ping Su, Shih-Jen Tsai, Tzeng-Ji Chen, Fu-Chi Yang, Mu-Hong Chen, Chih-Sung Liang
Summary: Individuals with dementia who have multiple comorbidities such as fractures, urinary and pulmonary infections, upper gastrointestinal bleeding, and nasogastric intubation face a higher risk of mortality within 5 years compared to those with cancer or cardiometabolic comorbidities.
PSYCHIATRY INVESTIGATION
(2023)
Review
Medicine, General & Internal
Berne Ting, Daniel Tzu-Li Chen, Wei-Ti Hsu, Chih-Sung Liang, Ikbal Andrian Malau, Wei-Chih Li, Sheau-Ling Lee, Li Jingling, Kuan-Pin Su
Summary: Music interventions have been widely used to relieve anxiety in dementia patients, and a limited meta-analysis with randomized controlled trials was conducted. The results showed that music interventions significantly reduced anxiety symptoms, especially for Alzheimer's disease and mixed-type dementia. Significant improvements in agitation and depression in dementia were also observed. Several psychological mechanisms related to music interventions were comprehensively reviewed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychiatry
Yang-Chieh Brian Chen, Po-Han Chou, Yu-Kang Tu, Andre R. Brunoni, Kuan-Pin Su, Ping-Tao Tseng, Chih-Sung Liang, Pao-Yen Lin, Andre F. Carvalho, Kuo-Chuan Hung, Chih-Wei Hsu, Cheng-Ta Li
Summary: This meta-analysis investigated the follow-up effect of acute repetitive transcranial magnetic stimulation (rTMS) for major depressive episodes and the benefits of maintenance rTMS. The results showed that maintenance rTMS could keep patients' mood relatively stable for up to 5 months after acute rTMS. Monthly or more frequent maintenance rTMS offered greater benefits, with sustained effects for up to 6-12 months.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Chia-Ling Yu, Andre F. Carvalho, Trevor Thompson, Tzu-Cheng Tsai, Ping-Tao Tseng, Chih-Wei Hsu, Tien-Wei Hsu, Chih-Sung Liang
Summary: This study found that risperidone showed superior efficacy for acute mania, while brexpiprazole showed inferior efficacy. The antipsychotic dose equivalents for acute mania differed from those for schizophrenia, with higher doses for quetiapine and aripiprazole, and lower doses for haloperidol and risperidone.
Article
Endocrinology & Metabolism
Tien-Wei Hsu, Mu-Hong Chen, Ya-Mei Bai, Wen-Han Chang, Chih-Ming Cheng, Tung-Ping Su, Tzeng-Ji Chen, Shih-Jen Tsai, Chih-Sung Liang
Summary: This study aimed to examine the risk of T1D, MDD, ADHD, and ASD in first-degree relatives of T1D patients. The results showed that FDRs of individuals with T1D had a higher risk of T1D and MDD compared to controls. Stratified by sex and kinship, female FDRs had an increased risk of MDD, while male FDRs had an increased risk of ADHD. Furthermore, FDRs of individuals with T1D and DKA had a higher risk of MDD and ADHD.
ACTA DIABETOLOGICA
(2023)
Article
Medicine, General & Internal
Yu-Wei Lin, Yu-Kang Tu, Kuo-Chuan Hung, Chih-Sung Liang, Ping-Tao Tseng, Pao-Yen Lin, Edward Chia-Cheng Lai, Chih-Wei Hsu
Summary: Zuranolone, a promising antidepressant, has been found to effectively alleviate depression and anxiety symptoms. However, it is associated with potential side effects. A daily dose of 30 mg appears to be the optimal choice.
