期刊
JOURNAL OF CLINICAL MEDICINE
卷 8, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/jcm8122059
关键词
microvesicles; inflammation; lipoproteins; LDL cholesterol; microparticles; cardiovascular disease; platelets; endothelial cells; leukocytes; atherothrombosis
资金
- Spanish Ministry of Economy and Competitiveness of Science [SAF2016-76819-R]
- Institute of Health Carlos III (ISCIII) [TERCEL-RD16/0011/0018, CIBERCV CB16/11/00411]
- FEDER Una Manera de Hacer Europa
- Agency for Management of University and Research [2017SGR1480]
Atherothrombosis is the principal underlying cause of cardiovascular disease (CVD). Microvesicles (MV) are small blebs originated by an outward budding at the cell plasma membranes, which are released in normal conditions. However, MV release is increased in pathophysiologic conditions such as CVD. Low density lipoprotein (LDL) and MV contribute to atherothrombosis onset and progression by promoting inflammation and leukocyte recruitment to injured endothelium, as well as by increasing thrombosis and plaque vulnerability. Moreover, (oxidized)LDL induces MV release and vice-versa, perpetuating endothelium injury leading to CVD progression. Therefore, MV and lipoproteins exhibit common features, which should be considered in the interpretation of their respective roles in the pathophysiology of CVD. Understanding the pathways implicated in this process will aid in developing novel therapeutic approaches against atherothrombosis.
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