Article
Oncology
Fuqun Wei, Qizhen Huang, Yang Zhou, Liuping Luo, Yongyi Zeng
Summary: Both repeat hepatectomy and RFA are effective and safe treatment options for RHCC located in the subcapsular region, with no significant differences in terms of recurrence-free survival and overall survival between the two treatments.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Chenwei Wang, Kai Li, Zhenkun Huang, Yichuan Yuan, Wei He, Yun Zheng, Ruhai Zou, Binkui Li, Yunfei Yuan, Jiliang Qiu
Summary: This study compared the treatment efficacy of repeat hepatectomy (RH) and percutaneous ablation (PA) in early-stage rHCC patients with early or late recurrence. The results showed that both RH and PA can offer comparable survival rates and recurrence rates for early-stage rHCC patients, regardless of whether they experience early or late recurrence.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Chenwei Wang, Kai Li, Zhenkun Huang, Yichuan Yuan, Wei He, Yun Zheng, Ruhai Zou, Binkui Li, Yunfei Yuan, Jiliang Qiu
Summary: This study aimed to compare the treatment efficacy of repeat hepatectomy (RH) and percutaneous ablation (PA) in early-stage recurrent hepatocellular carcinoma (rHCC) patients with early or late recurrence. The results showed that RH and PA had similar 5-year overall survival (OS) and repeat recurrence-free survival (rRFS) rates for both early and late recurrence patients. Therefore, both RH and PA are feasible treatment options for early-stage rHCC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tae Hyun Kim, Young Hwan Koh, Bo Hyun Kim, Min Ju Kim, Ju Hee Lee, Boram Park, Joong-Won Park
Summary: The study compared proton beam radiotherapy (PBT) and radiofrequency ablation (RFA) outcomes in patients with recurrent/residual HCC, demonstrating non-inferiority of PBT in terms of 2-year local progression-free survival (LPFS). The most common adverse events with PBT were radiation pneumonitis and decreased leukocyte counts, while RFA resulted in increased alanine aminotransferase levels and abdominal pain. PBT was found to be a tolerable and safe treatment option for patients with small recurrent hepatocellular carcinoma.
JOURNAL OF HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Yi-gang Zhang, Zhi-duan Xu, Hong-xiang Yin, Xiang-yang Zhao, Bo-wen Jiang, Yong Gao, Yi Tan
Summary: In the treatment of recurrent hepatocellular carcinoma (RHCC), this study compared the effectiveness of repeat hepatectomy (RH) and radiofrequency ablation (RFA). The results showed that RH was associated with better disease-free survival rates at 3 and 5 years, but had a higher morbidity rate compared to RFA.
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
(2022)
Article
Oncology
Xin Zheng, Yanqiao Ren, Hanqing Hu, Kun Qian
Summary: This study compared the efficacy and safety of TACE-RFA and repeat hepatectomy in treating recurrent HCC after curative resection. The results showed similar overall survival and progression-free survival between the two groups, but a significantly higher rate of major complications in the repeat hepatectomy group.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Nikolaos Machairas, Dimitrios Papaconstantinou, Panagiotis Dorovinis, Diamantis I. Tsilimigras, Myrto D. Keramida, Stylianos Kykalos, Dimitrios Schizas, Timothy M. Pawlik
Summary: In patients with recurrent hepatocellular carcinoma (HCC), both repeat hepatectomy (RH) and radiofrequency ablation (RFA) are viable treatment options. This systematic review and meta-analysis aimed to compare the outcomes of patients undergoing RH versus RFA for recurrent HCC. The results showed that both treatments had comparable overall and disease-free survival rates, but patients undergoing RH were less likely to develop a second recurrence. However, RH was associated with higher overall and major morbidity rates. Despite this, repeat resection remains the preferred option due to its better disease control.
Article
Oncology
Yeshong Park, Ho-Seong Han, Yoo-Seok Yoon, Chang Jin Yoon, Hae Won Lee, Boram Lee, Meeyoung Kang, Jinju Kim, Jai Young Cho
Summary: This study investigated the role of salvage hepatectomy (SH) as a rescue therapy for recurrent hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). The study found that SH showed safety and effectiveness equivalent to primary resection in terms of short-term and long-term outcomes. However, due to the higher grade and more aggressive behavior of recurrent tumors, more extensive resections with wide surgical margins are necessary to prevent recurrence.
Article
Surgery
Tomoki Ryu, Yuko Takami, Yoshiyuki Wada, Shin Sasaki, Hajime Imamura, Hiroki Ureshino, Hideki Saitsu
Summary: This study retrospectively reviewed 81 patients with multifocal hepatocellular carcinoma who underwent combined hepatectomy and microwave ablation, finding an overall survival rate of 54% at 5 years. The major complication rate post-surgery was 10%, with certain factors like des-gamma-carboxy prothrombin level and tumor characteristics identified as independent risk factors for survival outcomes. The study concludes that the combined procedure is safe and feasible for selected patients with multifocal HCC.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Gastroenterology & Hepatology
Wenzhen Ding, Jie Yu, Fangyi Liu, Xiaoling Yu, Zhigang Cheng, Zhiyu Han, Ping Liang
Summary: This study compares the practicability and medium-term therapeutic efficacy between microwave ablation and robot-assisted hepatectomy for early hepatocellular carcinoma. The results showed that both treatments achieved good and comparable medium-term therapeutic effects. Microwave ablation was found to be more minimally invasive, while robot-assisted hepatectomy had better accuracy and caused less damage to the liver parenchyma.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Maurizio Iaria, Giorgio Bianchi, Federico Fazio, Francesco Ardito, Pasquale Perri, Nicholas Pontarolo, Simone Conci, Matteo Donadon, Matteo Zanello, Quirino Lai, Simone Famularo, Sarah Molfino, Ivano Sciannamea, Luca Fumagalli, Paola Germani, Antonio Floridi, Cecilia Ferrari, Giuseppe Zimmitti, Albert Troci, Mauro Zago, Valentina Ferraro, Federica Cipriani, Stefan Patauner, Giuliano La Barba, Maurizio Romano, Giacomo Zanus, Giorgio Ercolani, Antonio Frena, Luca Aldrighetti, Riccardo Memeo, Enrico Pinotti, Michele Crespi, Moh'd Abu Hilal, Guido Griseri, Paola Tarchi, Marco Chiarelli, Adelmo Antonucci, Gian L. Baiocchi, Fabrizio Romano, Massimo Rossi, Elio Jovine, Guido Torzilli, Andrea Ruzzenente, Marcello Maestri, Gian L. Grazi, Felice Giuliante, Alessandro Ferrero, Raffaele Dalla Valle
Summary: In this study, the perioperative and long-term oncological outcomes of salvage hepatectomy for recurrent hepatocellular carcinoma after primary hepatectomy or locoregional treatments were evaluated in a large Western cohort. The results showed that salvage hepatectomy is as safe, feasible, and effective as primary hepatectomy in terms of long-term outcomes.
Review
Oncology
Fulong Hao, Hancong Li, Nan Li, Jiaxin Li, Hong Wu
Summary: This meta-analysis aimed to investigate the safety and overall effect of laparoscopic repeat hepatectomy (LRH) compared to open repeat hepatectomy (ORH) in patients with recurrent hepatocellular carcinoma (RHCC). The analysis revealed non-significant differences in several factors including operative time, blood transfusion, overall complications, mortality rates, and survival rates between LRH and ORH. However, LRH was associated with less bleeding volume and shorter length of stay compared to ORH.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Hidetoshi Gon, Masahiro Kido, Motofumi Tanaka, Kaori Kuramitsu, Shohei Komatsu, Masahide Awazu, Shinichi So, Hirochika Toyama, Takumi Fukumoto
Summary: Comparing surgical outcomes, it was found that laparoscopic repeat hepatectomy (LRH) was more favorable than open repeat hepatectomy (ORH) in treating patients with contralateral recurrent HCC, showing shorter operation time, less blood loss, similar postoperative complications, and shorter hospital stay.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Hong Jae Jeon, Hyuk Soo Eun, In Sun Kwon, Byung Seok Lee, Eaum Seok Lee, Woo Sun Rou, Jae Kyu Sung, Hee Seok Moon, Sun Hyung Kang, Hyun Seok Lee, Seok-Hwan Kim, Kwangsik Chun, Seok Hyun Kim
Summary: This study compared the therapeutic outcomes of laparoscopic radiofrequency ablation (LRFA) and percutaneous radiofrequency ablation (PRFA) in patients with hepatocellular carcinoma (HCC). The results revealed that LRFA was associated with longer recurrence-free survival and favorable overall survival compared to PRFA. Therefore, LRFA should be considered as the primary therapy for eligible HCC patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Surgery
Xiaozhun Huang, Yibin Liu, Lin Xu, Teng Ma, Xin Yin, Zhangkan Huang, Caibin Wang, Zhen Huang, Xinyu Bi, Xu Che
Summary: A meta-analysis comparing surgical radiofrequency ablation (SRFA) and percutaneous radiofrequency ablation (PRFA) for hepatocellular carcinoma (HCC) found that SRFA was superior to PRFA in terms of local control rate. However, there were no significant differences between the two approaches in terms of complete ablation rate, postoperative complications, overall survival rate, and disease-free survival.
FRONTIERS IN SURGERY
(2022)
Article
Surgery
Hao Xing, Li-Yang Sun, Wen-Tao Yan, Bing Quan, Lei Liang, Chao Li, Ya-Hao Zhou, Hong Wang, Jian-Hong Zhong, Wei-Min Gu, Ting-Hao Chen, Ming-Da Wang, Han Wu, Timothy M. Pawlik, Wan Yee Lau, Meng-Chao Wu, Feng Shen, Tian Yang
Summary: The study showed that patients who underwent repeat hepatectomy for early recurrence of hepatocellular carcinoma had worse overall survival and disease-free survival compared to those with late recurrence. These findings can provide guidance for physicians in selecting patients for repeat hepatectomy.
Editorial Material
Medicine, Research & Experimental
Xin-Fei Xu, Lei Liang, Hao Xing, Feng Shen, Dong-Sheng Huang, Wan Yee Lau, Tian Yang
BIOMARKERS IN MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Han Wu, Ming-Da Wang, Lei Liang, Hao Xing, Cheng-Wu Zhang, Feng Shen, Dong-Sheng Huang, Tian Yang
Summary: Nanotechnology has gained extensive attention in surveillance, imaging, and treatment of hepatocellular carcinoma. Nanomedicines focus on early diagnosis and precise treatment of HCC, offering promising potential applications in future clinical practice.
Article
Surgery
Yong-Kang Diao, Jun-Wei Liu, Han Wu, Ming-Da Wang, Xin-Ping Fan, Ting-Hao Chen, Jian-Yu Wang, Ya-Hao Zhou, Wei-Min Gu, Hong Wang, Jie Li, Ying-Jian Liang, Zhi-Yu Chen, Wan Yee Lau, Lei Liang, Chao Li, Cheng-Wu Zhang, Feng Shen, Dong-Sheng Huang, Tian Yang
Summary: Adolescents and young adults (AYAs) in areas with endemic hepatitis B virus infection are more likely to develop hepatocellular carcinoma (HCC). After undergoing HCC resection, AYAs have a higher risk of recurrence than older adults, indicating a need for enhanced surveillance for postoperative recurrence among AYAs.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Gastroenterology & Hepatology
Lei Liang, Bing Quan, Han Wu, Yong-Kang Diao, Jie Li, Ting-Hao Chen, Yao-Ming Zhang, Ya-Hao Zhou, Wan-Guang Zhang, Hong Wang, Matteo Serenari, Matteo Cescon, Myron Schwartz, Yong-Yi Zeng, Ying-Jian Liang, Hang-Dong Jia, Hao Xing, Chao Li, Ming-Da Wang, Wen-Tao Yan, Wan-Yuan Chen, Wan Yee Lau, Cheng-Wu Zhang, Timothy M. Pawlik, Dong-Sheng Huang, Feng Shen, Tian Yang
Summary: An individualized patient-specific tool was developed and validated to predict the benefit of surgery for hepatocellular carcinoma (HCC) patients. The tool showed good performance in identifying patients at highest risk of death within 6 months of surgery, which may help guide surgical decision-making to avoid futile surgery.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Oncology
Lei Liang, Ming-Da Wang, Yao-Ming Zhang, Wan-Guang Zhang, Cheng-Wu Zhang, Wan Yee Lau, Feng Shen, Timothy M. Pawlik, Dong-Sheng Huang, Tian Yang
Summary: This study investigated long-term recurrence and survival after hepatectomy for high-AFP HCC, finding that postoperative incomplete biomarker response was the strongest risk factor for predicting poor overall survival and recurrence-free survival in these patients.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Oncology
Shilei Bai, Pinghua Yang, Zhihao Xie, Jun Li, Zhengqing Lei, Yong Xia, Guojun Qian, Baohua Zhang, Timothy M. Pawlik, Wan Yee Lau, Feng Shen
Summary: The study aimed to compare prognosis between liver resection (LR) and percutaneous radiofrequency ablation (PRFA) for hepatocellular carcinoma (HCC) based on preoperative predicted microvascular invasion (MVI) risk. LR was found to be oncologically superior over PRFA for early HCC patients with predicted high-risk of MVI and associated with improved local disease control in these patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Letter
Gastroenterology & Hepatology
Li-Yang Sun, Hang-Dong Jia, Lei Liang, Dong-Sheng Huang, Tian Yang
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Surgery
Ming-Da Wang, Li-Yang Sun, Guo-Jun Qian, Chao Li, Li-Hui Gu, Lan-Qing Yao, Yong-Kang Diao, Timothy M. Pawlik, Wan Yee Lau, Dong-Sheng Huang, Feng Shen, Tian Yang
Summary: This study evaluated and compared the use of AFP and PIVKA-II as biomarkers for detecting and predicting HCC. The results showed that preoperative PIVKA-II positivity was an independent risk factor for early recurrence after HCC resection, while the positivity rate of AFP was lower.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Immunology
Hongwei Fang, Zhun Sun, Zhouyi Chen, Anning Chen, Donglin Sun, Yan Kong, Hao Fang, Guojun Qian
Summary: Through bioinformatics and systems biology analysis, we identified common pathways and molecular biomarkers between COVID-19 and asthma, as well as potential molecular mechanisms and candidate drugs for treating patients with both COVID-19 and asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jian Liu, Hao Shen, Shengyu Huang, Jianbo Lin, Zhenlin Yan, Guojun Qian, Zhenghua Lu, Xuying Wan, Fabiao Zhang, Kui Wang, Yongjie Zhang, Jun Li
Summary: This study observed the effect of antiviral therapy (AVT) on viral reactivation and long-term outcomes after percutaneous radiofrequency ablation (PRFA) for HBV-related HCC. The results showed that AVT can reduce the occurrence of viral reactivation, decrease distal intrahepatic recurrence and late recurrence after 2 years, and improve the overall survival of patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Immunology
Anning Chen, Zhun Sun, Donglin Sun, Meiying Huang, Hongwei Fang, Jinyuan Zhang, Guojun Qian
Summary: This study identified chromatin-modifying enzyme-related genes, especially KDM6B, as critical players in the pathogenesis and progression of IPF. The findings provide new insights and potential targets for the diagnosis and treatment of IPF.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Zhun Sun, Anning Chen, Hongwei Fang, Donglin Sun, Meiying Huang, Erdeng Cheng, Mengyuan Luo, Xiaoren Zhang, Hao Fang, Guojun Qian
Summary: This study reveals that IL-10 derived from B cells plays a critical role in the resolution of acute lung injury (ALI). IL-10 inhibits inflammation and reduces leukocyte infiltration and prolonged damage. This finding has potential implications for the development of new therapeutic approaches.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Guojun Qian, Hongwei Fang, Anning Chen, Zhun Sun, Meiying Huang, Mengyuan Luo, Erdeng Cheng, Shengyi Zhang, Xiaokai Wang, Hao Fang
Summary: This study identified hub genes, shared pathways, molecular biomarkers, and candidate therapeutics for managing sepsis and sepsis-induced ARDS in the context of COVID-19 infection. The investigation revealed differentially expressed genes shared among COVID-19 and sepsis datasets, and key hub genes were validated using murine sepsis-ARDS models and blood samples from geriatric patients. The study provided insights into the immune response in geriatric patients with sepsis-induced ARDS, highlighted the association between sepsis/sepsis-ARDS and COVID-19, and proposed potential alternative pathways for targeted therapeutic interventions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Guojun Qian, Wenxia Jiang, Donglin Sun, Zhun Sun, Anning Chen, Hongwei Fang, Jingyao Wang, Yongzhong Liu, Zhinan Yin, Haiming Wei, Hao Fang, Xiaoren Zhang
Summary: IL-10 released from B cells plays a role in promoting allergic sensitization in asthma, and Bcl-3 inhibits this process by suppressing IL-10 production.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)