Article
Gastroenterology & Hepatology
Landry Laure Tsoumtsa Meda, Luce Landraud, Serena Petracchini, Stephane Descorps-Declere, Emeline Perthame, Marie-Anne Nahori, Laura Ramirez Finn, Molly A. Ingersoll, Rafael Patino-Navarrete, Philippe Glaser, Richard Bonnet, Olivier Dussurget, Erick Denamur, Amel Mettouchi, Emmanuel Lemichez
Summary: Bioinformatic analysis of E. coli genomes suggests the preferential distribution of the cnf1 gene in the pandemic MDR lineage ST131, leading to an expansion of cnf1-positive strains. The cnf1 gene enhances gut colonization capacities of ST131-H30Rx/C2.
Article
Microbiology
Giovanni Vedel, Xavier Triado-Margarit, Olmo Linares, Jose Manuel Moreno-Rojas, Eva de la Pena, Ignacio Garcia-Bocanegra, Debora Jimenez-Martin, Juan Carranza, Emilio O. Casamayor
Summary: We surveyed the gut microbiota of wild boar populations using 16S rRNA gene analysis of fresh faeces, and found that diet, gender, and form status were major factors influencing the composition and diversity of the gut microbiota. The abundance of Enterobacteriaceae in the gut microbiota was associated with lower diversity, particularly in males. Additionally, we observed an inverse relationship between thoracic circumference and Enterobacteriaceae abundance in males. Continuous artificial feeding in hunting estates may negatively affect the gut microbiota and form status of wild boars.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Ecology
Ewa Pikus, Peter O. Dunn, Piotr Minias
Summary: This study examined the relationship between MHC gene diversity and fitness-related traits in a population of Eurasian coot. The results showed that high MHC gene diversity was associated with poorer condition, weaker ornament expression, later onset of breeding, and smaller clutches. The study suggests that the costs of high MHC diversity outweighed the benefits in an urban landscape.
JOURNAL OF ANIMAL ECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kristopher D. Parker, Akhilendra K. Maurya, Hend Ibrahim, Sangeeta Rao, Petronella R. Hove, Dileep Kumar, Rama Kant, Bupinder Raina, Rajesh Agarwal, Kristine A. Kuhn, Komal Raina, Elizabeth P. Ryan
Summary: The study demonstrates that modified gut microbiota from humans consuming rice bran can protect mice from colon carcinogenesis, with specific microbial communities associated with colon health. The findings suggest that integrated dietary-FMT intervention strategies could be effective for colorectal cancer control, treatment, and prevention.
Article
Biology
Tian (Autumn) Qiu, Cindy J. Lee, Chen Huang, Dong-Kyu Lee, Stanislav S. Rubakhin, Elena V. Romanova, Jonathan V. Sweedler
Summary: The microbial metabolite d-alanine, derived from food and gut microbiota, accumulates in the pancreas, brain, and pituitary of mice. The sources of d-alanine in mice are shown to be microbiota and diet, rather than endogenous racemization. This research highlights the importance of investigating the biological functions of gut-microbiome derived d-alanine, especially its role in NMDAR-related activities in the microbiome-gut-brain axis.
COMMUNICATIONS BIOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Sainan Wang, Junyao Wang, Jiarui Zhang, Wenhao Liu, Wendan Jing, Bo Lyu, Hansong Yu, Zhao Zhang
Summary: High-purity IDF derived from okara (HPSIDF) combined with intermittent fasting (IF) treatment synergistically alleviated dyslipidemia, impaired glucose homeostasis, systemic inflammation, and fat accumulation induced by a high-fat diet (HFD). Furthermore, HPSIDF combined with IF treatment recovered gut microbiota dysbiosis and lowered short-chain fatty acid synthesis. Metabolomic analysis revealed that HPSIDF combined with IF treatment reversed the alterations of metabolic pathways and differential metabolites induced by HFD, which were linked to the modulations of the gut microbiota.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Dairy & Animal Science
Dimitrios Galamatis, Georgios A. Papadopoulos, Diamanto Lazari, Dimitrios Fletouris, Evanthia Petridou, Georgios Arsenos, Paschalis Fortomaris
Summary: The study found that supplementing organic laying hens' diet with 1% concentration of Salvia officinalis L. can improve the antioxidant status of eggs and reduce the microbial load in organic egg production systems.
Article
Microbiology
Lin Hu, Yu Yang
Summary: A new strain BIT-L3(T) belonging to a new genus and species within the family Enterobacteriaceae was isolated from the gut of plastic-eating meal-worm Tenebrio molitor L. Phylogenetic and biochemical analysis showed its uniqueness compared to other related species.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Cong Wang, Qing Liu, Fengchun Ye, Hongbo Tang, Yanpeng Xiong, Yongfei Wu, Luping Wang, Xuanbiao Feng, Shuiyin Zhang, Yongmei Wan, Jianhua Huang
Summary: The study demonstrates that adding purslane to feed can significantly improve the growth performance of Sanhuang broilers and positively influence their gut microbiota. The inclusion of purslane increases the abundance of Lactobacillus in the gut, promotes carbohydrate metabolism, and enhances the growth performance of Sanhuang broilers.
Article
Food Science & Technology
Jian Li, Qianying Deng, Yaqi Zhang, Daren Wu, Guiling Li, Jingwen Liu, Lingyu Zhang, Hui-Min David Wang
Summary: The study extracted three phenolic compounds from pickled radish and found that these compounds can inhibit lipid accumulation, prevent weight gain, and improve gut microbiota imbalance.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yuekun Wu, Lu Dong, Yujie Song, Yajing Wu, Yan Zhang, Shuo Wang
Summary: This study found that Physalis alkekengi L. fruit polysaccharide (PFP) can prevent insulin resistance induced by dietary advanced glycation end products (AGEs). PFP improved hyperglycemia, dyslipidemia, and insulin sensitivity in mice. The mechanism involves modulation of the gut microbiota and increased microbial metabolites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Carolina Simo, Tiziana Fornari, Monica R. Garcia-Risco, Ainize Pena-Cearra, Leticia Abecia, Juan Anguita, Hector Rodriguez, Virginia Garcia-Canas
Summary: In this study, a novel screening strategy was developed to evaluate the effects of food and natural extract on Klebsiella pneumoniae's TMA production. Oregano and red thyme extracts were found to have the potential to inhibit TMA formation.
Article
Veterinary Sciences
Liang Xiong, WenFei Zhang, Hao Zhao, ZheZhe Tian, Man Ren, Fang Chen, WuTai Guan, ShiHai Zhang
Summary: This study investigated the effects of dietary enzymatically treated Artemisia annua L. supplementation on heat-stressed sows. The results showed that enzymatically treated Artemisia annua L. improved sow performance, decreased inflammatory cytokine levels, and promoted the growth and gut development of piglets.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agriculture, Multidisciplinary
Mei Deng, Shuai Zhang, Lihong Dong, Fei Huang, Xuchao Jia, Dongxiao Su, Jianwei Chi, Zafarullah Muhammad, Qin Ma, Dong Zhao, Mingwei Zhang, Ruifen Zhang
Summary: This study aimed to explore the separate and combined anti-hyperlipidemic effect of Shatianyu (Citrus grandis L. Osbeck) flavonoids (SPFEs) and DF (SPDF) on HFD-fed mice. The results showed that SPFEs and SPDF were more effective together than separately in improving serum lipid profiles and decreasing hepatic lipid accumulation. The study also found that butyrate, which has been previously proven to have an anti-hyperlipidemic effect, was negatively correlated with serum/liver lipid but positively correlated with fecal total bile acids levels. SPDF + SPFEs had the most fecal butyrate in this study. Additionally, SPDF or SPFEs enriched microbiota related to acetic and propionic acids production, while SPDF + SPFEs also bloomed norank_f_Muribaculaceae, Dubosiella, Lachnoclostridium, and norank_f_Eubacterium_coprostanoligenes_group, which were positively correlated to fecal butyrate contents.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Fisheries
Ashild Krogdahl, Elvis M. Chikwati, Aleksei Krasnov, Anusha Dhanasiri, Gerd M. Berge, Violetta Aru, Bekzod Khakimov, Soren Balling Engelsen, Hilde Vinje, Trond M. Kortner
Summary: This study aimed to investigate whether increased fishmeal levels and supplementation with choline, beta-glucan, and nucleotides could reduce the symptoms of steatosis and inflammation in Atlantic salmon fed plant rich diets. The results showed that increasing fishmeal levels and supplementation reduced steatosis but had no effect on inflammation. Choline level appeared to be related to these effects. The study also found that increasing fishmeal levels increased microbial richness and diversity in the gut, but only for unsupplemented diets. An average choline requirement of 3.5 g/kg was indicated for Atlantic salmon in the present life stage and condition.
AQUACULTURE NUTRITION
(2023)
Article
Multidisciplinary Sciences
Yuki Maruyama, Yuichiro Nishimoto, Kouta Umezawa, Ryosuke Kawamata, Yuko Ichiba, Kota Tsutsumi, Mitsuo Kimura, Shinnosuke Murakami, Yasushi Kakizawa, Takashi Kumagai, Takuji Yamada, Shinji Fukuda
Summary: Saliva contains a wealth of biological information, but collecting saliva is time-consuming. This study found that mouth-rinsed water can be used as an alternative to saliva in oral metabolome analysis, as they have similar types and amounts of metabolites.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Ryan W. Stidham, Deahan Yu, Xinyan Zhao, Shrinivas Bishu, Michael Rice, Charlie Bourque, Vinod V. G. Vydiswaran
Summary: This study developed a natural language processing (NLP) system to identify the presence and status of extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD) patients using clinical notes. The results showed that NLP methods can accurately detect and infer the activity status of EIMs, offering exciting possibilities for population-based research and decision support in IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Oncology
Akimasa Kure, Tomoya Tsukimi, Chiharu Ishii, Wanping Aw, Nozomu Obana, Gaku Nakato, Akiyoshi Hirayama, Haruna Kawano, Toshiyuki China, Fumitaka Shimizu, Masayoshi Nagata, Shinji Isotani, Satoru Muto, Shigeo Horie, Shinji Fukuda
Summary: This study found that androgen deprivation therapy (ADT) leads to detrimental changes in gut microbiota in patients with prostate cancer, potentially increasing their frailty and risk of adverse outcomes.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Cell Biology
Kohei Sugihara, Sho Kitamoto, Prakaimuk Saraithong, Hiroko Nagao-Kitamoto, Matthew Hoostal, Caroline McCarthy, Alexandra Rosevelt, Chithra K. Muraleedharan, Merritt G. Gillilland, Jin Imai, Maiko Omi, Shrinivas Bishu, John Y. Kao, Christopher J. Alteri, Nicolas Barnich, Thomas M. Schmidt, Asma Nusrat, Naohiro Inohara, Jonathan L. Golob, Nobuhiko Kamada
Summary: Pathobiont AIEC can overcome dietary L-serine restriction and adapt to the gut by switching nutrient sources with the help of mucolytic bacteria, promoting the encroachment to the epithelial niche and acquiring L-serine from the colonic epithelium for proliferation.
Article
Endocrinology & Metabolism
Dante Picchioni, Kathleen C. Schmidt, Inna Loutaev, Adriana J. Pavletic, Carrie Sheeler, Shrinivas Bishu, Thomas J. Balkin, Carolyn B. Smith
Summary: During sleep, protein synthesis is active in N1 and N2 stages, while similar to sleep-deprived awake state in N3 stage.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Health Care Sciences & Services
Katsuma Miyaho, Kenji Sanada, Shunya Kurokawa, Arisa Tanaka, Tomoyuki Tachibana, Chiharu Ishii, Yoshihiro Noda, Shinichiro Nakajima, Shinji Fukuda, Masaru Mimura, Taishiro Kishimoto, Akira Iwanami
Summary: This study aimed to investigate the impact of aging on the relationship among gut microbiota composition, gastrointestinal symptoms, and treatment course for MDD. The findings revealed that several gut microbes had higher relative abundances in the late-life group, along with higher diversity in the Chao1 index at baseline, compared to the middle-aged group. Additionally, possible microbial taxa related to GI symptoms in late-life depression were identified.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Elliot M. Berinstein, Jessica L. Sheehan, Janson Jacob, Calen A. Steiner, Ryan W. Stidham, Carol Shannon, Shrinivas Bishu, Jacob Levine, Shirley A. Cohen-Mekelburg, Akbar K. Waljee, Peter D. R. Higgins, Jeffrey A. Berinstein
Summary: Dual targeted therapy is a promising approach for improving the treatment of inflammatory bowel disease in patients who do not respond well to targeted monotherapy. However, more research is needed to confirm its effectiveness and identify the patients who would benefit the most from this treatment.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Microbiology
Rika Tanaka, Jin Imai, Hitoshi Tsugawa, Karl Bil Eap, Masaki Yazawa, Motoki Kaneko, Masashi Ohno, Kohei Sugihara, Sho Kitamoto, Hiroko Nagao-Kitamoto, Nicolas Barnich, Masashi Matsushima, Takayoshi Suzuki, Tatehiro Kagawa, Yasuhiro Nishizaki, Hidekazu Suzuki, Nobuhiko Kamada, Katsuto Hozumi
Summary: This study found that specific IgA produced by host immunity can recognize and restrict adherent-invasive E. coli (AIEC), a pathogen associated with Crohn's disease, from invading the colonic epithelium. This finding contributes to our understanding of the host immune response to AIEC and provides new insights for the treatment of Crohn's disease.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuxin Wang, Tatsuya Morishima, Maiko Sezaki, Ryo Sato, Gaku Nakato, Shinji Fukuda, Kouji Kobiyama, Ken J. Ishii, Yuhua Li, Hitoshi Takizawa
Summary: Bacterial infections can activate hematopoietic stem and progenitor cells to migrate from the bone marrow to the spleen, a process known as extramedullary hematopoiesis. Recent studies have shown that gut commensal bacteria not only regulate the host immune system, but also hematopoietic homeostasis. This study reveals that Akkermansia muciniphila, a mucin-degrading bacterium, can rapidly activate bone marrow myelopoiesis and induce delayed extramedullary hematopoiesis through the MYD88/TRIF innate immune signaling pathway.
Review
Immunology
Sho Kitamoto, Nobuhiko Kamada
Summary: This article provides an overview of the causal relationship between periodontal disease and intestinal inflammation, emphasizing the systemic interactions between the oral cavity and the gut. Research has shown that potentially harmful oral resident bacteria and immune cells can migrate to the gastrointestinal tract, thereby aggravating intestinal inflammation.
INFLAMMATION AND REGENERATION
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Jake Levine, Jey McKibbin, Rebecca Ham, Peter Higgins, Shrinivas Bishu, Jeffrey Berinstein
Review
Immunology
Yeji Kim, Nobuhiko Kamada
Summary: The microbiota plays a crucial role in the development and maintenance of the host immune system. It not only affects the local mucosal tissues but also influences distal organs. The microbiota-derived signals directly or indirectly regulate the generation of myeloid cells in the bone marrow, both in steady-state conditions and during inflammation. Understanding the relationship between the microbiota and myelopoiesis helps us comprehend how the microbiota regulates immune responses beyond the local mucosa at a systemic level.
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Microbiology
Kota Oshibuchi, Jiayue Yang, Nozomu Obana, Shinji Fukuda, Kazuharu Arakawa
Summary: In this study, the complete genome sequence of Solobacterium moorei JCM 10645(T), a Gram-positive bacterium associated with sepsis, bacteremia, halitosis, and periodontal disease, was reported.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Gastroenterology & Hepatology
Yoshimi Yukawa-Muto, Tomonori Kamiya, Hideki Fujii, Hiroshi Mori, Atsushi Toyoda, Ikuya Sato, Yusuke Konishi, Akiyoshi Hirayama, Eiji Hara, Shinji Fukuda, Norifumi Kawada, Naoko Ohtani
Summary: This study identified specific gut bacterial species abundant in patients with HE and verified their functions linked to HE pathophysiology. Targeting these bacteria could be a potentially effective strategy to treat HE.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Yongshou Yang, Thanutchaporn Kumrungsee, Norihisa Kato, Shinji Fukuda, Manabu Kuroda, Shotaro Yamaguchi
Summary: This study investigates the effects of Aspergillus-derived cellulase on the gut microbiota of rats fed a high-fat diet. The results demonstrate that cellulase can significantly increase the abundance of Bifidobacterium and Lactobacillus, showing prebiotic-like effects.
FERMENTATION-BASEL
(2022)