Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens

Investigation of (S)-(–)-acidomycin: A selective antimycobacterial natural product that inhibits biotin synthase

(2019) Matthew R Bockman et al.   ACS Infectious Diseases

Targeting protein biotinylation enhances tuberculosis chemotherapy

(2018) Divya Tiwari et al.   Science Translational Medicine

Enterotoxigenic E. coli virulence gene regulation in human infections

(2018) Alexander A. Crofts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a novel class of small compounds with anti-tuberculosis activity by in silico structure-based drug screening

(2017) Junichi Taira et al.   JOURNAL OF ANTIBIOTICS

Structure-Based Optimization of Pyridoxal 5′-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis

(2017) Feng Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Serum biotin in Japanese children: Enzyme-linked immunosorbent assay measurement

(2016) Kenji Wakabayashi et al.   PEDIATRICS INTERNATIONAL

Analysis of Two Complementary Single-Gene Deletion Mutant Libraries of Salmonella Typhimurium in Intraperitoneal Infection of BALB/c Mice

(2016) Cecilia A. Silva-Valenzuela et al.   Frontiers in Microbiology

Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis

(2015) Sae Woong Park et al.   CHEMISTRY & BIOLOGY

Resources for Genetic and Genomic Analysis of Emerging Pathogen Acinetobacter baumannii

(2015) Larry A. Gallagher et al.   JOURNAL OF BACTERIOLOGY

Genome-Wide Identification of Klebsiella pneumoniae Fitness Genes during Lung Infection

(2015) Michael A. Bachman et al.   mBio

Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection

(2015) Sargurunathan Subashchandrabose et al.   mSphere

Inhibition ofMycobacterium tuberculosisTransaminase BioA by Aryl Hydrazines and Hydrazides

(2014) Ran Dai et al.   CHEMBIOCHEM

Pregnancy and Lactation Alter Biomarkers of Biotin Metabolism in Women Consuming a Controlled Diet

(2014) Cydne A Perry et al.   JOURNAL OF NUTRITION

Genes Contributing to Staphylococcus aureus Fitness in Abscess- and Infection-Related Ecologies

(2014) M. D. Valentino et al.   mBio

Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation

(2013) Soumaya Zlitni et al.   Nature Chemical Biology

Genome-Wide Detection of Fitness Genes in Uropathogenic Escherichia coli during Systemic Infection

(2013) Sargurunathan Subashchandrabose et al.   PLoS Pathogens

A Comprehensive Analysis of In Vitro and In Vivo Genetic Fitness of Pseudomonas aeruginosa Using High-Throughput Sequencing of Transposon Libraries

(2013) David Skurnik et al.   PLoS Pathogens

A microplate fluorescence assay for DAPA aminotransferase by detection of the vicinal diamine 7,8-diaminopelargonic acid

(2012) Stéphane Mann et al.   ANALYTICAL BIOCHEMISTRY

Sequence-Verified Two-Allele Transposon Mutant Library for Pseudomonas aeruginosa PAO1

(2012) Kiara Held et al.   JOURNAL OF BACTERIOLOGY

The BioCO-Methyltransferase Catalyzes Methyl Esterification of Malonyl-Acyl Carrier Protein, an Essential Step in Biotin Synthesis

(2012) Steven Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OrtholugeDB: a bacterial and archaeal orthology resource for improved comparative genomic analysis

(2012) Matthew D. Whiteside et al.   NUCLEIC ACIDS RESEARCH

Link between intraphagosomal biotin and rapid phagosomal escape in Francisella

(2012) B. A. Napier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Expression of Salmonella enterica Serotype Typhi Genes in the Blood of Patients with Typhoid Fever in Bangladesh

(2011) Alaullah Sheikh et al.   PLoS Neglected Tropical Diseases

Evaluating the Sensitivity of Mycobacterium tuberculosis to Biotin Deprivation Using Regulated Gene Expression

(2011) Sae Woong Park et al.   PLoS Pathogens

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Biotin synthesis begins by hijacking the fatty acid synthetic pathway

(2010) Steven Lin et al.   Nature Chemical Biology

Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

(2009) Nicolas Legrand et al.   Cell Host & Microbe